Age‐related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy
Abstract
Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by a progressive degeneration of the striatonigral, olivo‐ponto‐cerebellar, and autonomic systems. Glial cytoplasmic inclusions (GCIs) containing alpha‐synuclein represent the hallmark of MSA and are recapitulated in mice expressing alpha‐synuclein in oligodendrocytes. To assess if oligodendroglial expression of human wild‐type alpha‐synuclein in mice (proteolipid promoter, PLP‐SYN) could be associated with age‐related deficits, PLP‐SYN and wild‐type mice were assessed for motor function, brain morphometry, striatal levels of dopamine and metabolites, dopaminergic loss, and distribution of GCIs. PLP‐SYN displayed age‐related impairments on a beam‐traversing task. MRI revealed a significantly smaller brain volume in PLP‐SYN mice at 12 months, which further decreased at 18 months together with increased volume of ventricles and cortical atrophy. The distribution of GCIs was reminiscent of MSA with a high burden in the basal ganglia. Mild dopaminergic cell loss was associated with decreased dopamine turnover at 18 months. These data indicate that PLP‐SYN mice may recapitulate some of the progressive features of MSA and deliver endpoints for the evaluation of therapeutic strategies. Synapse 68:98–106, 2014. © 2013 Wiley Periodicals, Inc.
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Later studies using the same PLP promoter demonstrated subtle motor impairment and a 31.4% loss of nigral neurons.
“Later studies using the same PLP promoter demonstrated subtle motor impairment and a 31.4% loss of nigral neurons [16, 52].”
From Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates (2017) · cites this paper as [16]
Cites
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816 · see citing works
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · cited 1× · see citing works
“The estimated total number of neurons was calculated based on the following formula: N 5 RQ(2) 3 1/ssf 3 1/asf 3 t/h (West et al., 1991), where N is the estimate of the total number of cells, RQ(2) is the number of objects counted, ssf is the section sampling fraction, asf is the area sampling fraction, and t/h is the…”
MethodCarter, R. J., Lione, L. A., Humby, T., Mangiarini, L., Mahal, A., Bates, G. P., Dunnett, S. B., & Morton, A. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03248.1999 · Cited by 949 · see citing works
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308947200 · Cited by 913 · see citing works
McCormack, A. L., Thiruchelvam, M. J., Manning-Bog, A., Thiffault, C., Langston, J. W., Cory‐Slechta, D. A., & Monte, D. A. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838 · see citing works
Tests to assess motor phenotype in mice: a user's guide
Brooks, S. P., & Dunnett, S. B. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2652 · Cited by 668 · see citing works
Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes
Kahle, P. J., Neumann, M., Ozmen, L., Müller, V., Jacobsen, H., Spooren, W., Fuss, B., Mallon, B., Macklin, W. B., Fujiwara, H., et al. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf109 · Cited by 314 · see citing works
Yazawa, I., Giasson, B. I., Sasaki, R., Zhang, B., Joyce, S., Uryu, K., Trojanowski, J. Q., & Lee, V. M.-Y. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.032 · Cited by 301 · see citing works
Fearnley, J., & Lees, A. J. (1990) · Brain · doi:10.1093/brain/113.6.1823 · Cited by 297 · see citing works
Elsworth, J. D., & Roth, R. H. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6379 · Cited by 282 · see citing works
Shults, C. W., Rockenstein, E., Crews, L., Adame, A., Mante, M., Larrea, G., Hashimoto, M., Song, D., Iwatsubo, T., Tsuboi, K., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3527-05.2005 · Cited by 254 · see citing works
Stefanova, N., Reindl, M., Neumann, M., Kahle, P. J., Poewe, W. H., & Wenning, G. K. (2007) · Movement Disorders · doi:10.1002/mds.21671 · Cited by 217 · see citing works
Stefanova, N., Reindl, M., Neumann, M., Haass, C., Poewe, W., Kahle, P. J., & Wenning, G. K. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62307-3 · Cited by 208 · see citing works
p25α Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy
Song, Y. J. C., Lundvig, D. M. S., Huang, Y. M., Gai, W., Blumbergs, P. C., Højrup, P., Otzen, D. E., Halliday, G. M., & Jensen, P. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070201 · Cited by 201 · see citing works
Alpha-synuclein and transgenic mouse models
Fernagut, P., & Chesselet, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.001 · Cited by 199 · see citing works
Self-citationBehavioral phenotyping of mouse models of Parkinson's disease
Taylor, T. N., Greene, J. G., & Miller, G. W. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.004 · Cited by 198 · see citing works
Fernagut, P., Hutson, C. B., Fleming, S. M., Tetreaut, N. A., Salcedo, J. D., Masliah, E., & Chesselet, M.-F. (2007) · Synapse · doi:10.1002/syn.20456 · Cited by 196 · see citing works
Self-citationTillerson, J. L., Caudle, W. M., Reveron, M. E., & Miller, G. W. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8021 · Cited by 192 · see citing works
Microglial Activation Parallels System Degeneration in Multiple System Atrophy
Ishizawa, K., Komori, T., Sasaki, S., Arai, N., Mizutani, T., & Hirose, T. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.1.43 · Cited by 172 · see citing works
Voxel‐based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
Brenneis, C., Seppi, K., Schocke, M. F., Müller, J., Luginger, E., Bösch, S., Löscher, W. N., Büchel, C., Poewe, W., & Wenning, G. K. (2003) · Movement Disorders · doi:10.1002/mds.10502 · Cited by 167 · see citing works
Messina, D., Cerasa, A., Condino, F., Arabia, G., Novellino, F., Nicoletti, G., Salsone, M., Morelli, M., Lanza, P. L., & Quattrone, A. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.12.010 · Cited by 163 · see citing works
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
Fellner, L., Jellinger, K. A., Wenning, G. K., & Stefanova, N. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0833-z · Cited by 162 · see citing works
Ubhi, K., Rockenstein, E., Mante, M., Inglis, C., Adame, A., Patrick, C., Whitney, K., & Masliah, E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0567-10.2010 · Cited by 147 · see citing works
α-Synucleinopathy models and human neuropathology: similarities and differences
Kahle, P. J. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0302-x · Cited by 126 · see citing works
Kikuchi, A., Takeda, A., Okamura, N., Tashiro, M., Hasegawa, T., Furumoto, S., Kobayashi, M., Sugeno, N., Baba, T., Miki, Y., et al. (2010) · Brain · doi:10.1093/brain/awq091 · Cited by 113 · see citing works
Ahmed, Z., Asi, Y. T., Lees, A. J., Révész, T., & Holton, J. L. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00637.x · Cited by 92 · see citing works
Fernagut, P., Diguet, E., Bioulac, B. H., & Tison, F. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.09.014 · Cited by 67 · see citing works
Self-citationProgressive cerebral atrophy in multiple system atrophy
Konagaya, M., Konagaya, Y., Sakai, M., Matsuoka, Y., & Hashizume, Y. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00692-x · Cited by 52 · see citing works
Animal models of multiple system atrophy
Fernagut, P., & Tison, F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.044 · Cited by 37 · see citing works
Self-citationAlpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice.
Plaas, M., Karis, A., Innos, J., Rebane, E., Baekelandt, V., Vaarmann, A., Luuk, H., Vasar, E., & Kõks, S. (2008) · PubMed · Cited by 36 · see citing works
Diguet, E., Fernagut, P., Scherfler, C., Wenning, G. K., & Tison, F. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0206-z · Cited by 29 · see citing works
Self-citationFleming, S. M. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)89003-x · Cited by 25 · see citing works
Flagged first, then by citations
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Heras‐Garvin, A., Weckbecker, D., Ryazanov, S., Leonov, A., Griesinger, C., Giese, A., Wenning, G. K., & Stefanova, N. (2018) · Movement Disorders · doi:10.1002/mds.27562 · Cited by 120 · see citing works
“The PLP-hαSyn transgenic mouse model recapitulates most of the clinical and pathophysiological features of MSA by overexpressing human α-syn under the oligodendrocyte PLP (myelin proteolipid protein) promoter, which leads to GCI formation, microglial activation, and selective neurodegeneration.(6-16) Microglial activa…”
BackgroundBassil, F., Fernagut, P., Bézard, E., Pruvost, A., Lesté-Lasserre, T., Hoang, Q. Q., Ringe, D., Petsko, G. A., & Meissner, W. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609291113 · Cited by 113 · see citing works
“Some studies have shown that C-terminally truncated α-syn is found in GCIs in MSA (48, 49) as well as in Lewy bodies of PD and DLB patient brains (11, 12, 39, 50, 51).”
BackgroundMethodInfluentialSelf-citationInsulin resistance and exendin-4 treatment for multiple system atrophy
Bassil, F., Canron, M., Vital, A., Bézard, E., Li, Y., Greig, N. H., Gulyani, S., Kapogiannis, D., Fernagut, P., & Meissner, W. G. (2017) · Brain · doi:10.1093/brain/awx044 · Cited by 108 · see citing works
Self-citationReduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction
Yu, Z., Shi, M. Y., Stewart, T., Fernagut, P., Huang, Y. X. R., Tian, C., Dehay, B., Atik, A., Yang, D., Giorgi, F. D., et al. (2020) · Brain · doi:10.1093/brain/awaa110 · Cited by 108 · see citing works
“progressive nigral and striatal degeneration) has been observed in these mice (Fernagut et al., 2014; Refolo et al., 2018).”
BackgroundSelf-citationTranscription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Arotçarena, M.-L., Bourdenx, M., Dutheil, N., Thiolat, M.-L., Doudnikoff, É., Doveró, S., Ballabio, A., Fernagut, P., Meissner, W. G., Bézard, E., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129719 · Cited by 82 · see citing works
Self-citationOligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy
Hoffmann, A., Ettle, B., Battis, K., Reiprich, S., Schlachetzki, J. C. M., Masliah, E., Wegner, M., Kuhlmann, T., Riemenschneider, M. J., & Winkler, J. (2019) · Brain Pathology · doi:10.1111/bpa.12678 · Cited by 83 · see citing works
“Although PLP-hα-syn mice show oligodendroglial α-syn inclusions, there is no myelin deficit and a later onset of functional deficits in comparison to MBP29-hα-syn mice (21, 43).”
BackgroundRefolo, V., Bez, F., Polissidis, A., Kuzdas-Wood, D., Sturm, E., Kamaratou, M., Poewe, W., Stefanis, L., Angela Cenci, M., Romero-Ramos, M., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0504-y · Cited by 67 · see citing works
“Abbreviations: ci, capsula interna; SNc, substantia nigra pars compacta; SNr, substantia nigra pars reticulata; pn, pontine nuclei; gl, granular layer; ml, molecular layer; cwm, cerebellar white matter; io, inferior olives.”
BackgroundResultInfluentialFerrer, I. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.07.004 · Cited by 62 · see citing works
“Mice lacking CNP show early axonal damage and disruption of the paranodal architecture, followed by axonal degeneration and myelin damage (Lappe-Siefke et al., 2003; Rasband et al., 2005; Edgar et al., 2009).”
BackgroundInfluentialMandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J., & Kordower, J. H. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0451-7 · Cited by 56 · see citing works
Viral‐mediated oligodendroglial alpha‐synuclein expression models multiple system atrophy
Bassil, F., Guerin, P. A., Dutheil, N., Li, Q., Klugmann, M., Meissner, W. G., Bézard, E., & Fernagut, P. (2017) · Movement Disorders · doi:10.1002/mds.27041 · Cited by 48 · see citing works
Self-citationTargeting α‐synuclein: Therapeutic options
Dehay, B., Decressac, M., Bourdenx, M., Guadagnino, I., Fernagut, P., Tamburrino, A., Bassil, F., Meissner, W. G., & Bézard, E. (2016) · Movement Disorders · doi:10.1002/mds.26568 · Cited by 40 · see citing works
Self-citationLemos, M., Venezia, S., Refolo, V., Heras‐Garvin, A., Schmidhuber, S. M., Giese, A., Leonov, A., Ryazanov, S., Griesinger, C., Galabova, G., et al. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00217-y · Cited by 38 · see citing works
Kallab, M., Herrera-Vaquero, M., Johannesson, M., Eriksson, F., Sigvardson, J., Poewe, W. H., Wenning, G. K., Nordström, E. K. L., & Stefanova, N. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00452 · Cited by 34 · see citing works
Arcuri, L., Viaro, R., Bido, S., Longo, F., Calcagno, M., Fernagut, P., Zaveri, N. T., Calò, G., Bézard, E., & Morari, M. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.016 · Cited by 27 · see citing works
Self-citationATH434 Reduces α‐Synuclein‐Related Neurodegeneration in a Murine Model of Multiple System Atrophy
Heras‐Garvin, A., Refolo, V., Schmidt, C., Malfertheiner, K., Wenning, G. K., BRADBURY, M. J., Stamler, D. A., & Stefanova, N. (2021) · Movement Disorders · doi:10.1002/mds.28714 · Cited by 27 · see citing works
Marmion, D. J., Rutkowski, A., Chatterjee, D., Hiller, B. M., Werner, M. H., Bézard, E., Kirik, D., McCown, T. J., Gray, S. J., & Kordower, J. H. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105184 · Cited by 26 · see citing works
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Teil, M., Doveró, S., Bourdenx, M., Arotçarena, M.-L., Camus, S. M. J., Porras, G., Thiolat, M.-L., Trigo‐Damas, I., Perier, C., Estrada, C. M., et al. (2021) · Brain · doi:10.1093/brain/awab374 · Cited by 26 · see citing works
“8,48,49 Also, another recent study where preformed fibrils of a -syn were injected in both young and old wild-type C57Bl6/J mice showed the presence of oligodendroglial a -syn aggregates starting at 12–18months.”
Self-citationLaferrière, F., He, X., Zinghirino, F., Doudnikoff, É., Faggiani, E., Meissner, W. G., Bézard, E., Giorgi, F. D., & Ichas, F. (2020) · Cells · doi:10.3390/cells9112371 · Cited by 21 · see citing works
“The absence of fibrillar α-syn amyloid species in the brain of the PLP-αSyn mice seems to be in line with the notion put forward by certain authors that the clinical manifestations seen in these animals are “mild” [24,25] compared to MSA.”
BackgroundResultSelf-citationTherapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy
Shukla, J. J., Stefanova, N., Bush, A. I., McColl, G., Finkelstein, D. I., & McAllum, E. J. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105509 · Cited by 20 · see citing works
“Multiple system atrophy: experimental models and reality”.
Overk, C., Rockenstein, E., Valera, E., Stefanova, N., Wenning, G., & Masliah, E. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1772-0 · Cited by 22 · see citing works
“Only mild motor changes in mice after 12 months of age [33, 126] were found.”
BackgroundHeras‐Garvin, A., Refolo, V., Reindl, M., Wenning, G. K., & Stefanova, N. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1714-y · Cited by 20 · see citing works
Animal modeling an oligodendrogliopathy – multiple system atrophy
Bleasel, J. M., Halliday, G. M., & Kim, W. S. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0279-6 · Cited by 19 · see citing works
“A more recent study [54] reported widespread α-synuclein pathology with distribution analysis revealing the highest burden in the globus pallidus.”
BackgroundCaspase-1 clipping causes complications for α-synuclein
Nuber, S., & Selkoe, D. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610993113 · Cited by 15 · see citing works
In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells
Abati, E., Fonzo, A. D., & Corti, S. P. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13563 · Cited by 14 · see citing works
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
Cuina, M. L., Guerin, P. A., Canron, M., Delamarre, A., Dehay, B., Bézard, E., Meissner, W. G., & Fernagut, P. (2020) · Movement Disorders · doi:10.1002/mds.28034 · Cited by 14 · see citing works
“PLP-SYN mice classically show about 30%–40% loss of TH-positive neurons in the SNc.(18,20,21) A 1-way FIG.”
BackgroundMethodInfluentialSelf-citationMarmion, D. J., Peelaerts, W., & Kordower, J. H. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02419-8 · Cited by 13 · see citing works
“Despite the formation of GCIs, oligodendroglial dysfunction was not observed, supported by the lack of demyelination or oligodendrocyte loss (Stefanova et al. 2005, 2007; Fernagut et al. 2014).”
BackgroundTranslational therapies for multiple system atrophy: Bottlenecks and future directions
Stefanova, N. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.09.016 · Cited by 12 · see citing works
“…et al., 2005;Stefanova et al., 2007;Krismer et al., 2013;Boudes et al., 2013;Kuzdas et al., 2013;Stefanova et al., 2013;Flabeau et al., 2014;Fernagut et al., 2014;Bassil et al., 2017b;Mandel et al., 2017;Hartner et al., 2016;Stefanova et al., 2014) AC CE PT ED M AN US CR IPT improvement…”
Pathological and Molecular Insights into the Early Stage of Multiple System Atrophy
Tanaka, M. T., Miki, Y., Kon, T., Mori, F., & Wakabayashi, K. (2025) · Cells · doi:10.3390/cells14241966 · Cited by 5 · see citing works
Oligodendrocytes, the Forgotten Target of Gene Therapy
Ozgür-Gunes, Y., Stunff, C. L., & Bougneres, P. F. (2024) · Cells · doi:10.3390/cells13231973 · Cited by 4 · see citing works
Modeling synucleinopathies in rodents
Janer, A. B., Vonck, E., & Baekelandt, V. (2021) · International review of movement disorders · doi:10.1016/bs.irmvd.2021.09.001 · Cited by 3 · see citing works
Glial Cells as Key Orchestrators of Neural Degeneration in Basal Ganglia Disorders
Bhaduri, B., & Alladi, P. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_15 · Cited by 2 · see citing works
Kermorgant, M., Fernagut, P., Meissner, W. G., Arvanitis, D. N., N’Guyen, D., Sénard, J., & Traon, A. P. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.874155 · Cited by 1 · see citing works
“PLP-α-syn mice have been shown to recapitulate several features of MSA such as motor dysfunction/parkinsonism (17, 18), respiratory dysfunction (20) and dysautonomia (21).”
BackgroundSelf-citationRADIOSENSITIVITY OF SOME PHAGES OF S. MARCESCENS AND E. COLI.
Janovská, E., Koudelka, J., & Kleinwächter, V. (1964) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
- Authors
- Fernagut, P. O., Meissner, W. G., Biran, M., Fantin, M., Bassil, F., Franconi, J. M., & Tison, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Corresponding author
- Fernagut, P.O.
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 2013-11-15
- Volume
- 68
- Issue
- 3
- Pages
- 98-106
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W2144139165
- Cited by
- 35
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 7 · 2017: 5 · 2016: 5
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- multiple system atrophy, alpha-synuclein, glial cytoplasmic inclusions, dopaminergic neuron loss, dopamine turnover, striatum, brain atrophy, ventriculomegaly, basal ganglia, neurodegeneration, mouse model
- MeSH terms
- Age Factors, Animals, Atrophy, Brain, Cerebral Ventricles, Corpus Striatum, Dopamine, Humans, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Movement Disorders, Neuroglia, Organ Size, Cell Death, Multiple System Atrophy, Mice, alpha-Synuclein
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