Patterns of brain atrophy in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy
Abstract
Background and purpose Quantitative analysis of brain atrophy may be useful in differentiating Parkinson's Disease (PD) from Progressive Supranuclear Palsy (PSP) and parkinsonian variant of Multiple System Atrophy (MSA-P); the aim of this study was to identify the volumetric differences of subcortical structures in patients with PD, PSP and MSA-P using a novel and validated fully-automated whole brain segmentation method. Methods Volumetric MRIs were obtained in 72 patients with PD, 32 patients with PSP, 15 patients with MSA-P, and in 46 control subjects. Subcortical volume was measured automatically by FreeSurfer. Multivariate analysis of covariance, adjusted for intracranial volume (ICV), sex and age, was used to explore group differences. Results No volumetric differences were found between PD and controls group; otherwise the volumes of the cerebellum, the thalamus, the putamen, the pallidum, the hippocampus, and the brainstem were significantly reduced in PSP and MSA-P compared to patients with PD and control subjects. PSP and MSA-P patients only differed in thalamus volume which was smaller in PSP group (p Conclusions Volumetric data obtained with automated segmentation of cerebral regions show a significant atrophy of different brain structures in parkinsonisms rather than in PD. Our study also demonstrates that the atrophy of the thalamus only occurs in PSP while the enlargement of the whole ventricular system characterizes both PSP and MSA-P.
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An extensive body of literature has relied on Freesurfer segmentations.
“At present, an important body of literature and neuropsychiatry findings are based on Freesurfer segmentations (Kikinis et al., 2010; Rohrer2011; Messina et al., 2011; Sabuncu et al., 2011).”
From A comparison of Freesurfer and multi-atlas MUSE for brain anatomy segmentation: Findings about size and age bias, and inter-scanner stability in multi-site aging studies (2020) · cites this paper as Messina et al., 2011
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- Authors
- Messina, D., Cerasa, A., Condino, F., Arabia, G., Novellino, F., Nicoletti, G., Salsone, M., Morelli, M., Lanza, P. L., & Quattrone, A.
- Affiliations
- Magna Graecia University (IT)
- Institute of Neurological Sciences (IT)
- National Research Council (IT)
- Corresponding author
- Quattrone, Aldo
- ORCID
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 17
- Issue
- 3
- Pages
- 172-176
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2034761873
- Cited by
- 163
- References
- 24
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 16 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 18 · 2012: 13
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- brain atrophy, Parkinson's disease
- MeSH terms
- Aged, Atrophy, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Supranuclear Palsy, Progressive, Case-Control Studies, Statistics, Nonparametric, Multiple System Atrophy
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