Targeting dementias through cancer kinases inhibition
Open accessAbstract
The failures in Alzheimer's disease (AD) therapy strongly suggest the importance of reconsidering the research strategies analyzing other mechanisms that may take place in AD as well as, in general, in other neurodegenerative dementias. Taking into account that in AD a variety of defects result in neurotransmitter activity and signaling efficiency imbalance, neuronal cell degeneration and defects in damage/repair systems, aberrant and abortive cell cycle, glial dysfunction, and neuroinflammation, a target may be represented by the intracellular signaling machinery provided by the kinome. In particular, based on the observations of a relationship between cancer and AD, we focused on cancer kinases for targeting neurodegeneration, highlighting the importance of targeting the intracellular pathways at the intersection between cell metabolism control/duplication, the inhibition of which may stop a progression in neurodegeneration.
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Saracatinib (AZD0530) is a tyrosine kinase inhibitor undergoing Phase II trials and has been demonstrated to improve memory in transgenic mice models of AD.
“The tyrosine kinase inhibitor saracatinib (AZD0530 (labeled as 14, Figure 5)) is undergoing Phase II trials [174,175,176] and has been demonstrated to improve memory in transgenic mice models of AD.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [174]
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Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56 · see citing works
“The tyrosine kinase inhibitor saracatinib (AZD0530 (labeled as 14 , Figure 5)) is undergoing Phase II trials [174–176] and has been demonstrated to improve memory in transgenic mice models of AD.”
BackgroundMasitinib for the Treatment of Alzheimer’s Disease
Ettcheto, M., Cano, A., Sanchez-López, E., Verdaguer, E., Folch, J., Auladell, C., & Camins, A. (2021) · Neurodegenerative Disease Management · doi:10.2217/nmt-2021-0019 · Cited by 28 · see citing works
- Authors
- Fagiani, F., Lanni, C., Racchi, M., & Govoni, S.
- Affiliations
- University of Pavia (IT)
- Corresponding author
- Lanni, Cristina
- Venue
- Alzheimer's & Dementia: Translational Research & Clinical Interventions
- Publisher
- Wiley
- Published
- 2020-01
- Volume
- 6
- Issue
- 1
- Pages
- e12044-e12044
- ISSN
- 2352-8737 (ISSN-L)
- PMC
- PMC7341824
- OpenAlex
- W3040958797
- Cited by
- 43
- References
- 66
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università degli Studi di Pavia
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, kinase inhibitors, neurodegeneration, kinome, cellular metabolism, cell cycle, neuroinflammation, glial dysfunction, neurotransmitter signaling, dementia
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