Cited by 43Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Targeting dementias through cancer kinases inhibition

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Fagiani, Francesca, Lanni, Cristina, Racchi, Marco, Govoni, Stefano·2020·Alzheimer's & Dementia: Translational Research & Clinical Interventions

Abstract

The failures in Alzheimer's disease (AD) therapy strongly suggest the importance of reconsidering the research strategies analyzing other mechanisms that may take place in AD as well as, in general, in other neurodegenerative dementias. Taking into account that in AD a variety of defects result in neurotransmitter activity and signaling efficiency imbalance, neuronal cell degeneration and defects in damage/repair systems, aberrant and abortive cell cycle, glial dysfunction, and neuroinflammation, a target may be represented by the intracellular signaling machinery provided by the kinome. In particular, based on the observations of a relationship between cancer and AD, we focused on cancer kinases for targeting neurodegeneration, highlighting the importance of targeting the intracellular pathways at the intersection between cell metabolism control/duplication, the inhibition of which may stop a progression in neurodegeneration.

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Crossref · 10.1002/trc2.12044

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  • Saracatinib (AZD0530) is a tyrosine kinase inhibitor undergoing Phase II trials and has been demonstrated to improve memory in transgenic mice models of AD.

    “The tyrosine kinase inhibitor saracatinib (AZD0530 (labeled as 14, Figure 5)) is undergoing Phase II trials [174,175,176] and has been demonstrated to improve memory in transgenic mice models of AD.”

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Authors
Fagiani, F., Lanni, C., Racchi, M., & Govoni, S.
Affiliations
University of Pavia (IT)
Corresponding author
Lanni, Cristina
Venue
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publisher
Wiley
Published
2020-01
Volume
6
Issue
1
Pages
e12044-e12044
ISSN
2352-8737 (ISSN-L)
OpenAlex
W3040958797
Cited by
43
References
66
Citations by year
2026: 2 · 2025: 5 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 1
FWCI
4.06
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Università degli Studi di Pavia
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, kinase inhibitors, neurodegeneration, kinome, cellular metabolism, cell cycle, neuroinflammation, glial dysfunction, neurotransmitter signaling, dementia

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