Worldwide prevalence and burden of gastroparesis‐like symptoms as defined by the United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis
Open accessAbstract
Background/Objectives: The global epidemiology of gastroparesis is unknown. The European UEG and European Society for Neurogastroenterology and motility consensus defines Gastroparesis as a condition characterized by delayed gastric emptying in the absence of mechanical obstruction, with a symptom pattern of nausea and/or vomiting and overlapping postprandial distress syndrome (PDS). Real‐world evidence of this gastroparesis‐like symptom pattern is a crucial step in understanding the epidemiology of gastroparesis. Methods: In the Rome Foundation Global Epidemiology Study, 54,127 respondents from 26 countries completed the Rome IV Diagnostic Questionnaire and variables associated with disorders of gut‐brain interaction via Internet. We selected subjects with gastroparesis‐like symptoms (GPLS) (nausea and/or vomiting ≥1 day/week and simultaneous PDS). Patients reporting organic gastrointestinal disease, or fulfilling criteria for self‐induced vomiting, cyclic vomiting or cannabinoid hyperemesis syndrome were excluded. We determined prevalence, associated comorbidities, quality of life (QoL) (PROMIS Global‐10), symptoms of anxiety and depression (PHQ‐4), somatic symptoms (PHQ‐12), and healthcare utilization. Results: The global prevalence of GPLS was 0.9% overall and 1.3% among diabetic individuals. Subjects with GPLS showed frequent overlapping of epigastric pain syndrome and irritable bowel syndrome. Subjects with GPLS had significantly lower body mass index, QoL, more non‐gastrointestinal somatic complaints, symptoms of anxiety and depression, higher medication usage and doctor visits in the overall and diabetic population, compared to subjects without these symptoms. Conclusions: GPLS are common worldwide and more common in diabetic patients. The symptom complex is associated with multiple aspects of illness and an increased healthcare consumption.
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Risk correlates for DGP include long disease duration, poor glycemic control, presence of other diabetic complications (especially peripheral and autonomic neuropathy), prior bariatric surgery, and female sex.
“Risk correlates include long disease duration [8, 11, 12], poor glycemic control [3, 13], presence of other diabetic complications (especially peripheral and autonomic neuropathy) [4, 13], prior bariatric surgery [14, 15], and female sex [16, 17]”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [11]
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- Authors
- Huang, I., Schol, J., Khatun, R., Carbone, F., Van den Houte, K., Colomier, E., Balsiger, L. M., Törnblom, H., Vanuytsel, T., Sundelin, E., Simrén, M., Palsson, O. S., Bangdiwala, S. I., Sperber, A. D., & Tack, J.
- Affiliations
- Tri-Service General Hospital (TW)
- KU Leuven (BE)
- Population Health Research Institute (CA)
- Universitair Ziekenhuis Leuven (BE)
- Translational Research Center for Gastrointestinal Disorders University of Leuven Leuven Belgium
- University of Gothenburg (SE)
- Aarhus University Hospital (DK)
- University of North Carolina at Chapel Hill (US)
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Tack, Jan
- ORCID
- Venue
- United European Gastroenterology Journal
- Publisher
- Wiley
- Published
- 2022-08-19
- Volume
- 10
- Issue
- 8
- Pages
- 888-897
- ISSN
- 2050-6406 (ISSN-L)
- 2050-6414
- PMC
- PMC9557951
- OpenAlex
- W4294007277
- Cited by
- 57
- References
- 24
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 16 · 2023: 15 · 2022: 3
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- United European Gastroenterology Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, cc-by-nc-nd)
- Funders
- Allergan
- Ironwood Pharmaceuticals, Incorporated
- Takeda Pharmaceutical Company
- Shire
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- delayed gastric emptying, postprandial distress syndrome, nausea and vomiting, prevalence, diabetes mellitus, quality of life, anxiety and depression, health care utilization, epigastric pain syndrome, irritable bowel syndrome, gut-brain axis
- MeSH terms
- Cannabinoids, Dyspepsia, Gastroenterology, Humans, Nausea, Quality of Life, Vomiting, Prevalence, Gastroparesis, Consensus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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