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Cited by 15Ultrasound in Clinical ApplicationsPregnancy and preeclampsia studiesUltrasound Imaging and Elastography

Inapplicability of fractional moving blood volume technique to standardize Virtual Organ Computer-aided AnaLysis indices for quantified three-dimensional power Doppler

Welsh, A. W., Collins, S. L., Stevenson, G. N., Noble, J. A., Impey, L.·2012·Ultrasound in Obstetrics & Gynecology
DOI 10.1002/uog.11139
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Abstract

OBJECTIVE: To determine whether the technique of fractional moving blood volume (FMBV) is applicable to Virtual Organ Computer-aided AnaLysis II (VOCAL II™)-based indices to quantify three-dimensional power Doppler ultrasound (3D-PDU) by investigating the effect of gain level on the indices measured at a possible reference point for standardization. METHODS: Ten women with singleton pregnancy between 33+3 and 37+5 weeks' gestation were recruited. The optimal position for 3D acquisition of cord insertion into the placenta was identified and static 3D-PDU volumes were acquired using consistent machine configurations. Without moving the probe or the participant changing position, successive 3D volumes were stored at -3, -5, -7 and -9 dB and at the individualized sub-noise gain (SNG) level. Volumes were excluded if flash artifact was present, in which case all five volumes were reacquired. Using 4D View software, the cord insertion was magnified and the smallest sphere possible was used to measure vascularization index (VI), flow index (FI) and vascularization flow index (VFI). The associations between VOCAL indices and gain level were assessed using Pearson's correlation coefficient. RESULTS: VOCAL indices for cord insertion correlated poorly with gain level, whether fundamental or relative to SNG level (R(2) = 0.07 and 0.04, respectively). VI was consistently 100% and mean FI and VFI were 99.5 (SD, 0.57), with all values > 97 irrespective of gain level. CONCLUSIONS: Whilst previous work has shown that gain correlates well with placental tissue VOCAL indices, the correlation between gain level and VOCAL indices in an area of 100% vascularity at the cord insertion is poor. Regions of 100% vascularity appear to be artificially assigned a value approaching 100% for all VOCAL indices irrespective of gain level. This precludes using the technique of VOCAL indices from large vessels to standardize power Doppler measurements and the FMBV index is therefore not applicable to image analysis using VOCAL.

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Authors
Welsh, A. W., Collins, S. L., Stevenson, G. N., Noble, J. A., & Impey, L.
Affiliations
  • Royal Hospital for Women (AU)
  • John Radcliffe Hospital (GB)
  • University of Oxford (GB)
Corresponding author
Welsh, A. W.
ORCID
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2012-11-29
Volume
40
Issue
6
Pages
688-692
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
DOI
10.1002/uog.11139
OpenAlex
W1507052179
Cited by
15
References
21
Citations by year
2024: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.34
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute for Health and Care Research
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Ultrasound in Clinical Applications
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
Keywords
fractional moving blood volume, virtual organ computer-aided analysis, three-dimensional power Doppler, placental cord insertion, vascularization index, flow index, vascularization flow index, measurement standardization, placental vascularization
MeSH terms
Adolescent, Adult, Blood Volume, Blood Volume Determination, Female, Humans, Image Processing, Computer-Assisted, Pregnancy, Pregnancy Trimester, Third, User-Computer Interface, Ultrasonography, Prenatal, Ultrasonography, Doppler, Placental Circulation, Imaging, Three-Dimensional, Young Adult

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