Cited by 97Congenital Heart Disease StudiesCardiovascular Conditions and TreatmentsCongenital heart defects research

Prenatal detection of transposition of the great arteries reduces mortality and morbidity

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van Velzen, C. L., Haak, M. C., Reijnders, G., Rijlaarsdam, M. E. B., Bax, C. J., Pajkrt, E., Hruda, J., Galindo‐Garre, F. +4 more·2015·Ultrasound in Obstetrics & Gynecology

Abstract

Objectives: To evaluate the prenatal detection of transposition of the great arteries ( TGA ), after the introduction of a Dutch screening program in 2007, as well as the effect of prenatal detection on pre‐ and postsurgical mortality and morbidity. Methods: In a geographical cohort study, all infants with TGA who were born between 1 January 2002 and 1 January 2012 were included. The cases were divided into two groups: those with and those without a prenatal diagnosis. Pre‐ and postsurgical mortality was assessed, with a follow‐up of 1 year. Presurgical morbidity was assessed in terms of cardiovascular compromise, metabolic acidosis, renal and/or hepatic dysfunction and closure of the duct before initiation of therapy. Results: Of all cases ( n = 144), 26.4% were diagnosed prenatally, with detection rates of 15.7% and 41.0% in the first and last 5 years of the study period, respectively. First‐year mortality was significantly lower in cases with a prenatal diagnosis of TGA than in those without (0.0% vs 11.4%, respectively). Presurgical mortality (4.9%) only occurred in undetected simple TGA cases. Closure of the duct before treatment, renal dysfunction and hypoxia occurred significantly more often in the group without a prenatal diagnosis. Conclusions: The prenatal detection rate of TGA has increased significantly since the introduction of the screening program in 2007. Prenatal diagnosis is an important factor that contributes to survival of the infant in the first postnatal year. Furthermore, some morbidity indicators were significantly higher in the group without a prenatal diagnosis. These results justify efforts to improve prenatal screening programs. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.

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Crossref · 10.1002/uog.14689

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Authors
van Velzen, C. L., Haak, M. C., Reijnders, G., Rijlaarsdam, M. E. B., Bax, C. J., Pajkrt, E., Hruda, J., Galindo‐Garre, F., Bilardo, C. M., de Groot, C. J. M., Blom, N. A., & Clur, S. A.
Affiliations
  • Department of Obstetrics and Gynecology VU University Medical Center Amsterdam The Netherlands
  • Leiden University Medical Center (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • University Medical Center Groningen (NL)
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2015-01-27
Volume
45
Issue
3
Pages
320-325
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
OpenAlex
W2008944385
Cited by
97
References
25
Citations by year
2026: 1 · 2025: 10 · 2024: 16 · 2023: 10 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5
FWCI
5.29
Type
journal article
Language
en
Open access
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
transposition of the great arteries, prenatal diagnosis, neonatal mortality, ductus arteriosus closure, renal dysfunction, hypoxia, metabolic acidosis, congenital heart disease
MeSH terms
Adult, Female, Follow-Up Studies, Humans, Infant, Infant Mortality, Infant, Newborn, Male, Mass Screening, Netherlands, Pregnancy, Transposition of Great Vessels, Ultrasonography, Prenatal

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