Prenatal detection of transposition of the great arteries reduces mortality and morbidity
Open accessAbstract
Objectives: To evaluate the prenatal detection of transposition of the great arteries ( TGA ), after the introduction of a Dutch screening program in 2007, as well as the effect of prenatal detection on pre‐ and postsurgical mortality and morbidity. Methods: In a geographical cohort study, all infants with TGA who were born between 1 January 2002 and 1 January 2012 were included. The cases were divided into two groups: those with and those without a prenatal diagnosis. Pre‐ and postsurgical mortality was assessed, with a follow‐up of 1 year. Presurgical morbidity was assessed in terms of cardiovascular compromise, metabolic acidosis, renal and/or hepatic dysfunction and closure of the duct before initiation of therapy. Results: Of all cases ( n = 144), 26.4% were diagnosed prenatally, with detection rates of 15.7% and 41.0% in the first and last 5 years of the study period, respectively. First‐year mortality was significantly lower in cases with a prenatal diagnosis of TGA than in those without (0.0% vs 11.4%, respectively). Presurgical mortality (4.9%) only occurred in undetected simple TGA cases. Closure of the duct before treatment, renal dysfunction and hypoxia occurred significantly more often in the group without a prenatal diagnosis. Conclusions: The prenatal detection rate of TGA has increased significantly since the introduction of the screening program in 2007. Prenatal diagnosis is an important factor that contributes to survival of the infant in the first postnatal year. Furthermore, some morbidity indicators were significantly higher in the group without a prenatal diagnosis. These results justify efforts to improve prenatal screening programs. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
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Does a prenatal diagnosis affect mortality and morbidity for neonatal arterial switch operation
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TRANSPOSIÇÃO DE GRANDES ARTÉRIAS
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Girdhar, A., & Ewer, A. K. (2023) · Critical Care Nursing Clinics of North America · doi:10.1016/j.cnc.2023.09.001
Prenatal transposition of great arteries diagnosis and management: a Chinese single-center study
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Villalaín, C., de la Parte, B., Montes, E. G., & Galindo, A. (2024) · Clínica e Investigación en Ginecología y Obstetricia · doi:10.1016/j.gine.2024.100991
Wang, A., Cummins, M., Flerlage, E., Toro-Salazar, O. H., Brimacombe, M. B., & Davey, B. (2024) · Pediatric Cardiology · doi:10.1007/s00246-024-03675-7
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Bravo‐Valenzuela, N. J., Nieblas, C. D. O., Giffoni, M. C., & Malho, A. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-87175-7_5
Newborn Pulse-Oximetry Screening
Kumar, H., Abbas, A., & Ewer, A. K. (2025) · Clinics in Perinatology · doi:10.1016/j.clp.2025.06.011
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- Authors
- van Velzen, C. L., Haak, M. C., Reijnders, G., Rijlaarsdam, M. E. B., Bax, C. J., Pajkrt, E., Hruda, J., Galindo‐Garre, F., Bilardo, C. M., de Groot, C. J. M., Blom, N. A., & Clur, S. A.
- Affiliations
- Department of Obstetrics and Gynecology VU University Medical Center Amsterdam The Netherlands
- Leiden University Medical Center (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- University Medical Center Groningen (NL)
- ORCID
- Venue
- Ultrasound in Obstetrics & Gynecology
- Publisher
- Wiley
- Published
- 2015-01-27
- Volume
- 45
- Issue
- 3
- Pages
- 320-325
- ISSN
- 0960-7692 (ISSN-L)
- 1469-0705
- OpenAlex
- W2008944385
- Cited by
- 97
- References
- 25
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 16 · 2023: 10 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Ultrasound in Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- transposition of the great arteries, prenatal diagnosis, neonatal mortality, ductus arteriosus closure, renal dysfunction, hypoxia, metabolic acidosis, congenital heart disease
- MeSH terms
- Adult, Female, Follow-Up Studies, Humans, Infant, Infant Mortality, Infant, Newborn, Male, Mass Screening, Netherlands, Pregnancy, Transposition of Great Vessels, Ultrasonography, Prenatal
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