Longitudinal changes in uterine, umbilical and fetal cerebral Doppler indices in late-onset small-for-gestational age fetuses
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Objectives: To determine the longitudinal trends and rates of conversion of normal to abnormal uterine (UtA), umbilical (UA) and middle cerebral artery (MCA) Doppler velocimetry throughout the third trimester in late‐onset small‐for‐gestational‐age (SGA) fetuses. Methods: UtA, UA and MCA Doppler velocimetry was serially performed in a cohort of singleton consecutive late‐onset SGA fetuses with normal Doppler values at diagnosis. The rate of conversion of normal to abnormal Doppler values was evaluated by survival analysis. Longitudinal trends were modeled by means of multilevel analysis. Results: A total of 616 scans were performed on 171 SGA fetuses. Mean gestational age at inclusion and at delivery was 34.1 (SD 1.6) and 38.7 (SD 1.7) weeks, respectively. The proportions of abnormal UtA (2.3 vs. 4.1%) and UA (2.3 vs. 2.9%) pulsatility index (PI) were not significantly different between 37 weeks and before delivery. On the other hand, the proportions of abnormal MCA‐PI (4.1 vs. 13.5%) and cerebroplacental ratio (CPR) (7 vs. 22.8%) were significantly different between these two examinations. The remaining proportion of cases with normal UtA‐, UA‐ and MCA‐PIs and CPR at 40 weeks were 98.6, 94.5, 85 and 49.6%, respectively. Whereas a slight increasing trend was observed for the UtA‐PI (β = 0.002) and UA‐PI (β = 0.01), MCA‐PI (β = 0.044) and CPR (β = 0.124) showed a progressive decrease until delivery. Conclusions: Late‐onset SGA fetuses with normal Doppler velocimetry upon diagnosis show progression from 37 weeks' gestation with worsening CPR followed by a decrease in MCA‐PI. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
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Evidence suggests that umbilical artery Doppler does not reliably predict adverse pregnancy outcome in late-onset FGR.
“Evidence suggests that umbilical artery Doppler does not reliably predict adverse pregnancy outcome in late-onset FGR.101”
From Society for Maternal-Fetal Medicine Consult Series #52: Diagnosis and management of fetal growth restriction (2020) · cites this paper as [101]
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- Authors
- Oros, D., Figueras, F., Cruz‐Martinez, R., Meler, E., Munmany, M., & Gratacos, E.
- Affiliations
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Corresponding author
- Figueras, F.
- Venue
- Ultrasound in Obstetrics & Gynecology
- Publisher
- Wiley
- Published
- 2011-01-24
- Volume
- 37
- Issue
- 2
- Pages
- 191-195
- ISSN
- 0960-7692 (ISSN-L)
- 1469-0705
- OpenAlex
- W2056522417
- Semantic Scholar
- 86307adf461206fec87e0a05210711a57284f6f4
- Cited by
- 256
- References
- 37
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 20 · 2023: 14 · 2022: 24 · 2021: 26 · 2020: 12 · 2019: 14 · 2018: 26 · 2017: 11 · 2016: 19 · 2015: 16 · 2014: 20 · 2013: 14 · 2012: 9
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Ultrasound in Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cerebra
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- uterine artery Doppler, umbilical artery Doppler, middle cerebral artery Doppler, pulsatility index, cerebroplacental ratio, fetal growth restriction, third trimester, fetal hemodynamics
- MeSH terms
- Blood Flow Velocity, Female, Fetal Growth Retardation, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age, Placenta, Pregnancy, Pregnancy Trimester, Third, Prospective Studies, Umbilical Arteries, Ultrasonography, Prenatal, Middle Cerebral Artery
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