A therapeutic application of the experience sampling method in the treatment of depression: a randomized controlled trial

Kramer, Ingrid, Simons, Claudia J.P., Hartmann, Jessica A., Menne-Lothmann, Claudia, Viechtbauer, Wolfgang, Peeters, Frenk, Schruers, Koen, van Bemmel, Alex L. +4 more·2014·World Psychiatry
DOI 10.1002/wps.20090

Cited by (306)

Items 201–300 of 306

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  2. Feasibility of a novel blended-care intervention for fatigue after acquired brain injury: a pilot study of the Tied by Tiredness intervention
    Ela Lazeron-Savu, Bert Lenaert, Jeanette B. Dijkstra, Rudolf Ponds, Caroline M Van Heugten · 2024 · Brain Injury
  3. The Effect of the Virtual Reality–Based Biofeedback Intervention DEEP on Stress, Emotional Tension, and Anger in Forensic Psychiatric Inpatients: Mixed Methods Single-Case Experimental Design
    Lisa Klein Haneveld, Tessa Dekkers, Yvonne H. A. Bouman, Hanneke Scholten, Joanneke Weerdmeester, Saskia M. Kelders, Hanneke Kip · 2025 · JMIR Formative Research
  4. Transdiagnostic Psychopathology in a Help-Seeking Population of an Early Recognition Center for Mental Disorders: Protocol for an Experience Sampling Study
    Marlene Rosen, Linda T. Betz, Christian Montag, Christopher Kannen, Joseph P. Kambeitz · 2022 · JMIR Research Protocols
  5. From a Sensorimotor Account of Perception to an Interactive Approach to Psychopathology
    Erik Myin, John Kevin O'Regan, Inez Myin‐Germeys · 2015 · The MIT Press eBooks
  6. A Pre-Post Design for Testing Insight from Personalized Feedback about Positive Affect in Contexts
    IJsbrand Leertouwer, Jeroen Kornelis Vermunt, Noémi Katalin Schuurman · 2022
  7. Let sleeping dogs lie? How to deal with the night gap problem in ESM data
    Sophie Wilhelmina Berkhout, Noémi Katalin Schuurman, Ellen L. Hamaker · 2024
  8. Smartphone-Based Mindfulness and Mentalization Ecological Momentary Interventions for Common Mental Health Problems: Pilot Randomized Controlled Trial
    Ciarán O’Driscoll, Sarah O'Reilly, Agata Julita Jaremba, Tobias Nolte, Madiha Shaikh · 2025 · JMIR Mental Health
  9. Developing a qualitative and quantitative ambulatory assessment-based feedback system within cognitive behavioural interventions for people with persecutory beliefs
    L. Bringmann, E. Tolmeijer, Maarten Piot, M. Mestdagh, S. Verdonck, Gert Stulp, F. Waite, Louise Isham, Anton B. P. Staring, Daniel Freeman et al. · 2025 · Internet Interventions
  10. Can experience sampling self-monitoring tools promote the activation of clients in mental healthcare? A qualitative study
    Lena de Thurah, Jeroen Dennis Merlijn Weermeijer, Lotte Uyttebroek, Martien Wampers, Rafaël Bonnier, Inez Myin‐Germeys, Glenn Kiekens · 2025 · Journal of Mental Health
  11. Integrative Paradigms for Knowledge Discovery in Mental Health: Overcoming the Fragmentation of Knowledge Inherent in Disparate Theoretical Paradigms
    Janna Hastings, Rasmus Rosenberg Larsen · 2021 · Health informatics
  12. A Review of Explicit and Implicit Assumptions When Providing Personalized Feedback Based on EMA Data.
    IJsbrand Leertouwer, Angélique O. J. Cramer, Jeroen Kornelis Vermunt, Noémi Katalin Schuurman · 2021
  13. A smartphone-based intervention for young people who self-harm (‘PRIMARY’): study protocol for a multicenter randomized controlled trial
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  14. The use of Experience Sampling Method in psychopharmacological studies: A systematic review
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  15. Ecological momentary assessment in adolescents with type 1 diabetes: A mixed‐methods feasibility study
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  16. Behavioral Activation With Remote Technology for Emotional Distress Following Moderate-Severe Traumatic Brain Injury: Results of a Randomized Controlled Trial
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  17. Beyond RCTs—Better Research Designs and Methods for Psychosocial Efficacy Studies in Mental Health
    Tania Lecomte, Ian Matthew Raugh, Meryl Caiada, Mahesh Menon · 2026 · The Canadian Journal of Psychiatry
  18. Investigating the mobile messenger app-based intervention delivered by a therapeutic companion agent for young adults with depressive symptoms: A proof-of-concept and quasi-experimental study
    Youngjae Yoo, Minuk Kim, Soyoung Kim, Gayeon Lee, Jinwoo Kim · 2026 · Digital Health
  19. Effect of brief, personalized feedback derived from momentary data on the mental health of women with risk of common mental disorders in Hong Kong: A randomized clinical trial
    Yi Nam Suen, Jezreel Yeung Yau, Pui Sze Wong, Yee Kwan Li, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Wing Chung Chang, Eric Yu Hai Chen · 2022 · Psychiatry Research
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  21. Interventions in dynamic systems: A causal approach to continuous-time mediation analysis
    Oisín Ryan · 2018
  22. Validation of a brief measure of aggression for experience sampling research: The Aggression-ES-A
    Aja Louise Murray, Manuel Eisner, Denis Ribeaud, Tom Booth · 2019
  23. Lenferink et al. 2023. Fluctuations of prolonged grief disorder reactions. Preprint
    Lonneke I. M. Lenferink, E. Terbrack, Janske H. W. van Eersel, Marij Zuidersma, Minita Franzen, Harriëtte Riese · 2023
  24. Personalized exposure and experience sampling method feedback versus exposure as usual for obsessive–compulsive disorder: a study protocol for a randomized controlled trial
    Hoogerwerf, Elena, Greeven, Anja, Goekoop, Rutger, Spinhoven, Philip · 2024 · Trials
  25. The Experience Sampling Method in Small Fiber Neuropathy: The Influence of Psychosocial Factors on Pain Intensity and Physical Activity
    Aysun Damci, Janneke G. J. Hoeijmakers, Marlies den Hollander, Catharina Gerritdina Faber, Sophie F. Waardenburg, Charlotte C. M. van Laake‐Geelen, Albere J. A. Köke, Jeanine Verbunt · 2024 · Journal of Pain Research
  26. Methods for Studying Everyday Experience in Its Natural Context
    Harry T. Reis, Laura Sels, Shelly L. Gable · 2024 · Cambridge University Press eBooks
  27. Acceptability of a personalised single-session feedback intervention for eating disorders: a qualitative content analysis
    Laura Lapadat, Samantha Wilson, Lisa Yujia Zhu, Sarah Elizabeth Racine · 2025 · Journal of Eating Disorders
  28. Leveraging No-Code Digital Platforms for Designing an Integrated Smartphone-Based Ecological Momentary Intervention With Cognitive Behavioral Therapy for Mental Health Care: Development and Usability Study
    Stephanie Ming Yin Wong, Melody Ho Ching Ip, Jessica Kang Qi Lee, Terry Yat Sang Lum, Ralf Schwarzer · 2025 · JMIR Formative Research
  29. Requirements and Concerns of Individuals Remitted From Depression for an Early Relapse Detection mHealth App: Focus Group Study
    Tina Coenen, Matthias Maerevoet, Stephanie Chen, Mathias De Brouwer, Sofie Van Hoecke, Ernst H. W. Koster, Mariek Vanden Abeele, Klaas Bombeke · 2025 · JMIR mhealth and uhealth
  30. Rationale and description of Tied by Tiredness: A blended care intervention for fatigue after acquired brain injury
    Ela Lazeron-Savu, Tom Smejka, Bert Lenaert, Jeanette B. Dijkstra, Claire A. G. Wolfs, Vera P. M. Schepers, Rudolf Ponds, Caroline M Van Heugten · 2025 · Clinical Rehabilitation
  31. Ecological momentary interventions for depression: A systematic review and meta-analysis
    Suet Ying Yuen, Heidi Ka Ying Lo, Joyce Xu Hao Jin, Fiona Yan‐Yee Ho, Chun-Yin Poon, Wing-Fai Yeung, Branda Yee Man Yu, Chit Tat Lee, Inez Myin‐Germeys, Ka Fai Chung · 2026 · Journal of Affective Disorders
  32. Addressing mental health with daily-life ecological momentary interventions (ALERT) in people at increased risk for mental disorders: A micro-randomized trial
    Felix Fiß, Lukas Berndt, Serafima Anickova, Thomas Vaessen, Jannis T. Kraiss · 2026 · Journal of Affective Disorders
  33. Just-in-time adaptive interventions to improve positive emotions in daily life: a randomized controlled experience sampling study
    Marieke J. Schreuder, Leonie Schorrlepp, Dominique Maciejewski, Annelies Schipper, Eeske van Roekel · 2026 · The Journal of Positive Psychology
  34. Hiding in Plain Sight: Assessment and Treatment of Irritable Mood During Pregnancy and the Postpartum Period
    Danielle A. Swales, Samantha N. Hellberg, Tiffany A. Hopkins, Crystal Edler Schiller · 2023 · Journal of Health Service Psychology
  35. Advances in ESM-Derived Feedback Integrated into Psychotherapy
    Mila Hall, Michelle N. Servaas, Harriëtte Riese · 2025 · CBT: science into practice
  36. Electronic Technology and Advances in Assessment of Outcomes
    Iris E. de Wit, Lieuwe de Haan, Inez Myin‐Germeys · 2016 · Springer eBooks
  37. Experience sampling in dementia care
    van Knippenberg · 2017
  38. Positive emotion regulation: Forecasting the future, savoring the present and reminiscing about the past
    Desirée Colombo · 2020
  39. Within-Person and Between-Person Relationships Between Gratitude and the Functioning of Women with Symptoms of Depression: A Diary Study
    Joanna Tomczyk, Izabela Krejtz, John B. Nezlek · 2022
  40. Dispositional negativity in the wild: Social environment governs momentary emotional experience
    Alexander J. Shackman, Jennifer S. Weinstein, Stanton Hudja, Conor D. Bloomer, Matthew G. Barstead, Edward P. Lemay, Andrew S. Fox · 2017
  41. There and back again: a dynamical perspective on psychological resilience
    Anna Kuranova · 2022
  42. Sampling the self
    Maud Daemen · 2022
  43. Modeling categorical time-to-event data: The example of social interaction dynamics captured with event-contingent experience sampling methods
    Timon Elmer, Marijtje A. J. van Duijn, Nilám Ram, Laura Francina Bringmann · 2022
  44. Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness- implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Daniel Dančík, Manuela De Allegri, Simona Di Folco, Daniel Durstewitz et al. · 2024 · Research Square
  45. Affect dynamics : a focus on genes, stress, and an opportunity for change
    Claudia Menne‐Lothmann · 2015
  46. Understanding and treating obesity in daily life
    Boh · 2017
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  48. Psychiatric Taxonomies and Corresponding Measures
    Carina Coulacoglou, Donald H. Saklofske · 2017 · Elsevier eBooks
  49. Navigating through complexity
    Klippel · 2018
  50. ESPIM: um modelo para guiar o desenvolvimento de sistemas de intervenção a distância
    Bruna C.R. Cunha · 2019
  51. Diagnostic modalities and outcome measures in upper gastrointestinal disorders
    Smeets · 2019
  52. Using Intensive Longitudinal Data to Study Treatment Effects in Patients with Major Depression: A Systematic Review
    Cajsa Jonasson · 2019 · Journal for Person-Oriented Research
  53. Enhancing Self-Management of Distressing Voices Hearing Experiences Using Ecological Momentary Assessment and Intervention
    Imogen Bell · 2019 · Minerva Access (University of Melbourne)
  54. Monitoring everyday life in aging & dementia
    Sara Laureen Bartels · 2020
  55. Anxiety in late-life depression
    Date Claudius van der Veen · 2021
  56. Beyond the diagnosis: a PROactive approach to fatigue, daily life participation, and health-related quality of life in paediatric chronic disease
    Merel M. Nap-van der Vlist · 2021
  57. Digitale technologie in de geestelijke gezondheidszorg: een narratieve review en visietekst op weg naar gepersonaliseerde zorg
    Inez Myin‐Germeys, Lena de Thurah, Jeroen Dennis Merlijn Weermeijer, Rafaël Bonnier, Evelyne van Aubel, Glenn Kiekens · 2022 · Tijdschrift voor Geneeskunde
  58. Guidelines on Conducting Online Experiments with Repeated Measures and Using Smartphone Applications
    Intan Permatasari, Harry Susianto · 2022 · ANIMA Indonesian Psychological Journal
  59. Dispositional negativity in the wild: Social environment governs momentary emotional experience
    Alexander J. Shackman · 2017
  60. Modulating microcircuits in depression
    Milaine Roet · 2021
  61. Acceptance and Commitment Therapy in Daily Life (ACT-DL) in early psychosis: findings on treatment adherence and acceptability from the multi-center INTERACT randomized controlled trial (Preprint)
    Evelyne van Aubel, Thomas Vaessen, Henrietta Steinhart, Annelie Klippel, Tim Batink, Ruud van Winkel, Lieuwe de Haan, Mark van der Gaag, Thérèse van Amelsvoort, Machteld C. Marcelis et al. · 2021
  62. Automatic detection of emotions in depressed patients and healthy subjects: a mobile application study (Preprint)
    Min-Shan Li, Yen‐Lin Chen, Hsiao-Chi Chu, Yen-Ying Liao, Galen Chin‐Lun Hung · 2018
  63. Is it Suitable, Acceptable, and Feasible to Measure Grief in Daily Life Using Experience Sampling Methodology?
    Lonneke I. M. Lenferink, Janske H. W. van Eersel, Minita Franzen · 2022 · SSRN Electronic Journal
  64. Can digital tools improve clinical care in psychiatry?
    Inez Myin‐Germeys · 2023 · Dusunen Adam The Journal of Psychiatry and Neurological Sciences
  65. Can real-time personalized feedback in mHealth improve app engagement, user experience, and well-being? (Preprint)
    Evelien Dietvorst, Manon H. J. Hillegers, Jeroen S. Legerstee, Annabel Vreeker, Loes Keijsers · 2023
  66. Early-warning signals derived from actigraphy and electrocardiogram time series data
    Yoram Kevin Kunkels · 2023
  67. Insights in Public Mental Health: 2022
    Wulf Rössler A · 2024 · Frontiers research topics
  68. Opening the contextual black box: A case for idiographic experience sampling of context for clinical applications (Preprint)
    Lino von Klipstein, Marie Stadel, Fionneke Marijke Bos, Laura Francina Bringmann, Harriëtte Riese, Michelle N. Servaas · 2024
  69. Review Essay: Limits of the Numerical and the Personalized Measurement Trend in Mental Health Care
    Nina S. de Boer, Rosa W. Runhardt · 2024 · Philosophy of the Social Sciences
  70. Moving forward: challenges and directions for psychopathological network theory and methodology
    Eiko I. Fried, Angélique O. J. Cramer · 2016
  71. A playful experience sampling method to report emotions using smartwatches and emojis
    Shota Watanabe, Gaku Kutsuzawa, Yoshiyuki Kobayashi, Kohei Matsumura · 2025 · Entertainment Computing
  72. Comparative analysis of Mobile Crowdsensing and Ecological Momentary Assessment systems
    Michael Stach, Adnan Ramović, Manfred Reichert, Rüdiger C. Pryss · 2025 · Ecological Informatics
  73. Identifying Subgroups at Risk for Major Depression and Suicidal Ideation via Mobile App–Based Ecological Momentary Assessment: A Cluster Analysis (Preprint)
    Kyungmi Chung, Jin Young Park · 2025
  74. Understanding social anxiety in daily life—How e-diary methods and digital phenotyping can enhance monitoring, diagnostics, and interventions
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  75. Stand-Alone Mobile Mindfulness App for People Experiencing Infertility: A Pilot Randomised Controlled Trial (MoMiFer-RCT)
    Tessy Boedt, Nele Willaert, Sharon Lie Fong, Eline A.F. Dancet, Filip Raes, Katleen Van der Gucht · 2025 · Psychologica Belgica
  76. Enhancing group lifestyle intervention for depression with ecological momentary assessment: a pilot randomized controlled trial
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  77. How to Cultivate Sense of Purpose and Life Engagement
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  78. Additional file 9 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  79. Additional file 1 of Personalized exposure and experience sampling method feedback versus exposure as usual for obsessive–compulsive disorder: a study protocol for a randomized controlled trial
    Elena Hoogerwerf, Anja Greeven, Rutger Goekoop, Philip Spinhoven · 2024 · Figshare
  80. Additional file 1 of Personalized ESM monitoring and feedback to support psychological treatment for depression: a pragmatic randomized controlled trial (Therap-i)
    Harriëtte Riese, Lino von Klipstein, Schoevers, R. A., Date Claudius van der Veen, Servaas, M. N. · 2021 · Figshare
  81. Additional file 1 of A smartphone-based intervention for young people who self-harm (‘PRIMARY’): study protocol for a multicenter randomized controlled trial
    Anouk Aleva, van den Berg, Tessa, Odilia M. Laceulle, Marcel A. G. van Aken, Andrew M. Chanen, Jennifer K. Betts, Christel J. Hessels · 2024 · Figshare
  82. Additional file 10 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  83. Additional file 2 of Exploring the digital footprint of depression: a PRISMA systematic literature review of the empirical evidence
    Zarate, Daniel, Stavropoulos, Vasileios, Ball, Michelle, de Sena Collier, Gabriel, Nicholas C. Jacobson · 2022 · Figshare
  84. Additional file 1 of Exploring the digital footprint of depression: a PRISMA systematic literature review of the empirical evidence
    Zarate, Daniel, Stavropoulos, Vasileios, Ball, Michelle, de Sena Collier, Gabriel, Nicholas C. Jacobson · 2022 · Figshare
  85. Additional file 1 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  86. Additional file 8 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  87. Additional file 1 of Recommendations for the use of long-term experience sampling in bipolar disorder care: a qualitative study of patient and clinician experiences
    Fionneke Marijke Bos, Evelien Snippe, Richard Bruggeman, Bennard Doornbos, Marieke Wichers, Lian van der Krieke · 2020 · Figshare
  88. Additional file 11 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  89. Additional file 7 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  90. Additional file 5 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  91. Additional file 1 of Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
    Bénédicte Thonon, Evelyne van Aubel, Ginette Lafit, Clara Della Libera, Larøi, Frank · 2020 · Figshare
  92. Additional file 1 of Prevention and early intervention of depression in young people: an integrated narrative review of affective awareness and Ecological Momentary Assessment
    Joanne R. Beames, Katarina Kikas, Aliza Werner‐Seidler · 2021 · Figshare
  93. Additional file 2 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  94. Additional file 3 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  95. Additional file 6 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  96. Additional file 4 of Strategies, processes, outcomes, and costs of implementing experience sampling-based monitoring in routine mental health care in four European countries: study protocol for the IMMERSE effectiveness-implementation study
    Ulrich Reininghaus, Matthias Schwannauer, Islay Barne, Joanne R. Beames, Rafaël Bonnier, Manuel Brenner, Dagmar Breznoščáková, Daniel Dančík, Manuela De Allegri, Simona Di Folco et al. · 2024 · Figshare
  97. Within-person changes in emotional complexity are associated with concurrent changes in mental health symptoms
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  98. Response Time Dynamics From Noncognitive Ordinal Ecological Momentary Assessment as a Proxy for Symptom Change in Geriatric Depression: Longitudinal Observational Study
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  100. Affective dynamics in adolescents with major depressive disorder and subthreshold depression: an experience sampling study
    Tiffany C. Y. Liu, Nate Tsz-Kit Kwok, Sandra Sau-Man Chan, Flora Y. M. Mo, Edgar Wing-ka Ching, Steven Wai Ho Chau, Oscar W. H. Wong, Suk Ling Ma, Kelvin K.F. Tsoi, Kelly Y. C. Lai et al. · 2026 · Psychological Medicine