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The nucleolus: structure/function relationship in RNA metabolism
Abstract
The nucleolus is the ribosome factory of the cells. This is the nuclear domain where ribosomal RNAs are synthesized, processed, and assembled with ribosomal proteins. Here we describe the classical tripartite organization of the nucleolus in mammals, reflecting ribosomal gene transcription and pre‐ribosomal RNA (pre‐rRNA) processing efficiency: fibrillar center, dense fibrillar component, and granular component. We review the nucleolar organization across evolution from the bipartite organization in yeast to the tripartite organization in humans. We discuss the basic principles of nucleolar assembly and nucleolar structure/function relationship in RNA metabolism. The control of nucleolar assembly is presented as well as the role of pre‐existing machineries and pre‐rRNAs inherited from the previous cell cycle. In addition, nucleoli carry many essential extra ribosomal functions and are closely linked to cellular homeostasis and human health. The last part of this review presents recent advances in nucleolar dysfunctions in human pathology such as cancer and virus infections that modify the nucleolar organization. Copyright © 2010 John Wiley & Sons, Ltd. This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry Translation > Ribosome Biogenesis RNA in Disease and Development > RNA in Disease
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Cited by
A day in the life of the spliceosome
Matera, A. G., & Wang, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3742 · Cited by 1,074
The nucleolus as a multiphase liquid condensate
Lafontaine, D. L. J., Riback, J. A., Bascetin, R., & Brangwynne, C. P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0272-6 · Cited by 1,051
Self-citationAssembly and disassembly of the nucleolus during the cell cycle
Hernandez-Verdun, D. (2011) · Nucleus · doi:10.4161/nucl.2.3.16246 · Cited by 310
Self-citationCyclometalated iridium(III) complexes for life science
Caporale, C., & Massi, M. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.02.006 · Cited by 258
The Ribosome Biogenesis—Cancer Connection
Penzo, M., Montanaro, L., Treré, D., & Derenzini, M. (2019) · Cells · doi:10.3390/cells8010055 · Cited by 242
Metadata
- Authors
- Hernandez‐Verdun, D., Roussel, P., Thiry, M., Sirri, V., & Lafontaine, D. L. J.
- Venue
- WIREs RNA
- Publisher
- Wiley
- Published
- 2010-09-22
- Volume
- 1
- Issue
- 3
- Pages
- 415-431
- ISSN
- 1757-7004 (ISSN-L)
- 1757-7012
- OpenAlex
- W2084929037
- Cited by
- 261
- References
- 0
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hernandez‐Verdun, D., Roussel, P., Thiry, M., Sirri, V., & Lafontaine, D. L. J. (2010). The nucleolus: structure/function relationship in RNA metabolism. WIREs RNA. https://doi.org/10.1002/wrna.39
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