The Ribosome Biogenesis—Cancer Connection
Open accessAbstract
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: (1) allowed the understanding of the reasons for the nucleolar changes in cancer cells and their exploitation in tumor pathology, (2) defined the importance of the inhibition of ribosome biogenesis in cancer chemotherapy and (3) focused the attention on alterations of ribosome biogenesis in the pathogenesis of cancer. This review summarizes the research milestones regarding these relevant relationships between ribosome biogenesis and cancer. The structure and function of the nucleolus will also be briefly described.
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Disruption of specific pseudouridylation events impairs translation of structurally demanding mRNAs in experimental models.
“In experimental models, disruption of specific pseudouridylation events impairs translation of structurally demanding mRNAs, which may be especially relevant for the synthesis of major contractile proteins [192].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [192]
Section 4.2 reports that DKC1 mutations produce defectively pseudouridylated ribosomes and alter translation of specific mRNAs in X-DC. It does not identify disrupted individual pseudouridylation events or describe those mRNAs as structurally demanding; it also says translation is altered, not uniformly impaired. The proposed relevance to contractile proteins is the citing authors’ own inference. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe pattern of rRNA modification may change during periods of cellular growth, including modifications catalyzed by DKC1.
“Recent data suggest that the pattern of rRNA modification may change during periods of cellular growth, including modifications catalyzed by complexes such as dyskerin (DKC1) [190,192].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [192]
The Introduction (page not provided) says rRNA undergoes site-specific modifications, and section 4.2 (page not provided) identifies DKC1 as encoding the pseudouridine synthase dyskerin and discusses defectively pseudouridylated ribosomes. Neither passage says that the pattern of rRNA modification changes during periods of cellular growth; the growth-related part of the claim is unsupported. (LLM, conf=0.83)
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- Authors
- Penzo, M., Montanaro, L., Treré, D., & Derenzini, M.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Derenzini, Massimo
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-01-15
- Volume
- 8
- Issue
- 1
- Pages
- 55
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC6356843
- OpenAlex
- W2910848742
- Cited by
- 242
- References
- 100
- Citations by year
- 2026: 18 · 2025: 35 · 2024: 34 · 2023: 34 · 2022: 39 · 2021: 39 · 2020: 31 · 2019: 12
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro (MFAG-19941, IG-16962)
- Roberto and Cornelia Pallotti's Legacy for Cancer Research (000)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- ribosome biogenesis, cancer, nucleolus, cell proliferation, cancer chemotherapy, carcinogenesis
- MeSH terms
- Animals, Antineoplastic Agents, Cell Nucleolus, Cell Transformation, Neoplastic, Humans, Neoplasms, Ribosomal Proteins, Ribosomes, Tumor Suppressor Protein p53, Cell Proliferation, Mice
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