Cited by 425Bone Metabolism and DiseasesCellular Mechanics and InteractionsBone health and osteoporosis research

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Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation

Kleinnulend, J., Semeins, C.M., Ajubi, N.E., Nijweide, P.J., Burger, E.H.·1995·Biochemical and Biophysical Research Communications

DOI 10.1006/bbrc.1995.2822

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Abstract

Osteocytes are extremely sensitive to fluid shear stress, a phenomenon that may be related to mechanical adaptation of bone (FASEB J 9:441,1995). Here we examined the effect of pulsating fluid flow (PFF, 0.5 +/- 0.02 Pa, 5 Hz, 0.4 Pa/sec) on the release of NO, in relation with upregulation of prostaglandin E2 (PGE2). Chicken calvarial osteocytes, but not periosteal fibroblasts, as well as mouse calvarial cells responded to PFF with a rapid and transient 2 to 3-fold stimulation of NO release. The effect was maximal after 5 min and leveled off thereafter. PFF also stimulated PGE2 release. This effect was significant after 10 min and continued throughout 60 min PFF treatment. Inhibition of NO release by NG-monomethyl-L-arginine prevented the effect of PFF on NO as well as PGE2 release. These results suggest that NO is a mediator of mechanical effects in bone, leading to enhanced PGE2 release. They further strengthen the hypothesis that fluid flow through the osteocyte canalicular network provides the physical stimulus for mechanosensation in bone.

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Authors: Kleinnulend, J., Semeins, C. M., Ajubi, N. E., Nijweide, P. J., & Burger, E. H.
Affiliations: Leiden University (NL)
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 1995-12
Volume: 217
Issue: 2
Pages: 640-648
ISSN: 0006-291X (ISSN-L)
DOI: 10.1006/bbrc.1995.2822
OpenAlex: W2043098612
Cited by: 425
References: 0
Citations by year: 2026: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 9 · 2020: 13 · 2019: 13 · 2018: 5 · 2017: 16 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 19 · 2012: 18
FWCI: 2.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
VU Research Portal (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: nitric oxide production, osteocytes, prostaglandin E2, fluid shear stress, mechanotransduction, calvarial cells, L-NMMA
MeSH terms: Animals, Cell Separation, Chick Embryo, Fibroblasts, Nitric Oxide, Osteocytes, Periodicity, Periosteum, Prostaglandins, Rheology, Skull, Stress, Mechanical, Mice

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Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation

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