Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042

Mechanotransduction in bone—role of the lacunocanalicular network

Burger, E. H., & Klein‐Nulend, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9001.s101 · Cited by 897

Vibration as an exercise modality: how it may work, and what its potential might be

Rittweger, J. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1303-3 · Cited by 893

Silk fibroin as biomaterial for bone tissue engineering

Melke, J., Midha, S., Ghosh, S., Ito, K., & Hofmann, S. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.09.005 · Cited by 799

The Osteocyte: New Insights

Robling, A. G., & Bonewald, L. F. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034332 · Cited by 539

Biomaterials and bone mechanotransduction

Sikavitsas, V. I., Temenoff, J. S., & Mikos, A. G. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00002-3 · Cited by 519

Osteocytes: master orchestrators of bone

Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514

Mechanical Strain and Bone Cell Function: A Review

Ehrlich, P. J., & Lanyon, L. E. (2002) · Osteoporosis International · doi:10.1007/s001980200095 · Cited by 509

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060107 · Cited by 494

Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone

Noble, B., Peet, N. M., Stevens, H. Y., Brabbs, A. C., Mosley, J. R., Reilly, G. C., REEVE, J., Skerry, T. M., & Lanyon, L. E. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00234.2002 · Cited by 381

Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways

Kapur, S., Baylink, D. J., & Lau, K. ‐. W. (2003) · Bone · doi:10.1016/s8756-3282(02)00979-1 · Cited by 364

Oscillating fluid flow activation of gap junction hemichannels induces atp release from MLO‐Y4 osteocytes

Genetos, D. C., Kephart, C. J., Zhang, Y., Yellowley, C. E., & Donahue, H. J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21021 · Cited by 328

Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton

Klein‐Nulend, J., Bacabac, R. G., & Bakker, A. D. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a20 · Cited by 348

Nitric Oxide Synthase Expression in Bone Cells

Fox, S. W., & Chow, J. W. M. (1998) · Bone · doi:10.1016/s8756-3282(98)00070-2 · Cited by 320

“Whither flows the fluid in bone?” An osteocyte's perspective

Knothe Tate, M. L. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00123-4 · Cited by 309

Mechanobiology of bone tissue

Klein‐Nulend, J., Bacabac, R. G., & Mullender, M. G. (2005) · Pathologie Biologie · doi:10.1016/j.patbio.2004.12.005 · Cited by 302

Low‐Magnitude Mechanical Loading Becomes Osteogenic When Rest Is Inserted Between Each Load Cycle

Srinivasan, S., Weimer, D. A., Agans, S. C., Bain, S. D., & Gross, T. S. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.9.1613 · Cited by 301

In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation

Wittkowske, C., Reilly, G. C., Lacroix, D., & Perrault, C. M. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2016.00087 · Cited by 310

A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy

Kamioka, H., Honjo, T., & Takano‐Yamamoto, T. (2001) · Bone · doi:10.1016/s8756-3282(00)00421-x · Cited by 287

Molecular events caused by mechanical stress in bone

Nomura, S., & Takano‐Yamamoto, T. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00050-0 · Cited by 285

Pulsating Fluid Flow Stimulates Prostaglandin Release and Inducible Prostaglandin G/H Synthase mRNA Expression in Primary Mouse Bone Cells

Klein‐Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., & Pilbeam, C. C. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.1.45 · Cited by 285

Modulation of membrane traffic by mechanical stimuli

Apodaca, G. L. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2002.282.2.f179 · Cited by 273

Osteocyte: the unrecognized side of bone tissue

Rochefort, G. Y., Pallu, S., & Benhamou, C. L. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1194-5 · Cited by 268

Mechanical Strain Stimulates Nitric Oxide Production by Rapid Activation of Endothelial Nitric Oxide Synthase in Osteocytes

Zaman, G. D., Pitsillides, A. A., Rawlinson, S. C. F., Suswillo, R. F. L., Mosley, J. R., Cheng, M. Z., Platts, L. A. M., Hukkanen, M., Polak, J. M., & Lanyon, L. E. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1123 · Cited by 250

Role of Osteopontin in Bone Remodeling Caused by Mechanical Stress

Terai, K., Takano‐Yamamoto, T., Ohba, Y., Hiura, K., Sugimoto, M., Sato, M., Kawahata, H., Inaguma, N., Kitamura, Y., & Nomura, S. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.6.839 · Cited by 241

Defective Bone Formation and Anabolic Response to Exogenous Estrogen in Mice with Targeted Disruption of Endothelial Nitric Oxide Synthase**This study was supported by grants from the Arthritis Research Campaign (UK) and the Medical Research Council (UK).

Armour, K. E., Armour, K. J., Gallagher, M. E., Gödecke, A., Helfrich, M., Reid, D. M., & Ralston, S. H. (2001) · Endocrinology · doi:10.1210/endo.142.2.7977 · Cited by 239

Mechanotransduction of bone cellsin vitro: Mechanobiology of bone tissue

Mullender, M. G., Haj, A. J. E., Yang, Y., van Duin, M. A., Burger, E. H., & Klein‐Nulend, J. (2004) · Medical & Biological Engineering & Computing · doi:10.1007/bf02351006 · Cited by 238

Mechanobiology of tooth movement

Henneman, S., den Hoff, J. W. V., & Maltha, J. C. (2008) · European Journal of Orthodontics · doi:10.1093/ejo/cjn020 · Cited by 236

Effects of growth factors and cytokines on osteoblast differentiation

Hughes, F. J., Turner, W., Belibasakis, G. N., & Martuscelli, G. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00161.x · Cited by 237

The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone

Holmbeck, K., Bianco, P., Pidoux, I., Inoué, S., Billinghurst, R. C., Wu, W. K. K., Chrysovergis, K., Yamada, S. S., Birkedal‐Hansen, H., & Poole, A. R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01581 · Cited by 231

Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon—a proposal

Burger, E. H., Klein‐Nulend, J., & Smit, T. H. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00126-x · Cited by 236

Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions

Taylor, A. F., Saunders, M. M., Shingle, D. L., Cimbala, J. M., Zhou, Z., & Donahue, H. J. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00611.2005 · Cited by 220

Differentiation of Osteoblasts and Osteocytes from Mesenchymal Stem Cells

Heino, T. J., & Hentunen, T. A. (2008) · Current Stem Cell Research & Therapy · doi:10.2174/157488808784223032 · Cited by 218

Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

Pagnotti, G. M., Styner, M., Uzer, G., Patel, V. S., Wright, L. E., Ness, K. K., Guise, T. A., Rubin, J. E., & Rubin, C. T. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0170-1 · Cited by 218

Aging, Osteocytes, and Mechanotransduction

Hemmatian, H., Bakker, A. D., Klein‐Nulend, J., & van Lenthe, H. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0402-z · Cited by 229

Can shear stress direct stem cell fate?

Stolberg, S., & McCloskey, K. E. (2009) · Biotechnology Progress · doi:10.1002/btpr.124 · Cited by 216

Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption

Tan, S., de Vries, T. J., Kuijpers‐Jagtman, A. M., Semeins, C. M., Everts, V. E., & Klein‐Nulend, J. (2007) · Bone · doi:10.1016/j.bone.2007.07.019 · Cited by 212

Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte-Like MLO-Y4 Cells

Cheng, B., Zhao, S., Luo, J., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.249 · Cited by 211

Expression of Serotonin Receptors in Bone

Westbroek, I., van der Plas, A., de Rooij, K. E., Klein‐Nulend, J., & Nijweide, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101824200 · Cited by 206

Biomechanics of Bone

Cullinane, D. M., & Einhorn, T. A. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50104-9 · Cited by 205

Osteocyte Shape Is Dependent on Actin Filaments and Osteocyte Processes Are Unique Actin-Rich Projections

Tanaka-Kamioka, K., Kamioka, H., Ris, H., & Lim, S. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.10.1555 · Cited by 203

Osteoblast Isolation from Murine Calvaria and Long Bones

Bakker, A. D., & Klein‐Nulend, J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-415-5_2 · Cited by 203

Adipose Tissue-Derived Mesenchymal Stem Cells Acquire Bone Cell-Like Responsiveness to Fluid Shear Stress on Osteogenic Stimulation

Knippenberg, M., Helder, M. N., Zandieh‐Doulabi, B., Semeins, C. M., Wuisman, P. I. J. M., & Klein‐Nulend, J. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1780 · Cited by 202

Dynamic shear stress in parallel-plate flow chambers

Bacabac, R. G., Smit, T. H., Cowin, S. C., van Loon, J. J. W. A., Nieuwstadt, F. T. M., Heethaar, R. M., & Klein‐Nulend, J. (2004) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.03.020 · Cited by 202

Osteocyte Mechanobiology and Pericellular Mechanics

Jacobs, C. R., Temiyasathit, S., & Castillo, A. B. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105302 · Cited by 203

MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation

Riddle, R. C., Taylor, A. F., Genetos, D. C., & Donahue, H. J. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00082.2005 · Cited by 202

Signal transduction pathways involved in fluid flow-induced PGE2production by cultured osteocytes

Ajubi, N. E., Klein‐Nulend, J., Alblas, M. J., Burger, E. H., & Nijweide, P. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e171 · Cited by 203

Gap junctions and biophysical regulation of bone cell differentiation

Donahue, H. J. (2000) · Bone · doi:10.1016/s8756-3282(00)00245-3 · Cited by 189

Nitric oxide production by bone cells is fluid shear stress rate dependent

Bacabac, R. G., Smit, T. H., Mullender, M. G., Dijcks, S. J., van Loon, J. J. W. A., & Klein‐Nulend, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.138 · Cited by 188

PGE2 Is Essential for Gap Junction-Mediated Intercellular Communication between Osteocyte-Like MLO-Y4 Cells in Response to Mechanical Strain

Cheng, B., Kato, Y., Zhao, S., Luo, J., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2001) · Endocrinology · doi:10.1210/endo.142.8.8338 · Cited by 186

Shear stress inhibits while disuse promotes osteocyte apoptosis

Bakker, A. D., Klein‐Nulend, J., & Burger, E. H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.056 · Cited by 185

Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts

Heino, T. J., Hentunen, T. A., & Väänänen, H. K. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.11.016 · Cited by 184

Blood and interstitial flow in the hierarchical pore space architecture of bone tissue

Cowin, S. C., & Cardoso, L. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.12.013 · Cited by 174

Distinct Anabolic Response of Osteoblast to Low-Intensity Pulsed Ultrasound

Naruse, K., Miyauchi, A., Itoman, M., & Mikuni‐Takagaki, Y. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.2.360 · Cited by 173

Receptors for the Carboxyl-Terminal Region of PTH(1–84) Are Highly Expressed in Osteocytic Cells**This work was supported by the NIH Grant DK-11794.

Pajevic, P. D., Inomata, N., Chapin, K., Singh, R., Jüppner, H., & Bringhurst, F. R. (2001) · Endocrinology · doi:10.1210/endo.142.2.7955 · Cited by 169

Round versus flat: Bone cell morphology, elasticity, and mechanosensing

Bacabac, R. G., Mizuno, D., Schmidt, C. F., MacKintosh, F. C., van Loon, J. J. W. A., Klein‐Nulend, J., & Smit, T. H. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.01.031 · Cited by 167

From mechanical stimulus to bone formation: A review

Rosa, N., Simões, R., Magalhães, F. D., & Marques, A. T. (2015) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2015.05.015 · Cited by 177

Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density — Is there a role for mechanosensing?

van Hove, R. P., Nolte, P. A., Vatsa, A., Semeins, C. M., Salmon, P. L., Smit, T. H., & Klein‐Nulend, J. (2009) · Bone · doi:10.1016/j.bone.2009.04.238 · Cited by 161

In vitro and in vivo approaches to study osteocyte biology

Kalajzić, I., Matthews, B. G., Torreggiani, E., Harris, M. A., Pajevic, P. D., & Harris, S. E. (2012) · Bone · doi:10.1016/j.bone.2012.09.040 · Cited by 165

Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation

Vezeridis, P. S., Semeins, C. M., Chen, Q., & Klein‐Nulend, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.146 · Cited by 159

Gap junctions and hemichannels in signal transmission, function and development of bone

Batra, N. R., Kar, R., & Jiang, J. X. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.09.018 · Cited by 157

Expression of Nitric Oxide Synthase Isoforms in Bone and Bone Cell Cultures

Helfrich, M., Evans, D. M., Grabowski, P., Pollock, J. S., Ohshima, H., & Ralston, S. H. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.7.1108 · Cited by 155

Osteocyte primary cilium and its role in bone mechanotransduction

Temiyasathit, S., & Jacobs, C. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05243.x · Cited by 154

Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis

Klein‐Nulend, J., van Oers, R. F. M., Bakker, A. D., & Bacabac, R. G. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.12.007 · Cited by 155

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways

JESSOP, H. L., Rawlinson, S. C. F., Pitsillides, A. A., & Lanyon, L. E. (2002) · Bone · doi:10.1016/s8756-3282(02)00797-4 · Cited by 153

Bone microdamage and cell apoptosis

Noble, B. (2003) · European Cells and Materials · doi:10.22203/ecm.v006a05 · Cited by 152

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone

Kamel, M. A., Picconi, J. L., Lara-Castillo, N., & Johnson, M. L. (2010) · Bone · doi:10.1016/j.bone.2010.08.007 · Cited by 147

Is BMU-Coupling a Strain-Regulated Phenomenon? A Finite Element Analysis

Smit, T. H., & Burger, E. H. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.2.301 · Cited by 146

Primary cilium‐dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

Kwon, R. Y., Temiyasathit, S., Tummala, P., Quah, C. C., & Jacobs, C. R. (2010) · The FASEB Journal · doi:10.1096/fj.09-148007 · Cited by 149

Bone cell responses to high‐frequency vibration stress: does the nucleus oscillate within the cytoplasm?

Bacabac, R. G., Smit, T. H., van Loon, J. J. W. A., Zandieh‐Doulabi, B., Helder, M. N., & Klein‐Nulend, J. (2006) · The FASEB Journal · doi:10.1096/fj.05-4966.com · Cited by 137

Mechanosensation and fluid transport in living bone.

Cowin, S. C. (2002) · PubMed · Cited by 135

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

Lara-Castillo, N., Kim-Weroha, N., Kamel, M. A., Javaheri, B., Ellies, D. L., Krumlauf, R. K., Thiagarajan, G., & Johnson, M. L. (2015) · Bone · doi:10.1016/j.bone.2015.03.019 · Cited by 139

Evidence for a Pathogenic Role of Nitric Oxide in Inflammation-Induced Osteoporosis

Armour, K. E., Van 'T Hof, R. J., Grabowski, P. S., Reid, D. M., & Ralston, S. H. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2137 · Cited by 133

Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO‐Y4 osteocyte‐like cells and ROS 17/2.8 osteoblast‐like cells

Lohmann, C. H., Schwartz, Z., Liu, Y., Li, Z., Simon, B. J., Sylvia, V. L., Dean, D. D., Bonewald, L. F., Donahue, H. J., & Boyan, B. D. (2003) · Journal of Orthopaedic Research® · doi:10.1016/s0736-0266(02)00137-7 · Cited by 130

The Role of the Osteocyte in Bone and Nonbone Disease

Bonewald, L. F. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.09.003 · Cited by 134

1997 Whitaker Distinguished Lecture: Models to Solve Mysteries in Biomechanics at the Cellular Level; A New View of Fiber Matrix Layers

Weinbaum, S. (1998) · Annals of Biomedical Engineering · doi:10.1114/1.134 · Cited by 129

Mechanotransduction in Stretched Osteocytes—Temporal Expression of Immediate Early and Other Genes

Kawata, A., & Mikuni‐Takagaki, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8632 · Cited by 127

Osteoblast Isolation from Murine Calvariae and Long Bones

Bakker, A. D., & Klein‐Nulend, J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-366-6:19 · Cited by 126

A Case for Strain-Induced Fluid Flow as a Regulator of BMU-Coupling and Osteonal Alignment

Smit, T. H., Burger, E. H., & Huyghe, J. M. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.2021 · Cited by 126

Ceramic and PMMA particles differentially affect osteoblast phenotype

Lohmann, C. H., Dean, D. D., Köster, G., Casasola, D., BUCHHORN, G. H., Fink, U., Schwartz, Z., & Boyan, B. D. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00312-x · Cited by 125

Dental Pulp Stem Cell Mechanoresponsiveness: Effects of Mechanical Stimuli on Dental Pulp Stem Cell Behavior

Marrelli, M., Codispoti, B., Shelton, R. M., Scheven, B. A. A., Cooper, P. R., Tatullo, M., & Paduano, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01685 · Cited by 124

Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent

Donahue, S. W., Jacobs, C. R., & Donahue, H. J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.5.c1635 · Cited by 124

Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport

Donahue, T. L. H., Haut, T. R., Yellowley, C. E., Donahue, H. J., & Jacobs, C. R. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00118-0 · Cited by 123

Responses of Bone Cells to Biomechanical Forces in Vitro

Burger, E. H., & Klein‐Nulend, J. (1999) · Advances in Dental Research · doi:10.1177/08959374990130012201 · Cited by 122

Tensile Stress Induces Bone Morphogenetic Protein 4 in Preosteoblastic and Fibroblastic Cells, Which Later Differentiate into Osteoblasts Leading to Osteogenesis in the Mouse Calvariae in Organ Culture

Ikegame, M., Ishibashi, O., Yoshizawa, T., Shimomura, J., Komori, T., Ozawa, H., & Kawashima, H. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.24 · Cited by 121

Response of normal and osteoporotic human bone cells to mechanical stress in vitro

Sterck, J. G. H., Klein‐Nulend, J., Lips, P. T. A. M., & Burger, E. H. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.6.e1113 · Cited by 120

Nitric oxide and bone

Wimalawansa, S. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05230.x · Cited by 119

Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells

JESSOP, H. L., Sjöberg, M., Cheng, M. Z., Zaman, G., Wheeler-Jones, C. P. D., & Lanyon, L. E. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1045 · Cited by 115

Osteocyte and bone structure

Klein‐Nulend, J., Nijweide, P. J., & Burger, E. H. (2003) · Current Osteoporosis Reports · doi:10.1007/s11914-003-0002-y · Cited by 114

In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading

Jing, D., Baik, A. D., Lu, X. L., Zhou, B., Lai, X., Wang, L., Luo, E., & Guo, X.-D. E. (2013) · The FASEB Journal · doi:10.1096/fj.13-237578 · Cited by 112

Silk fibroin/hydroxyapatite scaffold: a highly compatible material for bone regeneration

Saleem, M., Rasheed, S., & Yougen, C. (2020) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2020.1748520 · Cited by 115

Nitric oxide mediates the effects of pulsed electromagnetic field stimulation on the osteoblast proliferation and differentiation

Diniz, P., Soejima, K., & Ito, G. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00004-6 · Cited by 112

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

Santos, A., Bakker, A. D., Zandieh‐Doulabi, B., Semeins, C. M., & Klein‐Nulend, J. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20888 · Cited by 109

The role of osteocytes in bone mechanotransduction

Santos, A., Bakker, A. D., & Klein‐Nulend, J. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0858-5 · Cited by 110

Osteoclast heterogeneity:

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