The DOI matches its Crossref record.
Rapid Formation of Advanced Glycation End Products by Intermediate Metabolites of Glycolytic Pathway and Polyol Pathway
Abstract
To clarify roles of intermediate metabolites of the glycolytic pathway and the polyol pathway in nonenzymatic glycation under physiological conditions, we incubated bovine serum albumin with intermediates of both pathways in the micromolar range as well as with 20 mmol/l glucose, and observed the formation of advanced glycation end products (AGEs). We found that triose phosphates, glyceraldehyde, and a novel polyol pathway-related metabolite, fructose 3-phosphate along with its breakdown product, 3-deoxyglucosone were extremely potent glycating agents that at nearly physiological concentrations on incubation with albumin produced substantial amounts of AGEs as early as 24 hours, while 20 mmol/l glucose afforded trace amounts of AGEs after two week incubation. The results along with the previous evidence of the increased level of intermediates in diabetic states may suggest that the intermediate metabolites rather than glucose contribute to enhanced glycation in diabetic tissues, inspite of the much lower concentrations compared with glucose.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Excess glucose is metabolized through the polyol pathway to fructose and its metabolites, which are potent glycating agents.”
From The Vasculature in Prediabetes (2018) · cites this paper as [54]
Citations
Cited by
Sorted by citations
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890
“glycolytic or Kreb’s cycle intermediates or reactive oxygen species would also lead to modification of proteins by advanced glycation (230).”
BackgroundMolecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications
Sheetz, M. J. (2002) · JAMA · doi:10.1001/jama.288.20.2579 · Cited by 1,005
Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives
Khalid, M., Petroianu, G. A., & Adem, A. (2022) · Biomolecules · doi:10.3390/biom12040542 · Cited by 972
Kislinger, T., Fu, C., Huber, B., Qu, W., Taguchi, A., Yan, S. D., Hofmann, M. A., Yan, S. F., Pischetsrieder, M., Stern, D. M., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31740 · Cited by 868
Vistoli, G., De Maddis, D., Cipak, A., Zarkovic, N., Carini, M., & Aldini, G. (2013) · Free Radical Research · doi:10.3109/10715762.2013.815348 · Cited by 823
González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 948
“On the other hand, it is known that fructose could be further metabolized to produce 3-deoxyglucose and fructose-3-phosphate, both of which are potent nonenzymatic glycation agents [74].”
BackgroundReactive oxygen species (ROS) in macrophage activation and function in diabetes
Rendra, E., Riabov, V., Mossel, D. M., Sevastyanova, T., Harmsen, M. C., & Kzhyshkowska, J. (2019) · Immunobiology · doi:10.1016/j.imbio.2018.11.010 · Cited by 636
Maillard reaction products in tissue proteins: New products and new perspectives
Thorpe, S. R., & Baynes, J. (2003) · Amino Acids · doi:10.1007/s00726-003-0017-9 · Cited by 543
“For several years now, Maillard researchers have been changing their focus from AGEs formed on extracellular proteins from the relatively inert precursor glucose, to AGEs formed on intracellular proteins from more reactive intermediates (Hamada et al., 1996).”
BackgroundBaking, Ageing, Diabetes: A Short History of the Maillard Reaction
Hellwig, M., & Henle, T. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308808 · Cited by 477
Aldose Reductase, Oxidative Stress, and Diabetic Mellitus
Tang, W. H., Martin, K. A., & Hwa, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00087 · Cited by 458
“Third, the polyol pathway converts glucose to fructose, and fructose can be further metabolized into fructose-3-phosphate and 3-deoxyglucosone, which are more potent non-enzymatic glycation agent than glucose (Hamada et al., 1996a,b).”
The role of AGEs in aging: causation or correlation
Baynes, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00138-3 · Cited by 329
Aragno, M., & Mastrocola, R. (2017) · Nutrients · doi:10.3390/nu9040385 · Cited by 239
“A second aspect linking high fructose levels to AGE production is related to the peculiar fructose metabolism that evokes rapid generation and accumulation of GAP and DHAP, both effective glycating agents and precursors of the dicarbonyls compounds glyoxal and methylglyoxal, which, in turn, are precursors of more stab…”
BackgroundCai, W., Gao, Q.-D., Zhu, L., Peppa, Μ., He, C., & Vlassara, H. (2002) · Molecular Medicine · doi:10.1007/bf03402014 · Cited by 236
“Molecular Medicine 8(7): 337–346, 2002”
Zandt, M. C. V., Jones, M. L., Gunn, D., Geraci, L. S., Jones, J. H., Sawicki, D. R., Sredy, J., JACOT, J. L., DiCioccio, A. T., Petrova, T. E., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0492094 · Cited by 230
Washburn, N., Schwab, I., Ortiz, D., Bhatnagar, N., Lansing, J. C., Medeiros, A., Tyler, S., Mekala, D., Cochran, E., Sarvaiya, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422481112 · Cited by 225
“Proteomic analysis of the sialyltransferase enzyme preparations identified different glycolytic enzymes as background proteins in addition to the sialyltransferase that, according to previous reports (34), could contribute to the formation of AGEs found on the sialylated recombinant human IgG1 Fc product (Table S1).”
ResultOxidative Stress and Microvascular Alterations in Diabetic Retinopathy: Future Therapies
Rodríguez, M. L., Pérez, S., Mena, S., Desco, C., & Ortega, Á. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4940825 · Cited by 234
“On the other hand, fructose synthesised from sorbitol by the polyol pathway is phosphorylated to fructose-3phosphate which, in turn, is broken down to 3-deoxyglucosone, a glycosylating agent that can contribute to the formation of AGEs [75].”
BackgroundInfluentialFructose-mediated non-enzymatic glycation: sweet coupling or bad modification
Schalkwijk, C. G., Stehouwer, C. D. A., & van Hinsbergh, V. W. M. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.488 · Cited by 206
“Both trioses are precursors of methylglyoxal [54] and these trioses are potent AGE-forming compounds [48].”
BackgroundAldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders
Srivastava, S. K., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N. H., Bhatnagar, A., Petrash, M. J., Srivastava, S., et al. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.023 · Cited by 210
“It has been demonstrated that sorbitol-3-phosphate generated by AKR1B1 is converted to fructose 3phosphate, which is a better glycosylating agent than glucose, so that AKR1B1-mediated catalysis can generate potent glycosylating agents [91].”
BackgroundAldose reductase inhibitors: therapeutic implications for diabetic complications
Oates, P. J., & Mylari, B. L. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.12.2095 · Cited by 196
Mitogen-activated protein kinases as glucose transducers for diabetic complications
Tomlinson, D. R. (1999) · Diabetologia · doi:10.1007/s001250051439 · Cited by 190
Metz, T., Alderson, N. L., Thorpe, S. R., & Baynes, J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.021 · Cited by 190
Dei, R., Takeda, A., Niwa, H., Li, M., Nakagomi, Y., Watanabe, M., Inagaki, T., Washimi, Y., Yasuda, Y., Horie, K., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0523-y · Cited by 179
“oxygen radicals, carbonyl compounds, and other reactive molecules [17, 19 , 42].”
BackgroundPhysiological and Pathological Roles of Aldose Reductase
Singh, M., Kapoor, A., & Bhatnagar, A. (2021) · Metabolites · doi:10.3390/metabo11100655 · Cited by 197
“In the past, it was reported that sorbitol-3-phosphate generated by AR is converted to fructose 3-phosphate, which is a better glycosylating agent than glucose, and that AR-mediated catalysis can generate potent glycosylating agents [168].”
BackgroundInositols in Insulin Signaling and Glucose Metabolism
Bevilacqua, A., & Bizzarri, M. (2018) · International Journal of Endocrinology · doi:10.1155/2018/1968450 · Cited by 192
“This worsens insulin resistance and diabetes complications, impairs cellular redox and free radical defenses, and increases oxidative glycation stress [52, 53].”
BackgroundAdvanced Glycation End Products and Diabetic Cardiovascular Disease
Prasad, A., Bekker, P., & Tsimikas, S. (2012) · Cardiology in Review · doi:10.1097/crd.0b013e318244e57c · Cited by 150
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups
Hipkiss, A. R., Brownson, C., & CARRIER, M. J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00272-x · Cited by 150
The Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137
“through the polyol pathway to fructose and its metabolites, which are potent glycating agents.(54) In glycation, the aldehyde”
BackgroundCaturano, A., Rocco, M. P., Tagliaferri, G., Piacevole, A., Nilo, D., Lorenzo, G. D., Iadicicco, I., Donnarumma, M., Galiero, R., Acierno, C., et al. (2025) · Antioxidants · doi:10.3390/antiox14010072 · Cited by 178
Hodgkinson, A., Bartlett, T., Oates, P. J., Millward, B. A., & Demaine, A. G. (2003) · Diabetes · doi:10.2337/diabetes.52.3.846 · Cited by 132
Jaisson, S., & Gillery, P. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.145201 · Cited by 133
Role of advanced glycation end products in carcinogenesis and their therapeutic implications
Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126
Boor, P., Celec, P., Behuliak, M., Grančič, P., Kebis, A., Kukan, M., Prónayová, N., Liptaj, T., Ostendorf, T., & Šebeková, K. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.025 · Cited by 121
Baba, S. P., Barski, O. A., Ahmed, Y., O’Toole, T. E., Conklin, D. J., Bhatnagar, A., & Srivastava, S. (2009) · Diabetes · doi:10.2337/db09-0375 · Cited by 117
Bhatti, F. N., Mankhey, R. W., Asico, L. D., et al. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00214.x · Cited by 111
“In diabetes, reactive oxygen species are generated from an excess shunting of glucose into the polyol and glucosamine pathways [38], which leads to the formation and activation of protein kinase C, formation of AGEs and glycation [39, 40].”
BackgroundDinicola, S., Minini, M., Unfer, V., Verna, R., Cucina, A., & Bizzarri, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102187 · Cited by 114
“Myo-inositol depletion, in turn, may worsen insulin resistance and diabetes complication, including disturbances in cellular redox and free radical defense, increased oxidative glycation stress [121,122], and renal function.”
BackgroundCarnosine reacts with a glycated protein
Brownson, C., & Hipkiss, A. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00270-7 · Cited by 110
George, S., & Sivakami, S. (2004) · Biogerontology · doi:10.1007/s10522-004-3189-0 · Cited by 108
“In fact, certain intermediates like dihydroxyacetone phosphate, glyceraldehyde3-phosphate and fructose-3-phosphate can form AGEs faster than glucose (Hamada et al. 1996; Sharma et al. 2002).”
BackgroundExtending the Spectrum of α-Dicarbonyl Compounds in Vivo
Henning, C., Liehr, K., Girndt, M., Ulrich, C., & Glomb, M. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.563593 · Cited by 104
“There are multiple sources and mechanisms of AGE formation in vivo, involving oxidative and nonoxidative chemistry of reducing sugars, Schiff bases, Amadori adducts, ascorbic acid and metabolic intermediates (4, 5).”
BackgroundMapanga, R. F., & Essop, M. F. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00206.2015 · Cited by 106
Aldose Reductase and the Polyol Pathway in Schwann Cells: Old and New Problems
Niimi, N., Yako, H., Takaku, S., Chung, S. K., & Sango, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031031 · Cited by 102
“Fructose is further metabolized into dicarbonyl compounds such as 3-deoxyglucose (3-DG) and me ylgly xal (MG), which are recognized as potent glycati g ag nts and participate in the formation of AGEs [49,50].”
BackgroundInfluentialOttum, M. S., & Mistry, A. M. (2015) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-3 · Cited by 101
Myo-inositol: its metabolism and potential implications for poultry nutrition—a review
Gonzalez-Uarquin, F., Rodehutscord, M., & Huber, K. (2019) · Poultry Science · doi:10.1016/j.psj.2019.10.014 · Cited by 98
“, 2007; Deranieh and Greenberg, 2009), and also the impairment of cell development, transformation, and differentiation (Oishi et al., 1990; Steele et al., 1993; Hamada et al., 1996).”
BackgroundMcFarland, G. A., & Holliday, R. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00056-4 · Cited by 98
Recent development of plant products with anti-glycation activity: a review
Chinchansure, A. A., Korwar, A. M., Kulkarni, M. J., & Joshi, S. P. (2015) · RSC Advances · doi:10.1039/c4ra14211j · Cited by 96
Hamada, Y., Nakamura, J., Naruse, K., Komori, T., Kato, K., Kasuya, Y., Nagai, R., Horiuchi, S., & Hotta, N. (2000) · Diabetes Care · doi:10.2337/diacare.23.10.1539 · Cited by 92
Self-citationMao, Z., Shen, S., Wan, Y., Sun, W., Chen, H.-L., Huang, M., Yang, J., Wu, W., Tang, H., & Tang, R. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.07.036 · Cited by 91
“…over-expression of transforming growth factor (TGF)β, as well as the excess of nicotinamide adenine dinucleotide phosphate (NADPH), all of which lead to increased reactive oxygen species (ROS) formation and OS in vivo (Etoh et al., 2003; Hamada et al., 1996; Ha and Kim, 1999; Singh et al., 2011).”
BackgroundC9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
Allen, S. P., Hall, B., Woof, R., Francis, L. I., Gatto, N., Shaw, A. C., Myszczynska, M. A., Hemingway, J., Coldicott, I., Willcock, A., et al. (2019) · Brain · doi:10.1093/brain/awz302 · Cited by 89
Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus
Leh, H. E., & Lee, L. K. (2022) · Molecules · doi:10.3390/molecules27072335 · Cited by 100
Kinetin Inhibits Protein Oxidation and Glycoxidation in Vitro
Verbeke, P., Siboska, G. E., Clark, B. F. C., & Rattan, S. I. S. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3616 · Cited by 85
Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease
Pamplona, R., Naudí, A., Gavı́n, R., Pastrana, M. A., Sajnani, G., Ilieva, E. V., del Rı́o, J. A., Portero‐Otín, M., Ferrer, I., & Requena, J. R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.07.009 · Cited by 85
Contribution of collagen network features to functional properties of engineered cartilage
Bastiaansen-Jenniskens, Y. M., Koevoet, W., de Bart, A. C. W., et al. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.07.003 · Cited by 79
Tissue-Specific Fructose Metabolism in Obesity and Diabetes
Helsley, R. N., Moreau, F., Gupta, M. K., Radulescu, A., DeBosch, B. J., & Softic, S. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01342-8 · Cited by 80
Miyamoto, S. (2002) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.12.5.621 · Cited by 78
“This compound, along with its breakdown product, 3-deoxyglucosone, is a much more potent glycating agent than glucose [17].”
BackgroundKaji, Y., Amano, S., Usui, T., Oshika, T., Yamashiro, K., Ishida, S., Suzuki, K., Tanaka, S., Adamis, A. P., Nagai, R., et al. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0268 · Cited by 77
Self-citationPharmacological approaches to the treatment of diabetic complications
Costantino, L., Rastelli, G., Gamberini, M. C., & Barlocco, D. (2000) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.10.8.1245 · Cited by 77
“This compound, along with its breakdown product, 3-deoxyglucosone, is much more potent as a glycating agent than glucose [12].”
BackgroundGlycolysis-mediated control of blood-brain barrier development and function
Salmina, A. B., Kuvacheva, N. V., Morgun, A. V., Komleva, Y. K., Пожиленкова, Е. А., Lopatina, O. L., Gorina, Y. V., Таранушенко, Т. Е., & Petrova, L. L. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.04.005 · Cited by 76
Evidence for non‐enzymatic glycosylation in Escherichia coli
Mironova, R., Niwa, T., Hayashi, H., Dimitrova, R., & Ivanov, I. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02304.x · Cited by 75
“We suppose that 3-DG and/or highly reactive metabolites of the glycolytic pathway (Hamada et al., 1996) could account for the accelerated glycation in E. coli under physiological conditions.”
BackgroundInfluentialEvidence for non‐enzymatic glycosylation of Escherichia coli chromosomal DNA
Mironova, R., Niwa, T., Handzhiyski, Y., Bozhinov, A., & Ivanov, I. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04504.x · Cited by 76
Chatzinikolaou, P. N., Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Vrabas, I. S., Kyparos, A., D’Alessandro, A., & Nikolaidis, M. G. (2024) · Acta Physiologica · doi:10.1111/apha.14081 · Cited by 79
“161,162 For instance, in patients with diabetes, accumulation of sorbitol due to increased activity of the enzyme aldose reductase has been associated with the development of diabetic autonomic neuropathy.”
BackgroundAdvanced glycation endproducts and osteoarthritis
Saudek, D. M., & Kay, J. (2003) · Current Rheumatology Reports · doi:10.1007/s11926-003-0081-x · Cited by 74
“Thus, AGE are not direct products of a single Maillard reaction with glucose, but instead are derived from a series of reactions (hence, the term advanced) [ 9 ].”
BackgroundToo sweet: Problems of protein glycation in the eye
Bejarano, E., & Taylor, A. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.08.017 · Cited by 64
“glyceraldehyde-3-phosphate or glucose-6-phosphate) are much more reactive, resulting in an accelerated production of reactive dicarbonyls that culminates in a faster production of AGEs (Hamada et al., 1996; Sadowska-Bartosz et al., 2014; Suarez et al., 1989) (Fig.”
Ketabi, S., & Rahmani, L. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.12.058 · Cited by 63
Oxidative Stress and Advanced Glycation in Diabetic Nephropathy
Coughlan, M. T., Mibus, A., & Forbes, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1433.018 · Cited by 59
Vlassara, H., Uribarri, J., Ferrucci, L., Cai, W., Torreggiani, M., Post, J. B., Zheng, F., & Striker, G. E. (2009) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2009.07.013 · Cited by 60
Nakamura, N., Obayashi, H., Fujii, M., Fukui, M., Yoshimori, K., Ogata, M., Hasegawa, G., Shigeta, H., Kitagawa, Y., Yoshikawa, T., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00286-0 · Cited by 56
Presence of fructose transporter GLUT5 in the S3 proximal tubules in the rat kidney
Sugawara-Yokoo, M., Suzuki, T., Matsuzaki, T., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00635.x · Cited by 56
“Fructose was shown to be one of potent agents for the formation of advanced glycation end product, the nonenzymatic modification product of proteins by sugar”
BackgroundNiwa, H., Takeda, A., Wakai, M., Miyata, T., Yasuda, Y., Mitsuma, T., Kurokawa, K., & Sobue, G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8899 · Cited by 56
Thorne, C. A., Grey, A. C., Lim, J. C.-H., & Donaldson, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169042 · Cited by 59
“With this in mind, we have proposed a model (Figure 4) in which both osmotic and oxidative stress resulting from the hyperglycaemic metabolism 6).”
BackgroundDiabetes-Induced Alterations in the Extracellular Matrix and Their Impact on Myocardial Function
Law, B. A., Fowlkes, V., Goldsmith, J. G., Carver, W. E., & Goldsmith, E. C. (2012) · Microscopy and Microanalysis · doi:10.1017/s1431927611012256 · Cited by 59
Takeda, A., Wakai, M., Niwa, H., Dei, R., Yamamoto, M., Li, M., Goto, Y., Yasuda, T., Nakagomi, Y., Watanabe, M., et al. (2001) · Acta Neuropathologica · doi:10.1007/s004010000256 · Cited by 55
“Recently, it was found that the formation of AGEs is accelerated in pathological conditions associated with increased levels of oxygen radicals, carbonyl compounds, or other reactive molecules [3, 4 , 5]. Carbonyl compounds and various oxygen radicals have been demonstrated to be increased in the AD brains [30, 31, 32…”
BackgroundA New Approach to Control the Enigmatic Activity of Aldose Reductase
CORSO, A. D., Balestri, F., Bugno, E. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074076 · Cited by 53
“products [7-9].”
A Snapshot of the Plant Glycated Proteome
Bilova, T. E., Lukasheva, E., Brauch, D., Greifenhagen, U., Paudel, G., Tarakhovskaya, E., Frolova, N., Mittasch, J., Balcke, G. U., Tissier, A. F., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.678581 · Cited by 52
“8) was reported previously for in vitro protein glycation studies, although the authors could not identify the products formed from each individual metabolite (53).”
BackgroundLing, X., Nagai, R., Sakashita, N., Takeya, M., Horiuchi, S., & Takahashi, K. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780294 · Cited by 50
“Rapid formation of AGE by intermediate metabolites of the glycolytic and polyol pathways was reported under physiologic conditions (Hamada et al, 1996).”
BackgroundSelf-citationThorpe, S. R., & Baynes, J. (2002) · International Congress Series · doi:10.1016/s0531-5131(02)00881-6 · Cited by 50
Cumbie, B. C., & Hermayer, K. L. (2007) · PubMed Central · Cited by 48
Zandt, M. C. V., Sibley, E., McCann, E. E., et al. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.07.062 · Cited by 48
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids
Colín-Lozano, B., Estrada-Soto, S. E., Chávez-Silva, F., Gutiérrez-Hernández, A., Cerón‐Romero, L., Giacoman‐Martínez, A., Almanza-Pérez, J. C., Hernández‐Núñez, E., Wang, Z., Xie, X., et al. (2018) · Molecules · doi:10.3390/molecules23020340 · Cited by 50
Varsha, M. K. N. S., Raman, T., & Manikandan, R. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.09.007 · Cited by 43
“AGEs are important sources of free radicals and their formation is known to increase in hyperglycemic conditions (Hamada et al., 1996).”
BackgroundHotta, N. (1997) · PubMed · doi:10.18999/nagjms.60.3-4.89 · Cited by 43
Self-citationInositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies
Lepore, E., Lauretta, R., Bianchini, M., Mormando, M., Lorenzo, C. D., & Unfer, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136796 · Cited by 43
Yang, S.-J., Chen, C., Chang, G.-D., Wen, H., Chen, C., Chang, S.-C., Liao, J., & Chang, C.-H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058100 · Cited by 42
Sun, W., An, X., Zhang, Y., Zhao, X., Sun, Y., Yang, C., Kang, X., Jiang, L., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1270145 · Cited by 44
Zhuang, X., Pang, X., Zhang, W., et al. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.10.025 · Cited by 39
Renal Microvascular Injury in Diabetes: RAGE and Redox Signaling
Coughlan, M. T., Cooper, M. E., & Forbes, J. M. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1469 · Cited by 37
“RAGE has a central role in mediating the effects of AGEs on the development of vascular disease in diabetes (46).”
Bulterijs, S. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1153 · Cited by 37
Non-enzymatic glycation mediated structure–function changes in proteins: case of serum albumin
Awasthi, S., & Saraswathi, N. T. (2016) · RSC Advances · doi:10.1039/c6ra08283a · Cited by 36
A Study on the Effects to Diabetic Nephropathy of Hachimi-jio-gan in Rats
Yokozawa, T., Yamabe, N., Cho, E. J., et al. (2004) · Nephron Experimental Nephrology · doi:10.1159/000078405 · Cited by 34
Hodgkinson, A., Page, T., Millward, B. A., et al. (2005) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2004.07.002 · Cited by 33
Ahmad, S., Ahmad, M. F. A., Khan, S., Alouffi, S., Khan, M., Prakash, C., Khan, M. W. A., & Ansari, I. A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135761 · Cited by 33
Effect of carbonyl compounds on red blood cells deformability
Iwata, H., Ukeda, H., Maruyama, T., Fujino, T., & Sawamura, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.026 · Cited by 31
Nakahara, M. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2004.049841 · Cited by 29
Beltramo, E., Buttiglieri, S., Pomero, F., Allione, A., Dalu, F. A., Ponte, E., & Porta, M. (2003) · Diabetologia · doi:10.1007/s00125-003-1043-6 · Cited by 29
“D-glucose and D-galactose need quite long periods to directly glycate, while some of their metabolites, such as glucose-6-phosphate, fructose-6-phosphate, glyceraldehyde-3-phosphate and a polyol pathway-related metabolite, fructose-3-phosphate, are able to produce AGEs within 24 h [19, 20 ].”
BackgroundZandt, M. C. V., Doan, B. D., Sawicki, D. R., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.02.037 · Cited by 28
Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy
Sango, K., Yanagisawa, H., Takaku, S., et al. (2011) · Experimental Diabetes Research · doi:10.1155/2011/374943 · Cited by 27
“It is also important to note that some AGE precursors, such as methylglyoxal (MG) and 3-deoxyglucosone (3DG), are generated via the polyol pathway [43].”
BackgroundAmyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts
Gerou, M., Hall, B., Woof, R., Allsop, J., Kolb, S. J., Meyer, K., Shaw, P. J., & Allen, S. P. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.04.013 · Cited by 26
“Increased levels of both intermediates enhance the production of dicarbonyls such as methylglyoxal, which in turn lead to more stable advanced glycation end products (AGEs) ( Hamada et al., 1996 ).”
Evolution of enzymes in a series is driven by dissimilar functional demands
Salvador, A., & Savageau, M. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510776103 · Cited by 25
Santos, H. O., & Penha‐Silva, N. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-01028-8 · Cited by 22
Vora, S. R., Patil, R. B., & Pillai, M. M. (2009) · PubMed · Cited by 23
Naudí, A., Jové, M., Cacabelos, D., et al. (2012) · Amino Acids · doi:10.1007/s00726-012-1339-2 · Cited by 23
“The described AGEs/ALEs are mostly derivatives of lysine and arginine residues formed by reaction of the amino or guanidino groups on protein with electrophilic intermediates derived from carbohydrate and lipid oxidation or metabolism (Hamada et al. 1996; Nagai et al. 2007).”
Moiz, B., Garcia, J., Basehore, S. E., Sun, A., Li, A., Padmanabhan, S., Albus, K., Jang, C., Sriram, G., & Clyne, A. M. (2021) · Metabolites · doi:10.3390/metabo11040226 · Cited by 22
“Fructose can then be converted to 3-deoxyglucosone (3-DG), which promotes formation of damaging advanced glycation end products (AGE) [12].”
Background
Metadata
- Authors
- Hamada, Y., Araki, N., Koh, N., Nakamura, J., Horiuchi, S., & Hotta, N.
- Affiliations
- Nagoya University (JP)
- Kumamoto University (JP)
- Nagoya University Hospital (JP)
- Corresponding author
- Hamada, Yoji
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 228
- Issue
- 2
- Pages
- 539-543
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2035592628
- Cited by
- 169
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- advanced glycation end products, glycation, polyol pathway, 3-deoxyglucosone, glyceraldehyde, triose phosphate, bovine serum albumin, diabetes mellitus
- MeSH terms
- Glycated Serum Albumin, Animals, Cattle, Deoxyglucose, Glucose, Glyceraldehyde, Glycolysis, Glycosylation, Kinetics, Serum Albumin, Serum Albumin, Bovine, Sorbitol, Substrate Specificity, Sugar Phosphates, Glycation End Products, Advanced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
