Fructose-mediated non-enzymatic glycation: sweet coupling or bad modification
Abstract
The Maillard reaction is a process in which reducing sugars react spontaneously with amino groups in proteins to advanced glycation end products (AGEs). Although an elevated level of glucose had been thought to play a primary role in the Maillard reaction, on a molecular basis, glucose is among the least reactive sugars within biological systems. The formation of AGEs is now also known to result from the action of various metabolites other than glucose, which are primarily located intracellularly and participate in the non-enzymatic glycation reaction at a much faster rate, such as fructose, trioses and dicarbonyl compounds. In this review, we considered the glycation reaction with particular attention to the potential role of fructose and fructose metabolites. The two sources for fructose are an exogenous supply from the diet and the endogenous formation from glucose through the aldose reductase pathway. Despite its approximately eightfold higher reactivity, the contribution of extracellular glycation by fructose is considerably less than that by glucose, because of the low plasma concentration of fructose (5 mmol/L glucose vs 35 micro mol/L fructose). Intracellularly, fructose is elevated in a number of tissues of diabetic patients in which the polyol pathway is active. In the cells of these tissues, the concentrations of fructose and glucose are of the same magnitude. Although direct evidence is not yet available, it is likely that the high reactivity of fructose and its metabolites may substantially contribute to the formation of intracellular AGEs and may contribute to alterations of cellular proteins, dysfunction of cells and, subsequently, to vascular complications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reactive oxygen species produced by the Maillard reaction damage pancreatic beta cells and lead to a subcellular stress response that drives insulin inadequacy.
“Reactive oxygen species are produced by the Maillard reaction [20], [21], damaging pancreatic beta cells, and leading to a subcellular stress response (the “unfolded protein response” in the endoplasmic reticulum) that drives insulin inadequacy [22], [23].”
From The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data (2013) · cites this paper as [20]
Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597 · see citing works
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312 · see citing works
Hyperglycemic Pseudohypoxia and Diabetic Complications
Williamson, J. R., Chang, K. C., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., Nyengaard, J. R., den Enden, M. V., Kilo, C., & Tilton, R. G. (1993) · Diabetes · doi:10.2337/diab.42.6.801 · Cited by 1,092 · see citing works
Fructose, weight gain, and the insulin resistance syndrome,,
Elliott, S. S., Keim, N. L., Stern, J. S., Teff, K. L., & Havel, P. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.911 · Cited by 1,031 · see citing works
The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus
Bunn, H. F., Gabbay, K. H., & Gallop, P. M. (1978) · Science · doi:10.1126/science.635569 · Cited by 872 · see citing works
Vlassara, H., Bucala, R., & Striker, L. J. (1994) · PubMed · Cited by 851 · see citing works
Hammes, H.-P., Du, X., Edelstein, D., Taguchi, T., Matsumura, T., Ju, Q., Lin, J., Bierhaus, A., Nawroth, P., Hannak, D., et al. (2003) · Nature Medicine · doi:10.1038/nm834 · Cited by 785 · see citing works
YONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716 · see citing works
Diabetes and advanced glycation endproducts
Vlassara, H., & Palace, M. R. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00932.x · Cited by 716 · see citing works
Intermediary metabolism of fructose
Mayes, P. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.754s · Cited by 669 · see citing works
Reaction of Monosaccharides with Proteins: Possible Evolutionary Significance
Bunn, H. F., & Higgins, P. J. (1981) · Science · doi:10.1126/science.12192669 · Cited by 598 · see citing works
Wells‐Knecht, K. J., Zyzak, D. V., Litchfield, J., Thorpe, S. R., & Baynes, J. (1995) · Biochemistry · doi:10.1021/bi00011a027 · Cited by 594 · see citing works
Thornalley, P. J. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02054-3 · Cited by 591 · see citing works
Wolff, L. F., Smith, Q. T., Snyder, W. K., Bedrick, J. A., Liljemark, W. F., Aeppli, D. M., & Bandt, C. L. (1988) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1988.tb01003.x · Cited by 577 · see citing works
Glomb, M. A., & Monnier, V. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10017 · Cited by 576 · see citing works
RAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice
Bucciarelli, L. G., Wendt, T., Qu, W., Lu, Y., Lalla, E., Rong, L., Goova, M. T., Moser, B., Kislinger, T., Lee, D. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000039325.03698.36 · Cited by 562 · see citing works
Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic Complications
McLellan, A. C., Thornalley, P. J., Benn, J. J., & Sönksen, P. H. (1994) · Clinical Science · doi:10.1042/cs0870021 · Cited by 557 · see citing works
Fructose transporter in human spermatozoa and small intestine is GLUT5.
Burant, C., Takeda, J., Brot‐Laroche, E., Bell, G. I., & Davidson, N. O. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42067-4 · Cited by 545 · see citing works
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE
Basta, G., Lazzerini, G., Massaro, M., Simoncini, T., Tanganelli, P., Fu, C., Kislinger, T., Stern, D. M., Schmidt, A. M., & Caterina, R. D. (2002) · Circulation · doi:10.1161/hc0702.104183 · Cited by 544 · see citing works
Dyer, D. G., Blackledge, J. A., Thorpe, S. R., & Baynes, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99007-1 · Cited by 535 · see citing works
Glycoxidation and lipoxidation in atherogenesis
Baynes, J., & Thorpe, S. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00228-8 · Cited by 515 · see citing works
Shinohara, M., Thornalley, P. J., Giardino, I., Beisswenger, P. J., Thorpe, S. R., Onorato, J., & Brownlee, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119885 · Cited by 513 · see citing works
Human diabetic endoneurial sorbitol, fructose, and myo‐inositol related to sural nerve morphometry
Dyck, P. J. B., Sherman, W. R., Hallcher, L. M., Service, F. J., O’Brien, P. C., Grina, L. A., Palumbo, P. J., & Swanson, C. (1980) · Annals of Neurology · doi:10.1002/ana.410080608 · Cited by 510 · see citing works
Grandhee, S. K., & Monnier, V. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99006-x · Cited by 459 · see citing works
Advanced Glycation End Products in Alzheimer's Disease and Other Neurodegenerative Diseases
Sasaki, N., Fukatsu, R., Tsuzuki, K., Hayashi, Y., Yoshida, T., Fujii, N., Koike, T., WAKAYAMA, I., Yanagihara, R. T., Garruto, R. M., et al. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65659-3 · Cited by 409 · see citing works
Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.
Iberg, N., & Flückiger, R. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67052-8 · Cited by 380 · see citing works
Glucose and diabetic vascular disease 1
Ruderman, N. B., Williamson, J. R., & Brownlee, M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.11.1644256 · Cited by 375 · see citing works
Giardino, I., Edelstein, D., & Brownlee, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117296 · Cited by 364 · see citing works
Metabolic effects of dietary fructose
Hallfrisch, J. G. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.9.2189777 · Cited by 359 · see citing works
Role of fructose in glycation and cross-linking of proteins
McPherson, J. D., Shilton, B. H., & Walton, D. J. (1988) · Biochemistry · doi:10.1021/bi00406a016 · Cited by 329 · see citing works
The role of AGEs in aging: causation or correlation
Baynes, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00138-3 · Cited by 329 · see citing works
Hyperglycemia, Polyol Metabolism, and Complications of Diabetes Mellitus
Gabbay, K. H. (1975) · Annual Review of Medicine · doi:10.1146/annurev.me.26.020175.002513 · Cited by 329 · see citing works
Polyol pathway and diabetic peripheral neuropathy
Oates, P. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)50082-9 · Cited by 327 · see citing works
Kuniyasu, H., Oue, N., Wakikawa, A., Shigeishi, H., Matsutani, N., Kuraoka, K., Ito, R., Yokozaki, H., & Yasui, W. (2001) · The Journal of Pathology · doi:10.1002/path.1031 · Cited by 326 · see citing works
Expression of monosaccharide transporters in intestine of diabetic humans
Dyer, J., Wood, I. S., Palejwala, A., Ellis, A., & Shirazi-Beechey, S. P. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00310.2001 · Cited by 320 · see citing works
Yaylayan, V. A., Huyghues‐Despointes, A., & Feather, M. S. (1994) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399409527667 · Cited by 314 · see citing works
Monnier, V. M., Sell, D. R., Nagaraj, R. H., Miyata, S., Grandhee, S. K., Odetti, P. R., & Ibrahim, S. A. (1992) · Diabetes · doi:10.2337/diab.41.2.s36 · Cited by 309 · see citing works
Thornalley, P. J. (1998) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(97)00157-9 · Cited by 308 · see citing works
Hayase, F., Nagaraj, R. H., Miyata, S., Njoroge, F. G., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84914-1 · Cited by 306 · see citing works
Advanced glycation: an important pathological event in diabetic and age related ocular disease
Stitt, A. W. (2001) · British Journal of Ophthalmology · doi:10.1136/bjo.85.6.746 · Cited by 305 · see citing works
(2002) · PubMed · Cited by 292 · see citing works
Jagt, D. L. V., Robinson, B., Taylor, K. K., & Hunsaker, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42844-x · Cited by 280 · see citing works
Shipanova, I. N., Glomb, M. A., & Nagaraj, R. H. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0195 · Cited by 279 · see citing works
Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes
Stern, D., Yan, S. D., Yan, S. D., & SCHMIDT, A. (2002) · Ageing Research Reviews · doi:10.1016/s0047-6374(01)00366-9 · Cited by 267 · see citing works
Giardino, I., Edelstein, D., & Brownlee, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118563 · Cited by 258 · see citing works
Increased Fructose Concentrations in Blood and Urine in Patients With Diabetes
Kawasaki, T., Akanuma, H., & Yamanouchi, T. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.353 · Cited by 253 · see citing works
Nonenzymatic Glycation of Bovine Serum Albumin by Fructose (Fructation)
Suárez, G., Rajaram, R., Oronsky, A. L., & Gawinowicz, M. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84904-9 · Cited by 244 · see citing works
Glycation in diabetic neuropathy: Characteristics, consequences, causes, and therapeutic options
Thornalley, P. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)50072-6 · Cited by 243 · see citing works
Modification of the glyoxalase system in human red blood cells by glucose in vitro
Thornalley, P. J. (1988) · Biochemical Journal · doi:10.1042/bj2540751 · Cited by 239 · see citing works
Westwood, M. E., & Thornalley, P. J. (1995) · Journal of Protein Chemistry · doi:10.1007/bf01886793 · Cited by 227 · see citing works
Identification of Fructose 3-Phosphate in the Lens of Diabetic Rats
Szwergold, B. S., Kappler, F. E., & Brown, T. R. (1990) · Science · doi:10.1126/science.2300805 · Cited by 213 · see citing works
Yamagishi, S., Amano, S., Inagaki, Y., Okamoto, T., Koga, K., Sasaki, N., Yamamoto, H., Takeuchi, M., & Makita, Z. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6312 · Cited by 210 · see citing works
Advanced Glycation End-products and Atherosclerosis
Vlassara, H. (1996) · Annals of Medicine · doi:10.3109/07853899608999102 · Cited by 209 · see citing works
Neurotoxicity of Advanced Glycation End-Products for Cultured Cortical Neurons
Takeuchi, M., Bucala, R., Suzuki, T., Ohkubo, T., Yamazaki, M., Koike, T., Kameda, Y., & Makita, Z. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.12.1094 · Cited by 198 · see citing works
Faist, V., & Erbersdobler, H. F. (2001) · Annals of Nutrition and Metabolism · doi:10.1159/000046699 · Cited by 192 · see citing works
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy
Corman, B., Duriez, M., Poitevin, P., Heudes, D., Bruneval, P., Tedgui, A., & Levy, B. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1301 · Cited by 189 · see citing works
Szwergold, B. S., Howell, S. K., & Beisswenger, P. J. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2139 · Cited by 174 · see citing works
Riby, J., Fujisawa, T., & Kretchmer, N. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.748s · Cited by 173 · see citing works
Hydroxyl Radical Mediates Nϵ-(Carboxymethyl)lysine Formation from Amadori Product
Nagai, R., Ikeda, K., Higashi, T., Sano, H., Jinnouchi, Y., Araki, T., & Horiuchi, S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6608 · Cited by 172 · see citing works
Protein fructosylation: fructose and the Maillard reaction
Dills, W. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.779s · Cited by 171 · see citing works
Hamada, Y., Araki, N., Koh, N., Nakamura, J., Horiuchi, S., & Hotta, N. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1695 · Cited by 169 · cited 3× · see citing works
“Both trioses are precursors of methylglyoxal [54] and these trioses are potent AGE-forming compounds [48].”
BackgroundSequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5
Rand, E. B., DePaoli, A. M., Davidson, N. O., Bell, G. I., & Burant, C. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.264.6.g1169 · Cited by 165 · see citing works
The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.
Jedziniak, J. A., Chylack, L. T., Cheng, H., Gillis, M. K., Kalustian, A. A., & Tung, W. H. (1981) · PubMed · Cited by 164 · see citing works
Red Cell Sorbitol: An Indicator of Diabetic Control
Malone, J. I., Knox, G. F., Benford, S. A., & Tedesco, T. A. (1980) · Diabetes · doi:10.2337/diab.29.11.861 · Cited by 161 · see citing works
Watkins, N. G., Thorpe, S. R., & Baynes, J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85131-1 · Cited by 158 · see citing works
Effects of glucose intolerance on myocardial function and collagen-linked glycation.
Avendaño, G., Agarwal, R., Bashey, R. I., Lyons, M. M., Soni, B. J., Jyothirmayi, G. N., & Regan, T. J. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1443 · Cited by 158 · see citing works
Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.
Delpierre, G., Rider, M. H., Collard, F., Stroobant, V., Vanstapel, F. J. L. A., Santos, H., & SCHAFTINGEN, E. V. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1627 · Cited by 154 · see citing works
3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication
Niwa, T. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(99)00113-9 · Cited by 144 · see citing works
Modification of the glyoxalase system in streptozotocin-induced diabetic rats
Phillips, S. A., Mirrlees, D. J., & Thornalley, P. J. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90488-i · Cited by 141 · see citing works
Biemel, K. M., Reihl, O., Conrad, J., & Lederer, M. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102035200 · Cited by 141 · see citing works
Long-Term Fructose Consumption Accelerates Glycation and Several Age-Related Variables in Male Rats
Levi, B., & Werman, M. J. (1998) · Journal of Nutrition · doi:10.1093/jn/128.9.1442 · Cited by 132 · see citing works
Enzymes Involved in Fructose Metabolism in Liver and the Glyceraldehyde Metabolic Crossroads
Sillero, M. A. G., Sillero, A., & Sols, A. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00696.x · Cited by 129 · see citing works
Cefalu, W. T., Bell–Farrow, A. D., Wang, Z. Q., Sonntag, W. E., Fu, M.-X., Baynes, J., & Thorpe, S. R. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.b337 · Cited by 128 · see citing works
Reactivities of d -glucose and d -fructose during Glycation of Bovine Serum Albumin
Yeboah, F. K., Alli, I., & Yaylayan, V. A. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981289v · Cited by 120 · see citing works
Knecht, K. J., Feather, M. S., & Baynes, J. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90146-n · Cited by 118 · see citing works
Vlassara, H., & Bucala, R. (1996) · Diabetes · doi:10.2337/diab.45.3.s65 · Cited by 117 · see citing works
Ascorbic acid-induced crosslinking of lens proteins: evidence supporting a Maillard reaction
ORTWERTH, B. J., & Olesen, P. R. (1988) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(88)90292-0 · Cited by 115 · see citing works
Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes
Delpierre, G., Collard, F., Fortpied, J., & SCHAFTINGEN, E. V. (2002) · Biochemical Journal · doi:10.1042/bj20020325 · Cited by 115 · see citing works
Scavenger Receptors that Recognize Advanced Glycation End Products
Miyazaki, A. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(02)00171-8 · Cited by 113 · see citing works
Mayhew, J., Gillon, K. R. W., & Hawthorne, J. N. (1983) · Diabetologia · doi:10.1007/bf00275940 · Cited by 111 · see citing works
Aldose reductase inhibitors and diabetic complications
Tomlinson, D. R., Willars, G. B., & Carrington, A. L. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90031-t · Cited by 110 · see citing works
Genotoxicity of advanced glycation end products in mammalian cells
Stopper, H., Schinzel, R., Šebeková, K., & Heidland, A. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00626-2 · Cited by 108 · see citing works
Implications of aldose reductase in cataracts in human diabetes.
Varma, S. D., Schocket, S. S., & Richards, R. D. (1979) · PubMed · Cited by 105 · see citing works
Metabolism of Fructose-3-phosphate in the Diabetic Rat Lens
Lal, S., Szwergold, B. S., Taylor, A. H., Randall, W. C., Kappler, F. E., Wells‐Knecht, K. J., Baynes, J., & Brown, T. R. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1220 · Cited by 102 · see citing works
Tessier, F. J., Monnier, V. M., Sayre, L. M., & Kornfield, J. A. (2003) · Biochemical Journal · doi:10.1042/bj20020668 · Cited by 102 · see citing works
Protein glycation in the kidney: Role in diabetes and aging
Vlassara, H. (1996) · Kidney International · doi:10.1038/ki.1996.270 · Cited by 102 · see citing works
Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats
Busserolles, J., Rock, E., Gueux, E., Mazur, A., Grolier, P., & RAYSSIGUIER, Y. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn2002524 · Cited by 98 · see citing works
Hamada, Y., Nakamura, J., Naruse, K., Komori, T., Kato, K., Kasuya, Y., Nagai, R., Horiuchi, S., & Hotta, N. (2000) · Diabetes Care · doi:10.2337/diacare.23.10.1539 · Cited by 92 · see citing works
Reiser, K. M. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.b71 · Cited by 89 · see citing works
Dietary fructose enhances intestinal fructose transport and GLUT5 expression in weaning rats
SHU, R., David, E. S., & Ferraris, R. P. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.3.g446 · Cited by 89 · see citing works
Hammes, H., Brownlee, M., Lin, J., Schleicher, E., & Bretzel, R. G. (1999) · Diabetologia · doi:10.1007/s001250051201 · Cited by 85 · see citing works
Atherogenesis and Advanced Glycation: Promotion, Progression, and Preventiona
Stitt, A. W., Bucala, R., & Vlassara, H. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51994.x · Cited by 82 · see citing works
Hajduch, É., Darakhshan, F., & Hundal, H. S. (1998) · Diabetologia · doi:10.1007/s001250050993 · Cited by 79 · see citing works
Metabolic Effects of Dietary Sucrose and Fructose in Type II Diabetic Subjects
Malerbi, D. A. C., Paiva, E. S. A., Duarte, A. L., & WAJCHENBERG, B. L. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1249 · Cited by 76 · see citing works
Maillard Reaction and Food Processing
Chuyên, N. V. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1925-0_18 · Cited by 70 · see citing works
Hotta, N., Kakuta, H., Fukasawa, H., Kimura, M., Koh, N., Iida, M., Terashima, H., Morimura, T., & Sakamoto, N. (1985) · Diabetologia · doi:10.1007/bf00273868 · Cited by 68 · see citing works
15 th Golgi lecture: from hyperglycaemia to the dysregulation of vascular remodelling in diabetes
Mario, U. D., & Pugliese, G. (2001) · Diabetologia · doi:10.1007/s001250051676 · Cited by 68 · see citing works
Diabetic vascular dysfunction: Links to glucose‐induced reductive stress and VEGF
Tilton, R. G. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10092 · Cited by 65 · see citing works
Westwood, M. E., & Thornalley, P. J. (1996) · Immunology Letters · doi:10.1016/0165-2478(96)02496-0 · Cited by 64 · see citing works
Increased erythrocyte 3-DG and AGEs in diabetic hemodialysis patients: Role of the polyol pathway
Tsukushi, S., Katsuzaki, T., Aoyama, I., Takayama, F., Miyazaki, T., Shimokata, K., & Niwa, T. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00418.x · Cited by 63 · see citing works
Suárez, G., Rajaram, R., Bhuyan, K. C., Oronsky, A. L., & Goidl, J. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113641 · Cited by 63 · see citing works
Pitkänen, E. (1996) · Clinica Chimica Acta · doi:10.1016/0009-8981(96)06284-5 · Cited by 62 · see citing works
Role of polyol pathway in nonenzymatic glycation
Hamada, Y., Araki, N., Horiuchi, S., & Hotta, N. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.supp5.95 · Cited by 62 · see citing works
Relation Between Serum 3-Deoxyglucosone and Development of Diabetic Microangiopathy
Kusunoki, H., Miyata, S., Ohara, T., Liu, B.-F., Uriuhara, A., Kojima, H., Suzuki, K., Miyazaki, H., Yamashita, Y., Inaba, K., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1889 · Cited by 60 · see citing works
Development of high-affinity ligands and photoaffinity labels for the d-fructose transporter GLUT5
Yang, J., Dowden, J., Tatibouët, A., Hatanaka, Y., & Holman, G. D. (2002) · Biochemical Journal · doi:10.1042/bj20020843 · Cited by 58 · see citing works
High-fructose diet decreases catalase mRNA levels in rat tissues
Cavarape, A., Feletto, F., Mercuri, F., Quagliaro, L., Damante, G., & Ceriello, A. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343940 · Cited by 57 · see citing works
Niwa, T., Katsuzaki, T., Ishizaki, Y., Hayase, F., Miyazaki, T., Uematsu, T., Tatemichi, N., & Takei, Y. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00362-1 · Cited by 56 · see citing works
Kashiwagi, A., Shinozaki, K., Nishio, Y., Okamura, T., Toda, N., & Kikkawa, R. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00062-5 · Cited by 56 · see citing works
Early Glycation Products Produce Pentosidine Cross-links on Native Proteins
Chellan, P., & Nagaraj, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008626200 · Cited by 55 · see citing works
Formation of methylglyoxal and d -lactate in human red blood cells in vitro
Phillips, S. A., & Thornalley, P. J. (1993) · Biochemical Society Transactions · doi:10.1042/bst021163s · Cited by 54 · see citing works
Failure of Common Glycation Assays to Detect Glycation by Fructose
Ahmed, N., & Furth, A. J. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.7.1301 · Cited by 53 · see citing works
Niwa, T., Takeda, N., Miyazaki, T., Yoshizumi, H., Tatematsu, A., Maeda, K., Ohara, M., Tomiyama, S., & Niimura, K. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000188516 · Cited by 52 · see citing works
Lingelbach, L. B., Mitchell, A. E., Rucker, R. B., & McDonald, R. B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1247 · Cited by 52 · see citing works
Glucose and fructose absorption in idiopathic steatorrhoea.
Holdsworth, C. D., & Dawson, A. M. (1965) · Gut · doi:10.1136/gut.6.4.387 · Cited by 51 · see citing works
Shu, R., David, E. S., & Ferraris, R. P. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.2.g232 · Cited by 51 · see citing works
Teillet, L., Verbeke, P., Gouraud, S. S., Bakala, H., Borot, C., Heudes, D., Bruneval, P., & Corman, B. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1181488 · Cited by 48 · see citing works
Monnier, V. M., Stevens, V. J., & Cerami, A. (1981) · PubMed · Cited by 48 · see citing works
Fructose induced deactivation of antioxidant enzymes: Preventive effect of pyruvate
Zhao, W. L., Devamanoharan, P. S., & Varma, S. D. (2000) · Free Radical Research · doi:10.1080/10715760000300581 · Cited by 46 · see citing works
Aldose reductase and its inhibition in the control of diabetic complications.
Narayanan, S. (1993) · PubMed · Cited by 45 · see citing works
Increase in cardiac muscle fructose content in streptozotocin-induced diabetic rats
Kashiwagi, A., Obata, T., Suzaki, M., Takagi, Y., Kida, Y., Ogawa, T., Tanaka, Y., Asahina, T., Ikebuchi, M., Saeki, Y., et al. (1992) · Metabolism · doi:10.1016/0026-0495(92)90283-g · Cited by 45 · see citing works
Suppression of Pentosidine Formation in Galactosemic Rat Lens by an Inhibitor of Aldose Reductase
Nagaraj, R. H., Prabhakaram, M., ORTWERTH, B. J., & Monnier, V. M. (1994) · Diabetes · doi:10.2337/diab.43.4.580 · Cited by 45 · see citing works
Münch, G. W., Deuther‐Conrad, W., & Gasic‐Milenkovic, J. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_28 · Cited by 44 · see citing works
Fructose metabolism in the human erythrocyte. Phosphorylation to fructose 3-phosphate
Petersen, A., Kappler, F. E., Szwergold, B. S., & Brown, T. R. (1992) · Biochemical Journal · doi:10.1042/bj2840363 · Cited by 42 · see citing works
Petersen, A., Szwergold, B. S., Kappler, F. E., Weingarten, M., & Brown, T. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38178-x · Cited by 41 · see citing works
3-Deoxyglucosone, an intermediate product of the Maillard reaction.
Kato, H., Hayase, F., Db, S., Oimomi, M., & Baba, S. (1989) · PubMed · Cited by 41 · see citing works
Yoshii, H., Uchino, H., Ohmura, C., Watanabe, K., Tanaka, Y., & Kawamori, R. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00221-7 · Cited by 39 · see citing works
Sell, D. R., & Monnier, V. M. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.5.b277 · Cited by 39 · see citing works
Dialysis‐Related Amyloidosis: Pathogenesis Focusing on AGE Modification
Niwa, T. (2001) · Seminars in Dialysis · doi:10.1046/j.1525-139x.2001.00031.x · Cited by 35 · see citing works
Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts
Lal, S., Randall, W. C., Taylor, A. H., Kappler, F. E., Walker, M. A., Brown, T. R., & Szwergold, B. S. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90240-7 · Cited by 34 · see citing works
Nε-(carboxymethyl)lysine (CML) as a Biomarker of Oxidative Stress in Long-Lived Tissue Proteins
Shaw, J., Baynes, J., & Thorpe, S. R. (2003) · Humana Press eBooks · doi:10.1385/1-59259-173-6:129 · Cited by 34 · see citing works
Detection of fructose-3-phosphokinase activity in intact mammalian lenses by 31P NMR spectroscopy.
Lal, S., Szwergold, B. S., Kappler, F. E., & Brown, T. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53023-4 · Cited by 32 · see citing works
Shinozaki, K., Kashiwagi, A., Masada, M., & Okamura, T. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.187 · Cited by 32 · see citing works
Protein Glycation in the Aging Male Sprague-Dawley Rat: Effects of Antiaging Diet Restrictions
Novelli, M., Masiello, P., Bombara, M., & Bergamini, E. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.2.b94 · Cited by 31 · see citing works
Mechanism of development and possible prevention of sugar cataracts.
Kh, G., & Jh, K. (1973) · PubMed · Cited by 31 · see citing works
Prabhakaram, M., & ORTWERTH, B. J. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1046 · Cited by 29 · see citing works
Polyol Pathway Metabolites in Human Cataracts
Lerner, B. C. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040030737033 · Cited by 28 · see citing works
Structural organization of the human sorbitol dehydrogenase gene (SORD)
Iwata, T., Popescu, N. C., Zimonjic, D. B., Karlsson, C., Höög, J., Vaca, G., Rodríguez, I. R., & Carper, D. A. (1995) · Genomics · doi:10.1016/0888-7543(95)80082-w · Cited by 28 · see citing works
Production of fructose and fructose-3-phosphate in maturing rat lenses.
Lal, S., Szwergold, B. S., Taylor, A. H., Randall, W. C., Kappler, F. E., & Brown, T. R. (1995) · PubMed · Cited by 25 · see citing works
Conversion of a synthetic fructosamine into its 3-phospho derivative in human erythrocytes
Delpierre, G., Vanstapel, F. J. L. A., Stroobant, V., & SCHAFTINGEN, E. V. (2000) · Biochemical Journal · doi:10.1042/bj3520835 · Cited by 25 · see citing works
Hamada, Y., Odagaki, Y., Sakakibara, F., Naruse, K., Koh, N., & Hotta, N. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00239-3 · Cited by 25 · see citing works
Acharya, A. S., Cho, Y. J., & Manjula, B. N. (1988) · Biochemistry · doi:10.1021/bi00412a045 · Cited by 23 · see citing works
Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase
Nagaraj, R. H., Prabhakaram, M., Ortwerth, B. J., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.4.580 · Cited by 21 · see citing works
Maekawa, K., Tanimoto, T., & Okada, S. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.88.123 · Cited by 16 · see citing works
Metabolitmuster in Rattenleber nach Fructoseapplikation
Heinz, F., & JUNGHÄNEL, J. (1969) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1969.350.2.859 · Cited by 15 · see citing works
Fructose mediated crosslinking of proteins.
Walton, D. J., McPherson, J. D., & Shilton, B. H. (1989) · PubMed · Cited by 12 · see citing works
Alzheimer's disease: inside, outside, upside down
Yan, S. D., Schmidt, A. M., & Stern, D. M. (2001) · Biochemical Society Symposia · doi:10.1042/bss0670015 · Cited by 10 · see citing works
[Metabolite model in rat liver following application of fructose].
Heinz, F., & JUNGHÄNEL, J. (1969) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Vistoli, G., De Maddis, D., Cipak, A., Zarkovic, N., Carini, M., & Aldini, G. (2013) · Free Radical Research · doi:10.3109/10715762.2013.815348 · Cited by 823 · see citing works
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771 · see citing works
Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834 · see citing works
Schalkwijk, C., & Stehouwer, C. D. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00001.2019 · Cited by 630 · see citing works
Self-citationBasu, S., Yoffe, P., Hills, N., & Lustig, R. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057873 · Cited by 435 · see citing works
“reaction [20,21], damaging pancreatic b-cells, and leading to a subcellular stress response (the “unfolded protein response” in the endoplasmic reticulum) that drives insulin inadequacy [22,23].”
BackgroundFructose: Metabolic, Hedonic, and Societal Parallels with Ethanol
Lustig, R. H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.06.008 · Cited by 310 · see citing works
Mooradian, A. D., Smith, M., & Tokuda, M. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.01.004 · Cited by 303 · see citing works
AGE restriction in diabetes mellitus: a paradigm shift
Vlassara, H., & Striker, G. E. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.74 · Cited by 277 · see citing works
Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE)
Xie, J., Reverdatto, S., Frolov, A., Hoffmann, R., Burz, D. S., & Shekhtman, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801622200 · Cited by 252 · see citing works
Fructose: It’s “Alcohol Without the Buzz”
Lustig, R. H. (2013) · Advances in Nutrition · doi:10.3945/an.112.002998 · Cited by 241 · see citing works
Aragno, M., & Mastrocola, R. (2017) · Nutrients · doi:10.3390/nu9040385 · Cited by 239 · see citing works
Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix
Sell, D. R., Biemel, K. M., Reihl, O., Lederer, M. O., Strauch, C., & Monnier, V. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500733200 · Cited by 212 · see citing works
Advanced glycation end products and diabetic foot disease
Huijberts, M. S., Schaper, N. C., & Schalkwijk, C. G. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.861 · Cited by 202 · see citing works
Self-citationLustig, R. H., Mulligan, K. M., Noworolski, S. M., Tai, V., Wen, M., Erkin‐Cakmak, A., Gugliucci, A., & Schwarz, J. (2015) · Obesity · doi:10.1002/oby.21371 · Cited by 185 · see citing works
Intestinal Absorption of Fructose
Ferraris, R. P., Choe, J.-Y., & Patel, C. R. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051707 · Cited by 180 · see citing works
DiNicolantonio, J. J., O’Keefe, J. H., & Lucan, S. C. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.12.019 · Cited by 154 · see citing works
Extracellular Matrix and Ageing
Birch, H. L. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_7 · Cited by 151 · see citing works
Toxic Advanced Glycation End Products (TAGE) Theory in Alzheimer’s Disease
Sato, T., Shimogaito, N., Wu, X., Kikuchi, S., Yamagishi, S., & Takeuchi, M. (2006) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317506289277 · Cited by 133 · see citing works
Novel insights into the relationship between diabetes and osteoporosis
de Paula, F. J. A., Horowitz, M. C., & Rosen, C. J. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1135 · Cited by 125 · see citing works
Ramu, R., Shirahatti, P. S., Zameer, F., Ranganatha, L., & Prasad, M. N. N. (2014) · South African Journal of Botany · doi:10.1016/j.sajb.2014.08.001 · Cited by 124 · see citing works
Rovenko, B. M., Kubrak, O. I., Gospodaryov, D. V., Perkhulyn, N. V., Yurkevych, I. S., Sanz, A., Lushchak, O. V., & Lushchak, V. I. (2015) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2015.05.007 · Cited by 116 · see citing works
Neurodegeneration and Inflammation
DeLegge, M. H., & Smoke, A. (2008) · Nutrition in Clinical Practice · doi:10.1177/011542650802300135 · Cited by 114 · see citing works
Ardestani, A. D., & Yazdanparast, R. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.07.014 · Cited by 114 · see citing works
Advanced glycation end products accumulate in the reproductive tract of men with diabetes
Mallidis, C., Agbaje, I., Rogers, D. A., Glenn, J. V., Pringle, R., Atkinson, A. B., Steger, K., Stitt, A. W., & McClure, N. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00849.x · Cited by 110 · see citing works
Ottum, M. S., & Mistry, A. (2015) · Journal of clinical biochemistry and nutrition · doi:10.3164/jcbn.15-3 · Cited by 97 · see citing works
Seo, Y., Kingsley, S. F., Walker, G., Mondoux, M. A., & Tissenbaum, H. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714178115 · Cited by 94 · see citing works
The Maillard reaction and pet food processing: effects on nutritive value and pet health
van Rooijen, C., Bosch, G., van der Poel, A. F. B., Wierenga, P. A., Alexander, L. G., & Hendriks, W. H. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000103 · Cited by 89 · see citing works
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats
Wang, X., Jia, X., Chang, T., Desai, K. M., & Wu, L. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f4a13c · Cited by 88 · see citing works
Takeuchi, M., Takino, J.-I., Furuno, S., Shirai, H., Kawakami, M., Muramatsu, M., Kobayashi, Y., & Yamagishi, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118652 · Cited by 85 · see citing works
Dietary Fructose and Hypertension
Madero, M., Perez-Pozo, S. E., Jalal, D. I., Johnson, R. J., & Sánchez‐Lozada, L. G. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0163-x · Cited by 85 · see citing works
Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models
Spagnuolo, M. S., Iossa, S., & Cigliano, L. (2020) · Nutrients · doi:10.3390/nu13010001 · Cited by 83 · see citing works
Jump, D. Β., Depner, C. M., Tripathy, S., & Lytle, K. A. (2015) · Advances in Nutrition · doi:10.3945/an.115.009423 · Cited by 82 · see citing works
Alteration of human serum albumin binding properties induced by modifications: A review
Maciążek-Jurczyk, M., Szkudlarek, A., Chudzik, M., Pożycka, J., & Sułkowska, A. (2017) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2017.05.023 · Cited by 82 · see citing works
Iizuka, K. (2017) · Nutrients · doi:10.3390/nu9020181 · Cited by 79 · see citing works
The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights
Federico, A., Rosato, V., Masarone, M., Torre, P., Dallio, M., Romeo, M., & Persico, M. (2021) · Nutrients · doi:10.3390/nu13041314 · Cited by 80 · see citing works
Feruloylated oligosaccharides: Structure, metabolism and function
Ou, J., & Sun, Z. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.09.028 · Cited by 79 · see citing works
Bone Cells and Bone Turnover in Diabetes Mellitus
Rubin, M. R. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0265-0 · Cited by 75 · see citing works
Deluyker, D., Evens, L., & Bito, V. (2017) · Amino Acids · doi:10.1007/s00726-017-2464-8 · Cited by 74 · see citing works
Adisakwattana, S., Thilavech, T., & Chusak, C. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-130 · Cited by 72 · see citing works
A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications
Babel, R. A., & Dandekar, M. P. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666201103143818 · Cited by 76 · see citing works
Bose, T., & Chakraborti, A. S. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.02.001 · Cited by 72 · see citing works
Direct Spectrophotometric Determination of Serum Fructose in Pancreatic Cancer Patients
Hui, H., Huang, D., McArthur, D. L., Nissen, N., Boros, L. G., & Heaney, A. P. (2009) · Pancreas · doi:10.1097/mpa.0b013e3181a7c6e5 · Cited by 72 · see citing works
Patel, C. R., Sugimoto, K., Douard, V., Shah, A., Inui, H., Yamanouchi, T., & Ferraris, R. (2015) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00188.2015 · Cited by 71 · see citing works
Mastrocola, R., Ferrocino, I., Liberto, E., Chiazza, F., Cento, A. S., Collotta, D., Querio, G., Nigro, D., Bitonto, V., Cutrin, J. C., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.003 · Cited by 68 · see citing works
Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide
Sima, A. A. F., Zhang, W., Kreipke, C. W., Rafols, J. A., & Hoffman, W. H. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.37 · Cited by 67 · see citing works
Mastrocola, R., Nigro, D., Cento, A. S., Chiazza, F., Collino, M., & Aragno, M. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.005 · Cited by 67 · see citing works
Analysis of protein glycation using phenylboronate acrylamide gel electrophoresis
Morais, M. P. P., Mackay, J. D., Bhamra, S. K., BUCHANAN, J. G., James, T. D., Fossey, J., & van den Elsen, J. M. H. (2009) · PROTEOMICS · doi:10.1002/pmic.200900269 · Cited by 65 · see citing works
Prediction of Glycosylation Sites in Proteins
Julenius, K., Johansen, M. B., Zhang, Y., Brunak, S., & Gupta, R. (2009) · doi:10.1002/9780470029619.ch9 · Cited by 65 · see citing works
Mastrocola, R., Collino, M., Rogazzo, M., Medana, C., Nigro, D., Boccuzzi, G., & Aragno, M. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00450.2012 · Cited by 63 · see citing works
Immunological detection of fructose-derived advanced glycation end-products
Takeuchi, M., Iwaki, M., Takino, J.-I., Shirai, H., Kawakami, M., Bucala, R., & Yamagishi, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.62 · Cited by 60 · see citing works
Thorne, C. A., Grey, A. C., Lim, J. C.-H., & Donaldson, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169042 · Cited by 59 · see citing works
Uric Acid and Fructose: Potential Biological Mechanisms
Lanaspa, M. A., Tapia, E., Soto, V., Sautin, Y. Y., & Sánchez‐Lozada, L. G. (2011) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2011.08.006 · Cited by 58 · see citing works
Uzozie, A. C., Nanni, P., Staiano, T., Grossmann, J., Barkow‐Oesterreicher, S., Shay, J. W., Tiwari, A. K., Buffoli, F., Laczkó, E., & Marra, G. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.035105 · Cited by 52 · see citing works
Bakhti, M., Habibi-Rezaei, M., Moosavi‐Movahedi, A. A., & Khazaei, M. R. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvm096 · Cited by 52 · see citing works
Takeuchi, M. (2016) · Diagnostics · doi:10.3390/diagnostics6020023 · Cited by 52 · see citing works
From Food to Genes: Transcriptional Regulation of Metabolism by Lipids and Carbohydrates
Bravo-Ruiz, I., Medina, M. Á., & Martı́nez-Poveda, B. (2021) · Nutrients · doi:10.3390/nu13051513 · Cited by 51 · see citing works
Oxidation as an important factor of protein damage: Implications for Maillard reaction
Trnková, L., Dršata, J., & Boušová, I. (2015) · Journal of Biosciences · doi:10.1007/s12038-015-9523-7 · Cited by 51 · see citing works
Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology
Delbridge, L. M. D., Benson, V. L., Ritchie, R. H., & Mellor, K. M. (2016) · Diabetes · doi:10.2337/db16-0682 · Cited by 50 · see citing works
Treps, L., Conradi, L., Harjes, U., & Carmeliet, P. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012492 · Cited by 49 · see citing works
Energy metabolism, proteotoxic stress and age-related dysfunction – Protection by carnosine
Hipkiss, A. R. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.004 · Cited by 48 · see citing works
Synergistic antioxidant interaction between sugars and phenolics from a sweet wine
Peinado, J., de Lerma, N. L., & Peinado, R. A. (2010) · European Food Research and Technology · doi:10.1007/s00217-010-1279-6 · Cited by 46 · see citing works
Rapin, J. R., & Wiernsperger, N. F. (2010) · Clinics · doi:10.1590/s1807-59322010000600012 · Cited by 46 · see citing works
Elevated dietary sugar and the heart: experimental models and myocardial remodeling
Mellor, K. M., Ritchie, R. H., Davidoff, A. J., & Delbridge, L. M. D. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-005 · Cited by 45 · see citing works
Takeuchi, M., Sato, T., Takino, J.-I., Kobayashi, Y., Furuno, S., Kikuchi, S., & Yamagishi, S. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.12.017 · Cited by 42 · see citing works
Rai, A. K., Jaiswal, N., Maurya, C. K., Sharma, A., Ahmad, I., Ahmad, S., Gupta, A. P., Gayen, J. R., & Tamrakar, A. K. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.016 · Cited by 40 · see citing works
Greifenhagen, U., Frolov, A., Blüher, M., & Hoffmann, R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.702860 · Cited by 40 · see citing works
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD
Takeuchi, M., Takino, J.-I., Sakai, A., Takata, T., & Tsutsumi, M. (2017) · Nutrients · doi:10.3390/nu9060634 · Cited by 40 · see citing works
Cannizzaro, L., Rossoni, G., Savi, F., Altomare, A., Marinello, C., Saethang, T., Carini, M., Payne, D. M., Pisitkun, T., Aldini, G., et al. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-016-0149-z · Cited by 38 · see citing works
Sugimoto, K., Hosotani, T., Kawasaki, T., Nakagawa, K., Hayashi, S., Nakano, Y., Inui, H., & Yamanouchi, T. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-93 · Cited by 37 · see citing works
Greifenhagen, U., Frolov, A., Blüher, M., & Hoffmann, R. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9651-4 · Cited by 37 · see citing works
Goodarzi, M. T., Moosavi‐Movahedi, A. A., Habibi-Rezaei, M., Shourian, M., Ghourchian, H., Ahmad, F., Farhadi, M. R., Saboury, A. A., & Sheibani, N. (2014) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2014.04.056 · Cited by 37 · see citing works
Fructose Modulates Cardiomyocyte Excitation-Contraction Coupling and Ca2+ Handling In Vitro
Mellor, K. M., Bell, J. R., Wendt, I. R., Davidoff, A. J., Ritchie, R. H., & Delbridge, L. M. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025204 · Cited by 36 · see citing works
Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice
Jump, D. Β., Depner, C. M., Tripathy, S., & Lytle, K. A. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s002966511500244x · Cited by 36 · see citing works
Hypertension Due to Toxic White Crystals in the Diet: Should We Blame Salt or Sugar?
DiNicolantonio, J. J., & O’Keefe, J. H. (2016) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2016.07.004 · Cited by 36 · see citing works
Hassel, B., Elsais, A., Frøland, A., Taubøll, E., Gjerstad, L., Quan, Y., Dingledine, R. J., & Rise, F. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13079 · Cited by 36 · see citing works
Characteristics, Formation, and Pathophysiology of Glucosepane: A Major Protein Cross-Link
Sjöberg, J. S., & Bulterijs, S. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0846 · Cited by 34 · see citing works
Lysine-Derived Protein-Bound Heyns Compounds in Bakery Products
Treibmann, S., Hellwig, A., Hellwig, M., & Henle, T. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04172 · Cited by 35 · see citing works
Rahman, M. M., Park, H.-M., Kim, S.-J., Go, H. M., Kim, G., Hong, C. U., Lee, Y.-U., Kim, S.-Z., Kim, J.-S., & Kang, H. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.4 · Cited by 35 · see citing works
Felice, J. I., Schurman, L., McCarthy, A. D., Sedlinsky, C., Aguirre, J. I., & Cortizo, A. M. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.02.011 · Cited by 34 · see citing works
Glucose as an agent of post-translational modification in diabetes — New cardiac epigenetic insights
Mellor, K. M., Brimble, M. A., & Delbridge, L. M. D. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.03.020 · Cited by 33 · see citing works
Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies
Takeuchi, M. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i12.880 · Cited by 32 · see citing works
Todhunter, M. E., Sayaman, R. W., Miyano, M., & LaBarge, M. A. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.05.016 · Cited by 32 · see citing works
Chang, K., & Petrash, J. M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-98788-0_13 · Cited by 34 · see citing works
Fructose and fructose kinase in cancer and other pathologies
Jiang, H., Lin, Q., Ma, L., Luo, S., Jiang, X., Fang, J., & Lu, Z. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.06.006 · Cited by 31 · see citing works
Adisakwattana, S., Thilavech, T., Sompong, W., & Pasukamonset, P. (2017) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2017.03.004 · Cited by 31 · see citing works
Muraoka, M. Y., Justino, A. B., Caixeta, D. C., Queiroz, J. S., Silva, R. S., & Espíndola, F. S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262369 · Cited by 31 · see citing works
Weber, K., Simon, M., Strassburger, K., Markgraf, D., Buyken, A., Szendroedi, J., Müssig, K., & Roden, M. (2018) · Nutrients · doi:10.3390/nu10060774 · Cited by 25 · see citing works
Fernandes, A. C. F., Martins, I. M., Moreira, D. K. T., & Macêdo, G. A. (2020) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.14397 · Cited by 30 · see citing works
New Insight into the Molecular Drug Target of Diabetic Nephropathy
Soetikno, V., Arozal, W., Louisa, M., & Setiabudy, R. (2014) · International Journal of Endocrinology · doi:10.1155/2014/968681 · Cited by 30 · see citing works
Collier, T. A., Nash, A., Birch, H. L., & de Leeuw, N. H. (2017) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2017.11.021 · Cited by 34 · see citing works
Pacholko, A. G., Wotton, C. A., & Bekar, L. K. (2019) · Neurodegenerative Diseases · doi:10.1159/000503451 · Cited by 29 · see citing works
Protein glycation in diabetes mellitus
Shin, A., Connolly, S. M., & Kabytaev, K. (2023) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.11.003 · Cited by 30 · see citing works
Rohilla, M., Rishabh, R., Bansal, S., Garg, A., Dhiman, S., Dhankhar, S., Saini, M., Chauhan, S., Alsubaie, N., Batiha, G. E., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115881 · Cited by 29 · see citing works
Fructose-induced modifications of myoglobin: Change of structure from met (Fe3+) to oxy (Fe2+) form
Bhattacherjee, A., & Chakraborti, A. S. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.11.003 · Cited by 29 · see citing works
Shen, C., Lu, C., Cheng, C., Li, K., Kuo, Y., Wu, C.-H., Liu, C., Hsieh, S., Tsai, C., & Yu, C. (2024) · Biomedicines · doi:10.3390/biomedicines12081699 · Cited by 28 · see citing works
Fructose and NAFLD: metabolic implications and models of induction in rats
de Castro, G. S., Cardoso, J. F. R., Vannucchi, H., Zucoloto, S., & Jordão, A. A. (2011) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502011000800009 · Cited by 28 · see citing works
Fructose Metabolism and Cardiac Metabolic Stress
Annandale, M., Daniels, L. J., Li, X., Neale, J. P. H., Chau, A. H. L., Ambalawanar, H. A., James, S. L., Koutsifeli, P., Delbridge, L. M. D., & Mellor, K. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.695486 · Cited by 28 · see citing works
Usha, R., Jaimohan, S. M., Rajaram, A., & Mandal, A. B. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.06.009 · Cited by 28 · see citing works
Demiot, C., Fromy, B., Saumet, J., & Sigaudo‐Roussel, D. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.09.005 · Cited by 27 · see citing works
Takeuchi, M., Sakai, A., Takata, T., Ueda, T., Takino, J.-I., Tsutsumi, M., Hyogo, H., & Yamagishi, S. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.02.002 · Cited by 26 · see citing works
- Authors
- Schalkwijk, C. G., Stehouwer, C. D. A., & van Hinsbergh, V. W. M.
- Affiliations
- Amsterdam Cardiovascular Sciences (NL)
- Corresponding author
- Schalkwijk, Casper G.
- Venue
- Diabetes/Metabolism Research and Reviews
- Publisher
- Wiley
- Published
- 2004-06-21
- Volume
- 20
- Issue
- 5
- Pages
- 369-382
- ISSN
- 1520-7552 (ISSN-L)
- 1520-7560
- OpenAlex
- W2151763813
- Cited by
- 206
- References
- 152
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 14 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 19 · 2014: 16 · 2013: 8 · 2012: 7
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes/Metabolism Research and Reviews (publishedVersion)
- PubMed (publishedVersion)
- TNO Repository (submittedVersion)
- Funders
- Vrije Universiteit Amsterdam
- Diabetes Fonds
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Keywords
- fructose, glycation, Maillard reaction, advanced glycation end products, polyol pathway, diabetic vascular complications, protein modification
- MeSH terms
- Animals, Diabetes Mellitus, Fructose, Glycosylation, Humans, Maillard Reaction, Glycation End Products, Advanced, Dietary Sucrose
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review