Reactive oxygen species (ROS) in macrophage activation and function in diabetes
Open accessAbstract
In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This contributes to the vascular complications of diabetes. Recent studies have shown that ROS formation is exacerbated in diabetic monocytes and macrophages due to a glycolytic metabolic shift. Macrophages are important players in the progression of diabetes and promote inflammation through the release of pro-inflammatory cytokines and proteases. Because ROS is an important mediator for the activation of pro-inflammatory signaling pathways, obesity and hyperglycemia-induced ROS production may favor induction of M1-like pro-inflammatory macrophages during diabetes onset and progression. ROS induces MAPK, STAT1, STAT6 and NFκB signaling, and interferes with macrophage differentiation via epigenetic (re)programming. Therefore, a comprehensive understanding of the impact of ROS on macrophage phenotype and function is needed in order to improve treatment of diabetes and its vascular complications. In the current comprehensive review, we dissect the role of ROS in macrophage polarization, and analyze how ROS production links metabolism and inflammation in diabetes and its complications. Finally, we discuss the contribution of ROS to the crosstalk between macrophages and endothelial cells in diabetic complications.
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Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
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A Synopsis of the Associations of Oxidative Stress, ROS, and Antioxidants with Diabetes Mellitus
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- Authors
- Rendra, E., Riabov, V., Mossel, D. M., Sevastyanova, T., Harmsen, M. C., & Kzhyshkowska, J.
- Affiliations
- University Medical Center Groningen (NL)
- National Research Tomsk State University (RU)
- Heidelberg University (DE)
- Corresponding author
- Kzhyshkowska, Julia
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 224
- Issue
- 2
- Pages
- 242-253
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W2903169176
- Cited by
- 636
- References
- 147
- Citations by year
- 2026: 66 · 2025: 100 · 2024: 127 · 2023: 117 · 2022: 107 · 2021: 66 · 2020: 42 · 2019: 9 · 2015: 1
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Immunobiology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- DFG GRK 1874 DIAMICOM and the Program of increasing the competitiveness of TSU (8.1.23.2018)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- reactive oxygen species, macrophage activation, diabetes mellitus, macrophage polarization, M1 macrophages, inflammatory cytokines, NF-κB signaling, MAPK signaling, STAT1, STAT6, epigenetic reprogramming, macrophage differentiation, diabetic vascular complications, hyperglycemia, obesity, inflammation
- MeSH terms
- Animals, Diabetes Mellitus, Disease Susceptibility, Energy Metabolism, Humans, Macrophage Activation, Macrophages, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Immunomodulation
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