Cited by 95Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchCellular transport and secretion

Differential Involvement of Synaptic Vesicle and Presynaptic Plasma Membrane Proteins in Alzheimer's Disease

Shimohama, Shun, Kamiya, Shinji, Taniguchi, Takashi, Akagawa, Kimiaki, Kimura, Jun·1997·Biochemical and Biophysical Research Communications

Abstract

Alzheimer's disease (AD) is characterized by progressive cognitive decline. Recent studies have shown that synaptic loss in the cortex is the major correlate of cognitive decline in AD. In the present study we assessed synaptic proteins such as synaptobrevin, synaptophysin, synaptotagmin, synaptosomal-associated protein 25 (SNAP-25), and syntaxin1/HPC-1 in control and AD brains to determine whether synaptic proteins are equally or differentially affected in AD. Western analysis showed that in AD levels of synaptobrevin and synaptophysin were decreased by some 30% from amounts in controls, while those of synaptotagmin, SNAP-25, and syntaxin 1/HPC-1 were decreased by only about 10%. As synaptobrevin and synaptophysin are localized mainly in transmitter-containing synaptic vesicles while SNAP-25 and syntaxin 1/HPC-1 are found in presynaptic plasma membranes, these results suggest differential involvement of synaptic components in AD.

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Crossref · 10.1006/bbrc.1997.6940

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Authors
Shimohama, S., Kamiya, S., Taniguchi, T., Akagawa, K., & Kimura, J.
Affiliations
  • Kyoto University (JP)
  • Kyoto Pharmaceutical University (JP)
  • Kyorin University (JP)
Corresponding author
Shimohama, Shun
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1997-07
Volume
236
Issue
2
Pages
239-242
ISSN
0006-291X (ISSN-L)
OpenAlex
W2024626366
Cited by
95
References
21
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.84
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Takeda Medical Research Foundation
  • Ministry of Education, Culture, Sports, Science and Technology
  • Smoking Research Foundation
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
Alzheimer's disease, synaptic proteins, synaptic vesicles, presynaptic plasma membrane, synaptobrevin, synaptophysin, synaptotagmin, SNAP-25, syntaxin-1, synaptic loss, cognitive decline, brain
MeSH terms
Alzheimer Disease, Animals, Calcium-Binding Proteins, Membrane Glycoproteins, Membrane Proteins, Nerve Tissue Proteins, Synaptic Membranes, Synaptic Vesicles, Temporal Lobe, Blotting, Western, Synaptophysin, R-SNARE Proteins, Synaptosomal-Associated Protein 25, Synaptotagmins, Rats

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