Alzheimer's disease
Abstract
THE landmark case report of Alzheimer's disease, which was published in 1907,1 described the autopsy findings in a woman who died at 55 with progressive dementia and in whom newly available silver stains demonstrated the presence of abnormal nerve cells containing tangles of fibers (neurofibrillary tangles) and clusters of degenerating nerve endings (neuritic plaques) in the cerebral cortex. The medical world accepted this condition as Alzheimer's disease, a cause of presenile dementia.2 However, during the next several decades, there was conflict among neurologists about whether Alzheimer's disease–like changes that occurred in very elderly persons were identical to those that occurred . . .
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Both mothers and fathers contribute to their offspring's AD risk, but mothers contribute more because mtDNA is maternally inherited.
“In this respect, both mothers and fathers contribute to their offspring's AD risk, but because mitochondrial DNA (mtDNA) is maternally inherited mothers contribute more.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [112]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Self-citationBlessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works
Validation of a short Orientation-Memory-Concentration Test of cognitive impairment
Katzman, R., Brown, T., Fuld, P. A., Peck, A., Schechter, R., & Schimmel, H. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.6.734 · Cited by 2,119 · see citing works
Self-citationObservations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Perry, E., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P., & Perry, R. H. (1978) · British medical journal · doi:10.1136/bmj.2.6150.1457 · Cited by 2,043 · see citing works
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693 · see citing works
Human Memory and the Cholinergic System
Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398 · see citing works
Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease
KIDD, M. (1963) · Nature · doi:10.1038/197192b0 · Cited by 1,012 · see citing works
Perl, D. P., & Brody, A. R. (1980) · Science · doi:10.1126/science.7367858 · Cited by 985 · see citing works
HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy
Shaw, G. M., Harper, M., Hahn, B. H., et al. (1985) · Science · doi:10.1126/science.2981429 · Cited by 899 · see citing works
Davies, P., Katzman, R., & Terry, R. D. (1980) · Nature · doi:10.1038/288279a0 · Cited by 882 · see citing works
Self-citationSome morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801 · see citing works
The Natural History of Mental Disorder in Old Age
Roth, M. (1955) · Journal of Mental Science · doi:10.1192/bjp.101.423.281 · Cited by 723 · see citing works
Mash, D. C., Flynn, D. D., & Potter, L. T. (1985) · Science · doi:10.1126/science.3992249 · Cited by 702 · see citing works
Appel, S. H. (1981) · Annals of Neurology · doi:10.1002/ana.410100602 · Cited by 698 · see citing works
Frackowiak, R. S. J., Pozzilli, C., Legg, N. J., du Boulay, G. H., MARSHALL, J., Lenzi, G. L., & Jones, T. (1981) · Brain · doi:10.1093/brain/104.4.753 · Cited by 685 · see citing works
The Prevalence and Malignancy of Alzheimer Disease
Katzman, R. (1976) · Archives of Neurology · doi:10.1001/archneur.1976.00500040001001 · Cited by 623 · see citing works
Self-citationAlzheimer's disease: A study of epidemiological aspects
Heyman, A., Wilkinson, W. E., Stafford, J. A., Helms, M. J., Sigmon, A. H., & Weinberg, T. (1984) · Annals of Neurology · doi:10.1002/ana.410150406 · Cited by 525 · see citing works
Vinters, H. V., & Gilbert, J. J. (1983) · Stroke · doi:10.1161/01.str.14.6.924 · Cited by 504 · see citing works
NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE
White, P., Goodhardt, M., Keet, J. P., Hiley, C. R., Carrasco, L. H., Williams, I. E. I., & Bowen, D. M. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92114-6 · Cited by 489 · see citing works
Evidence for a cholinergic projection to neocortex from neurons in basal forebrain.
Johnston, M. V., McKinney, M., & Coyle, J. T. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5392 · Cited by 460 · see citing works
Cell loss in the locus coeruleus in senile dementia of Alzheimer type
Tomlinson, B. E., Irving, D., & Blessed, G. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90031-9 · Cited by 453 · see citing works
Dementia of the Alzheimer Type
Heston, L. L. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780350019001 · Cited by 450 · see citing works
ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE
Candy, J., Klinowski, J., Perry, R. H., Perry, E. K., FAIRBAIRN, A. F., Oakley, A. E., Carpenter, T. A., Atack, J. R., Blessed, G., & Edwardson, J. A. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92319-6 · Cited by 450 · see citing works
Rossor, M. N., Emson, P. C., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90177-9 · Cited by 433 · see citing works
A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA
Ball, M. J., Hachinski, V., Fox, A. J., Kirshen, A. J., Fisman, M., Blume, W. T., Kral, V. A., Fox, H., & Merskey, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90965-1 · Cited by 427 · see citing works
Selkoe, D. J., Ihara, Y., & Salazar, F. J. (1982) · Science · doi:10.1126/science.6120571 · Cited by 394 · see citing works
Cortical abnormalities in Alzheimer's disease
Foster, N. L., Chase, T. N., Mansi, L., Brooks, R., Fedio, P., Patronas, N. J., & Chiro, G. D. (1984) · Annals of Neurology · doi:10.1002/ana.410160605 · Cited by 378 · see citing works
Coexistence of cognitive impairment and depression in geriatric outpatients
Reifler, B. V., Larson, E. B., & Hanley, R. J. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.5.623 · Cited by 373 · see citing works
Neurofibrillary tangles of paired helical filaments
Wı́sniewski, H. M., Narang, H. K., & Terry, R. D. (1976) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(76)90059-9 · Cited by 370 · see citing works
Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats
Gage, F. H., Björklund, A., Stenevi, U., et al. (1984) · Science · doi:10.1126/science.6539949 · Cited by 367 · see citing works
Neurochemical Studies of Early-Onset Alzheimer's Disease
Francis, P. T., Palmer, A. M., Sims, N. R., Bowen, D. M., DAVISON, A. N., Esiri, M. M., Neary, D., Snowden, J. S., & Wilcock, G. K. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507043130102 · Cited by 353 · see citing works
Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
Yamamoto, T., & Hirano, A. (1985) · Annals of Neurology · doi:10.1002/ana.410170608 · Cited by 338 · see citing works
Davies, P., & Verth, A. H. (1977) · Brain Research · doi:10.1016/0006-8993(77)90758-2 · Cited by 314 · see citing works
Head injury as a risk factor for Alzheimer's disease
Mortimer, J. A., French, L., Hutton, J. T., & Schuman, L. M. (1985) · Neurology · doi:10.1212/wnl.35.2.264 · Cited by 308 · see citing works
Ishii, T. (1966) · Acta Neuropathologica · doi:10.1007/bf00686763 · Cited by 303 · see citing works
Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease
Cross, A. J., Crow, T. J., Perry, E. K., Perry, R. H., Blessed, G., & Tomlinson, B. E. (1981) · BMJ · doi:10.1136/bmj.282.6258.93 · Cited by 267 · see citing works
Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients
Morrison, J. H., Rogers, J., Scherr, S., Benoit, R., & Bloom, F. E. (1985) · Nature · doi:10.1038/314090a0 · Cited by 264 · see citing works
Diagnostic Accuracy in Presenile Dementia
Ron, M. A., Toone, B., Garralda, M. E., & Lishman, W. (1979) · The British Journal of Psychiatry · doi:10.1192/bjp.134.2.161 · Cited by 262 · see citing works
Reduced Numbers of Somatostatin Receptors in the Cerebral Cortex in Alzheimer's Disease
Beal, M. F., Mazurek, M. F., Tran, V. T., Chattha, G., Bird, E. D., & Martin, J. B. (1985) · Science · doi:10.1126/science.2861661 · Cited by 251 · see citing works
Wı́sniewski, H. M., TEKRY, R. D., & HIHANO, A. (1970) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197004000-00001 · Cited by 243 · see citing works
THE INVESTIGATION OF DEMENTIA: RESULTS IN 200 CONSECUTIVE ADMISSIONS
Smith, J. S., & Kiloh, L. G. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92692-1 · Cited by 230 · see citing works
Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex on Guam
Hirano, A. (1966) · Archives of Neurology · doi:10.1001/archneur.1966.00470130039004 · Cited by 226 · see citing works
Neuropeptides in Alzheimer type dementia
Ferrier, I. N., Cross, A. J., Johnson, J. A., Roberts, G. W., Crow, T. J., Corsellis, J., Lee, Y. C., O'Shaughnessy, D., Adrian, T. E., McGregor, G. P., et al. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90196-x · Cited by 215 · see citing works
Location of neuronal tangles in somatostatin neurones in Alzheimer's disease
Roberts, G. W., Crow, T. J., & Polak, J. M. (1985) · Nature · doi:10.1038/314092a0 · Cited by 213 · see citing works
Effects of physostigmine and lecithin on memory in Alzheimer disease
Peters, B. H., & Levin, H. S. (1979) · Annals of Neurology · doi:10.1002/ana.410060307 · Cited by 196 · see citing works
Bowen, D. M., Benton, J. S., Spillane, J. A., Smith, C., & Allen, S. J. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90026-0 · Cited by 195 · see citing works
ALZHEIMER-LIKE CHOLINERGIC DEFICIENCY IN DOWN SYNDROME
Yates, C. M., Simpson, J., Maloney, A. F. J., Gordon, A., & Reid, A. H. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92137-6 · Cited by 190 · see citing works
Friedland, R. P., Budinger, T. F., Koss, E., & Ober, B. A. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90543-9 · Cited by 181 · see citing works
Biopsy‐proved Alzheimer disease presenting as a right parietal lobe syndrome
Crystal, H., Horoupian, D. S., Katzman, R., & Jotkowitz, S. (1982) · Annals of Neurology · doi:10.1002/ana.410120210 · Cited by 173 · see citing works
Self-citationVolumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls.
Gado, M., Hughes, C. P., Danziger, W. L., Chi, D., Jošt, G., & van den Berg, L. (1982) · Radiology · doi:10.1148/radiology.144.3.7100467 · Cited by 168 · see citing works
Bissette, G. (1985) · JAMA · doi:10.1001/jama.254.21.3067 · Cited by 167 · see citing works
Norepinephrine and MHPG Levels in CSF and Plasma in Alzheimer's Disease
Raskind, M. A. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790150033006 · Cited by 165 · see citing works
GERONTO‐PSYCHIATRIC PERIOD‐PREVALENCE INVESTIGATION IN A GEOGRAPHICALLY DELIMITED POPULATION
Nielsen, J. (1962) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1962.tb01802.x · Cited by 155 · see citing works
PATHOLOGICAL AND POSITRON EMISSION TOMOGRAPHIC CORRELATIONS IN ALZHEIMER'S DISEASE
Friedland, R. P., Brun, A. E., & Budinger, T. F. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92074-4 · Cited by 142 · see citing works
Crystal, H., & Davies, P. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb06665.x · Cited by 142 · see citing works
The clinical utility of the Dementia Rating Scale for assessing Alzheimer patients
VITALIANO, P. P., Breen, A. R., Russo, J. E., Albert, M., Vitiello, M. V., & Prinz, P. N. (1984) · Journal of Chronic Diseases · doi:10.1016/0021-9681(84)90043-2 · Cited by 132 · see citing works
Rossor, M. N., Fahrenkrug, J., Emson, P. C., Mountjoy, C. Q., Iversen, L., & Roth, M. (1980) · Brain Research · doi:10.1016/0006-8993(80)90795-7 · Cited by 130 · see citing works
A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease.
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.2.201 · Cited by 123 · see citing works
Cook-Deegan, R. M., Ward, B. E., & Austin, J. H. (1979) · Neurology · doi:10.1212/wnl.29.10.1402 · Cited by 117 · see citing works
Reality Orientation and Dementia: A Controlled Trial of Two Approaches
Hanley, I. G., McGuire, R., & Boyd, W. D. (1981) · The British Journal of Psychiatry · doi:10.1192/bjp.138.1.10 · Cited by 111 · see citing works
The Association of Actin with Hirano Bodies
Goldman, J. E. (1983) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198303000-00004 · Cited by 110 · see citing works
Elevation of neuropeptide Y (NPY) in substantia innominata in Alzheimer's type dementia
Allen, J. M., Ferrier, I. N., Roberts, G. W., et al. (1984) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(84)90180-1 · Cited by 104 · see citing works
Blass, J. P., & Zemcov, A. (1984) · Neurochemical Pathology · doi:10.1007/bf02834249 · Cited by 103 · see citing works
Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin
Goudsmit, J., White, B. J., WEITKAMP, L. R., Keats, B. J. B., Morrow, C. H., & Gajdusek, D. C. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90190-8 · Cited by 102 · see citing works
Does the Incidence of Age Psychosis Decrease?
Hagnell, O., Lanke, J., Rorsman, B., et al. (2008) · Neuropsychobiology · doi:10.1159/000117852 · Cited by 98 · see citing works
Neural transplantation: A review of recent developments and potential applications to the aged brain
Gash, D. M., Collier, T. J., & Sladek, J. R. (1985) · Neurobiology of Aging · doi:10.1016/0197-4580(85)90031-4 · Cited by 93 · see citing works
Perry, E. K., Atack, J. R., Perry, R. H., Hardy, J., Dodd, P. R., Edwardson, J. A., Blessed, G., Tomlinson, B. E., & FAIRBAIRN, A. F. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02801.x · Cited by 92 · see citing works
Somatostatin-like immunoreactivity within neuritic plaques
Armstrong, D. M., LeRoy, S., Shields, D., & Terry, R. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90249-5 · Cited by 88 · see citing works
García, C., REDING, M. J., & Blass, J. P. (1981) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1981.tb02379.x · Cited by 87 · see citing works
Organic Brain Syndrome and Aging
Jarvik, L. F. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780160050005 · Cited by 87 · see citing works
ALZHEIMER'S DISEASE AS A DISORDER OF ISODENDRITIC CORE
Benton, J. S., Bowen, D. M., Allen, S. J., Haan, E., DAVISON, A. N., Neary, D., Murphy, R., & Snowden, J. S. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91667-1 · Cited by 81 · see citing works
Rossor, M. N., Rehfeld, J. F., Emson, P. C., et al. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90334-9 · Cited by 77 · see citing works
Miller, A., Neighbour, P. A., Katzman, R., Aronson, M. K., & Lipkowitz, R. (1981) · Annals of Neurology · doi:10.1002/ana.410100603 · Cited by 74 · see citing works
Self-citationMuramoto, O., Sugishita, M., & Ando, K. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.5.485 · Cited by 72 · see citing works
Twins With Alzheimer's Disease
Cook-Deegan, R. M., Schneck, S. A., & Clark, D. B. (1981) · Archives of Neurology · doi:10.1001/archneur.1981.00510050066011 · Cited by 66 · see citing works
Neuropeptide Y-like immunoreactivity in neuritic plaques of Alzheimer's disease
Dawbarn, D., & Emson, P. C. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90604-7 · Cited by 61 · see citing works
Studies in Ageing of the Brain
Nikaido, T. (1972) · Archives of Neurology · doi:10.1001/archneur.1972.00490180085017 · Cited by 61 · see citing works
Kidd, M., Allsop, D., & Landon, M. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91054-2 · Cited by 60 · see citing works
Simpson, J., Yates, C., Gordon, A., et al. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.10.1138-a · Cited by 55 · see citing works
Physostigmine and its effect on six patients with dementia
Ashford, J. W., Soldinger, S., Schaeffer, J., et al. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.6.829 · Cited by 48 · see citing works
Choline chloride effects on memory in the elderly☆
Mohs, R. C., Davis, K. L., Tinklenberg, J. R., et al. (1980) · Neurobiology of Aging · doi:10.1016/0197-4580(80)90020-2 · Cited by 44 · see citing works
Reminiscence Group Therapy with Psychotic Geriatric Inpatients
Lesser, J., Lazarus, L. W., Frankel, R. M., et al. (1981) · The Gerontologist · doi:10.1093/geront/21.3.291 · Cited by 43 · see citing works
Substance P immunoreactivity within neuritic plaques
Armstrong, D. M., & Terry, R. D. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90343-x · Cited by 42 · see citing works
Atypical Presentations of Dementia of the Alzheimer Type
Shuttleworth, E. C. (1984) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1984.tb02232.x · Cited by 32 · see citing works
Hanin, I., Reynolds, C. F., Kupfer, D. J., et al. (1984) · Psychiatry Research · doi:10.1016/0165-1781(84)90060-x · Cited by 23 · see citing works
182 BRAIN TRACE ELEMENT LEVELS IN ALZHEIMERʼS DISEASE BY INSTRUMENTAL NEUTRON ACTIVATION ANALYSIS
Markesbery, W. R., Ehmann, W. D., Hossain, T., et al. (1981) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198105000-00189 · Cited by 22 · see citing works
Red blood cell choline. I: Choline in Alzheimer's disease
GREENWALD, B. S., Edasery, J. P., Mohs, R. C., Shah, N., Trigos, G. G., & Davis, K. L. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90039-3 · Cited by 21 · see citing works
Double Blind Study of Lecithin in Patients with Alzheimer's Disease
Fisman, M., Merskey, H., Helmes, E., et al. (1981) · The Canadian Journal of Psychiatry · doi:10.1177/070674378102600608 · Cited by 14 · see citing works
Choline chloride in Alzheimer disease
Thal, L. J., Rosen, W. G., Sharpless, N. S., et al. (1981) · Annals of Neurology · doi:10.1002/ana.410100617 · Cited by 13 · see citing works
Harbaugh, R. E., Roberts, D. W., Coombs, D. W., Saunders, R. L., & Reeder, T. M. (1984) · Neurosurgery · doi:10.1097/00006123-198410000-00007 · Cited by 9 · see citing works
Katzman, R. (1985) · Neurobiology of Aging · doi:10.1016/0197-4580(85)90033-8 · Cited by 1 · see citing works
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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Aβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938 · see citing works
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Self-citationMedial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128 · see citing works
The Medical Review Article: State of the Science
MULROW, C. D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-3-485 · Cited by 856 · see citing works
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works
Molecular mechanisms of neurodegeneration in Alzheimer's disease
Crews, L., & Masliah, E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq160 · Cited by 772 · see citing works
A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758 · see citing works
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100339 · Cited by 562 · see citing works
Synaptic degeneration in Alzheimer's disease
Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works
Quantitative assessment of cortical synaptic density in Alzheimer's disease
Scheff, S. W., DeKosky, S. T., & Price, D. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90059-9 · Cited by 446 · see citing works
Activation of NADPH Oxidase in Alzheimer’s Disease Brains
Shimohama, S., Tanino, H., Kawakami, N., Okamura, N., Kodama, H., Yamaguchi, T., Hayakawa, T., Nunomura, A., Chiba, S., Perry, G., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2897 · Cited by 292 · see citing works
Cytochrome c oxidase is decreased in Alzheimer’s disease platelets
Cardoso, S. M., Proença, M. T., Santos, S., Santana, I., & Oliveira, C. R. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00033-2 · Cited by 281 · see citing works
Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
Espuny-Camacho, I., Arranz, A. M., Fiers, M., Snellinx, A., Ando, K., Munck, S., Bonnefont, J., Lambot, L., Corthout, N., Omodho, L., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.001 · Cited by 244 · see citing works
Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders
Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258 · see citing works
Wertkin, A. M., Turner, R. S., Pleasure, S. J., Golde, T. E., Younkin, S. G., Trojanowski, J. Q., & Lee, V. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9513 · Cited by 231 · see citing works
Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works
Wong, T. P., Debeir, T., Duff, K., & Cuello, A. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02706.1999 · Cited by 196 · see citing works
Tricco, A. C., Ashoor, H. M., Soobiah, C., Rios, P., Veroniki, A. A., Hamid, J. S., Ivory, J. D., Khan, P. A., Yazdi, F., Ghassemi, M., et al. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15069 · Cited by 137 · see citing works
LANGE, K. L., BONDI, M. W., SALMON, D. P., GALASKO, D., DELIS, D. C., THOMAS, R. G., & THAL, L. J. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702870096 · Cited by 129 · see citing works
Mitochondria in Alzheimer's disease
Swerdlow, R. H., & Kish, S. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53013-0 · Cited by 126 · see citing works
Bassil, R., Shields, K., Granger, K., Zein, I., Ng, S., & Chih, B. (2021) · Nature Communications · doi:10.1038/s41467-021-25344-6 · Cited by 106 · see citing works
Bhattacharya, S. K., Kumar, A., & Ghosal, S. (1995) · Phytotherapy Research · doi:10.1002/ptr.2650090206 · Cited by 112 · see citing works
Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies
Dominantly Inherited Alzheimer Network, Ringman, J. M., Goate, A., Masters, C. L., Cairns, N. J., Danek, A., Graff-Radford, N., Ghetti, B., & Morris, J. C. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0499-8 · Cited by 96 · see citing works
Shimohama, S., Kamiya, S., Taniguchi, T., Akagawa, K., & Kimura, J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6940 · Cited by 95 · see citing works
Hypothesis: microtubules, a key to Alzheimer disease
Matsuyama, S. S., & Jarvik, L. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8152 · Cited by 95 · see citing works
Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides
Stokin, G. B., Almenar-Queralt, A., Gunawardena, S., Rodrigues, E. M., Falzone, T., Kim, J., Lillo, C., Mount, S. L., Roberts, E. A., McGowan, E., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn240 · Cited by 72 · see citing works
Walia, V., Kaushik, D., Mittal, V., Kumar, K., Verma, R., Parashar, J., Akter, R., Rahman, M. H., Bhatia, S., Al-Harrasi, A., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02617-1 · Cited by 47 · see citing works
Li, G., Zou, L., Cao, C., & Yang, E. S. (2005) · BioFactors · doi:10.1002/biof.5520250111 · Cited by 41 · see citing works
H. Swerdlow, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798072535 · Cited by 35 · see citing works
Yoon, G., Shah, S. A., Ali, T., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0847-1 · Cited by 34 · see citing works
Class balancing diversity multimodal ensemble for Alzheimer’s disease diagnosis and early detection
Francesconi, A., di Biase, L., Cappetta, D., Rebecchi, F., Soda, P., Sicilia, R., & Guarrasi, V. (2025) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2025.102529 · Cited by 30 · see citing works
“It primarily affects regions of the brain that are involved in memory, cognition, and language, leading to significant impairment in an individual’s ability to engage in conversation and interact with their surroundings [1].”
- Authors
- Katzman, R.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Katzman, Robert
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-04-10
- Volume
- 314
- Issue
- 15
- Pages
- 964-973
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4244678912
- Semantic Scholar
- 3f01e33b0a4ad7cc45cc1facbce4763a20fb55e1
- Cited by
- 801
- References
- 96
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 11 · 2012: 7
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (2 PO1 AG 02478, P50AG005131, P50-AG05131)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary tangles, neuritic plaques, early-onset dementia, progressive dementia, cerebral cortex, history of Alzheimer's disease, silver staining, neuropathology
- MeSH terms
- Acetylcholine, Acetylcholinesterase, Age Factors, Aged, Aluminum, Alzheimer Disease, Amyloid, Brain, Brain Chemistry, Cell Count, Cognition, Delirium, Dementia, Diagnosis, Differential, Female, Craniocerebral Trauma, Humans, Interpersonal Relations, Male, Memory, Middle Aged, Neurofibrils, Personality, Sex Factors, Silicon, Thyroid Diseases, Tomography, Emission-Computed, Amyloid beta-Peptides, Neurotransmitter Agents
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