The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.
Open accessAbstract
We have used a slot-blot radioimmunoassay to quantitate the levels of hyaluronan-binding chondroitin sulfate proteoglycans in developing rat brain from embryonic day 14 (E 14) to eight months postnatal. Recombinant nonhomologous regions of the core proteins were used for immunization to obtain polyclonal antibodies specific for aggrecan, the alpha and beta domains of versican mRNA splice variants, and N- and C-terminal portions of neurocan, while brevican was quantitated using a specific monoclonal antibody. The concentration of aggrecan increased steadily during brain development up to 5 months of age, when it reached a level that was 18-fold higher than at E14. Alternatively spliced versican isoforms containing the alpha domain of the glycosaminoglycan attachment region were present at a relatively low level during the late embryonic and early postnatal period, decreased by approximately 50% between 1 and 2 weeks postnatal, and then increased steadily in concentration to reach a maximum at 100 days that was 7-fold that present at 10 days postnatal. In contrast to these results, versican isoforms containing the beta domain more than doubled in concentration between E14 and birth, after which they decreased by greater than 90% to reach a low "mature" level that remained unchanged between 2 and 8 months. The N- and C-terminal portions of neurocan (produced by a developmentally-regulated proteolytic cleavage in the middle of its chondroitin sulfate attachment region) both increased in embryonic brain during development, reached a peak in the early postnatal period, and then declined thereafter. As in the case of aggrecan, only traces of brevican were detected in embryonic brain and its concentration increased steadily after birth to reach an adult level that was approximately 14-fold higher than that present in neonatal brain. These striking and distinctive changes in the concentrations of the different members of this family of structurally related proteoglycans in developing brain, including changes in opposite directions for versican mRNA splice variants, indicate that the individual proteoglycans and their isoforms probably serve unique functions during nervous tissue histogenesis.
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“Neurocan expression also increased between E14 and postnatal day (P) 3 and then decreased during early-late adolescence and into adulthood (Meyer-Puttlitz et al., 1996; Miller et al., 1996; Milev et al., 1998; Brückner et al., 2000).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Milev et al., 1998
In the citing paper
“A developmental upregulation of aggrecan and brevican, which peak in adulthood, was reported in rat brain (Milev et al., 1998; Brückner et al., 2000; Popp et al., 2003).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Milev et al., 1998
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Cites
Multiple domains of the large fibroblast proteoglycan, versican.
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Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.
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Self-citationRauch, U., Gao, P., Janetzko, A., Flaccus, A., Hilgenberg, L., Tekotte, H., Margolis, R. K., & Margolis, R. U. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98755-7 · Cited by 267
Self-citationDours-Zimmermann, M. T., & Zimmermann, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30089-2 · Cited by 249
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Self-citationEvered, D. C., & Whelan, J. (1989) · Wiley eBooks · Cited by 224
Chondroitin sulfate proteoglycans as mediators of axon growth and pathfinding
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Self-citationNeurocan and phosphacan: two major nervous tissue-specific chondroitin sulfate proteoglycans.
Margolis, R. K., Rauch, U., Maurel, P., & Margolis, R. U. (1996) · PubMed · Cited by 160
Self-citationZako, M., Shinomura, T., Ujita, M., Ito, K., & Kimata, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.3914 · Cited by 127
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- LeBaron, 1996, Perspect. Dev. Neurobiol., 3, 261
- Margolis, 1996, Perspect. Dev. Neurobiol., 3, 273
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Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642
Self-citationProteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Versican: a versatile extracellular matrix proteoglycan in cell biology
Wight, T. N. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00375-7 · Cited by 576
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495
Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
Asher, R. A., Morgenstern, D. A., Fidler, P. S., Adcock, K. H., Oohira, A., Braistead, J. E., Levine, J. M., Margolis, R. U., ROGERS, J. H., & Fawcett, J. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02427.2000 · Cited by 482
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Metadata
- Authors
- Milev, P., Maurel, P., Chiba, A., Mevissen, M., Popp, S., Yamaguchi, Y., Margolis, R. K., & Margolis, R. U.
- Affiliations
- NYU Langone Health (US)
- State University of New York (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Margolis, Richard U.
- ORCID
- Yamaguchi, Yu
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 247
- Issue
- 2
- Pages
- 207-212
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2137502661
- Cited by
- 219
- References
- 20
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 10
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- chondroitin sulfate proteoglycans, brain development, aggrecan, versican, neurocan, brevican, splice variants, proteolytic cleavage, embryonic brain, postnatal brain
- MeSH terms
- Animals, Brain, Carrier Proteins, Hyaluronic Acid, Nerve Tissue Proteins, Chondroitin Sulfate Proteoglycans, Proteoglycans, RNA, Messenger, Extracellular Matrix Proteins, Alternative Splicing, Gene Expression Regulation, Developmental, Lectins, C-Type, Rats, Aggrecans, Versicans, Neurocan, Brevican
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