Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Abstract
Proteoglycans are a heterogeneous class of proteins bearing sulfated glycosaminoglycans. Some of the proteoglycans have distinct core protein structures, and others display similarities and thus may be grouped into families such as the syndecans, the glypicans, or the hyalectans (or lecticans). Proteoglycans can be found in almost all tissues being present in the extracellular matrix, on cellular surfaces, or in intracellular granules. In recent years, brain proteoglycans have attracted growing interest due to their highly regulated spatiotemporal expression during nervous system development and maturation. There is increasing evidence that different proteoglycans act as regulators of cell migration, axonal pathfinding, synaptogenesis, and structural plasticity. This review summarizes the most recent data on structures and functions of brain proteoglycans and focuses on new physiological concepts for their potential roles in the developing central nervous system.
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During development, the ECM and CSPGs regulate neuronal migration, axon outgrowth, synaptogenesis and synaptic maturation.
“During development, the ECM, and CSPGs in particular, regulate neuronal migration, axon outgrowth, synaptogenesis and synaptic maturation.23, 27, 28, 29, 30, 31”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [27]
A juvenile form of ECM supportive of neurogenesis, cell migration, axonal outgrowth, and synaptogenesis is substituted by an adult form that predominantly restricts plasticity.
“A juvenile form of ECM, supportive of neurogenesis, cell migration, axonal outgrowth and synaptogenesis, is substituted by an adult form, which predominantly restricts plasticity (Bandtlow and Zimmermann, 2000; Faissner et al., 2010; Fawcett, 2009; Galtrey and Fawcett, 2007).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Bandtlow and Zimmermann, 2000
Glial cells express core CNS nodal ECMs including versican V2 and brevican.
“Those glial cells express core CNS nodal ECMs including versican V2 and brevican (Bandtlow and Zimmermann, 2000).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Bandtlow and Zimmermann, 2000
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- Authors
- Bandtlow, C. E., & Zimmermann, D. R.
- Affiliations
- University of Zurich (CH)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2000-01-10
- Volume
- 80
- Issue
- 4
- Pages
- 1267-1290
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1913314522
- Cited by
- 632
- References
- 7
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 9 · 2023: 17 · 2022: 24 · 2021: 22 · 2020: 17 · 2019: 26 · 2018: 20 · 2017: 21 · 2016: 22 · 2015: 26 · 2014: 35 · 2013: 25 · 2012: 25
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- proteoglycans, brain development, central nervous system development, glycosaminoglycans, syndecans, glypicans, lecticans, extracellular matrix, cell migration, axon guidance, synaptogenesis, structural plasticity
- MeSH terms
- Animals, Axons, Brain, Cell Movement, Glycosaminoglycans, Humans, Ligands, Membrane Glycoproteins, Nerve Tissue Proteins, Synaptic Transmission, Neuroglia, Neuronal Plasticity, Neurons, Chondroitin Sulfate Proteoglycans, Proteoglycans, Neurites, Protein Tyrosine Phosphatases, Heparan Sulfate Proteoglycans, Syndecans, Receptor-Like Protein Tyrosine Phosphatases, Class 5
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