A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,515 · see citing works

Autism as a strongly genetic disorder: evidence from a British twin study

Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works

Structural Variation of Chromosomes in Autism Spectrum Disorder

Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works

The Tuberous Sclerosis Complex

Crino, P. B., Nathanson, K. L., & Henske, E. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmra055323 · Cited by 1,793 · see citing works

Wnt signalling regulates adult hippocampal neurogenesis

Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,510 · see citing works

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism

Sanders, S. J., Ercan-Sencicek, A. G., Hus, V., Luo, R., Murtha, M. T., Moreno-De-Luca, D., Chu, S. H., Moreau, M. P., Gupta, A. R., Thomson, S. A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.002 · Cited by 1,263 · see citing works

Common genetic variants on 5p14.1 associate with autism spectrum disorders

Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works

Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism

Schneider, T., & Przewłocki, R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300518 · Cited by 959 · see citing works

Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes

Mefford, H. C., Sharp, A. J., Baker, C., Itsara, A., Jiang, Z., Buysse, K., Huang, S., Maloney, V. K., Crolla, J. A., Baralle, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805384 · Cited by 804 · see citing works

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., Tassa, C., Berry-Scott, E., Soda, T., Singh, K. K., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.044 · Cited by 768 · see citing works

Dishevelled: The hub of Wnt signaling

Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 751 · see citing works

Association within a family of a balanced autosomal translocation with major mental illness

St Clair, D., Blackwood, D., Muir, W., Walker, M., St Clair, D., Muir, W., Carothers, A., Spowart, G., Gosden, C., & Evans, H. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91520-k · Cited by 727 · see citing works

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses

Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701 · see citing works

Balancing cell adhesion and Wnt signaling, the key role of β-catenin

Brembeck, F. H., Rosário, M., & Birchmeier, W. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.007 · Cited by 668 · see citing works

The genetics of autistic disorders and its clinical relevance: a review of the literature

Freitag, C. M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001896 · Cited by 638 · see citing works

A local Wnt-3a signal is required for development of the mammalian hippocampus

Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.3.457 · Cited by 636 · see citing works

Cadherin superfamily genes: functions, genomic organization, and neurologic diversityPreprint

Yagi, T., & Takeichi, M. (2000) · Genes & Development · doi:10.1101/gad.14.10.1169 · Cited by 635 · see citing works

Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities

Brunetti-Pierri, N., Berg, J. S., Scaglia, F., Belmont, J., Bacino, C. A., Sahoo, T., Lalani, S. R., Graham, B., Lee, B., Shinawi, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.279 · Cited by 625 · see citing works

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt SignalingPreprint

Heuberger, J., & Birchmeier, W. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002915 · Cited by 616 · see citing works

The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates

Hecht, A., Vleminckx, K., Stemmler, M. P., Roy, F. M. V., & Kemler, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1839 · Cited by 602 · see citing works

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Kramps, T., Peter, O., Brunner, E., Anthamatten, D., Froesch, B. A., Chatterjee, S., Murone, M., Züllig, S., & Basler, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00679-7 · Cited by 562 · see citing works

A clinical study of 57 children with fetal anticonvulsant syndromes

Moore, S. J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D. J., Montgomery, T., & Dean, J. C. S. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.7.489 · Cited by 562 · see citing works

The Wnt signaling pathway and its role in tumor development

Lustig, B., & Behrens, J. (2003) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-003-0431-0 · Cited by 521 · see citing works

Autism and tuberous sclerosis

Smalley, S. L., Tanguay, P. E., Smith, M., & Gutierrez, G. (1992) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01048239 · Cited by 518 · see citing works

Antidepressant Use During Pregnancy and Childhood Autism Spectrum Disorders

Croen, L. A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.73 · Cited by 510 · see citing works

Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs

Rosenberg, R. E., Law, J. K., Yenokyan, G., McGready, J., Kaufmann, W. E., & Law, P. A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.98 · Cited by 495 · see citing works

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., et al. (2008) · Development · doi:10.1242/dev.013540 · Cited by 492 · see citing works

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · cited 2× · see citing works

Characteristics of fetal anticonvulsant syndrome associated autistic disorder

Rasalam, A., Hailey, H., Williams, J., Moore, S., Turnpenny, P., Lloyd, D., & Dean, J. (2005) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162205001076 · Cited by 456 · see citing works

β-catenin is critical for dendritic morphogenesis

Yu, X., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn1132 · Cited by 454 · see citing works

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

Brandon, N. J., & Sawa, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3120 · Cited by 422 · see citing works

Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ

Meng, K., Rodríguez‐Peña, A., Dimitrov, T., Chen, W., Yamin, M., Noda, M., & Deuel, T. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.020487997 · Cited by 414 · see citing works

The Drosophila Wnt, Wingless, Provides an Essential Signal for Pre- and Postsynaptic Differentiation

Packard, M. C., Koo, E. S., Gorczyca, M. G., Sharpe, J., Cumberledge, S., & Budnik, V. (2002) · Cell · doi:10.1016/s0092-8674(02)01047-4 · Cited by 410 · see citing works

Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome

Ferland, R. J., Eyaid, W., Collura, R. V., Tully, L. D., Hill, R. S., Al-Nouri, D., Al-Rumayyan, A., Topcu, M., Gascon, G., Bodell, A., et al. (2004) · Nature Genetics · doi:10.1038/ng1419 · Cited by 408 · see citing works

The tuberous sclerosis complex

Orlova, K. A., & Crino, P. B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05117.x · Cited by 405 · see citing works

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1

Galcerán, J., Miyashita-Lin, E. M., Devaney, E. J., Rubenstein, J. L. R., & Grosschedl, R. (2000) · Development · doi:10.1242/dev.127.3.469 · Cited by 399 · see citing works

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia

Pletnikov, M. V., Ayhan, Y., Nikolskaia, O. V., Xu, Y., Ovanesov, M. V., Huang, H., Mori, S., Moran, T. H., & Ross, C. A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002079 · Cited by 339 · see citing works

Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type-Specific Deficits, Epilepsy, and Behavioral Dysfunction

Powell, E. M., Campbell, D. B., Stanwood, G. D., Davis, C., Noebels, J. L., & Levitt, P. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00622.2003 · Cited by 333 · see citing works

Key role for gene dosage and synaptic homeostasis in autism spectrum disorders

Toro, R., Konyukh, M., Delorme, R., Leblond, C., Chaste, P., Fauchereau, F., Coleman, M., Leboyer, M., Gillberg, C., & Bourgeron, T. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.05.007 · Cited by 331 · see citing works

Autism: A “Critical Period” Disorder?

LeBlanc, J. J., & Fagiolini, M. (2011) · Neural Plasticity · doi:10.1155/2011/921680 · Cited by 301 · see citing works

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298 · see citing works

Cadherins and catenins at synapses: Roles in synaptogenesis and synaptic plasticity.

Arikkath, J., & Reichardt, L. F. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.001 · Cited by 289 · see citing works

The ins and outs of APC and β‐catenin nuclear transport

Henderson, B. R., & Fagotto, F. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf181 · Cited by 287 · see citing works

A Chaperone-Dependent GSK3β Transitional Intermediate Mediates Activation-Loop Autophosphorylation

Lochhead, P. A., Kinstrie, R., Sibbet, G. J., Rawjee, T., MORRICE, N. A., & Cleghon, V. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.10.009 · Cited by 283 · see citing works

New Insights into the Mechanism of Wnt Signaling Pathway Activation

Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00002-1 · Cited by 259 · see citing works

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works

Joubert syndrome (and related disorders) (OMIM 213300)

Parisi, M. A., Doherty, D., Chance, P. F., & Glass, I. A. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201648 · Cited by 246 · see citing works

Autism and autism spectrum disorders: diagnostic issues for the coming decade

Volkmar, F. R., State, M. W., & Klin, A. J. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02010.x · Cited by 235 · see citing works

A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

Hussman, J. P., Chung, R.-H., Griswold, A. J., Jaworski, J. M., Salyakina, D., Ma, D., Konidari, I., Whitehead, P. L., Vance, J. M., Martin, E. R., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-1 · Cited by 231 · see citing works

Protein interactome reveals converging molecular pathways among autism disorders

Sakai, Y., Shaw, C. A., Dawson, B. C., Dugas, D. V., Al-Mohtaseb, Z., Hill, D. E., & Zoghbi, H. Y. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002166 · Cited by 226 · see citing works

The ups and downs of Wnt signaling in prevalent neurological disorders

Ferrari, G. V. D., & Moon, R. T. (2006) · Oncogene · doi:10.1038/sj.onc.1210064 · Cited by 221 · see citing works

Rubinstein–Taybi syndrome: clinical and molecular overview

Roelfsema, J. H., & Peters, D. J. M. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000415 · Cited by 217 · see citing works

Toward a developmental neurobiology of autism

Polleux, F., & Lauder, J. M. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20044 · Cited by 216 · see citing works

Fourteen new cases contribute to the characterization of the 7q11.23 microduplication syndrome

Van der Aa, N., Rooms, L., Vandeweyer, G., van den Ende, J., Reyniers, E., Fichera, M., Romano, C., Delle Chiaie, B., Mortier, G., Menten, B., et al. (2009) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2009.02.006 · Cited by 216 · see citing works

Expression of L1-CAM and ADAM10 in Human Colon Cancer Cells Induces Metastasis

Gavert, N. S., Sheffer, M., Raveh, S., Spaderna, S., Shtutman, M. S., Brabletz, T., Barany, F., Paty, P. B., Notterman, D. A., Domany, E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0991 · Cited by 214 · see citing works

Autism and tuberous sclerosis

Wiznitzer, M. (2004) · Journal of Child Neurology · doi:10.1177/08830738040190090701 · Cited by 214 · see citing works

Evidence supporting WNT2 as an autism susceptibility gene

Wassink, T. H., Piven, J., Vieland, V. J., Huang, J., Swiderski, R. E., Pietila, J., Braun, T. A., Beck, G. E., Folstein, S. E., Haines, J. L., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1401 · Cited by 206 · see citing works

Transcription under the Control of Nuclear Arm/β-Catenin

Städeli, R., Hoffmans, R., & Basler, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.019 · Cited by 200 · see citing works

WNT-3, Expressed by Motoneurons, Regulates Terminal Arborization of Neurotrophin-3-Responsive Spinal Sensory Neurons

Krylova, O. Y., Herreros, J., Cleverley, K., Ehler, E., Henríquez, J. P., Hughes, S. M., & Salinas, P. C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00860-7 · Cited by 199 · see citing works

Perinatal antidepressant exposure alters cortical network function in rodents

Simpson, K. L., Weaver, K. J., de Villers‐Sidani, E., Lu, J. Y.-F., Cai, Z., Pang, Y., Rodriguez‐Porcel, F. E., Paul, I. A., Merzenich, M. M., & Lin, R. C. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109353108 · Cited by 196 · see citing works

Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production and Radial Glial Scaffolding Abnormalities

Zhou, C. J., Zhao, C., & Pleasure, S. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-03.2004 · Cited by 196 · see citing works

Disruption of cerebral cortex MET signaling in autism spectrum disorder

Campbell, D. B., D'Oronzio, R., Garbett, K., Ebert, P. J., Mirnics, K., Levitt, P., & Persico, A. M. (2007) · Annals of Neurology · doi:10.1002/ana.21180 · Cited by 193 · see citing works

Association of DISC1 with autism and Asperger syndrome

Kilpinen, H., Ylisaukko‐oja, T., Hennah, W., Palo, O. M., Varilo, T., Vanhala, R., Wendt, T. N., von Wendt, L., Paunio, T., & Peltonen, L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002031 · Cited by 193 · see citing works

Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region

Berg, J. S., Brunetti-Pierri, N., Peters, S. U., Kang, S.-H. L., Fong, C.-T., Salamone, J., Freedenberg, D., Hannig, V. L., Prock, L. A., Miller, D. T., et al. (2007) · Genetics in Medicine · doi:10.1097/gim.0b013e3180986192 · Cited by 193 · see citing works

Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation

Wexler, E., Geschwind, D. H., & Palmer, T. D. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002093 · Cited by 191 · see citing works

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder

Cheh, M. A., Millonig, J. H., Roselli, L. M., Ming, X., Jacobsen, E. P., Kamdar, S., & Wagner, G. C. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.086 · Cited by 190 · see citing works

WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells

Papkoff, J., & Aikawa, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8888 · Cited by 184 · see citing works

Inhibition of GSK3 by Wnt signalling – two contrasting models

Metcalfe, C., & Bienz, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.091991 · Cited by 181 · see citing works

Impaired Wnt–β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy

Lancaster, M. A., Louie, C. M., Silhavy, J. L., Sintasath, L., DeCambre, M., Nigam, S. K., Willert, K., & Gleeson, J. G. (2009) · Nature Medicine · doi:10.1038/nm.2010 · Cited by 175 · see citing works

A Novel Role of the WNT-Dishevelled-GSK3  Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-11.2011 · Cited by 170 · see citing works

Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome

Willemsen, M. H., Fernandez, B. A., Bacino, C. A., Gerkes, E. H., de Brouwer, A. P. M., Pfundt, R., Sikkema‐Raddatz, B., Scherer, S. W., Marshall, C. R., Potocki, L., et al. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.192 · Cited by 160 · see citing works

Copy number variants at Williams–Beuren syndrome 7q11.23 region

Merla, G., Brunetti‐Pierri, N., Micale, L., & Fusco, C. (2010) · Human Genetics · doi:10.1007/s00439-010-0827-2 · Cited by 152 · see citing works

Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.

Barber, J. C. K., Ellis, K. H., Bowles, L., Delhanty, J. D. A., Ede, R. F., Male, B. M., & Eccles, D. (1994) · Journal of Medical Genetics · doi:10.1136/jmg.31.4.312 · Cited by 144 · see citing works

Synaptic Wnt signaling—a contributor to major psychiatric disorders?

Okerlund, N. D., & Cheyette, B. N. R. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9083-6 · Cited by 143 · see citing works

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L–DOCK4 gene region in autism susceptibility

IMGSAC, Maestrini, E., Pagnamenta, A. T., Lamb, J. A., Bacchelli, E., Sykes, N. H., Sousa, I., Toma, C., Barnby, G., Butler, H., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.34 · Cited by 143 · see citing works

Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.

Pagnamenta, A. T., Bacchelli, E., de Jonge, M. V., Mirza, G., Scerri, T. S., Minopoli, F., Chiocchetti, A., Ludwig, K. U., Hoffmann, P., Paracchini, S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.002 · Cited by 139 · see citing works

A Review of Subtyping in Autism and Proposed Dimensional Classification Model

Beglinger, L. J., & Smith, T. H. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010616719877 · Cited by 137 · see citing works

DISC1 at 10: connecting psychiatric genetics and neuroscience

Porteous, D. J., Millar, J. K., Brandon, N. J., & Sawa, A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.09.002 · Cited by 137 · see citing works

The first five years of the Wnt targetome

Vlad-Fiegen, A., Röhrs, S., Klein‐Hitpaß, L., & Müller, O. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.031 · Cited by 134 · see citing works

Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval

Zhao, C., Avilés, C., Abel, R., Almli, C. R., McQuillen, P. S., & Pleasure, S. J. (2005) · Development · doi:10.1242/dev.01871 · Cited by 126 · see citing works

Association of the HGF/SF Receptor, c-met, with the Cell-Surface Adhesion Molecule, E-Cadherin, and Catenins in Human Tumor Cells

Hiscox, S., & Jiang, W. G. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1002 · Cited by 126 · see citing works

Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus

McGrew, L. L., Takemaru, K., Bates, R. L., & Moon, R. T. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00136-7 · Cited by 126 · see citing works

Duplications of the critical Rubinstein–Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome

Thienpont, B., Bena, F. S., Breckpot, J., Philip, N., Menten, B., Esch, H. V., Scalais, E., Salamone, J., Fong, C.-T., Kussmann, J. L., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.070573 · Cited by 124 · see citing works

A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence

Yang, M. S., & Gill, M. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2006.12.002 · Cited by 118 · see citing works

Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression

Haegele, L., Ingold, B., Naumann, H., Tabatabai, G., Ledermann, B., & Brandner, S. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00232-x · Cited by 117 · see citing works

Wnt2 Expression and Signaling Is Increased by Different Classes of Antidepressant Treatments

Okamoto, H., Voleti, B., Banasr, M., Sarhan, M., Đurić, V., Girgenti, M. J., Dileone, R., Newton, S. S., & Duman, R. S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.023 · Cited by 116 · see citing works

Regulation of MET by FOXP2, Genes Implicated in Higher Cognitive Dysfunction and Autism Risk

Mukamel, Z., Konopka, G., Wexler, E., Osborn, G. E., Dong, H., Bergman, M. Y., Levitt, P. R., & Geschwind, D. H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0181-11.2011 · Cited by 116 · see citing works

Genotype–phenotype correlations in Rubinstein–Taybi syndrome

Schorry, E. K., Keddache, M. A., Lanphear, N. E., et al. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32424 · Cited by 115 · see citing works

Lack of evidence for an association between WNT2 and RELN polymorphisms and autism

Li, J. Z., Nguyen, L., Gleason, C., Lotspeich, L. J., Spiker, D., RISCH, N. J., & Myers, R. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20122 · Cited by 113 · see citing works

Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability

Pagnamenta, A. T., Khan, H., Walker, S., Gerrelli, D., Wing, K., Bonaglia, M. C., Giorda, R., Berney, T. P., Mani, E., Molteni, M., et al. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2010.079426 · Cited by 112 · see citing works

Cancer morbidity in psychiatric patients: influence of lithium carbonate treatment

Cohen, Y., Chetrit, A., Cohen, Y., et al. (1998) · Medical Oncology · doi:10.1007/bf02787342 · Cited by 111 · see citing works

No association between the WNT2 gene and autistic disorder

McCoy, P. A., Shao, Y., Wolpert, C. M., Donnelly, S. L., Ashley‐Koch, A. E., Abel, H., Ravan, S. A., Abramson, R. K., Wright, H. H., DeLong, G. R., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.10182 · Cited by 109 · see citing works

Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases

Bernatík, O., Ganji, R. S., Dijksterhuis, J. P., Koník, P., Červenka, I., Polonio, T., Krejčı́, P., Schulte, G., & Bryja, V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169870 · Cited by 108 · see citing works

Genes and Schizophrenia: Beyond Schizophrenia: The Role of DISC1 in Major Mental Illness

Hennah, W., Thomson, P. A., Peltonen, L., & Porteous, D. J. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj079 · Cited by 103 · see citing works

Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

Lee, H., Wang, N. X., Shi, D., & Zheng, J. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902981 · Cited by 101 · see citing works

Frizzled-9 Is Activated by Wnt-2 and Functions in Wnt/β-Catenin Signaling

Karasawa, T., Yokokura, H., Kitajewski, J., & Lombroso, P. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205658200 · Cited by 100 · see citing works

Macrocephaly and the control of brain growth in autistic disorders

McCaffery, P. J. A., & Deutsch, C. K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.10.005 · Cited by 99 · see citing works

The Tuberin-Hamartin Complex Negatively Regulates β-Catenin Signaling Activity

Mak, B. C., Takemaru, K., Kenerson, H. L., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200473200 · Cited by 99 · see citing works

Association of common variants in the Joubert syndrome gene (AHI1) with autism

Alvarez Retuerto, A. I., Cantor, R. M., Gleeson, J. G., Ustaszewska, A., Schackwitz, W. S., Pennacchio, L. A., & Geschwind, D. H. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn291 · Cited by 96 · see citing works

Chromosome 7q: Where Autism Meets Language Disorder?

Folstein, S. E., & Mankoski, R. E. (2000) · The American Journal of Human Genetics · doi:10.1086/303034 · Cited by 95 · see citing works

Role of a BCL9-Related β-Catenin-Binding Protein, B9L, in Tumorigenesis Induced by Aberrant Activation of Wnt Signaling

Adachi, S., Jigami, T., Yasui, T., 中野, 哲., Ohwada, S., Omori, Y., Sugano, S., Ohkawara, B., Shibuyà, H., Nakamura, T., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2254 · Cited by 88 · see citing works

Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism

Maussion, G., Carayol, J., Lepagnol-Bestel, A.-M., Torès, F., Loe-Mie, Y., Milbreta, U., Rousseau, F., Fontaine, K., Renaud, J., Moalic, J., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn154 · Cited by 84 · see citing works

Autism-Associated Haplotype Affects the Regulation of the Homeobox Gene, ENGRAILED 2

Benayed, R., Choi, J., Matteson, P. G., Gharani, N., Kamdar, S., Brzustowicz, L. M., & Millonig, J. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.027 · Cited by 80 · see citing works

Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrain

Judson, M. C., Bergman, M. Y., Campbell, D. B., Eagleson, K. L., & Levitt, P. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21969 · Cited by 80 · see citing works

Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain

Sousa, K. M., Villaescusa, C., Čajánek, L., Ondr, J. K., Castelo‐Branco, G., Hofstra, W. A., Bryja, V., Palmberg, C., Bergman, T., Wainwright, B. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.079822 · Cited by 77 · see citing works

Increased susceptibility to kainic acid–induced seizures in Engrailed-2 knockout mice

Tripathi, P. P., Sgadò, P., Scali, M., Viaggi, C., Casarosa, S., Simon, H. H., Vaglini, F., Corsini, G. U., & Bozzi, Y. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.007 · Cited by 74 · see citing works

The behavioral phenotype of Williams syndrome: A recognizable pattern of neurodevelopment

Morris, C. A. (2010) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30286 · Cited by 72 · see citing works

Interaction between LRP5 and Frat1 Mediates the Activation of the Wnt Canonical Pathway

Haÿ, E., Faucheu, C., Suc-Royer, I., Touitou, R., Stiot, V., Vayssière, B., Baron, R., Roman‐Roman, S., & Rawadi, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411999200 · Cited by 71 · see citing works

Identification of WNT/ -CATENIN signaling pathway components in human cumulus cells

Wang, H.-X., Tekpetey, F. R., & Kidder, G. M. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan070 · Cited by 71 · see citing works

Duplication of the Rubinstein–Taybi region on 16p13.3 is associated with a distinctive phenotype

Marangi, G., Leuzzi, V., Orteschi, D., Grimaldi, M. E., Lecce, R., Neri, G., & Zollino, M. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32460 · Cited by 67 · see citing works

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

Wan, X.-Z., Li, B., Li, Y.-C., Yang, X., Zhang, W., Zhong, L., & Tang, S.-J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3916-11.2012 · Cited by 66 · see citing works

Molecular association between β-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/β-catenin signaling

Upadhyay, G., Goessling, W., North, T. E., Xavier, R. J., Zon, L. I., & Yajnik, V. (2008) · Oncogene · doi:10.1038/onc.2008.202 · Cited by 65 · see citing works

Sulindac suppresses β-catenin expression in human cancer cells

Han, A., Song, Z., Tong, C., Hu, D. G., Bi, X., Augenlicht, L. H., & Yang, W. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.034 · Cited by 61 · see citing works

Dock4 regulates dendritic development in hippocampal neurons.

Ueda, S., Fujimoto, S., Hiramoto, K., Negishi, M., & Katoh, H. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21763 · Cited by 61 · see citing works

Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice

Gould, T. D. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00096-3 · Cited by 60 · see citing works

Wnt Signaling

Buechling, T., & Boutros, M. (2011) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385975-4.00008-5 · Cited by 58 · see citing works

Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential β-catenin phosphorylation

David, M. D., Yeramian, A., Duñach, M., Llovera, M., Cantı́, C., de Herreros, A. G., Comella, J. X., & Herreros, J. (2008) · Journal of Cell Science · doi:10.1242/jcs.029660 · Cited by 55 · see citing works

Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain

Rawal, N., Castelo‐Branco, G., Sousa, K. M., Kele, J., Kobayashi, K., Okano, H., & Arenas, E. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.01.032 · Cited by 55 · see citing works

The DISC1 promoter: characterization and regulation by FOXP2

Walker, R. M., Hill, A. E., Newman, A. C., Hamilton, G., Torrance, H. S., Anderson, S. M., Ogawa, F., Deriziotis, P., Nicod, J., Vernes, S. C., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds111 · Cited by 54 · see citing works

Demethylation of Specific Wnt/β‐Catenin Pathway Genes and its Upregulation in Rat Brain Induced by Prenatal Valproate Exposure

Wang, Z., Xu, L., Zhu, X., Cui, W., Sun, Y., Nishijo, H., Peng, Y., & Li, R. (2010) · The Anatomical Record · doi:10.1002/ar.21232 · Cited by 51 · see citing works

Dissecting the locus heterogeneity of autism: significant linkage to chromosome 12q14

Q, D., Cuccaro, M. L., Jaworski, J. M., Haynes, C. S., Stephan, D. A., Parod, J. M., Abramson, R. K., Wright, H. H., Gilbert, J. R., Haines, J. L., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001927 · Cited by 50 · see citing works

Species differences in the expression of Ahi1, a protein implicated in the neurodevelopmental disorder Joubert syndrome, with preferential accumulation to stigmoid bodies

Doering, J., Kane, K. A., Hsiao, Y., Yao, C., Shi, B., Slowik, A. D., Dhagat-Mehta, B., Scott, D. D., Ault, J. G., Page-McCaw, P., et al. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21824 · Cited by 46 · see citing works

Dendritic localization and activity-dependent translation of Engrailed1 transcription factor

Nardo, A. A. D., Nedelec, S., Trembleau, A., Volovitch, M., Prochiantz, A., & Montesinos, M. L. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.015 · Cited by 45 · see citing works

Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders

The Autism Genome Project, Anney, R. J. L., Kenny, E. M., O'Dushlaine, C., Yaspan, B. L., Parkhomenka, E., Buxbaum, J. D., Sutcliffe, J., Gill, M., Gallagher, L., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.75 · Cited by 43 · see citing works

Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene

Marui, T., Funatogawa, I., Koishi, S., Yamamoto, K., Matsumoto, H., Hashimoto, O., Jinde, S., Nishida, H., Sugiyama, T., Kasai, K., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990903 · Cited by 41 · see citing works

Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD)

Zhou, X., Giacobini, M., Anderlid, B., Anckarsäter, H. S., Omrani, D., Gillberg, C., Nordenskjöld, M., & Lindblom, A. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30415 · Cited by 38 · see citing works

Submicroscopic deletion in 7q31 encompassing CADPS2 and TSPAN12 in a child with autism spectrum disorder and PHPV

Okamoto, N., Hatsukawa, Y., Shimojima, K. Y., & Yamamoto, T. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34028 · Cited by 29 · see citing works

Intronic Single Nucleotide Polymorphisms of Engrailed Homeobox 2 Modulate the Disease Vulnerability of Autism in a Han Chinese Population

Yang, P., Shu, B., Hallmayer, J. F., et al. (2010) · Neuropsychobiology · doi:10.1159/000315441 · Cited by 23 · see citing works

The ongoing dissection of the genetic architecture of autistic spectrum disorder

Gillis, R. F., & Rouleau, G. A. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-12 · Cited by 21 · see citing works

Serotonin and the Autisms

Levitt, P. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.98 · Cited by 19 · see citing works

Cellular mechanisms underlying the regulation of dendritic development by hepatocyte growth factor

Finsterwald, C., & Martin, J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07839.x · Cited by 14 · see citing works

Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones

Hooper, C., Killick, R., Fernandes, C., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07349.x · Cited by 12 · see citing works

The ASD Living Biology: from cell proliferation to clinical phenotype

Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Durak, O., Gao, F., Kaeser-Woo, Y. J., Rueda, R., Martorell, A. J., Nott, A., Liu, C. Y., Watson, L. A., & Tsai, L.-H. (2016) · Nature Neuroscience · doi:10.1038/nn.4400 · Cited by 243 · see citing works

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167 · see citing works

Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue

Wong, C. C. Y., Smith, R. G., Hannon, E., Ramaswami, G., Parikshak, N. N., Assary, E., Troakes, C., Poschmann, J., Schalkwyk, L. C., Sun, W., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz052 · Cited by 98 · see citing works

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors

Belinson, H., Nakatani, J., Babineau, B. A., Birnbaum, R. Y., Ellegood, J., Bershteyn, M., McEvilly, R. J., Long, J. M., Willert, K., Klein, O. D., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.207 · Cited by 79 · see citing works

The Atypical Guanine Nucleotide Exchange Factor Dock4 Regulates Neurite Differentiation through Modulation of Rac1 GTPase and Actin Dynamics

Xiao, Y., Peng, Y., Wan, J., Tang, G., Chen, Y., Tang, J., Ye, W.-C., Ip, N. Y., & Shi, L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458612 · Cited by 71 · see citing works

De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder

Mirzaa, G., Chong, J. X., Piton, A., Popp, B., Foss, K., Guo, H., Harripaul, R., Xia, K., Scheck, J., Aldinger, K. A., et al. (2019) · Genetics in Medicine · doi:10.1038/s41436-019-0693-9 · Cited by 49 · see citing works

Comorbid Rate of Other Neurodevelopmental Disorder with Autism Spectrum Disorder in a Total Population Sample of 5-Years-Old Children.

Terui, A. (2019) · INSAR 2019 Annual Meeting

Genetic and Neurodevelopmental Influences in Autistic Disorder

Nicolson, R., & Szatmari, P. (2003) · Canadian journal of psychiatry. Revue canadienne de psychiatrie · doi:10.1177/070674370304800804 · Cited by 68 · see citing works

Signaling pathways that are influenced by SHANK3 mutation and related treatment for autism

Han, Y. (2022) · International Conference on Biomedical and Intelligent Systems (IC-BIS) · doi:10.1117/12.2660544