Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development
Abstract
During melanoma development, transformed cells evade keratinocyte-mediated control by downregulating cell adhesion molecules. This study investigated the regulation of cell adhesion by hepatocyte growth factor (HGF) in melanoma. Melanocytes and two melanoma lines, WM164 and WM35, expressed normal level E-cadherin and Desmoglein 1, whereas most melanomas (18 out of 20) expressed no E-cadherin and significantly reduced Desmoglein 1. Overexpression of dominant negative E-cadherin and Desmoglein in melanocytes demonstrated that both molecules contribute to adhesion between melanocytes and keratinocytes. In contrast to melanocytes, most melanomas expressed HGF. All melanocytic cells expressed the HGF receptor c-Met, and autocrine HGF caused constitutive activation of c-Met, MAPK and PI3K. When autocrine activation was induced with HGF-expressing adenovirus, E-cadherin and Desmoglein 1 were decreased in melanocytes, WM164 and WM35. MAPK inhibitor PD98059 and PI3K inhibitor wortmannin partially blocked the downregulation, suggesting that both pathways are involved in this process. c-Met was coimmunoprecipitated with E-cadherin, Desmoglein 1 and Plakoglobin, suggesting that they form a complex (es) that acts to regulate intercellular adhesion. Together, the results indicate that autocrine HGF decouples melanomas from keratinocytes by downregulating E-cadherin and Desmoglein 1, therefore frees melanoma cells from the control by keratinocytes and allows dissemination of the tumor mass.
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Melanoma cells promote growth and invasion through the secretion of protumorigenic factors.
“Given the ability of melanoma cells to promote growth and invasion through the secretion of protumorigenic factors (11–13), it is plausible that beyond cancer cell–intrinsic mechanisms, phenotype plasticity and ferroptosis vulnerability of drug-resistant clones may involve autocrine or paracrine circuits.”
From Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis (2024) · cites this paper as [12]
Cites
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
Gumbiner, B. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81279-9 · Cited by 3,471 · see citing works
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
Bottaro, D. P., Rubin, J. S., Faletto, D. L., Chan, A. M.-L., Kmiecik, T. E., Woude, G. F. V., & Aaronson, S. A. (1991) · Science · doi:10.1126/science.1846706 · Cited by 2,226 · see citing works
Molecular cloning and expression of human hepatocyte growth factor
Nakamura, T., Nishizawa, T., Hagiya, M., Seki, T., Shimonishi, M., Sugimura, A., Tashiro, K., & Shimizu, S. (1989) · Nature · doi:10.1038/342440a0 · Cited by 2,158 · see citing works
Parker, S. L., Tong, T., Bolden, S., & Wingo, P. A. (1997) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.47.1.5 · Cited by 2,000 · see citing works
Morphogenetic roles of classic cadherins
Takeichi, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80102-2 · Cited by 1,457 · see citing works
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
Stoker, M. G. P., Gherardi, E., Perryman, M., & Gray, J. (1987) · Nature · doi:10.1038/327239a0 · Cited by 1,316 · see citing works
Drubin, D. G., & Nelson, W. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81278-7 · Cited by 1,030 · see citing works
Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., Zonca, P. D., Giordano, S., Graziani, A., Panayotou, G., & Comoglio, P. M. (1994) · Cell · doi:10.1016/0092-8674(94)90318-2 · Cited by 994 · see citing works
Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers
Hirohashi, S. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65575-7 · Cited by 839 · see citing works
Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., & Saito, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1320 · Cited by 788 · see citing works
Albelda, S. M., Mette, S. A., Elder, D. E., Stewart, R., Damjanovich, L., Herlyn, M., & Buck, C. A. (1990) · PubMed · Cited by 760 · see citing works
Self-citationHoschuetzky, H., Aberle, H., & Kemler, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1375 · Cited by 712 · see citing works
Sonnenberg, E., Meyer, D., Weidner, K. M., & Birchmeier, C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.1.223 · Cited by 699 · see citing works
Kanegae, Y., Lee, G., Sato, Y., Tanaka, M., Nakal, M., Sakaki, T., Sugano, S., & Saito, I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.19.3816 · Cited by 606 · see citing works
Assembly of the cadherin-catenin complex in vitro with recombinant proteins
Aberle, H., Butz, S., Stappert, J., Weissig, H., Kemler, R., & Hoschuetzky, H. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.12.3655 · Cited by 551 · see citing works
Savagner, P., Yamada, K. M., & Thiery, J. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1403 · Cited by 520 · see citing works
Plakoglobin: A protein common to different kinds of intercellular adhering junctions
Cowin, P., Kapprell, H., Franke, W. W., Tamkun, J. W., & Hynes, R. O. (1986) · Cell · doi:10.1016/0092-8674(86)90706-3 · Cited by 503 · see citing works
Marshall, C. J. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80066-4 · Cited by 463 · see citing works
Takayama, H., LaRochelle, W. J., Sharp, R., Otsuka, T., Kriebel, P., Anver, M. R., Aaronson, S. A., & Merlino, G. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.701 · Cited by 442 · see citing works
Koch, P. J., Mahoney, M. G., Ishikawa, H., Pulkkinen, L., Uitto, J., Shultz, L. D., Murphy, G. F., Whitaker‐Menezes, D., & Stanley, J. R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.5.1091 · Cited by 426 · see citing works
Gherardi, E., Gray, J. J., Stoker, M. G. P., Perryman, M., & Furlong, R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5844 · Cited by 405 · see citing works
Seo, Y., Baba, H., Fukuda, T., Takashima, M., & Sugimachi, K. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000515)88:10 · Cited by 400 · see citing works
Are desmosomes more than tethers for intermediate filaments?
Green, K. J., & Gaudry, C. A. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043032 · Cited by 393 · see citing works
Hsu, M., Meier, F. E., Nesbit, M., Hsu, J.-Y., Belle, P. A. V., Elder, D. E., & Herlyn, M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65023-7 · Cited by 362 · see citing works
Self-citationAmagai, M., Kárpáti, S., Prussick, R. B., Klaus-Kovtun, V., & Stanley, J. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115968 · Cited by 333 · see citing works
Potempa, S., & Ridley, A. J. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.8.2185 · Cited by 329 · see citing works
Garrod, D. R. (1993) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(05)80005-5 · Cited by 313 · see citing works
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.
Rong, S., Bodescot, M., Blair, D. G., Dunn, J., Nakamura, T., Mizuno, K., Park, M., Chan, A. M.-L., Aaronson, S. A., & Woude, G. F. V. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5152 · Cited by 312 · see citing works
Cell Adhesion Molecules in the Development and Progression of Malignant Melanoma
Johnson, J. P. (1999) · Cancer and Metastasis Reviews · doi:10.1023/a:1006304806799 · Cited by 294 · see citing works
E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro
Tang, A., Eller, M. S., Hara, M., Yaar, M., Hirohashi, S., & Gilchrest, B. A. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.4.983 · Cited by 291 · see citing works
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.
Kouklis, P. D., Hutton, E. R., & Fuchs, E. V. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.1049 · Cited by 283 · see citing works
Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.
Rosen, E. M., Nigám, S. K., & Goldberg, I. D. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1783 · Cited by 278 · see citing works
Cross-Talk between Adherens Junctions and Desmosomes Depends on Plakoglobin
Lewis, J. E., Wahl, J. K., Sass, K. M., Jensen, P. J., Johnson, K. R., & Wheelock, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.919 · Cited by 277 · see citing works
Armstrong, D. K. B. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.143 · Cited by 265 · see citing works
Defining the Interactions Between Intermediate Filaments and Desmosomes
Smith, E. A., & Fuchs, E. V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.5.1229 · Cited by 261 · see citing works
Stanley, J. R. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60503-9 · Cited by 261 · see citing works
Royal, I., & Park, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27780 · Cited by 238 · see citing works
Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments
Kowalczyk, A. P., Bornslaeger, E. A., Norvell, S. M., Palka, H. L., & Green, K. J. (1998) · International review of cytology · doi:10.1016/s0074-7696(08)60153-9 · Cited by 237 · see citing works
Kowalczyk, A. P., Bornslaeger, E. A., Borgwardt, J. E., Palka, H. L., Dhaliwal, A. S., Corcoran, C. M., Denning, M. F., & Green, K. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.773 · Cited by 233 · see citing works
Human Melanoma Progression in Skin Reconstructs
Meier, F. E., Nesbit, M., Hsu, M., Martin, B. G., Belle, P. A. V., Elder, D. E., Schaumburg‐Lever, G., Garbe, C., Walz, T. M., DONATIEN, P. D., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64719-0 · Cited by 226 · see citing works
Self-citationBornslaeger, E. A., Corcoran, C. M., Stappenbeck, T. S., & Green, K. J. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.985 · Cited by 224 · see citing works
Dijkstra, G. D. H., Moshage, H. J., van Dullemen, H. M., de Jager-Krikken, A., Tiebosch, A. T. M. G., Kleibeuker, J. H., Jansen, P. L. M., & van Goor, H. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199812)186:4 · Cited by 223 · see citing works
Molecular map of the desmosomal plaque
North, A. J., Bardsley, W. G., Hyam, J. L. M., Bornslaeger, E. A., Cordingley, H. C., Trinnaman, B. J., Hatzfeld, M., Green, K. J., Magee, A. I., & Garrod, D. R. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.23.4325 · Cited by 217 · see citing works
Franke, W. W., Goldschmidt, M. D., Zimbelmann, R., Mueller, H. M., Schiller, D. L., & Cowin, P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4027 · Cited by 215 · see citing works
Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth
Matsumoto, K., Tajima, H., & Nakamura, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90887-d · Cited by 214 · see citing works
Hsu, M., Shih, D.-T., Meier, F. E., Belle, P. A. V., Hsu, J.-Y., Elder, D. E., Buck, C. A., & Herlyn, M. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65730-6 · Cited by 208 · see citing works
Self-citationAmagai, M., Koch, P. J., Nishikawa, T., & Stanley, J. R. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343081 · Cited by 205 · see citing works
Natali, P., Nicotra, M., Renzo, M. F. D., Prat, M., Bigotti, A., Cavaliere, R., & Comoglio, P. M. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.422 · Cited by 205 · see citing works
Desmosomal cadherins: another growing multigene family of adhesion molecules
Koch, P. J., & Franke, W. W. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90094-9 · Cited by 196 · see citing works
Kamei, T., Matozaki, T., Sakisaka, T., Kodama, A., Yokoyama, S., Peng, Y.-F., Nakano, K., Takaishi, K., & Takai, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203114 · Cited by 196 · see citing works
Takayama, H., LaRochelle, W. J., Anver, M. R., Bockman, D. E., & Merlino, G. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5866 · Cited by 195 · see citing works
Stappenbeck, T. S., & Green, K. J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.5.1197 · Cited by 193 · see citing works
Desmosomes: differentiation, development, dynamics and disease
Garrod, D. R., Chidgey, M., & North, A. J. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80108-6 · Cited by 162 · see citing works
c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells
Ochiai, A., Akimoto, S., Kanai, Y., Shibata, T., Oyama, T., & Hirohashi, S. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2631 · Cited by 162 · see citing works
c-erbB-2 Gene Product Directly Associates with β-Catenin and Plakoglobin
Kanai, Y., Ochiai, A., Shibata, T., Oyama, T., Ushijima, S., Akimoto, S., & Hirohashi, S. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1443 · Cited by 161 · see citing works
Adhesion in Development: An Historical Overview
Steinberg, M. S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0312 · Cited by 161 · see citing works
Molecular events in melanoma development and progression
Herlyn, M. (1998) · Frontiers in bioscience · doi:10.2741/a341 · Cited by 151 · see citing works
Self-citationMelanoma cell lines from different stages of progression and their biological and molecular analyses
Satyamoorthy, K., Dejesus, E., Linnenbach, A. J., Kraj, B., Kornreich, D. L., Rendle, S., Elder, D. E., & Herlyn, M. (1997) · Melanoma Research · doi:10.1097/00008390-199708001-00007 · Cited by 149 · see citing works
Self-citationRodeck, U., Herlyn, M., Menssen, H. D., Furlanetto, R. W., & Koprowski, H. (1987) · International Journal of Cancer · doi:10.1002/ijc.2910400520 · Cited by 143 · see citing works
Self-citationInteractions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin.
Mathur, M., Goodwin, L. O., & Cowin, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36756-x · Cited by 138 · see citing works
Hiscox, S., & Jiang, W. G. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1002 · Cited by 126 · see citing works
Met–HGF/SF: Tumorigenesis, Invasion and Metastasis
Woude, G. F. V., Jeffers, M., Cortner, J., Alvord, G., Tsarfaty, I., & Resau, J. H. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515457.ch8 · Cited by 124 · see citing works
Progression-related expression of β3 integrin in melanomas and nevi
Belle, P. A. V., Elenitsas, R., Satyamoorthy, K., Wolfe, J. T., Guerry, D., Schuchter, L. M., Belle, T. J. V., Albelda, S., Tahin, P., Herlyn, M., et al. (1999) · Human Pathology · doi:10.1016/s0046-8177(99)90202-2 · Cited by 123 · see citing works
Self-citationDynamics of intercellular communication during melanoma development
Li, G., & Herlyn, M. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01692-0 · Cited by 122 · see citing works
Self-citationE-cadherin expression in human melanoma
Danen, E. H. J., de Vries, T. J., Morandini, R., Ghanem, G., Ruiter, D. J., & van Muijen, G. (1996) · Melanoma Research · doi:10.1097/00008390-199604000-00007 · Cited by 117 · see citing works
Distinct cadherin—catenin complexes in Ca2+ dependent cell—cell adhesion
Butz, S., & Kemler, R. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01205-9 · Cited by 117 · see citing works
Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes
Imokawa, G., Yada, Y., MORISAKI, N., & Kimura, M. (1998) · Biochemical Journal · doi:10.1042/bj3301235 · Cited by 108 · see citing works
Noonan, F. P., Otsuka, T., Bang, S., Anver, M. R., & Merlino, G. T. (2000) · PubMed · Cited by 107 · see citing works
Kanegae, Y., Takamori, K., Sato, Y., Lee, G., Nakai, M., & Saito, I. (1996) · Gene · doi:10.1016/s0378-1119(96)00516-1 · Cited by 107 · see citing works
Trusolino, L., Serini, G., Cecchini, G., Besati, C., Ambesi‐Impiombato, F. S., Marchisio, P. C., & Filippi, R. D. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.4.1145 · Cited by 107 · see citing works
The body language of cells: The intimate connection between cell adhesion and behavior
Klymkowsky, M. W., & Parr, B. A. (1995) · Cell · doi:10.1016/0092-8674(95)90226-0 · Cited by 107 · see citing works
Extracellular Domain of Pemphigus Vulgaris Antigen (Desmoglein 3) Mediates Weak Homophilic Adhesion
Amagai, M., Kárpáti, S., Klaus-Kovtun, V., Udey, M. C., & Stanley, J. R. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12372164 · Cited by 103 · see citing works
Hepatocyte Growth Factor/Scatter Factor‐MET Signaling in Neural Crest‐Derived Melanocyte Development
KOS, L., ARONZON, A., Takayama, H., Maina, F., Ponzetto, C., MERLBVO, G., & Pavan, W. J. (1999) · Pigment Cell Research · doi:10.1111/j.1600-0749.1999.tb00503.x · Cited by 87 · see citing works
Tumorigenicity of the met Proto-Oncogene and the Gene for Hepatocyte Growth Factor
Rong, S., Bodescot, M., Blair, D. G., Dunn, J., Nakamura, T., Mizuno, K., Park, M., Chan, A. M.-L., Aaronson, S. A., & Woude, G. F. V. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5152-5158.1992 · Cited by 83 · see citing works
Scott, G., & Cassidy, L. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00276.x · Cited by 66 · see citing works
EGF-r gene copy number changes in renal cell carcinoma detected by fluorescencein situ hybridization
Moch, H., Sauter, G., Gasser, T. C., Bubendorf, L., Richter, J., Presti, J. C., Waldman, F. M., & Mihatsch, M. J. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199804)184:4 · Cited by 64 · see citing works
Fradet, P., & Métayer, D. L. (1998) · Science of Computer Programming · doi:10.1016/s0167-6423(97)00023-3 · Cited by 63 · see citing works
Hanakawa, Y., Amagai, M., Shirakata, Y., Sayama, K., & Hashimoto, K. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.10.1803 · Cited by 59 · see citing works
Self-citationMoriyama, T., Kataoka, H., Koono, M., & Wakisaka, S. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.3.5.531 · Cited by 55 · see citing works
Roh, J. Y., & Stanley, J. R. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12606963 · Cited by 48 · see citing works
Expression of desmoglein I and plakoglobin in skin carcinomas
Tada, H., Hatoko, M., Tanaka, A., Kuwahara, M., & Muramatsu, T. (2000) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2000.027001024.x · Cited by 47 · see citing works
Modification of the E-cadherin-Catenin Complex in Mitotic Madin-Darby Canine Kidney Epithelial Cells
Bauer, A., Lickert, H., Kemler, R., & Stappert, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28314 · Cited by 45 · see citing works
Depondt, J., Shabana, A.-H. M., Florescu‐Zorila, S., Géhanno, P., & Forest, N. (1999) · European Journal Of Oral Sciences · doi:10.1046/j.0909-8836.1999.eos1070305.x · Cited by 44 · see citing works
Phaneuf, D., Chen, S., & Wilson, J. M. (2000) · Molecular Medicine · doi:10.1007/bf03401777 · Cited by 43 · see citing works
Plasticity of Cadherin–Catenin Expression in the Melanocyte Lineage
Jouneau, A., YU, Y., Pasdar, M., & Larue, L. (2000) · Pigment Cell Research · doi:10.1034/j.1600-0749.2000.130408.x · Cited by 39 · see citing works
Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro
Tamatani, T. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.957 · Cited by 38 · see citing works
Krunic, A., Garrod, D. R., Smith, N., Orchard, G., & Cvijetic, O. (1996) · Acta Dermato Venereologica · doi:10.2340/0001555576394398 · Cited by 37 · see citing works
Conn, I. G., Vilela, M. J., Garrod, D. R., Crocker, J., & Wallace, D. M. A. (1990) · British Journal of Urology · doi:10.1111/j.1464-410x.1990.tb14694.x · Cited by 33 · see citing works
Loss of Invasiveness in Squamous Cell Carcinoma Cells Overexpressing Desmosomal Cadherins
de Bruin, A., Müller, E. J., Wurm, S., Caldelari, R., Wyder, M., Wheelock, M. J., & Suter, M. M. (1999) · Cell Communication & Adhesion · doi:10.3109/15419069909034389 · Cited by 25 · see citing works
Rusciano, D., Lin, S., Lorenzoni, P., Casella, N., & Burger, M. M. (1998) · Tumor Biology · doi:10.1159/000030026 · Cited by 17 · see citing works
Cadherin-dependent organization and disorganization of epithelial architecture.
Takeichi, M., Watabe, M., Shibamoto, S., & Ito, F. (1994) · PubMed · Cited by 15 · see citing works
Molecular dissection of desmosomal assembly and intermediate filament anchorage.
Troyanovsky, S. M., & Leube, R. E. (1998) · PubMed · Cited by 10 · see citing works
(1993) · Vox Sanguinis · doi:10.1159/000462457 · Cited by 2 · see citing works
Tsao, H.-S. J. (1998) · Journal of Intelligent Transportation Systems · doi:10.1080/10248079808903733 · Cited by 2 · see citing works
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Sorted by citations
Cadherin Switch in Tumor Progression
Hazan, R. B., QIAO, R., Keren, R., Badano, I., & Suyama, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1294.016 · Cited by 595 · see citing works
Malignant melanoma: genetics and therapeutics in the genomic eraPreprint
Chin, L., Garraway, L. A., & Fisher, D. E. (2006) · Genes & Development · doi:10.1101/gad.1437206 · Cited by 509 · see citing works
c-Met: Structure, functions and potential for therapeutic inhibition
Ma, P. C., Maulik, G., Christensen, J. G., & Salgia, R. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023768811842 · Cited by 506 · see citing works
Melanoma: from mutations to medicine
Tsao, H., Chin, L., Garraway, L. A., & Fisher, D. E. (2012) · Genes & Development · doi:10.1101/gad.191999.112 · Cited by 496 · see citing works
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
Gupta, P. B., Kuperwasser, C., Brunet, J.-P., Ramaswamy, S., Kuo, W.-L., Gray, J. W., Naber, S. P., & Weinberg, R. A. (2005) · Nature Genetics · doi:10.1038/ng1634 · Cited by 439 · see citing works
Satyamoorthy, K., Li, G., Gerrero, M. R., Brose, M. S., Volpe, P., Weber, B. L., Belle, P. A. V., Elder, D. E., & Herlyn, M. (2003) · PubMed · Cited by 426 · see citing works
Self-citationA pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
Smalley, K. S. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.10978 · Cited by 320 · see citing works
The genetics of malignant melanoma: lessons from mouse and man
Chin, L. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1145 · Cited by 300 · see citing works
Integrin signaling in malignant melanoma
Kuphal, S., Bauer, R. J., & Bosserhoff, A. (2005) · Cancer and Metastasis Reviews · doi:10.1007/s10555-005-1572-1 · Cited by 287 · see citing works
Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?
Hölzel, M., Bovier, A., & Tüting, T. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3498 · Cited by 267 · see citing works
Friedegund, M. (2005) · Frontiers in bioscience · doi:10.2741/1755 · Cited by 265 · see citing works
Hepatocyte growth factor, its receptor, and their potential value in cancer therapies
Jiang, W. G., Martin, T. A., Parr, C., Davies, G., Matsumoto, K., & Nakamura, T. (2004) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.09.004 · Cited by 249 · see citing works
Haass, N. K., Sproesser, K., Nguyen, T. K., Contractor, R., Medina, C. A., Nathanson, K. L., Herlyn, M., & Smalley, K. S. M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1440 · Cited by 241 · see citing works
Self-citationRoles played by a subset of integrin signaling molecules in cadherin-based cell–cell adhesion
Yano, H., Mazaki, Y., Kurokawa, K., Hanks, S. K., Matsuda, M., & Sabe, H. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312013 · Cited by 234 · see citing works
Smalley, K. S. M., Contractor, R., Haass, N. K., Kulp, A. N., Atilla‐Gokcumen, G. E., Williams, D. S., Bregman, H. S., Flaherty, K. T., Soengas, M. S., Meggers, E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1538 · Cited by 229 · see citing works
Self-citationNormal Human Melanocyte Homeostasis as a Paradigm for Understanding Melanoma
Haass, N. K., & Herlyn, M. (2005) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1111/j.1087-0024.2005.200407.x · Cited by 224 · see citing works
Self-citationMelanoma and the tumor microenvironment
Villanueva, J., & Herlyn, M. (2008) · Current Oncology Reports · doi:10.1007/s11912-008-0067-y · Cited by 219 · see citing works
Self-citationMelanoma development and progression: a conspiracy between tumor and host
Hsu, M., Meier, F. E., & Herlyn, M. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700906.x · Cited by 190 · see citing works
Self-citationFunction and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil
Li, G., Satyamoorthy, K., Meier, F. E., Berking, C., Bogenrieder, T., & Herlyn, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206455 · Cited by 177 · see citing works
Self-citationc-Met Expression Is Regulated by Mitf in the Melanocyte Lineage
McGill, G. G., Haq, R., Nishimura, E. K., & Fisher, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513094200 · Cited by 174 · see citing works
Association between gene expression profile and tumor invasion in oral squamous cell carcinoma
Törüner, G., Ülger, C., Alkan, M., Galante, A., Rinaggio, J., Wilk, R., Tian, B., Soteropoulos, P., Hameed, M., Schwalb, M. N., et al. (2004) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2004.01.026 · Cited by 173 · see citing works
SPARC Represses E-Cadherin and Induces Mesenchymal Transition during Melanoma Development
Robert, G., Gaggioli, C., Bailet, O., Carine Chavey, A., Abbe, P., Aberdam, É., Sabatié, E., Cano, A., de Herreros, A. G., Ballotti, R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3189 · Cited by 172 · see citing works
The Role of Altered Cell–Cell Communication in Melanoma Progression
Haass, N. K., Smalley, K. S. M., & Herlyn, M. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000032362.35354.bb · Cited by 166 · see citing works
Self-citationc-Met Is a Potentially New Therapeutic Target for Treatment of Human Melanoma
Puri, N., Ahmed, S., Janamanchi, V., Tretiakova, M., Zumba, O., Krausz, T. N., Jagadeeswaran, R., & Salgia, R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0776 · Cited by 155 · see citing works
Luo, C., Tetteh, P. W., Merz, P., Dickes, E., Abukiwan, A., Hotz‐Wagenblatt, A., Holland-Cunz, S. G., Sinnberg, T. W., Schittek, B., Schadendorf, D., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.357 · Cited by 142 · see citing works
Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion
Cao, H., Cheng, C.-Y., Su, T., Fu, X., Guo, H., Li, T., Tse, A. K., Kwan, H. Y., Yu, H., & Yu, Z. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0367-4 · Cited by 134 · see citing works
Melanoma invasion – current knowledge and future directions
Gaggioli, C., & Sahai, E. A. (2007) · Pigment Cell Research · doi:10.1111/j.1600-0749.2007.00378.x · Cited by 131 · see citing works
c-Met and hepatocyte growth factor: Potential as novel targets in cancer therapy
Sattler, M., & Salgia, R. (2007) · Current Oncology Reports · doi:10.1007/s11912-007-0005-4 · Cited by 130 · see citing works
The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer
Wellbrock, C., & Arozarena, I. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00033 · Cited by 126 · see citing works
Overcoming resistance to BRAF inhibitors
Arozarena, I., & Wellbrock, C. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.06.09 · Cited by 125 · see citing works
Hansel, D. E., Rahman, A., Hidalgo, M. M., Thuluvath, P. J., Lillemoe, K. D., Shulick, R., Ku, J., Park, J., Miyazaki, K., Ashfaq, R., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63645-0 · Cited by 123 · see citing works
The role of the c-Met pathway in lung cancer and the potential for targeted therapy
Sattler, M., Hasina, R., Reddy, M. M., Gangadhar, T. C., & Salgia, R. (2011) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834011408636 · Cited by 117 · see citing works
Findlay, V. J., Wang, C., Watson, D. K., & Camp, E. R. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.15 · Cited by 114 · see citing works
Okano, J., Shiota, G., Matsumoto, K., Yasui, S., Kurimasa, A., Hisatome, I., Steinberg, P., & Murawaki, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.04.002 · Cited by 110 · see citing works
Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes
Pinnix, C. C., Lee, J. T., Liu, Z., McDaid, R., Balint, K., Beverly, L. J., Brafford, P. A., Xiao, M., Himes, B. T., Zabierowski, S. E., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3767 · Cited by 109 · see citing works
Self-citationTherapeutic Implications of the Emerging Molecular Biology of Uveal Melanoma
Patel, M. M., Smyth, E. C., Chapman, P. B., Wolchok, J. D., Schwartz, G. K., Abramson, D. H., & Carvajal, R. D. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3169 · Cited by 108 · see citing works
Identification of Core Genes and Pathways in Melanoma Metastasis via Bioinformatics Analysis
Xie, R., Li, B., Jia, L., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020794 · Cited by 107 · see citing works
Vitiligo: Pathogenetic Hypotheses and Targets for Current Therapies
Guerra, L., Dellambra, E., Brescia, S., & Raskovic, D. (2010) · Current Drug Metabolism · doi:10.2174/138920010791526105 · Cited by 100 · see citing works
Vergani, E., Vallacchi, V., Frigerio, S., Deho, P., Mondellini, P., Perego, P., Cassinelli, G., Lanzi, C., Testi, M., Rivoltini, L., et al. (2011) · Neoplasia · doi:10.1593/neo.111102 · Cited by 99 · see citing works
Progress of antibody-based inhibitors of the HGF–cMET axis in cancer therapy
Kim, K. H., & Kim, H. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.17 · Cited by 99 · see citing works
HGF/c-MET Signaling in Melanocytes and Melanoma
Czyż, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123844 · Cited by 99 · see citing works
Yang, J., Price, M. A., Li, G. Y., Bar‐Eli, M., Salgia, R., Jagedeeswaran, R., Carlson, J. H., Ferrone, S., Turley, E. A., & McCarthy, J. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4626 · Cited by 95 · see citing works
Self-citationReciprocal regulation of MelCAM and AKT in human melanoma
Li, G., Kalabis, J., Xu, X., Meier, F. E., Oka, M., Bogenrieder, T., & Herlyn, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206819 · Cited by 95 · see citing works
Self-citationPI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes
Larribère, L., Khaled, M., Tartare‐Deckert, S., Buscà, R., Luciano, F., Bille, K., Valony, G., Eychène, A., Auberger, P., Ortonne, J. ‐., et al. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401475 · Cited by 91 · see citing works
Microenvironmental influences in melanoma progression
Lee, J. T., & Herlyn, M. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21204 · Cited by 94 · see citing works
Self-citationPhase 2 study of RO 4929097, a gamma‐secretase inhibitor, in metastatic melanoma: SWOG 0933
Lee, S. M., Moon, J., Redman, B. G., Chidiac, T. A., Flaherty, L. E., Zha, Y., Othus, M. K. D., Ribas, A., Sondak, V. K., Gajewski, T. F., et al. (2014) · Cancer · doi:10.1002/cncr.29055 · Cited by 91 · see citing works
Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis.
Recio, J. A., Noonan, F. P., Takayama, H., Anver, M. R., Duray, P. H., Rush, W. L., Lindner, G., Fabo, E. C. D., DePinho, R. A., & Merlino, G. T. (2002) · PubMed · Cited by 91 · see citing works
Naphthoquinones from Onosma paniculata Induce Cell-Cycle Arrest and Apoptosis in Melanoma Cells
Kretschmer, N., Rinner, B., Deutsch, A. J. A., Lohberger, B., Knausz, H., Kunert, O., Blunder, M., Boechzelt, H. G., Schaider, H., & Bauer, R. (2012) · Journal of Natural Products · doi:10.1021/np2006499 · Cited by 87 · see citing works
Self-citationCutaneous melanoma in genetically modified animals
Larue, L., & Beermann, F. (2007) · Pigment Cell Research · doi:10.1111/j.1600-0749.2007.00411.x · Cited by 87 · see citing works
Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells
Fedorenko, I. V., Abel, E. V., Koomen, J. M., Fang, B., Wood, E. R., Chen, Y. A., Fisher, K. J., Iyengar, S., Dahlman, K. B., Wargo, J. A., et al. (2015) · Oncogene · doi:10.1038/onc.2015.188 · Cited by 85 · see citing works
Vitiligo Skin: Exploring the Dermal Compartment
Kovacs, D., Bastonini, E., Ottaviani, M., Cota, C., Migliano, E., Dell’Anna, M. L., & Picardo, M. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.06.033 · Cited by 85 · see citing works
Beuret, L., Flori, E., Denoyelle, C., Bille, K., Buscà, R., Picardo, M., Bertolotto, C., & Ballotti, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611563200 · Cited by 84 · see citing works
Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence
Leikam, C., Hufnagel, A., Schartl, M., & Meierjohann, S. (2008) · Oncogene · doi:10.1038/onc.2008.323 · Cited by 84 · see citing works
The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis
Heinrich, E. L., Walser, T. C., Krysan, K., Liclican, E. L., Grant, J. L., Rodriguez, N., & Dubinett, S. M. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0089-0 · Cited by 84 · see citing works
Gaggioli, C., Deckert, M., Robert, G., Abbe, P., Batoz, M., Ehrengruber, M. U., Ortonne, J. P., Ballotti, R., & Tartare‐Deckert, S. (2004) · Oncogene · doi:10.1038/sj.onc.1208318 · Cited by 78 · see citing works
Targeting the MET gene for the treatment of non-small-cell lung cancer
Gelsomino, F., Facchinetti, F., Haspinger, E. R., Garassino, M. C., Trusolino, L., de Braud, F., & Tiseo, M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.11.006 · Cited by 77 · see citing works
Orgaz, J. L., Ladhani, O., Hoek, K. S., Fernández‐Barral, A., Mihic‐Probst, D., Aguilera, O., Seftor, E. A., Bernad, A., Rodríguez‐Peralto, J. L., Hendrix, M. J. C., et al. (2009) · Oncogene · doi:10.1038/onc.2009.284 · Cited by 75 · see citing works
UV‐induced Skin Cancer: Similarities – Variations
Boukamp, P. (2005) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2005.05037.x · Cited by 74 · see citing works
Saladi, S. V., Keenen, B., Marathe, H. G., Qi, H., Chin, K., & de la Serna, I. L. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-280 · Cited by 74 · see citing works
Romano, V., Belviso, I., Venuta, A., Ruocco, M. R., Masone, S., Aliotta, F., Fiume, G., Montagnani, S., Avagliano, A., & Arcucci, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105283 · Cited by 73 · see citing works
Targeting oncogenic BRAF and aberrant MAPK activation in the treatment of cutaneous melanoma
Carlino, M. S., Long, G. V., Kefford, R. F., & Rizos, H. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.08.021 · Cited by 69 · see citing works
Yu, Y., & Merlino, G. T. (2002) · PubMed · Cited by 63 · see citing works
Mildner, M., Mlitz, V., Грубер, Ф., Wojta, J., & Tschachler, E. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700938 · Cited by 56 · see citing works
Selective evolutionary pressure from the tissue microenvironment drives tumor progression
Smalley, K. S. M., Brafford, P. A., & Herlyn, M. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.06.002 · Cited by 54 · see citing works
Self-citationN-cadherin as an invasion promoter: a novel target for antitumor therapy?
Cavallaro, U. (2004) · PubMed · Cited by 55 · see citing works
Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model
Miao, J., Mu, D., Ergel, B., Singavarapu, R., Duan, Z., Powers, S., Oliva, E., & Oršulić, S. (2008) · International Journal of Cancer · doi:10.1002/ijc.23726 · Cited by 54 · see citing works
Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner‐Tschakarjan, E., Steitz, J., Heukamp, L. C., Gütgemann, I., Buettner, R., Malumbres, M., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060017 · Cited by 54 · see citing works
Cell Adhesion Molecules in Plasticity and Metastasis
Smart, J. A., Oleksak, J. E., & Hartsough, E. J. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0595 · Cited by 54 · see citing works
150th Anniversary Series: Desmosomes and the Hallmarks of Cancer
Huber, O., & Petersen, I. (2015) · Cell Communication & Adhesion · doi:10.3109/15419061.2015.1039642 · Cited by 52 · see citing works
Semaphorin receptors meet receptor tyrosine kinases on the way of tumor progression
Cagnoni, G., & Tamagnone, L. (2013) · Oncogene · doi:10.1038/onc.2013.474 · Cited by 51 · see citing works
Prognostic and predictive value of MET deregulation in non-small cell lung cancer.
Finocchiaro, G., Toschi, L., Gianoncelli, L., Baretti, M., & Santoro, A. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.03.43 · Cited by 51 · see citing works
Christensen, C., & Guldberg, P. (2005) · Oncogene · doi:10.1038/sj.onc.1208758 · Cited by 48 · see citing works
Soong, J., Chen, Y.-L., Shustef, E., & Scott, G. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.414 · Cited by 50 · see citing works
Damm, S., Heidinger, P., Stefan, M., Wels, C., Méhes, G., Richtig, E., Kerl, H., Otte, M., & Schaider, H. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.45 · Cited by 48 · see citing works
Self-citationSchultz, J., Lorenz, P., Ibrahim, S. M., Kundt, G., Gross, G., & Kunz, M. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20452 · Cited by 48 · see citing works
Kim, N.-H., Choi, S., Lee, T. R., Lee, A., & Lee, A. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.257 · Cited by 47 · see citing works
Etnyre, D., Stone, A. L., Fong, J., Jacobs, R. J., Uppada, S. B., Botting, G. M., Rajanna, S., Moravec, D. N., Shambannagari, M. R., Crees, Z. D., et al. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.29451 · Cited by 46 · see citing works
Schag, K., Schmidt, S. M., Müller, M., Weinschenk, T., Appel, S., Weck, M. M., Grünebach, F., Stevanović, S., Rammensee, H., & Brossart, P. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0640 · Cited by 46 · see citing works
Schmitt, C. J., Franke, W. W., Goerdt, S., Falkowska-Hansen, B., Rickelt, S., & Peitsch, W. K. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700849 · Cited by 46 · see citing works
Desmosomes and disease: an update.
Chidgey, M. (2002) · PubMed · doi:10.14670/hh-17.1179 · Cited by 46 · see citing works
Fong, J., Jacobs, R. J., Moravec, D. N., Uppada, S. B., Botting, G. M., Nlend, M., & Puri, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078398 · Cited by 45 · see citing works
Targeting invasive properties of melanoma cells
Arozarena, I., & Wellbrock, C. (2017) · FEBS Journal · doi:10.1111/febs.14040 · Cited by 45 · see citing works
Smit, D. J., Gardiner, B., & Sturm, R. A. (2007) · International Journal of Cancer · doi:10.1002/ijc.23039 · Cited by 43 · see citing works
RTK Inhibitors in Melanoma: From Bench to Bedside
Sabbah, M., Najem, A., Krayem, M., Awada, A., Journé, F., & Ghanem, G. (2021) · Cancers · doi:10.3390/cancers13071685 · Cited by 38 · see citing works
Li, Y., Chen, C., He, Y., Cai, S., Yang, D., He, W., Xu, J., & Zhan, W.-H. (2012) · Journal of Surgical Oncology · doi:10.1002/jso.23008 · Cited by 42 · see citing works
Insights into melanoma: targeting the mTOR pathway for therapeutics
Pópulo, H., Soares, P., & Lopes, J. M. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.691472 · Cited by 42 · see citing works
Hwang, S., Kim, H., Min, M. S., Raghunathan, R., Panova, I. P., Munshi, R., & Ryu, B. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.160 · Cited by 40 · see citing works
Heidinger, P., Wels, C., Joshi, S., Damm, S., Steinbauer, E., Beham‐Schmid, C., Frank, S., Bergler, H., & Schaider, H. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00807.x · Cited by 38 · see citing works
Self-citationHino, K., Nagane, M., Fujioka, Y., & Shiokawa, Y. (2005) · Neurosurgery · doi:10.1227/01.neu.0000159716.45457.bc · Cited by 38 · see citing works
Landsberg, J., Gaffal, E., Cron, M., Sirokay, J. D., Renn, M., & Tüting, T. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00744.x · Cited by 37 · see citing works
Modulation of E-Cadherin by Hepatocyte Growth Factor Induces Aggressiveness of Gastric Carcinoma
Han, S., Lee, H.-Y., Lee, J., Kim, W., Nam, H.-J., Kim, H., Cho, Y.-K., Kim, M. W., & Lee, K. U. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000186171.85804.fe · Cited by 36 · see citing works
Kim, C., Kim, J., Kahng, H., & Choi, E. C. (2007) · Annals of Surgical Oncology · doi:10.1245/s10434-006-9320-5 · Cited by 36 · see citing works
Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion
Siret, C., Terciolo, C., Dobric, A., Habib, M.-C., Germain, S., Bonnier, R., Lombardo, D., Rigot, V., & André, F. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.358 · Cited by 36 · see citing works
Park, H.-J., Han, E. S., & Park, D. K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.07.052 · Cited by 35 · see citing works
The molecular pathology of cutaneous melanoma
Bogenrieder, T., & Herlyn, M. (2011) · Cancer Biomarkers · doi:10.3233/cbm-2011-0164 · Cited by 35 · see citing works
Self-citationThe genetics of malignant melanoma
Lomas, J. (2008) · Frontiers in bioscience · doi:10.2741/3065 · Cited by 34 · see citing works
Molhoek, K. R., Shada, A. L., Smolkin, M. E., Chowbina, S., Papin, J. A., Brautigan, D. L., & Slingluff, C. L. (2011) · Melanoma Research · doi:10.1097/cmr.0b013e328343a1d6 · Cited by 34 · see citing works
Makowiecka, A., Simiczyjew, A., Nowak, D., & Mazur, A. J. (2016) · European Journal of Histochemistry · doi:10.4081/ejh.2016.2728 · Cited by 34 · see citing works
The MET axis as a therapeutic target
Sattler, M., & Salgia, R. (2009) · Update on Cancer Therapeutics · doi:10.1016/j.uct.2009.01.001 · Cited by 33 · see citing works
Hammouda, M. B., Riahi-Chebbi, I., Souid, S., Othman, H., Aloui, Z., Srairi‐Abid, N., Karoui, H., Gasmi, A., Magnenat, E. M., Wells, T. N. C., et al. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.11.019 · Cited by 33 · see citing works
- Authors
- Li, G., Schaider, H., Satyamoorthy, K., Hanakawa, Y., Hashimoto, K., & Herlyn, M.
- Affiliations
- The Wistar Institute (US)
- Ehime University (JP)
- Corresponding author
- Herlyn, Meenhard
- Venue
- Oncogene
- Published
- 2001-12-06
- Volume
- 20
- Issue
- 56
- Pages
- 8125-8135
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2010980929
- Cited by
- 212
- References
- 94
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Tokyo
- National Institutes of Health
- National Cancer Institute (R01CA047159, CA 47159, R01CA080999, CA-10815, CA 76674, CA-25874, R01CA076674, CA80999, P01CA025874, P30CA010815)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- melanoma, hepatocyte growth factor, E-cadherin, desmoglein 1, c-Met, autocrine signaling, cell adhesion, plakoglobin, MAPK signaling, PI3K signaling, metastasis, melanocytes
- MeSH terms
- Cell Adhesion, Cytoskeletal Proteins, Humans, Melanocytes, Melanoma, Precipitin Tests, RNA, Neoplasm, Tumor Cells, Cultured, Signal Transduction, Down-Regulation, Keratinocytes, Cadherins, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Phosphatidylinositol 3-Kinases, Autocrine Communication, Mitogen-Activated Protein Kinases, Desmoplakins, Desmogleins, Desmoglein 1, gamma Catenin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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