The Leukemia-Associated Gene TEL Encodes a Transcription Repressor Which Associates with SMRT and mSin3A

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Untitled work

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The ets Family Member Tel Binds to the Fli-1 Oncoprotein and Inhibits Its Transcriptional Activity

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Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.

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PAX5/TEL Acts as a Transcriptional Repressor Causing Down-modulation of CD19, Enhances Migration to CXCL12, and Confers Survival Advantage in pre-BI Cells

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The leukaemia‐associated transcription factors EVI‐1 and MDS1/EVI1 repress transcription and interact with histone deacetylase

Vinatzer, U., Taplick, J., Seiser, C., Fonatsch, C., & Wieser, R. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02987.x · Cited by 54 · see citing works

Tel1/ETV6 Specifies Blood Stem Cells through the Agency of VEGF Signaling

Ciau‐Uitz, A., Pinheiro, P., Gupta, R., Enver, T., & Patient, R. K. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.009 · Cited by 53 · see citing works

Tel-2 Is a Novel Transcriptional Repressor Related to the Ets Factor Tel/ETV-6

Gu, X., Shin, B., Akbarali, Y., Weiss, A., Boltax, J., Oettgen, P., & Libermann, T. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010070200 · Cited by 52 · see citing works

The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor

Nordentoft, I., & Jørgensen, P. (2003) · Biochemical Journal · doi:10.1042/bj20030087 · Cited by 52 · see citing works

Tel induces a G1 arrest and suppresses Ras-induced transformation

Rompaey, L. V., Potter, M. D., Adams, C., & Grosveld, G. C. (2000) · Oncogene · doi:10.1038/sj.onc.1203899 · Cited by 52 · see citing works

The Ets-transcription factor family in embryonic development: lessons from the amphibian and bird

Remy, P., & Baltzinger, M. (2000) · Oncogene · doi:10.1038/sj.onc.1204044 · Cited by 52 · see citing works

SUMO Modification of the Ets-related Transcription Factor ERM Inhibits Its Transcriptional Activity

Degerny, C., Monté, D., Beaudoin, C., Jaffray, E., Portois, L., Hay, R. T., de Launoit, Y., & Baert, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411250200 · Cited by 46 · see citing works

The Novel ETS Factor TEL2 Cooperates with Myc in B Lymphomagenesis

Cardone, M., Kandilci, A., Carella, C., Nilsson, J. A., Brennan, J. A., Ekmekçi, S. S., Özbek, U., Boyd, K. L., Cleveland, J. L., & Grosveld, G. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2395-2405.2005 · Cited by 45 · see citing works

Native interface of the SAM domain polymer of TEL

Tran, H. H., Kim, C. A., Faham, S., Siddall, M.-C., & Bowie, J. U. (2002) · BMC Structural Biology · doi:10.1186/1472-6807-2-5 · Cited by 42 · see citing works

Transcription factor defects causing platelet disorders

Daly, M. E. (2016) · Blood Reviews · doi:10.1016/j.blre.2016.07.002 · Cited by 43 · see citing works

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

Lu, D. Y., Ellegast, J. M., Ross, K. N., Malone, C. F., Lin, S., Mabe, N. W., Dharia, N. V., Meyer, A., Conway, A. S., Su, A. H., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-022-01059-8 · Cited by 48 · see citing works

A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus

Montpetit, A., Boily, G., & Sinnett, D. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200766 · Cited by 42 · see citing works

FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain

Maurer, P., T'Sas, F., Coutte, L., Callens, N., Brenner, C., Lint, C. M. V., de Launoit, Y., & Baert, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206572 · Cited by 40 · see citing works

Genetic analysis of ETS genes in C. elegans

Hart, A. H., Reventar, R., & Bernstein, A. (2000) · Oncogene · doi:10.1038/sj.onc.1204040 · Cited by 36 · see citing works

Longevity is determined by ETS transcription factors in multiple tissues and diverse species

Dobson, A. J., Boulton-McDonald, R., Houchou, L., Svermova, T., Ren, Z., Subrini, J., Vazquez-Prada, M., Hoti, M., Rodríguez‐López, M., Ibrahim, R., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008212 · Cited by 37 · see citing works

Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain

Coyne, H. J., De, S., Okon, M., Green, S. M., Bhachech, N., Graves, B. J., & McIntosh, L. P. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.05.010 · Cited by 36 · see citing works

The Clinical Relevance of Steroid Hormone Receptor Corepressors

Kumar, R., Gururaj, A. E., Vadlamudi, R., & Rayala, S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1276 · Cited by 39 · see citing works

Polymer‐driven crystallization

Nauli, S., Farr, S., Lee, Y., Kim, H., Faham, S., & Bowie, J. U. (2007) · Protein Science · doi:10.1110/ps.073074207 · Cited by 34 · see citing works

TEL, a Putative Tumor Suppressor, Induces Apoptosis and Represses Transcription of Bcl-XL

Irvin, B. J., Wood, L. D., Wang, L., Fenrick, R., Sansam, C. G., Packham, G., Kinch, M. S., Yang, E., & Hiebert, S. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305189200 · Cited by 34 · see citing works

Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL

Poirel, H. A., Lopez, R. G., Penard‐Lacronique, V., Della-Valle, V., Mauchauffé, M., Berger, R., Ghysdael, J., & Bernard, O. (2000) · Oncogene · doi:10.1038/sj.onc.1203830 · Cited by 34 · see citing works

Cytogenetic and molecular heterogeneity of 7q36/12p13 rearrangements in childhood AML

Simmons, H., Oseth, L., Nguyen, P. L., O’Leary, M., Conklin, K., & Hirsch, B. A. (2002) · Leukemia · doi:10.1038/sj.leu.2402773 · Cited by 34 · see citing works

mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines

Loriol, C., Cassé, F., Khayachi, A., Poupon, G., Chafaï, M., Deval, E., Gwizdek, C., & Martin, S. (2014) · Nature Communications · doi:10.1038/ncomms6113 · Cited by 32 · see citing works

ETV6 and ETV7: Siblings in hematopoiesis and its disruption in disease

Rasighaemi, P., & Ward, A. C. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.05.011 · Cited by 32 · see citing works

MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression.

Meester-Smoor, M. A., Janssen, M. J. F. W., Grosveld, G., de Klein, A., van Ijcken, W. V., Douben, H., & Zwarthoff, E. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn168 · Cited by 33 · see citing works

MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice

Kawagoe, H., & Grosveld, G. C. (2005) · Blood · doi:10.1182/blood-2005-04-1674 · Cited by 29 · see citing works

TEL2, an ETS Factor Expressed in Human Leukemia, Regulates Monocytic Differentiation of U937 Cells and Blocks the Inhibitory Effect of TEL1 on Ras-Induced Cellular Transformation

Kawagoe, H., Potter, M. D., Ellis, J., & Grosveld, G. C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0839 · Cited by 29 · see citing works

Mechanism of ETV6-RUNX1 Leukemia

Sundaresh, A., & Williams, O. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-3233-2_13 · Cited by 29 · see citing works

TEL/ETV6 Is a Signal Transducer and Activator of Transcription 3 (Stat3)-induced Repressor of Stat3 Activity

Schick, N., Oakeley, E. J., Hynes, N. E., & Badache, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312581200 · Cited by 29 · see citing works

The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription

van Wely, K. H. M., Meester‐Smoor, M. A., Janssen, M. J. F. W., Aarnoudse, A.-J., Grosveld, G. C., & Zwarthoff, E. C. (2007) · Oncogene · doi:10.1038/sj.onc.1210382 · Cited by 28 · see citing works

ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes

Fisher, M. H., Kirkpatrick, G. D., Stevens, B. M., Jones, C. L., Callaghan, M. U., Rajpurkar, M., Fulbright, J. M., Cooper, M. A., Rowley, J. W., Porter, C. C., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.140332 · Cited by 30 · see citing works

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

Ghazavi, F., Lammens, T., Roy, N. V., Poppe, B. G., Speleman, F., Benoît, Y., Vlierberghe, P. V., & Moerloose, B. D. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.05.015 · Cited by 27 · see citing works

The Identification of (ETV6)/RUNX1-Regulated Genes in Lymphopoiesis Using Histone Deacetylase Inhibitors in ETV6/RUNX1-Positive Lymphoid Leukemic Cells

Starkova, J., Madzo, J., Cario, G., Kalina, T., Ford, A., Zaliova, M., Hrusak, O., & Trka, J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2569 · Cited by 24 · see citing works

Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the β-Catenin-TCF4 Complex

Song, L., & Gelmann, E. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800325200 · Cited by 22 · see citing works

A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma

Guo, C., Gao, C., Zhao, D., Li, J., Wang, J., Sun, X., Liu, Q., Hao, L., Greenaway, F. T., Tian, Y., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01559-1 · Cited by 22 · see citing works

Genomic Approaches Uncover Increasing Complexities in the Regulatory Landscape at the Human SCL (TAL1) Locus

Dhami, P., Bruce, A. W., Jim, J. H., Dillon, S. C., Hall, A., Cooper, J. L., Bonhoure, N., Chiang, K., Ellis, P. D., Langford, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009059 · Cited by 21 · see citing works

ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

Rasighaemi, P., Onnebo, S. M. N., Liongue, C., & Ward, A. C. (2014) · Haematologica · doi:10.3324/haematol.2014.104091 · Cited by 21 · see citing works

Abnormalities of chromatin in tumor cells

Drobic, B., Dunn, K. L., Espino, P. S., & Davie, J. (2006) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7378-4_2 · Cited by 21 · see citing works

The Impact of ETV6-NTRK3 Oncogenic Gene Fusions on Molecular and Signaling Pathway Alterations

Kinnunen, M., Liu, X., Niemelä, E. H., Öhman, T., Gawriyski, L. M., Salokas, K., Keskitalo, S., & Varjosalo, M. T. (2023) · Cancers · doi:10.3390/cancers15174246 · Cited by 20 · see citing works

Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7

Desravines, D. C., Martin, I. S., Schneider, R., Mas, P. J., Aleksandrova, N., Jensen, M. R., Blackledge, M. J., & Hart, D. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03718-5 · Cited by 19 · see citing works

Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

Li, L., Rispoli, R., Patient, R. K., Ciau‐Uitz, A., & Porcher, C. (2019) · Nature Communications · doi:10.1038/s41467-019-09050-y · Cited by 19 · see citing works

Establishment and cytogenetic characterization of a human acute lymphoblastic leukemia cell line (ALL-VG) with ETV6/ABL1 rearrangement

Baeumler, J., Szuhai, K., Falkenburg, J. H. F., van Schie, M. L. J., Ottmann, O. G., & Nijmeijer, B. A. (2008) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2008.05.001 · Cited by 19 · see citing works

Differential expression of TCL1 during pre–B-cell acute lymphoblastic leukemia progression

Fears, S. C., Chakrabarti, S. R., Nucifora, G., & Rowley, J. D. (2002) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(01)00655-0 · Cited by 18 · see citing works

Identification of transcripts modulated by ETV6 expression

Boily, G., Larose, J., Langlois, S., & Sinnett, D. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06377.x · Cited by 18 · see citing works

Directing oncogenic fusion genes into stem cells via an SCL enhancer

Eguchi, M., Eguchi‐Ishimae, M., Green, A. R., Enver, T., & Greaves, M. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405318102 · Cited by 18 · see citing works

Genetic lesions and perturbation of chromatin architecture: A road to cell transformation

Chakraborty, S., Senyuk, V. I., & Nucifora, G. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1165 · Cited by 18 · see citing works

TEL Is a Sequence-specific Transcriptional Repressor

Lopez, R. G., Carron, C., Oury, C., Gardellin, P., Bernard, O., & Ghysdael, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30132 · Cited by 174 · see citing works

Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9

Chakrabarti, S. R., Sood, R., Ganguly, S., Bohlander, S. K., Shen, Z., & Nucifora, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7467 · Cited by 80 · see citing works

TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3

Wang, L., & Hiebert, S. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204479 · Cited by 101 · see citing works

Tel-2 Is a Novel Transcriptional Repressor Related to the Ets Factor Tel/ETV-6

Gu, X., Shin, B., Akbarali, Y., Weiss, A., Boltax, J., Oettgen, P., & Libermann, T. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010070200 · Cited by 52 · see citing works

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

Kim, C. A., Phillips, M. L., Kim, W., Gingery, M., Tran, H. H., Robinson, M. A., Faham, S., & Bowie, J. U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4173 · Cited by 254 · see citing works