The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Possible Involvement of Orexin in the Stress Reaction in Rats
Open accessAbstract
We examined whether corticotropin-releasing factor (CRF) was involved in orexin-induced grooming and face-washing behaviors, and whether orexin was involved in the stress reaction. Administration of alpha-helical CRF, CRF antagonist, alone had no behavioral effect, but it blocked the orexin-induced grooming and face-washing behaviors in rats. The level of corticosterone increased in a dose-dependent manner 15 min after icv injection of orexin, and it remained high for at least 60 min. In 2-month-old rats, 1 h of immobilization stress increased orexin mRNA levels, but not the melanin-concentrating hormone (MCH) mRNA, in the lateral hypothalamic area (LHA). In 6-month-old rats, 30 min of cold stress increased the expression of orexin mRNA in the LHA. Unlike in the 2-month-old rats, immobilization stress did not change orexin mRNA expression in 6-month-old rats. These results suggest that CRF is involved in orexin-induced behaviors, and that orexin may play an important role in some stress reactions.
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
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Neurons containing hypocretin (orexin) project to multiple neuronal systems
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Narcolepsy in orexin Knockout Mice
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Self-citationInteracting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
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Orexin A activates locus coeruleus cell firing and increases arousal in the rat
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Cited by
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
Lee, M. G., Hassani, O. K., & Jones, B. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1887-05.2005 · Cited by 871
Afferents to the orexin neurons of the rat brain
Yoshida, K., McCormack, S., España, R. A., Crocker, A., & Scammell, T. E. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20859 · Cited by 572
Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., & de Lecea, L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3459-04.2004 · Cited by 462
The hypocretins: Setting the arousal threshold
Sutcliffe, J. G., & de Lecea, L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn808 · Cited by 422
Metadata
- Authors
- Ida, T., Nakahara, K., Murakami, T., Hanada, R., Nakazato, M., & Murakami, N.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 270
- Issue
- 1
- Pages
- 318-323
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1964288151
- Cited by
- 269
- References
- 38
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- green
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