Cited by 5,501Regulation of Appetite and ObesitySleep and Wakefulness ResearchNeuropeptides and Animal Physiology

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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Sakurai, Takeshi, Amemiya, Akira, Ishii, Makoto, Matsuzaki, Ichiyo, Chemelli, Richard M, Tanaka, Hirokazu, Williams, S.Clay, Richardson, James A +13 more·1998·Cell

Abstract

The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.

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Crossref · 10.1016/s0092-8674(00)80949-6

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  • The lateral hypothalamic area contains hypocretin/orexin neurons, which appear to play a critical role in arousal and probably reward.

    “Recent data suggest that the lateral hypothalamic area contains hyporcretin/orexin (de Lecea et al., 1998, Sakurai et al., 1998) neurons (Peyron et al., 1998), which appear to play a critical role in arousal (Siegel, 2004; Saper et al., 2005) and probably reward (Harris et al., 2005; Harris and Aston-Jones, 2006).”

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Authors
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W.-S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J., & Yanagisawa, M.
Affiliations
  • Howard Hughes Medical Institute (US)
  • The University of Texas Southwestern Medical Center (US)
Corresponding author
Yanagisawa, Masashi
Venue
Cell
Publisher
Elsevier BV
Published
1998-02
Volume
92
Issue
4
Pages
573-585
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2027740042
Cited by
5,501
References
57
Citations by year
2026: 93 · 2025: 158 · 2024: 169 · 2023: 186 · 2022: 207 · 2021: 197 · 2020: 189 · 2019: 191 · 2018: 239 · 2017: 211 · 2016: 211 · 2015: 239 · 2014: 274 · 2013: 252 · 2012: 242
FWCI
54.61
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
orexin-A, orexin B, orexin receptors, G protein-coupled receptors, hypothalamus, feeding behavior, energy homeostasis, neuropeptides, fasting, dietary intake, central regulation of feeding
MeSH terms
Orexins, Animals, Carrier Proteins, Chromatography, High Pressure Liquid, Fasting, Feeding Behavior, Cricetinae, Humans, Hypothalamus, Kidney, Male, Molecular Sequence Data, Neurons, Neuropeptides, Protein Precursors, Rabbits, RNA, Messenger, CHO Cells, Rats, Wistar, Sequence Homology, Amino Acid, Receptors, Neuropeptide, GTP-Binding Proteins, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Rats, Orexin Receptors

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