Regulatory Functions of 3′UTRs
Integrity signals
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Many conserved 3'-UTR sequences are likely involved in posttranscriptional regulatory mechanisms, for example by influencing subcellular localization, transcript stability, or translatability.
“It is likely that many conserved 3Ј-UTR sequences are involved in posttranscriptional regulatory mechanisms, e.g., by influencing subcellular localization, transcript stability, or translatability (Duret et al. 1993;Grzybowska et al. 2001;Mignone et al. 2002).”
From Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes (2005) · cites this paper as Grzybowska et al. 2001
Cites
AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948 · see citing works
A conserved family of elav-like genes in vertebrates.
Good, P. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4557 · Cited by 319 · see citing works
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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 4,408 · see citing works
Kaminska, B. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.08.017 · Cited by 1,285 · see citing works
Lai, P. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00296-7 · Cited by 57 · see citing works
- Authors
- Grzybowska, E. A., Wilczynska, A., & Siedlecki, J. A.
- Affiliations
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 288
- Issue
- 2
- Pages
- 291-295
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2146940512
- Cited by
- 177
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 5
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- recurrent vulvovaginal candidiasis, Candida albicans, IL-12, single nucleotide polymorphisms, genetic susceptibility, mRNA expression, 3' untranslated region, gene expression regulation
- MeSH terms
- Gene Expression Regulation, Humans, RNA, Messenger, Transcription, Genetic, 3' Untranslated Regions, RNA Stability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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