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Stress Downregulates Lipopolysaccharide-Induced Expression of Proinflammatory Cytokines in the Spleen, Pituitary, and Brain of Mice
Abstract
Mice injected with LPS (10 mu g/mouse, sc) or saline were submitted to a 15-min restraint stress and sacrificed 1 or 2 h later to assess the effect of stress on the induction of interleukin-1beta (IL-1beta) and other proinflammatory cytokines (IL-1alpha, IL-1ra, IL-6, and tumor necrosis factor-alpha) in the spleen, pituitary, hypothalamus, hippocampus, and striatum. LPS-induced cytokine gene expression, as determined by comparative RT-PCR, was lower in stressed than in nonstressed mice. LPS increased plasma and tissue levels of IL-1beta, as determined by ELISA, but this effect was less marked in stressed than in nonstressed mice. These results are discussed in relation to the modulatory effects of glucocorticoids on cytokine production.
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In the citing paper
“By contrast, acute stress post-LPS decreases the production of these same cytokines (Goujon et al., 1995).”
From The Stressed CNS: When Glucocorticoids Aggravate Inflammation (2009) · cites this paper as Goujon et al., 1995
In the citing paper
“Prior work established that acute stress or exogenous GCs can potentiate or conversely repress the same pro-inflammatory genes provided that they are respectively administered before or after LPS (140, 156).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [156]
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Items 101–105 of 105
Mi, W. (2006) · OakTrust (Texas A&M University Libraries)
Weber, M. D. (2015) · CU Scholar (University of Colorado Boulder)
Cytokines and Stressors: Implications for Cancer Immunotherapy
Kusnecov, A. W., & Anisman, H. (2010) · Springer eBooks · doi:10.1007/978-90-481-3725-1_1
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811351-6.00026-7
Stressor and cytokine interactions : implications in depressive-like pathology
Gibb, J. (2011) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2011-09658
Metadata
- Authors
- Goujon, E., Parnet, P., Laye, S., Combe, C., Kelley, K. W., & Dantzer, R.
- Affiliations
- Inserm (FR)
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 9
- Issue
- 4
- Pages
- 292-303
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2032191599
- Cited by
- 106
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (5r01dk049311-05)
- National Institute of Mental Health (1RO1 MH51569-01A2, R01MH051569)
- National Institute of Diabetes and Digestive and Kidney Diseases (1RO1 DK 49311)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- restraint stress, lipopolysaccharide, inflammatory cytokines, IL-1β, interleukin-1 alpha, interleukin-1 receptor antagonist, interleukin-6, TNF-α, glucocorticoids, hypothalamic-pituitary-adrenal axis, spleen, pituitary gland, hippocampus, striatum, cytokine gene expression, neuroimmune interactions
- MeSH terms
- Animals, Brain, Corpus Striatum, Corticosterone, Gene Expression Regulation, Hippocampus, Hypothalamus, Interleukin-1, Lipopolysaccharides, Male, Mice, Inbred ICR, Pituitary Gland, Restraint, Physical, RNA, Messenger, Sialoglycoproteins, Spleen, Stress, Physiological, Tumor Necrosis Factor-alpha, Neuroimmunomodulation, Interleukin-6, Mice, Interleukin 1 Receptor Antagonist Protein
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