Kelley, Keith W.

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 7,395

Twenty years of research on cytokine-induced sickness behavior

Dantzer, R., & Kelley, K. W. (2007) · Brain, Behavior, and Immunity

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,420

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 1,278

Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 813

Inflammation-associated depression: From serotonin to kynurenine

Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 726

Cytokine-induced sickness behavior

Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 716

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 630

Stress and immunity: An integrated view of relationships between the brain and the immune system

Dantzer, R., & Kelley, K. W. (1989) · Life Sciences

Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune Response

Cited by 534

Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior

Frenois, F., Moreau, M., O’Connor, J., Lawson, M., Micon, C., Lestage, J., Kelley, K. W., Dantzer, R., & Castanon, N. (2007) · Psychoneuroendocrinology

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 438

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

Walker, A. K., Budac, D. P., Bisulco, S., Lee, A. W., Smith, R. A., Beenders, B., Kelley, K. W., & Dantzer, R. (2013) · Neuropsychopharmacology

Tryptophan and brain disordersTreatment of Major Depression

Cited by 432

Immune–neural connections: how the immune system’s response to infectious agents influences behavior

McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology

Tryptophan and brain disordersVagus Nerve Stimulation Research

Cited by 429

Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?

Dantzer, R., Konsman, J.-P., Bluthé, R.-M., & Kelley, K. W. (2000) · Autonomic Neuroscience

Vagus Nerve Stimulation ResearchTryptophan and brain disorders

Cited by 400

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

Cui, B., Luo, Y., Tian, P., Peng, F., Lu, J., Yang, Y., Su, Q., Liu, B., Yu, J., Luo, X., et al. (2019) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismCancer, Stress, Anesthesia, and Immune Response

Cited by 308

Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 299

NIH public access policy

Kelley, K. W. (2008) · Brain, Behavior, and Immunity

HIV/AIDS Research and InterventionsHIV, Drug Use, Sexual Risk

Cited by 241

Regulation of IGF-I function by proinflammatory cytokines: At the interface of immunology and endocrinology

O’Connor, J. C., McCusker, R. H., Strle, K., Johnson, R. W., Dantzer, R., & Kelley, K. W. (2008) · Cellular Immunology

Growth Hormone and Insulin-like Growth FactorsCytokine Signaling Pathways and Interactions

Cited by 238

Protein hormones and immunity

Kelley, K. W., Weigent, D. A., & Kooijman, R. (2007) · Brain, Behavior, and Immunity

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 217

Cancer and stress: NextGen strategies

Cui, B., Peng, F., Lu, J., He, B., Su, Q., Luo, H., Deng, Z., Jiang, T., Su, K., Huang, Y., et al. (2021) · Brain, Behavior, and Immunity

Cancer, Stress, Anesthesia, and Immune ResponseStress Responses and Cortisol

Cited by 152

The pituitary gland is required for protection against lethal effects of Salmonella typhimurium

Edwards, C. K., Yunger, L. M., Lorence, R. M., Dantzer, R., & Kelley, K. W. (1991) · Proceedings of the National Academy of Sciences

Growth Hormone and Insulin-like Growth FactorsImmune Response and Inflammation

Cited by 127

Stress downregulates lipopolysaccharide-induced expression of proinflammatory cytokines in the spleen, pituitary, and brain of mice

Goujon, E., Parnet, P., Laye, S., Combe, C., Kelley, K. W., & Dantzer, R. (1995) · Brain Behavior and Immunity

Stress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

Cited by 106

IL-1β-Mediated Innate Immunity Is Amplified in the db/db Mouse Model of Type 2 Diabetes

O’Connor, J. C., Satpathy, A., Hartman, M. E., Horvath, E. M., Kelley, K. W., Dantzer, R., Johnson, R. W., & Freund, G. G. (2005) · The Journal of Immunology

Adipokines, Inflammation, and Metabolic DiseasesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 86

Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice

Lawson, M. A., McCusker, R. H., & Kelley, K. W. (2013) · Journal of Neuroinflammation

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 80

Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin

Kelley, K. W., O’Connor, J. C., Lawson, M. A., Dantzer, R., Rodriguez-Zas, S. L., & McCusker, R. H. (2013) · Brain, Behavior, and Immunity

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 49

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts

Strle, K., McCusker, R. H., Tran, L., King, A., Johnson, R. W., Freund, G. G., Dantzer, R., & Kelley, K. W. (2007) · Journal of Neuroimmunology

Muscle Physiology and DisordersCytokine Signaling Pathways and Interactions

Cited by 43