The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
OPTIMIZATION ALIGNMENT: THE END OF MULTIPLE SEQUENCE ALIGNMENT IN PHYLOGENETICS?
Abstract
Abstract—A method is described to assess directly the number of DNA sequence transformations, evolutionary events, required by a phylogenetic topology without the use of multiple sequence alignment. This is accomplished through a generalization of existing character optimization procedures to include insertion and deletion events (indels) in addition to base substitutions. The crux of the model is the treatment of indels as processes as opposed to the patterns implied by multiple sequence alignment. The results of this procedure are directly compatible with parsimony‐based tree lengths. In addition to the simplicity of the method, it appears to generate more efficient (simpler) explanations of sequence variation than does multiple alignment.
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Citations
Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cited by
FROST, D. R., GRANT, T., FAIVOVICH, J., BAIN, R. H., HAAS, A., HADDAD, C. F. B., DE SÁ, R. O., CHANNING, A., WILKINSON, M., DONNELLAN, S. C., et al. (2006) · Bulletin of the American Museum of Natural History · doi:10.1206/0003-0090(2006)297[0001:tatol]2.0.co;2 · Cited by 1,922
Self-citationGRANT, T., FROST, D. R., CALDWELL, J. P., GAGLIARDO, R., HADDAD, C. F. B., KOK, P. J. R., MEANS, D. B., NOONAN, B. P., SCHARGEL, W. E., & WHEELER, W. C. (2006) · Bulletin of the American Museum of Natural History · doi:10.1206/0003-0090(2006)299[1:psodfa]2.0.co;2 · Cited by 578
Self-citationThe Phylogeny of the Extant Hexapod Orders
Wheeler, W. (2001) · Cladistics · doi:10.1006/clad.2000.0147 · Cited by 503
Self-citationMolecular phylogenetics of Elateriformia (Coleoptera): evolution of bioluminescence and neoteny
Bocakova, M., Bocak, L., Hunt, T., Teraväinen, M., & Vogler, A. P. (2007) · Cladistics · doi:10.1111/j.1096-0031.2007.00164.x · Cited by 145
Bocak, L., Bocakova, M., Hunt, T., & Vogler, A. P. (2008) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2008.0476 · Cited by 103
Metadata
- Authors
- Wheeler, W.
- Venue
- Cladistics
- Publisher
- Wiley
- Published
- 1996-03
- Volume
- 12
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0748-3007 (ISSN-L)
- OpenAlex
- W2152327166
- Cited by
- 635
- References
- 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wheeler, W. (1996). OPTIMIZATION ALIGNMENT: THE END OF MULTIPLE SEQUENCE ALIGNMENT IN PHYLOGENETICS? Cladistics. https://doi.org/10.1006/clad.1996.0001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
