The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Early Postnatal Lethality inHoxa-5Mutant Mice Is Attributable to Respiratory Tract Defects
Open accessAbstract
To uncover roles for the Hoxa-5 gene during embryogenesis, we have focused on identifying structural and functional defects in organ systems underlying the perinatal lethality in Hoxa-5 homozygous mutants. Analysis of the mutant phenotype shows that Hoxa-5 is essential for normal organogenesis and function of the respiratory tract. In homozygous newborn mutants, improper tracheal and lung morphogenesis can lead to tracheal occlusion, and to respiratory distress associated with a marked decrease in the production of surfactant proteins. Collectively, these defects likely underlie the pronounced mortality of homozygous mutant pups. Furthermore, the loss of Hoxa-5 function results in altered TTF-1, HNF-3 beta, and N-myc gene expression in the pulmonary epithelium. Since expression of Hoxa-5 is confined to the mesenchymal component of the developing trachea and lung, the effects observed in epithelial cells may result from a disruption of normal epithelial-mesenchymal interactions.
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Citations
Cites
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
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“AID DB 8746 / 6x31$$$303 12-15-97 04:35:04 dbas in endoderm derivatives during embryogenesis (Sasaki and Hogan, 1993; Monaghan et al., 1993; Ang et al., 1993).”
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Cited by
The molecular basis of lung morphogenesis
Warburton, D., Schwarz, M., Tefft, D., Flores-Delgado, G., Anderson, K. D., & Cardoso, W. V. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00325-1 · Cited by 729
Regulation of early lung morphogenesis: questions, facts and controversies
Cardoso, W. V., & Lü, J. (2006) · Development · doi:10.1242/dev.02310 · Cited by 585
Transcriptional Control of Lung Morphogenesis
Maeda, Y., Davé, V., & Whitsett, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00028.2006 · Cited by 473
Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2
Gao, N., White, P., & Kaestner, K. H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.010 · Cited by 381
Multiple roles for Sox2 in the developing and adult mouse trachea
Que, J., Luo, X., Schwartz, R. J., & Hogan, B. L. M. (2009) · Development · doi:10.1242/dev.034629 · Cited by 321
Metadata
- Authors
- Aubin, J., Lemieux, M., Tremblay, M., Bérard, J., & Jeannotte, L.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 192
- Issue
- 2
- Pages
- 432-445
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2133201173
- Cited by
- 185
- References
- 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aubin, J., Lemieux, M., Tremblay, M., Bérard, J., & Jeannotte, L. (1997). Early Postnatal Lethality inHoxa-5Mutant Mice Is Attributable to Respiratory Tract Defects. Developmental Biology. https://doi.org/10.1006/dbio.1997.8746
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