The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon
Open accessAbstract
Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem cells emerge later in development in a temporally and spatially specific manner. By separately blocking EGF and FGF2 signaling, we also show that EGF alone and FGF2 alone can independently elicit neural stem cell proliferation and at relatively high cell densities separate cell nonautonomous effects can substantially enhance the mitogen-induced proliferation. At lower cell densities, neural stem cell proliferation is additive in the presence of EGF and FGF2 combined, revealing two different stem cell populations. However, both FGF-responsive and EGF-responsive neural stem cells retain their self-renewal and multilineage potential, regardless of growth factor conditions. These results support a model in which separate, lineage-related EGF- and FGF-responsive neural stem cells are present in the embryonic telencephalic germinal zone.
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Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Self-citationA Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase
Fry, D. W., Kraker, A. J., McMichael, A., Ambroso, L. A., Nelson, J. M., Leopold, W. R., Connors, R. W., & Bridges, A. J. (1994) · Science · doi:10.1126/science.8066447 · Cited by 806
Arsenijevic, Y., & Weiss, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02118.1998 · Cited by 243 · cited 1×
“For example, BDNF (Ahmed et al., 1995) and IGF-1 ( Arsenijevic and Weiss, 1998 ) have been shown to enhance the differentiation of neurons from EGF-derived neurospheres, while bone morphogenetic proteins (BMPs) (Gross et al., 1996) promote astrocyte differentiation from EGF-derived neurospheres.”
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Cited by
Ignatova, T. N., Kukekov, V. G., Laywell, E. D., Suslov, O. N., Vrionis, F. D., & Steindler, D. A. (2002) · Glia · doi:10.1002/glia.10094 · Cited by 992
Progesterone receptors: form and function in brain
Brinton, R. D., Thompson, R. F., Foy, M. R., Baudry, M., Wang, J., Finch, C. E., Morgan, T. E., Pike, C. J., Mack, W. J., Stanczyk, F. Z., et al. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.02.001 · Cited by 675
The integrated landscape of driver genomic alterations in glioblastoma
Frattini, V., Trifonov, V., Chan, J. M., Castano, A., Lia, M., Abate, F., Keir, S. T., Ji, A. X., Zoppoli, P., Niola, F., et al. (2013) · Nature Genetics · doi:10.1038/ng.2734 · Cited by 524
Kippin, T. E., Martens, D. J., & van der Kooy, D. (2005) · Genes & Development · doi:10.1101/gad.1272305 · Cited by 442
Self-citationLichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428
Metadata
- Authors
- Tropepe, V., Sibilia, M., Ciruna, B. G., Rossant, J., Wagner, E. F., & van der Kooy, D.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 208
- Issue
- 1
- Pages
- 166-188
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2166261688
- Cited by
- 815
- References
- 4
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tropepe, V., Sibilia, M., Ciruna, B. G., Rossant, J., Wagner, E. F., & van der Kooy, D. (1999). Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon. Developmental Biology. https://doi.org/10.1006/dbio.1998.9192
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
