The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Analysis of Loss of Adhesive Function in Sperm Lacking Cyritestin or Fertilin β
Open accessAbstract
We produced mice lacking the sperm surface protein cyritestin (ADAM 3) and found mutant males are infertile. Similar to fertilin beta (ADAM 2) null sperm (C. Cho et al., 1998, Science 281, 1857-1859), cyritestin null sperm are drastically deficient in adhesion to the egg zona pellucida (0.3% of wild type) and to the egg plasma membrane (9% of wild type). Thus sperm from male mice with a gene deletion of either ADAM have a loss of adhesive function in at least two steps of fertilization. We found deletion of either ADAM gene resulted in the loss of multiple gene products. This loss of multiple gene products (sperm membrane proteins) appears to result from a novel, developmental mechanism during sperm differentiation. Because the altered sperm protein expression must be responsible for the fertilization defects, our data suggest new models for the molecular basis of the affected steps in fertilization.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization
Zhu, G.-Z., Lin, Y., Myles, D. G., & Primakoff, P. (1999) · Gene · doi:10.1016/s0378-1119(99)00208-5 · Cited by 45
Self-citation
Cited by
EDWARDS, D., HANDSLEY, M., & PENNINGTON, C. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.001 · Cited by 1,161
Genetic dissection of mammalian fertility pathways
Matzuk, M. M., & Lamb, D. J. (2002) · Nature Cell Biology · doi:10.1038/ncb-nm-fertilitys41 · Cited by 579
Egg Activation at Fertilization: Where It All Begins
Runft, L. L., Jaffe, L. A., & Mehlmann, L. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0600 · Cited by 364
Mouse models of male infertility
Cooke, H. J., & Saunders, P. T. K. (2002) · Nature Reviews Genetics · doi:10.1038/nrg911 · Cited by 301
Chen, E. H., Grote, E., Mohler, W., & Vignery, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.033 · Cited by 263
Metadata
- Authors
- Nishimura, H., Cho, C., Branciforte, D. R., Myles, D. G., & Primakoff, P.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 233
- Issue
- 1
- Pages
- 204-213
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1998401946
- Cited by
- 255
- References
- 2
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nishimura, H., Cho, C., Branciforte, D. R., Myles, D. G., & Primakoff, P. (2001). Analysis of Loss of Adhesive Function in Sperm Lacking Cyritestin or Fertilin β. Developmental Biology. https://doi.org/10.1006/dbio.2001.0166
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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