A Reciprocal Relationship between Cutaneous Nerves and Repairing Skin Wounds in the Developing Chick Embryo
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Various studies have suggested that the rate of adult skin healing may be in some way dependent on signals emanating from cutaneous nerves. Further, it appears that adult wounds become hyperinnervated by sensory nerves during the process of healing. In order to investigate this reciprocal relationship further, we have used a simple embryonic model to look at the effect of wounds on nerves, and conversely, the effect of nerves on wounds. We find that wounds made to the dorsum of the chick wing bud, at a stage prior to normal innervation (at E4), or soon after the normal establishment of cutaneous innervation (at E7), subtly alter the pattern of branching by perturbing developmental guidance cues, but do not cause hyperinnervation, whereas wounding at E14 does cause hyperinnervation. By creating chicks with nerveless wings, we show that from E7, wound healing in the absence of nerves is significantly impaired. These observations suggest that, from the earliest stages of skin innervation, the presence of nerves is beneficial to the healing process, but that, in contrast to neonatal and adult tissues, wound healing in the embryo and early foetus does not trigger hyperinnervation.
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Chick embryo studies suggest a reciprocal positive association between nerves and wound repair, and clinical anecdotes hint that poor innervation makes for poor healing.
“Little is known about the role of nerves during skin healing, although studies in the chick embryo suggest a reciprocal positive association between nerves and wound repair (Fig. 4) (132), and several clinical anecdotes hint that poor innervation makes for poor healing.”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [132]
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- Authors
- Harsum, S., Clarke, J. D. W., & Martin, P.
- Affiliations
- University College London (GB)
- Corresponding author
- Martin, Paul
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 238
- Issue
- 1
- Pages
- 27-39
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2088899726
- Cited by
- 65
- References
- 56
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- cutaneous nerves, wound healing, skin development, chick embryo, hyperinnervation, nerve branching, wing bud, sensory innervation, embryonic wound healing
- MeSH terms
- Animals, Chick Embryo, Inflammation, Microscopy, Electron, Scanning, Neural Crest, Neurons, Skin, Time Factors, Ultraviolet Rays, Wound Healing
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