Cited by 796Stress Responses and CortisolRegulation of Appetite and ObesityAdrenal Hormones and Disorders

The DOI matches its Crossref record.

Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow

Dallman, Mary F., Strack, Alison M., Akana, Susan F., Bradbury, Margaret J., Hanson, Edward S., Scribner, Karen A., Smith, Michael·1993·Frontiers in Neuroendocrinology

DOI 10.1006/frne.1993.1010

Open this paper in CoChat — free account

Abstract

The hypothesis proposed in this review is that normal diurnal rhythms in the hypothalamic-pituitary-adrenal (HPA) axis are highly regulated by activity in medial hypothalamic nuclei to effect an interaction between corticosteroids and insulin such that optimal metabolism results in response to changes in the fed or fasted state of the animal. There are marked diurnal rhythms in function of the HPA axis under both basal and stress conditions. The HPA axis controls corticosteroid output from the adrenal and, in turn, forward elements of this axis are inhibited by feedback from circulating plasma corticosteroid levels. Basal activity in the HPA axis of mammals fed ad lib peaks about 2 h before the peak of the diurnal feeding rhythm, and is controlled by input from the suprachiasmatic nuclei. The rhythm in stress responsiveness is lowest at the time of the basal peak and highest at the time of the basal trough in the HPA axis activity. There are also diurnal rhythms in corticosteroid feedback sensitivity of basal and stress-induced ACTH secretion which peak at the time of the basal trough. These rhythms are all overridden when feeding, and thus insulin secretion, is disrupted. Corticosteroids interact with insulin on food intake and body composition, and corticosteroids also increase insulin secretion. Corticosteroids stimulate feeding at low doses but inhibit it at high doses; however, it is the high levels of insulin, induced by high levels of corticosteroids, that may inhibit feeding. The effects of corticosteroids on liver, fat, and muscle cell metabolism, with emphasis on their interactions with insulin, are briefly reviewed. Corticosteroids both synergize with and antagonize the effects of insulin. The effects of stress hormones, and their interactions with insulin on lipid and protein metabolism, followed by some of the metabolic effects of injury stress, with or without nutritional support, are evaluated. In the presence of elevated insulin stimulated by glucocorticoids and nutrition, stress causes less severe catabolic effects. In the central nervous system, regulation of function in the HPA axis is clearly affected by the activity of medial hypothalamic nuclei that also alter feeding, metabolism, and obesity in rats. Lesions of the arcuate (ARC) and ventromedial (VMN) paraventricular (PVN) nuclei result in obesity and hyperactivity in the HPA axis. Moreover, adrenalectomy inhibits or prevents development of the lesion-induced obesity. There are interactions among these nuclei; one mode of communication is via inputs of neuropeptide Y (NPY) cells in the ARC to the VMN, dorsomedial nuclei, and PVN.(ABSTRACT TRUNCATED AT 400 WORDS)

Integrity signals

Registry

Crossref · 10.1006/frne.1993.1010

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 501–600 of 796

Large‐scale spatial variation in feather corticosterone in invasive house sparrows ( P asser domesticus) in M exico is related to climate
Treen, G. D., Hobson, K. A., Marchant, T. A., et al. (2015) · Ecology and Evolution · doi:10.1002/ece3.1638 · Cited by 18
“GCs are involved in energy regulation, especially processes that provide energy for routine daily tasks such as glucose synthesis and fat breakdown (Dallman et al. 1993; Toates 1995).”
Chapter 11 Glucocorticoid‐Regulated Crosstalk Between Arachidonic Acid and Endocannabinoid Biochemical Pathways Coordinates Cognitive‐, Neuroimmune‐, and Energy Homeostasis‐Related Adaptations to Stress
Malcher‐Lopes, R., & Buzzi, M. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(09)81011-x · Cited by 19
Heterosynaptic modulation in the paraventricular nucleus of the hypothalamus
Sunstrum, J. K., & Inoue, W. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.004 · Cited by 19
Energy Balance, Ingestive Behavior, and Reproductive Success
Schneider, J. E., & Watts, A. G. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50009-3 · Cited by 18
Disentangling the Effects of Environment and Life‐History Stage on Corticosterone Modulation in Costa Rican Rufous‐Collared Sparrows, Zonotrichia capensis costaricensis
Busch, D. S., Addis, E. A., Clark, A. D., & Wingfield, J. C. (2009) · Physiological and Biochemical Zoology · doi:10.1086/648488 · Cited by 17
Constrained Corticotropin-Releasing Factor (CRF) Agonists and Antagonists withi−(i+3) Glu-Xaa- d Xbb-Lys Bridges
Koerber, S. C., Gulyás, J., Lahrichi, S. L., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980350k · Cited by 18
Aetiopathogenesis and Pathophysiology of Bulimia Nervosa
Brambilla, F. (2001) · CNS Drugs · doi:10.2165/00023210-200115020-00004 · Cited by 18
Photoperiodically-induced changes in hypothalamic–pituitary–adrenal axis sensitivity in captive house sparrows (Passer domesticus)
Romero, L. M., & Rich, E. L. (2007) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2007.02.004 · Cited by 18
Streptozotocin-induced diabetes produces a naltrexone-reversible lowering of self-stimulation threshold
Carr, K. D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91973-9 · Cited by 18
Corticosterone Secretion, Energetic Condition, and a Test of the Migration Modulation Hypothesis in the Hermit Thrush (Catharus Guttatus), A Short-Distance Migrant
Long, J., & Holberton, R. L. (2004) · The Auk · doi:10.1093/auk/121.4.1094 · Cited by 18
High fiber diet reduces stereotypic behavior of gilts but does not affect offspring performance
Bernardino, T., Tatemoto, P., de Moraes, J. E., et al. (2021) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2021.105433 · Cited by 17
Leucine kinetics in reference to the effect of the feeding mode as three discrete meals
Raguso, C. A., El-Khoury, A. E., & Young, V. R. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90147-6 · Cited by 17
Nycthemeral differences in response to restraint stress in CD-1 and C57BL/6 mice
Hotchkiss, A. K., Pyter, L. M., Neigh, G. N., & Nelson, R. J. (2003) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.09.010 · Cited by 17
“Reduced body mass in food-deprived control animals likely results from compressed feeding time during their active (dark) period [2,33].”
Caloric Restriction as a Mechanism Mediating Resistance to Environmental Disease
Frame, L. T., Hart, R. W., & Leakey, J. E. A. (1998) · Environmental Health Perspectives · doi:10.2307/3433933 · Cited by 17
Activity of body energy regulatory pathways in inflammation-induced anorexia
Lennie, T. A., Wortman, M. D., & Seeley, R. J. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00480-2 · Cited by 17
Developing a Stopover-CORT hypothesis: Corticosterone predicts body composition and refueling rate in Gray Catbirds during migratory stopover
DeSimone, J. G., Ramirez, M. G., Elowe, C. R., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104776 · Cited by 16
Association Between Clinical Severity of Childhood Asthma and Serum Leptin Levels
Tanju, İ. A., Çekmez, F., Aydınöz, S., et al. (2010) · The Indian Journal of Pediatrics · doi:10.1007/s12098-010-0281-0 · Cited by 16
“Moreover, one other reason for increased leptin secretion may be that leptin is secreted as a counter-regulatory answer to glucocorticoid induced hyperphagia and weight gain [ 16 ].”
Background
Basal and hormone-stimulated metabolism in lambs varies with breed and diet quality
Ponnampalam, E. N., Warner, R. D., & Dunshea, F. R. (2011) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2011.10.001 · Cited by 16
“The HPA axis can influence feeding behavior, pancreatic hormone secretion, energy expenditure, and protein-lipid balance [6], whereas the sympathetic nervous system can influence the use of energy stores as glycogen or lipid [7].”
Background
Metabolismo en el ayuno
Albero, R., Sanz, A., & Playán, J. (2004) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(04)74599-4 · Cited by 17
Sex-Specific Heterosis in Line Crosses of Mice Selectively Bred for High Locomotor Activity
Hannon, R. M., Meek, T. H., Acosta, W., et al. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9432-3 · Cited by 16
“2008), organisms with elevated corticosterone levels could have higher available energy and/or motivation to perform during exercise such as wheel running (Dallman et al. 1993; Pecoraro et al. 2006).”
Background
Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7
Mármol, P., Krapacher, F. A., & Ibáñez, C. F. (2020) · eLife · doi:10.7554/elife.54721 · Cited by 18
“Fasting is a well known stimulus of glucocorticoid release (Dallman et al., 1993), and through the GR, glucocorticoids can stimulate transcription of the Klf15 gene in liver and muscle cells (Gray et al.”
Background
Stress and Reproduction in Birds
Breuner, C. W. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374932-1.00043-3 · Cited by 16
Reinterpretation of Basal Glucocorticoid Feedback: Implications to Behavioral and Metabolic Disease
Laugero, K. D. (2004) · Vitamins and hormones · doi:10.1016/s0083-6729(04)69001-7 · Cited by 16
Intracerebroventricular administration of the β3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamus
Castillo-Meléndez, M., McKinley, M. J., & Summers, R. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01359-8 · Cited by 16
Minimal-Size, Constrained Corticotropin-Releasing Factor Agonists withi−(i+3) Glu−Lys and Lys−Glu Bridges
Rivier, J., Lahrichi, S. L., Gulyás, J., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980164e · Cited by 16
Serum leptin in children with asthma treated with inhaled budesonide
Heuck, C., & Wolthers, O. D. (1999) · Respiratory Medicine · doi:10.1016/s0954-6111(99)90023-9 · Cited by 16
Effects of Academic Stress on Students’ Academic Achievements and Its Implications for Their Future Lives
Gobena, G. A. (2024) · Anatolian Journal of Education · doi:10.29333/aje.2024.918a · Cited by 15
“Similarly, academic stress has been shown to be associated with increased appetite (Dallman et al., 2022) and higher body weight (Stephens et al., 2017).”
Background
Glucocorticoids enhance and suppress heart rate and behaviour in time dependent manner in greylag geese (Anser anser)
Kralj‐Fišer, S., Scheiber, I. B. R., Kotrschal, K. M., Weiß, B., & Wascher, C. A. F. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.04.005 · Cited by 15
“Also, low glucocorticoids stimulate food intake, whereas high increase inhibits food intake [9].”
Background
Reproductive state and water deprivation increase plasma corticosterone in a capital breeder
Brusch, G. A., DeNardo, D. F., & Lourdais, O. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113375 · Cited by 15
Interaction Between Circadian Rhythms, Energy Metabolism, and Cognitive Function
Ruiz‐Gayo, M., & Olmo, N. D. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200310145006 · Cited by 17
Sensitivity, reliability and the effects of diurnal variation on a test battery of field usable upper limb fatigue measures
Yung, M., & Wells, R. P. (2016) · Ergonomics · doi:10.1080/00140139.2016.1243734 · Cited by 15
Fasting or fear: disentangling the roles of predation risk and food deprivation in the nitrogen metabolism of consumers.
Dalton, C. M., Tracy, K. E., Hairston, N., & Flecker, A. (2018) · Ecology · doi:10.1002/ecy.2132 · Cited by 14
“Higher glucocorticoid expression is correlated with stimulated appetite and feeding behavior (Dallman et al. 1993, Kitaysky et al. 2003), preference for higher energy content foods (Hawlena and Schmitz 2010a), and deposition of short term energy stores in liver glycogen (Dallman et al. 1993).”
Background
Prenatal immobilization stress and postnatal maternal separation cause differential neuroendocrine responses to fasting stress in adult male rats
Roque, A., Ruiz‐González, R., Pineda, E., Torner, L., & Lajud, N. (2019) · Developmental Psychobiology · doi:10.1002/dev.21947 · Cited by 14
Glucocorticoid levels are linked to lifetime reproductive success and survival of adult barn owls
Béziers, P., Korner‐Nievergelt, F., Jenni, L., et al. (2020) · Journal of Evolutionary Biology · doi:10.1111/jeb.13707 · Cited by 15
The role of growth hormone and glucocorticoid in glucose handling in vivo
Johansen, T., Deckert, M., Mandrup-Poulsen, T. R., & Malmlöf, K. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620087 · Cited by 15
“Growth hormone (GH) and glucocorticoids are potent regulators of metabolism (Davidson 1987, Dallman et al. 1993, Yarasheski 1994, Haymond & Mauras 1996).”
Background
Influence of temperament on bovine hypothalamic-pituitary-adrenal function
Curley, K. O. (2006) · OakTrust (Texas A&M University Libraries) · Cited by 15
Ingesting alcohol prior to food can alter the activity of the hypothalamic-pituitary-adrenal axis
Kokavec, A., Lindner, A. J., Ryan, J. E., & Crowe, S. F. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.05.004 · Cited by 14
Variation in faecal corticosterone metabolites in an Arctic seabird, the Little Auk (Alle alle) during the nesting period
Kidawa, D., Wojczulanis‐Jakubas, K., Jakubas, D., Palme, R., Stempniewicz, L., Barcikowski, M., & Keslinka-Nawrot, L. (2014) · Polar Biology · doi:10.1007/s00300-014-1464-3 · Cited by 14
“Moreover, glucocorticoids might promote the availability of lipid energy from adipose tissue stores (Dallman et al. 1993).”
Background
Functional variability in corticosteroid receptors is a major component of strain differences in fat deposition and metabolic consequences of enriched diets in rat
Marissal‐Arvy, N., Langlois, A., Tridon, C., & Mormède, P. (2010) · Metabolism · doi:10.1016/j.metabol.2010.07.005 · Cited by 14
“The weight loss induced by DEX was attenuated by lard ingestion in F344 rats, suggesting that preference for high-fat diets could be exacerbated by GR activation to limit the weight loss and to provide the energetic fuel to cope with a stressful situation [41].”
Background
Sugar alters the level of serum insulin and plasma glucose and the serum cortisol:DHEAS ratio in female migraine sufferers
Kokavec, A., & Crebbin, S. J. (2010) · Appetite · doi:10.1016/j.appet.2010.09.007 · Cited by 14
Effect on Plasma Insulin and Plasma Glucose of Consuming White Wine Alone After a Meal
Kokavec, A., & Crowe, S. F. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000093600.86673.9c · Cited by 14
Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance
Savontaus, E., Pesonen, U., Rouru, J., Huupponen, R., & Koulu, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00120-4 · Cited by 14
Corticotropin Releasing Factor (CRF) Agonists with Reduced Amide Bonds and Ser7Substitutions
Cervini, L. A., Theobald, P. G., CORRIGAN, A. Z., et al. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980607e · Cited by 14
Glucocorticoid Action
Chrousos, G. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00099-8 · Cited by 14
Anatomy of Motivation
Watts, A. G., & Swanson, L. W. (2002) · Wiley eBooks · doi:10.1002/0471214426.pas0314 · Cited by 17
Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice
Sanghez, V., Çubuk, C., Sebastián-León, P., Carobbio, S., Dopazo, J., Vidal‐Puig, A., & Bartolomucci, A. (2016) · Stress · doi:10.3109/10253890.2016.1151491 · Cited by 14
“Moreover, elevated glucocorticoid concentrations increase hepatic gluconeogenesis, increase plasma glucose concentration, and impair the anabolic action of insulin (Dallman, 2010; Dallman et al., 1993; Sapolsky et al., 2000).”
Interannual measures of nutritional stress during a marine heatwave (the Blob) differ between two North Pacific seabird species
Tate, H. M., Studholme, K. R., Domalik, A. D., Drever, M. C., Romero, L. M., Gormally, B. M. G., Hobson, K. A., Hipfner, J. M., & Crossin, G. T. (2021) · Conservation Physiology · doi:10.1093/conphys/coab090 · Cited by 12
“Corticosterone is the principal hormonal mediator of allostasis or physiological stress in wild birds (Dallman et al., 1993), but when elevated can also play an adaptive role in daily metabolic regulation and energy balance, thus allowing individuals to respond to environmental stochasticity…”
Background
The Effect of a Combined Fast and Chronic Stress on Body Mass, Blood Metabolites, Corticosterone, and Behavior in House Sparrows (Passer domesticus).
Beattie, U. K., Ysrael, M. C., Lok, S. E., et al. (2022) · PubMed · Cited by 13
Relationship between plasma and tissue corticosterone in laying hens (Gallus gallus domesticus): implications for stress physiology and animal welfare
Ralph, C. R., Hemsworth, P. H., Leury, B. J., & Tilbrook, A. J. (2014) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2014.09.002 · Cited by 14
Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration
Garland, M. A., Sengupta, S., Mathew, L. K., Truong, L., de Jong, E., Piersma, A. H., Du, J. K. L., & Tanguay, R. L. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.05.013 · Cited by 13
Glucocorticoid and triiodothyronine concentrations do not correlate with behavior in vicuñas (Vicugna vicugna)
Pritchard, C. E., Palme, R., & Langkilde, T. L. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113299 · Cited by 10
Intermittent Fasting and Brain Health: Efficacy and Potential Mechanisms of Action
Francis, N. (2020) · OBM Geriatrics · doi:10.21926/obm.geriatr.2002121 · Cited by 14
Effects of acute low temperature stress on the endocrine reactions of the Qinghai toad-headed lizard
Li, C., Gu, Y., Tang, S., et al. (2011) · Current Zoology · doi:10.1093/czoolo/57.6.775 · Cited by 13
“Adrenal glucocorticoid is known to mobilize substances from peripheral energy deposits and insures a plentiful supply of glucose under conditions of stress (Dallman et al., 1993; 2007).”
Lipoprotein lipase and glucose-6-phosphate dehydrogenase activities in bovine and ovine adipose tissue incubated for 7 days: Effects of insulin and/or dexamethasone
Faulconnier, Y., Guillon, L., & Chilliard, Y. (1996) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)02063-2 · Cited by 13
Glucose and corticosterone changes in developing and adult rats following exposure to (±)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine
Graham, D. L., Herring, N. R., Schaefer, T. L., Vorhees, C. V., & Williams, M. T. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.08.012 · Cited by 13
“Tightly controlled glucose levels are required for homeostasis and are sensitive to perturbations that activate the HPA axis [6,16,37,43].”
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., Turek, F. W., & Cauter, E. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00011-3 · Cited by 14
Genetic linkage mapping of quantitative trait loci for behavioral and neuroendocrine stress response traits in pigs1
Désautés, C., Bidanel, J. P., Milan, D., et al. (2002) · Journal of Animal Science · doi:10.1093/ansci/80.9.2276 · Cited by 13
Muscle and liver protein metabolism in rats fed raw or heat-treated pea seeds
Alonso, R., Grant, G., Frühbeck, G., & Marzo, F. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00186-9 · Cited by 12
The cerebral glucose-fatty acid cycle: Evolutionary roots, regulation, and (patho)physiological importance
Heininger, K. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)51004-7 · Cited by 12
“Mammals go through attenuated cycles of caloric excess and deprivation with every meal followed by fasting and during sleep (Dallman et al., 1993; Dinneen et al., 1993).”
Background
PHYSIOLOGICAL CONDITION IN MAGELLANIC PENGUINS: DOES IT MATTER IF YOU HAVE TO WALK A LONG WAY TO YOUR NEST?
Walker, B., Boersma, P. D., & Wingfield, J. C. (2004) · Ornithological Applications · doi:10.1650/7495 · Cited by 12
“These elevated baseline levels of corticosterone are important for the maintenance of homeostatic energy balance in suboptimal conditions (Dallman et al. 1993).”
Background
The use of nitrous oxide in paediatric anaesthetic practice in the United Kingdom: a questionnaire survey*
Sheraton, T. E., Gildersleve, C. D., & Hall, J. E. (2006) · Anaesthesia · doi:10.1111/j.1365-2044.2006.04857.x · Cited by 13
Testing hypotheses about individual variation in plasma corticosterone in free-living salamanders
Thomas, J. R., Magyan, A. J., Freeman, P. E., & Woodley, S. K. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.149765 · Cited by 12
“HPA/I activity fluctuates with both daily and life-history events like development, reproduction, migration, etc. (Breuner et al., 1999; Dallman et al., 1993; Kalsbeek et al., 2012; Landys et al., 2006; Thurmond et al., 1986).”
Background
Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?
Chadwick, W., Wilson, G. A., van de Venter, M., et al. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.1.0013 · Cited by 12
“Neuropeptide Y increases the secretion of corticotrophin-releasing hormone, adrenocorticotropic hormone and corticosterone and also increases food intake (Dallman et al 1993; Stanley et al 1985).”
Background
Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats
Shen, L., Carey, K., Wang, D. Q. ‐., Woods, S. C., & Liu, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.004 · Cited by 12
“Interestingly, plasma CORT levels in RF rats rose at the onset of feeding and decreased to the basal range by the end of 4 h of feeding, demonstrating a tight relationship of CORTwith the onset of feeding behavior (Dallman et al., 1993).”
Glucocorticoid Action
Munck, A. U., & Náray‐Fejes‐Tóth, A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00097-6 · Cited by 12
Insulin, corticosterone and the autonomic nervous system in animal obesities: a viewpoint
Jeanrenaud, B. (1995) · Diabetologia · doi:10.1007/bf00400592 · Cited by 12
“The importance of the rhythmicity of hormones such as insulin and corticosterone in exerting their physiological role has been emphasised, as has been the pathological influence of the disappearance of this circadian rhythm [16-18].”
Background
Intraventricular Neuropeptide Y Does Not Stimulate Food Intake in the Baboon
Sipols, A. J., Figlewicz, D. P., Seeley, R. J., Chavez, M., Woods, S. C., & Porte, D. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00105-9 · Cited by 11
Aminoglutethimide, a corticosteroid synthesis inhibitor, facilitates brain stimulation reward in food-restricted rats: an investigation of underlying mechanisms
Abrahamsen, G. C., Kandawire, M. J., & Carr, K. D. (1997) · Psychopharmacology · doi:10.1007/s002130050421 · Cited by 12
“For example, transient suppression of corticosterone may have a delayed effect on central protein synthesis (Nichols and Finch 1994) or corticosterone responsive hormones within the hypothalamic-pituitary-adrenal axis (Jacobson et al. 1989; Bray 1993; Dallman et al. 1993 ), such that behavioral consequences manifest a…”
Post-surgical recovery and time-of-day mask potentiated responses of ACTH to repeated moderate hemorrhage in conscious rats
Lilly, M. P., Jones, R. O., Putney, D., et al. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1670205 · Cited by 12
“Eating is an important cue to entrain circadian rhythms and stress may effect food intake and thereby HPA responsiveness (Dallman et al. 1993).”
Background
Baseline corticosterone is associated with parental care in virgin Japanese quail (Coturnix japonica)
de Bruijn, R., Wright-Lichter, J. X., Khoshaba, E. R., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104781 · Cited by 11
CRH mRNA expression in the hypothalamic paraventricular nucleus is inhibited despite the activation of the hypothalamo-pituitary-adrenal axis during starvation
Nishiyama, M., Makino, S., Iwasaki, Y., Tanaka, Y., Pournajafi‐Nazarloo, H., Kaneda, T., Asaba, K., & Hashimoto, K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.065 · Cited by 10
“During starvation, circulating satiety signals, such as glucose, insulin and leptin, are decreased, whereas corticosterone (B) is markedly elevated (Ahima et al., 1996; Dallman et al., 1993; Schwartz et al., 1995).”
Kinetics and Persistence of Cardiovascular and Locomotor Effects of Immobilization Stress and Influence of ACTH Treatment
Sabban, E. L., Schilt, N., Serova, L. I., Masineni, S. N., & Stier, C. T. (2008) · Neuroendocrinology · doi:10.1159/000150099 · Cited by 11
Perceptions of dentists, dentistry undergraduate students, and the lay public about dental sedation
Costa, L. R., Dias, A. D., Pinheiro, L. S., Chaves, M. E. P. D. S., Ferreira, R. D. A. R., de Almeida, R. B., & Lima, A. R. D. A. (2004) · Journal of Applied Oral Science · doi:10.1590/s1678-77572004000300004 · Cited by 11
Insulin Resistance Is Associated With Hypercortisolemia in Polynesian Patients Treated With Antipsychotic Medication
Poa, N. R., & Edgar, P. F. (2007) · Diabetes Care · doi:10.2337/dc06-2057 · Cited by 11
The Ecology of Stress: linking life-history traits with physiological control mechanisms in free-living guanacos
Aguilar, R., Jahn, G. A., Soto-Gamboa, M. R., Novaro, A. J., & Carmanchahi, P. (2016) · PeerJ · doi:10.7717/peerj.2640 · Cited by 11
Consequences of circadian dysregulation on metabolism
Nelson, R. J., & Cissé, Y. M. (2016) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s100363 · Cited by 12
“Although traditionally considered stress hormones, glucocorticoids are primarily mediators of metabolism, generally favoring energy storage and fat deposition.(64) High-fat diet consumption, in addition to weight gain, disrupts locomotor and molecular circadian rhythms in the adipose tissue and the liver.”
Association of plasma stress markers at slaughter with carcass or meat quality in pigs.
Škrlep, M., Prevolnik, M., Šegula, B., et al. (2009) · Slovenian Veterinary Research · Cited by 11
Neurochemical Coding of Adaptive Responses in the Limbic System
Herbert, J., & Schulkin, J. A. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50013-5 · Cited by 11
Corticosterone secretion in response to adult alarm calls in American Kestrels
Dufty, A. M., & Crandall, M. B. (2005) · Journal of Field Ornithology · doi:10.1648/0273-8570-76.4.319 · Cited by 11
“Although corticosterone is associated with the daily regulation of energy supplies (Dallman et al. 1993), its secretion often increases in response to stressful situations, and investigators use baseline corticosterone levels and the adrenocortical response to a stressor (e.g., handling stress) as…”
Background
Exercise and Protein Metabolism
Evans, W. J. (2015) · World review of nutrition and dietetics · doi:10.1159/000422347 · Cited by 10
Non‐invasive measurement of glucocorticoids: The reptile perspective
Carbajal, A., Serres‐Corral, P., Olvera‐Maneu, S., & López‐Béjar, M. (2024) · Journal of Zoology · doi:10.1111/jzo.13157 · Cited by 12
Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice
Jenkins, B. W., Spina, H. A., Nicholson, K., Newman, A. E. M., & Khokhar, J. Y. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06737-z · Cited by 10
“At baseline, daily rhythmicity of CORT functions to regulate energy availability (Dallman et al. 1993) and cognition including learning and memory (Liston et al. 2013; Rimmele et al. 2010).”
Long-Term Measures of Climate Unpredictability Shape the Avian Endocrine Stress Axis
Guindre‐Parker, S., & Rubenstein, D. R. (2021) · The American Naturalist · doi:10.1086/715628 · Cited by 10
Effect of food limitation and reproductive activity on fecal glucocorticoid metabolite levels in banded mongooses
Laver, P. N., Ganswindt, A., Ganswindt, S. B., & Alexander, K. A. (2020) · BMC Ecology · doi:10.1186/s12898-020-00280-z · Cited by 10
Circadian Rhythms in Neuroendocrine Systems
Arble, D. M., Copinschi, G., Vitaterna, M. H., Cauter, E. V., & Turek, F. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10012-5 · Cited by 10
Nitrous Oxide Attenuates Pressor but Augments Norepinephrine Response to Laryngoscopy and Endotracheal Intubation
Yoo, K. Y., Jeong, S. T., Ha, I. H., & Lee, A. J. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000058842.05373.e3 · Cited by 82
Cold temperatures induce priming of the glucose stress response in tree swallows
Ryan, T. A., Taff, C. C., Zimmer, C., et al. (2023) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2023.111419 · Cited by 9
Effects of Gamisoyosan onin vitro fertilization and ovulation of stressed mice by electric shock
Kim, J. Y., Kwak, D. H., Ju, E. J., Kim, S., Lee, D. H., Keum, K. S., Lee, S., Jung, K. Y., Seo, B. B., & Choo, Y. K. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975124 · Cited by 9
Seasonal patterns in behavior and glucocorticoid secretion of a specialist Holarctic tree squirrel (Sciurus aberti)
Zhang, V. Y., & Buck, C. L. (2022) · Journal of Comparative Physiology B · doi:10.1007/s00360-022-01429-6 · Cited by 9
A motivational model based on artificial biological functions for the intelligent decision-making of social robots
Gómez, M. M., Malfáz, M., Castro‐González, Á., & Salichs, M. A. (2023) · Memetic Computing · doi:10.1007/s12293-023-00390-3 · Cited by 9
Factors of Diversity of Domestication-Related Behavior in Farm Animals of Different Species
Lankin, V. S., & Bouissou, M. F. (2001) · Russian Journal of Genetics · doi:10.1023/a:1016751010678 · Cited by 9
“Thus, this negative regulatory dependence of defensive responses on feeding responses, which exists in various animal species and is probably correlated with subordination of these traits (together with the responsiveness of HPAA) to the same hypothalamic mechanism [36, 37], determines their correlated variation and i…”
Background
The prevalence of impaired glucose regulation in psychiatric patients with sleep disorders and its relationship with altered hypothalamopituitary–adrenal and hypothalamopituitary–thyroid axis activity
Li, J., Sun, X., & Yu, Y. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.04.004 · Cited by 9
“Raised cortisol concentrations in the evening are thought to reflect an impairment of the negative-feedback control of the HPA axis and also to be involved in IR and memory impairment [25,26].”
Background
Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences
Kokavec, A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.022 · Cited by 9
“The role of cortisol, a glucocorticoid under the control of the hypothalamic–pituitary–adrenal axis, is to raise the level of glucose by stimulating gluconeogenesis when energy stores are low [10].”
Disturbances of Hormonal Circadian Rhythms in Shift Workers
Boivin, D. B. (2006) · Springer eBooks · doi:10.1007/0-387-23692-9_17 · Cited by 9
Effect of fasting and refeeding on the activities of monoamine oxidase and antioxidant enzymes in rat hypothalamus and brown adipose tissue.
Cvijić, G., Djordjevic, J. D., & Davidović, V. (2000) · PubMed · Cited by 9
Do glucocorticoids indicate stress? Meta-analysis reveals a tight association between glucocorticoids and metabolic ratePreprint
Jimeno, B., & Verhulst, S. (2023) · eLife · doi:10.7554/elife.88205.1 · Cited by 8
An Integrative Analysis of Reproduction and Stress in Free-Living Male Cottonmouths, Agkistrodon Piscivorus
Graham, S. P. (2022) · Digital Archive @ GSU · doi:10.57709/1059201 · Cited by 9
Corticosterone: foraging and fattening puppet master in pre-breeding greylag geese
Hoarau, M., Angelier, F., Touzalin, F., et al. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113666 · Cited by 8
Livetrapping is not biased by the endocrine stress response: a preliminary study in the degu (Octodon degus)
Lapointe, M. A., Bauer, C. M., Ebensperger, L. A., Reed, J. M., & Romero, L. M. (2015) · Journal of Mammalogy · doi:10.1093/jmammal/gyv081 · Cited by 8
“Because GC levels can be affected by many different factors including time of day (Dallman et al. 1993), season (Romero et al. 2008; Ouyang et al. 2011), number of trapping events (Häemäeläeinen et al. 2014), and environmental conditions (Romero et al. 2000), we assessed repeatability among…”
Background
When the ball is in the female’s court: How the scramble-competition mating system of the North American red squirrel has shaped male physiology and testosterone dynamics
Boonstra, R., Dušek, A., Lane, J. E., & Boutin, S. A. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.06.016 · Cited by 8

Authors: Dallman, M. F., Strack, A. M., Akana, S. F., Bradbury, M. J., Hanson, E. S., Scribner, K. A., & Smith, M.
Affiliations: University of California, San Francisco (US)
ORCID: Bradbury, Margaret J.
Smith, Michael
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 1993-10
Volume: 14
Issue: 4
Pages: 303-347
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1006/frne.1993.1010
OpenAlex: W1971922927
Cited by: 796
References: 0
Citations by year: 2026: 6 · 2025: 11 · 2024: 12 · 2023: 21 · 2022: 15 · 2021: 20 · 2020: 22 · 2019: 22 · 2018: 13 · 2017: 13 · 2016: 30 · 2015: 26 · 2014: 27 · 2013: 20 · 2012: 33
FWCI: 6.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, insulin, hypothalamic-pituitary-adrenal axis, diurnal cycle, feeding behavior, stress hormones, corticosteroid feedback, ACTH secretion, arcuate nucleus, neuropeptide Y, obesity, energy metabolism, lipid metabolism, protein metabolism, catabolism, adrenalectomy, body composition
MeSH terms: Animals, Circadian Rhythm, Eating, Energy Metabolism, Fasting, Feeding Behavior, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Insulin, Pituitary-Adrenal System, Stress, Physiological, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks