Cited by 296Abdominal vascular conditions and treatmentsBlood properties and coagulationGastrointestinal motility and disorders

Regulation of intestinal blood flow

Matheson, Paul J., Wilson, Mark A., Garrison, R.Neal·2000·Journal of Surgical Research

Abstract

The gastrointestinal system anatomically is positioned to perform two distinct functions: to digest and absorb ingested nutrients and to sustain barrier function to prevent transepithelial migration of bacteria and antigens. Alterations in these basic functions contribute to a variety of clinical scenarios. These primary functions intrinsically require splanchnic blood flow at both the macrovascular and microvascular levels of perfusion. Therefore, a greater understanding of the mechanisms that regulate intestinal vascular perfusion in the normal state and during pathophysiological conditions would be beneficial. The purpose of this review is to summarize the current understanding regarding the regulatory mechanisms of intestinal blood flow in fasted and fed conditions and during pathological stress.

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Registry

Crossref · 10.1006/jsre.2000.5862

Cites

143 of 143 references verified0 citation errors · 0 not checkable

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Authors
Matheson, P. J., Wilson, M. A., & Garrison, R. N.
Affiliations
University of Louisville (US)
Venue
Journal of Surgical Research
Publisher
Elsevier BV
Published
2000-09
Volume
93
Issue
1
Pages
182-196
ISSN
0022-4804 (ISSN-L)
OpenAlex
W2120366658
Cited by
296
References
148
Citations by year
2026: 10 · 2025: 8 · 2024: 12 · 2023: 21 · 2022: 14 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 18
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Surgical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
intestinal blood flow, intestinal perfusion, splanchnic circulation, microvascular blood flow, gastrointestinal barrier function, nutrient absorption, fasting and fed state, pathological stress, gut ischemia
MeSH terms
Animals, Gastrointestinal Hormones, Humans, Hyperemia, Hypertension, Portal, Intestines, Nitric Oxide, Reflex, Regional Blood Flow, Shock, Hemorrhagic, Shock, Septic, Postprandial Period

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