The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Exogenously Regulated Stem Cell-Mediated Gene Therapy for Bone Regeneration
Open accessAbstract
Regulated expression of transgene production and function is of great importance for gene therapy. Such regulation can potentially be used to monitor and control complex biological processes. We report here a regulated stem cell-based system for controlling bone regeneration, utilizing genetically engineered mesenchymal stem cells (MSCs) harboring a tetracycline-regulated expression vector encoding the osteogenic growth factor human BMP-2. We show that doxycycline (a tetracycline analogue) is able to control hBMP-2 expression and thus control MSC osteogenic differentiation both in vitro and in vivo. Following in vivo transplantation of genetically engineered MSCs, doxycycline administration controlled both bone formation and bone regeneration. Moreover, our findings showed increased angiogenesis accompanied by bone formation whenever genetically engineered MSCs were induced to express hBMP-2 in vivo. Thus, our results demonstrate that regulated gene expression in mesenchymal stem cells can be used as a means to control bone healing.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943
Tissue-engineered bone regeneration
Petite, H., Viateau, V., Bensaïd, W., Meunier, A., de Pollak, C., Bourguignon, M., Oudina, K., Sedel, L., & Guillemin, G. (2000) · Nature Biotechnology · doi:10.1038/79449 · Cited by 1,475
Cited by
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
Djouad, F., Plence, P., Bony, C., Tropel, P., Apparailly, F., Sany, J., Noël, D., & Jorgensen, C. (2003) · Blood · doi:10.1182/blood-2003-04-1193 · Cited by 1,166
Peng, H., Wright, V., Usas, A., Gearhart, B., Shen, H.-C., Cummins, J., & Huard, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15153 · Cited by 733
Toward delivery of multiple growth factors in tissue engineering
Chen, F.-M., Zhang, M., & Wu, Z.-F. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.053 · Cited by 649
Stem cell differentiation requires a paracrine pathway in the heart
Behfar, A., Zingman, L. V., Hodgson, D. M., Rauzier, J., Kane, G. C., Terzic, A., & Pucéat, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0072com · Cited by 477
Xiong, Y., Mi, B.-B., Lin, Z., Hu, Y.-Q., Yu, L., Zha, K.-K., Panayi, A. C., Yu, T., Chen, L., Liu, Z.-P., et al. (2022) · Military Medical Research · doi:10.1186/s40779-022-00426-8 · Cited by 291
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Metadata
- Authors
- Moutsatsos, I. K., Turgeman, G., Zhou, S., Kurkalli, B. G., Pelled, G., Tzur, L., Kelley, P., Stumm, N., Mi, S., Müller, R., Zilberman, Y., & Gazit, D.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 3
- Issue
- 4
- Pages
- 449-461
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2115560928
- Cited by
- 257
- References
- 2
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moutsatsos, I. K., Turgeman, G., Zhou, S., Kurkalli, B. G., Pelled, G., Tzur, L., Kelley, P., Stumm, N., Mi, S., Müller, R., Zilberman, Y., & Gazit, D. (2001). Exogenously Regulated Stem Cell-Mediated Gene Therapy for Bone Regeneration. Molecular Therapy. https://doi.org/10.1006/mthe.2001.0291
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