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Nitric Oxide Has a Vasodilatory Role in Cat Optic Nerve Head during Flicker Stimuli
Open accessAbstract
The role of nitric oxide (NO) in the regulation of optic nerve head (ONH) blood flow was investigated from direct electrochemical measurements of NO and simultaneous measurements of ONH blood flow by laser Doppler flowmetry during increased neuronal activity with diffuse luminance flickering light stimuli. For normal physiological conditions, there was a consistent increase in ONH blood flow with each flicker stimulus (n = 10 cats). Simultaneous NO measurements were made in the vitreous humor immediately in front of the ONH (n = 6 cats). During flicker, NO increased by 88 +/- 23 nM (P < 0.05) above basal NO levels. Measurements were repeated after inhibiting NO synthase by intravenous infusion of either NG-nitro-L-arginine (n = 5 cats) or NG-nitro-L-arginine methyl ester (n = 5 cats). After inhibition, NO levels were significantly reduced and both ONH blood flow and NO responses to flicker were significantly attenuated. We conclude that NO plays a key vasodilatory role in the ONH, modulating blood flow during greater neuronal activity with flicker stimuli.
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Cited by
Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C.-O., Buerk, D. G., Huang, P. L., & Jain, R. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041359198 · Cited by 1,020
Self-citationKur, J., Newman, E. A., & Chan-Ling, T. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.04.004 · Cited by 678
Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives
Simó, R., & Hernández, C. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.005 · Cited by 490
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Nitric Oxide Synthase in the Human Glaucomatous Optic Nerve Head
Neufeld, A. H. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150499009 · Cited by 342
Metadata
- Authors
- Buerk, D. G., Riva, C. E., & Cranstoun, S. D.
- Venue
- Microvascular Research
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 52
- Issue
- 1
- Pages
- 13-26
- ISSN
- 0026-2862 (ISSN-L)
- OpenAlex
- W1999629936
- Cited by
- 165
- References
- 0
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Buerk, D. G., Riva, C. E., & Cranstoun, S. D. (1996). Nitric Oxide Has a Vasodilatory Role in Cat Optic Nerve Head during Flicker Stimuli. Microvascular Research. https://doi.org/10.1006/mvre.1996.0040
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