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Cited by 678

The DOI matches its Crossref record; 278 of the 278 references it cites were found in a registry or an index.

Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease

Open access
Kur, Joanna, Newman, Eric A., Chan-Ling, Tailoi·2012·Progress in Retinal and Eye Research
DOI 10.1016/j.preteyeres.2012.04.004
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Abstract

We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the retina and the direct visual accessibility of fundus blood vessels, the eye offers unique opportunities for the non-invasive investigation of mechanisms of blood flow regulation. The ability of the retinal vasculature to regulate its blood flow is contrasted with the far more restricted ability of the choroidal circulation to regulate its blood flow by virtue of the absence of glial cells, the markedly reduced pericyte ensheathment of the choroidal vasculature, and the lack of intermediate filaments in choroidal pericytes. We review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and Alzheimer's disease. We close by discussing issues that remain to be explored.

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Metadata

Authors
Kur, J., Newman, E. A., & Chan-Ling, T.
Venue
Progress in Retinal and Eye Research
Publisher
Elsevier BV
Published
2012-09
Volume
31
Issue
5
Pages
377-406
ISSN
1350-9462 (ISSN-L)
DOI
10.1016/j.preteyeres.2012.04.004
OpenAlex
W2011540186
Cited by
678
References
278
FWCI
30.90
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. https://app.cochat.ai/papers/10.1016/j.preteyeres.2012.04.004
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Kur, J., Newman, E. A., & Chan-Ling, T. (2012). Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Progress in Retinal and Eye Research. https://doi.org/10.1016/j.preteyeres.2012.04.004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.