Manganese Superoxide Dismutase Overexpression Attenuates MPTP Toxicity

Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels

Beauchamp, C., & Fridovich, I. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90370-8 · Cited by 12,892

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,499

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023

Mitochondrial Superoxide Dismutase

Weisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43735-6 · Cited by 960

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863

An assay for superoxide dismutase activity in mammalian tissue homogenates

Spitz, D. R., & Oberley, L. W. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90192-9 · Cited by 751

Human copper-containing superoxide dismutase of high molecular weight.

Marklund, S. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7634 · Cited by 749

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

Beckman, J. S., & Crow, J. P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210330 · Cited by 674

Toxin-induced mitochondrial dysfunction

Browne, S. E., & Beal, M. F. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53010-5 · Cited by 17

Age-dependent redox status in the brain stem of NO-deficient hypertensive rats

Majzúnová, M., Pakanová, Z., Kvasnicka, P., Bališ, P., Čačányiová, S., & Dovinová, I. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0366-4 · Cited by 15

Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin.

Chiueh, C., Andoh, T., & Chock, P. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.03.020 · Cited by 15

Emerging Functional Connections Between Metabolism and Epigenetic Remodeling in Neural Differentiation

Sánchez-Ramírez, E., Ung, T. P. L., Stringari, C., & Aguilar‐Arnal, L. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04006-w · Cited by 15

Papel de las variantes GSTM1, GSTT1 y MnSOD en el desarrollo de enfermedad de Alzheimer de aparición tardía y su relación con el alelo 4 de APOE

de Mendonca, E., Alcalá, E. S., & Fernández‐Mestre, M. (2014) · Neurología · doi:10.1016/j.nrl.2014.10.012 · Cited by 14

MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Disease

Pasquali, L., Ienco, E. C., & Fornai, F. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_170 · Cited by 15

Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease

Liang, L., Huang, J., Fulton, R. E., Pearson-Smith, J. N., Day, B. J., & Patel, M. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.04.004 · Cited by 14

Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease

Šaponjić, J., Mejı́as, R., Nikolovski, N., Dragić, M., Canak, A., Papoutsopoulou, S., Özdemir, Y., Fladmark, K. E., Ntavaroukas, P., Muluk, N. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084330 · Cited by 13

The tolerable upper intake level of manganese alleviates Parkinson-like motor performance and neuronal loss by activating mitophagy

Han, X., Zhang, B., Gong, Q., Liu, T., Wang, C., Sun, Y., Jia, H., pu, Y., Hou, Q., & Yang, X. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.281 · Cited by 12

Mitochondrial Superoxide Dismutase Specifies Early Neural Commitment by Modulating Mitochondrial Dynamics

Bhaskar, S., Sheshadri, P., Joseph, J. P., Potdar, C., Prasanna, J., & Kumar, A. (2020) · iScience · doi:10.1016/j.isci.2020.101564 · Cited by 12

Age-related alterations of oxidative stress markers in the mouse hippocampal CA1 sector

Hayakawa, N., Yokoyama, H., Kato, H., & Araki, T. (2008) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2008.05.001 · Cited by 12

[51] Detection of 4-hydroxy-2-nonenol adducts following lipid peroxidation from ozone exposure

Szweda, L. I., Szweda, P. A., & Holian, A. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19053-6 · Cited by 12

Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice

Cadet, J. L. (2001) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00021-9 · Cited by 12

Role of genes GSTM1, GSTT1, and MnSOD in the development of late-onset Alzheimer disease and their relationship with APOE*4

de Mendonca, E., Alcalá, E. S., & Fernández‐Mestre, M. (2016) · Neurología (English Edition) · doi:10.1016/j.nrleng.2014.10.007 · Cited by 11

(-)-Hydroxycitric acid attenuates endoplasmic reticulum stress-mediated alterations in 3T3-L1 adipocytes by protecting mitochondria and downregulating inflammatory markers

Nisha, V. M., Priyanka, A., Anusree, S. S., & Raghu, K. G. (2014) · Free Radical Research · doi:10.3109/10715762.2014.959514 · Cited by 11

Induction of Manganese Superoxide Dismutase in Acute Spinal Cord Injury

Earnhardt, J. N., Streit, W. J., Anderson, D. K., O'Steen, W. A., & Nick, H. S. (2002) · Journal of Neurotrauma · doi:10.1089/089771502760341974 · Cited by 9

Mitochondrial Dysfunction in Parkinson’s Disease

Patel, M., & McElroy, P. B. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622888-00061 · Cited by 9

Are Dopamine, Norepinephrine, and Serotonin Precursors of Biologically Reactive Intermediates Involved in the Pathogenesis of Neurodegenerative Brain Disorders?

Dryhurst, G. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0667-6_61 · Cited by 7

Early Biochemical Alterations in Manganese Toxicity: Ameliorating Effects of Magnesium Nitrate and Vitamins

Zaidi, S. S. A., Patel, A. B., MEHTA, N., PATEL, K., Takiar, R., & Saiyed, H. N. (2005) · Industrial Health · doi:10.2486/indhealth.43.663 · Cited by 6

The superoxide dismutase mimetic GC4419 enhances tumor killing when combined with stereotactic ablative radiationPreprint

Sishc, B. J., Ding, L., Heer, C. D., Saha, D., Spitz, D. R., & Story, M. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.10.984443 · Cited by 5

Electrochemical micro- and nanobiosensors for in vivo reactive oxygen/nitrogen species measurement in the brain

Beigloo, F., Khoshkar-Vandi, S. A., Pourmand, E., Heydari, M., Molaabasi, F., Gharib, N., Zare, Y., Rhee, K. Y., & Park, S. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0124 · Cited by 6

From Man to Mouse: The MPTP Model of Parkinson Disease

Jackson-Lewis, V. R., & Smeyne, R. J. (2005) · Elsevier eBooks · doi:10.1016/b978-012088382-0/50012-8 · Cited by 5

From Man to Mouse

Jackson-Lewis, V., Lester, D. B., Kozina, E. A., Przedborski, S., & Smeyne, R. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00017-2 · Cited by 5

MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Disease

Ferrucci, M., & Fornai, F. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_239-1 · Cited by 4

Effects of Brain Factor‑7® against motor deficit and oxidative stress in a mouse model of MPTP‑induced Parkinson's disease

Lee, T.-K., Lee, J., Kim, D., Lee, J., Kim, S., Kim, H. I., Shin, M. C., Cho, J., Won, M., & Choi, S. Y. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11572 · Cited by 4

MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modelling of Parkinson’s Disease

Pasquali, L., Ienco, E. C., & Fornai, F. (2014) · CINECA IRIS Institutial research information system (University of Pisa) · Cited by 3

AP-1 Is Required For CMX-8933-Induced SOD Upregulation And Is Translocated In Response To A Human EPN Mimetic

Saif, S. (2004) · Digital WPI · Cited by 3

Nigrostriatal dopaminergic neurotoxicity of L-cysteine after stereotaxic administration into the substantia nigra of rats: Potential implications for MPTP-induced neurotoxicity and parkinson’s disease

Gu, L., Miller, K. E., & Dryhurst, G. (2000) · Neurotoxicity Research · doi:10.1007/bf03033344 · Cited by 2

Manganese Superoxide Dismutase

Kiningham, K. K. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622383-00077 · Cited by 2

Manganese Superoxide Dismutase (MnSOD) and Its Importance in Mitochondrial Function and Cancer

Holley, A. K., & Clair, D. K. S. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-30705-3_3 · Cited by 2

Manganese Superoxide Dismutase Transgenic Mice: Characteristics and Implications

Chow, C. K., Yen, H., Ibrahim, W. H., & Clair, D. K. S. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)53064-0 · Cited by 2

MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Disease

Ferrucci, M., & Fornai, F. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_239 · Cited by 1

Rodent Toxin Models of PD

Ries, V., & Burke, R. E. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374028-1.00010-5 · Cited by 1

Cellular Mechanisms of Resveratrol's Interaction with Mitochondrial Reactive Oxygen Species Metabolism

Robb, E. L. (2013) · Brock University Digital Repository (Brock University) · Cited by 1

Dopamine and Its Modulation of Drug-Induced Neuronal Damage

Kuhn, D. M. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-165-7_7 · Cited by 1

Synthetic Studies of Azulenyl and Pseudoazulenyl Nitrones

Kolhe, A. (2009) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fi10022526

Role of Inflammation in MPTP-Induced Dopaminergic Neuronal Death

Przedborski, S. (2008) · doi:10.21236/ada494929

This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine

Buettner, G. R., Oberley, L. W., Spitz, D. R., & Domann, F. E. (2003)

alpha-Synuclein: Synaptische Funktion und Rolle bei der Pathogenese der Parkinson-Syndrome

Schlüter, O. M. (2002) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-680

Exploring the Mechanism of Aging Using Rodent Models

Ikeno, Y., & Remmen, H. V. (2003) · Springer eBooks · doi:10.1007/978-94-017-0671-1_9

New Animal Models in Toxicology

Floyd, E. (2002) · Elsevier eBooks · doi:10.1016/b978-012330215-1/50014-4

The Environmental Contribution to Redox Dyshomeostasis in Parkinson’s Disease

Garza-Lombó, C., & Franco, R. (2022) · Molecular and integrative toxicology · doi:10.1007/978-3-030-87451-3_4

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

Przedborski, S., Kostić, V., Jackson-Lewis, V. R., Naini, A. B., Simonetti, S., Fahn, S., Carlson, E. J., Epstein, C. J., & Cadet, J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01658.1992 · Cited by 456

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

Maragos, W. F., Jakel, R. J., Chesnut, D., Pocernich, C. B., Butterfield, D. A., Clair, D. K. S., & Cass, W. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02707-4 · Cited by 52

Mice with a Partial Deficiency of Manganese Superoxide Dismutase Show Increased Vulnerability to the Mitochondrial Toxins Malonate, 3-Nitropropionic Acid, and MPTP

Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., Albers, D. W., Klivènyi, P., Carlson, E. J., Epstein, C. J., & Beal, M. F. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7525 · Cited by 114

Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals.

Andrews, A. M., Ladenheim, B., Epstein, C. J., Cadet, J. L., & Murphy, D. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09609-9 · Cited by 45

Gene expression of reactive oxygen species scavenging enzymes in substantia nigra and striatum of MPTP treated C57BL mice

Xue, X. (2002) · Zhongguo shenjing kexue zazhi