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Cited by 418

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A Trial-Based Experimental Design for fMRI

Open access
Zarahn, Eric, Aguirre, Geoff, D'Esposito, Mark·1997·NeuroImage

Abstract

An experimental design for functional MRI (fMRI) is presented whose conceptual units of analysis are behavioral trials, in contrast to blocks of trials. This type of design is referred to as a trial-based (TB) fMRI design. It is explained how TB designs can afford the ability to: (1) randomize the presentation of behavioral trials and (2) utilize intertrial variance in uncontrolled behavioral measures to examine their functional correlates. A particular type of TB design that involves modeling trial-evoked fMRI responses with one or more shifted impulse response functions is described. This design is capable of discriminating functional changes occurring during temporally separated behavioral subcomponents within trials. An example of such a design is implemented and its statistical specificity, functional sensitivity, and functional specificity are tested.

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Metadata

Authors
Zarahn, E., Aguirre, G., & D'Esposito, M.
Venue
NeuroImage
Publisher
Elsevier BV
Published
1997-08
Volume
6
Issue
2
Pages
122-138
ISSN
1053-8119 (ISSN-L)
OpenAlex
W1999651610
Cited by
418
References
5
FWCI
18.32
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: A Trial-Based Experimental Design for fMRI. https://app.cochat.ai/papers/10.1006/nimg.1997.0279
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Zarahn, E., Aguirre, G., & D'Esposito, M. (1997). A Trial-Based Experimental Design for fMRI. NeuroImage. https://doi.org/10.1006/nimg.1997.0279

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