Cited by 288Neurotransmitter Receptor Influence on BehaviorTryptophan and brain disordersTreatment of Major Depression

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Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion

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Morris, J.S., Smith, K.A., Cowen, P.J., Friston, K.J., Dolan, R.J.·1999·NeuroImage

DOI 10.1006/nimg.1999.0455

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Abstract

Abnormal serotonergic function is implicated in the pathogenesis of affective disorders. We induced transient depressive relapses in volunteer patients by rapidly depleting plasma tryptophan, the precursor of serotonin (5-HT), and measured neural activity during different cognitive tasks using positron emission tomography (PET). Neural activity in several 5-HT-related brain areas, e.g., dorsal raphé, habenula, septal region, amygdala, and orbitofrontal cortex, covaried significantly with plasma levels of tryptophan and ratings of depressed mood. Task-specific responses in left amygdala and left anterior cingulate were attenuated by tryptophan depletion. We used these PET data to test the hypothesis that projections from the habenula modulate dorsal raphé activity and that this modulation is enhanced in patients experiencing a profound mood change following serotonergic challenge. A strong linear correlation (r(2) > 0.5) between habenula and raphé activity was observed in subjects with postdepletion ratings >/=10 on a modified Hamilton depression scale, whereas subjects experiencing milder changes in mood had weaker habenula-raphé coupling (r(2) < 0.5). These data support a model of the serotonergic system in which the habenula projection to the raphé represents a convergent feedback pathway that controls the release of 5-HT throughout the brain. In our experiment we were able to engage this system in patients who were sensitive to tryptophan depletion.

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Authors: Morris, J. S., Smith, K. A., Cowen, P. J., Friston, K. J., & Dolan, R. J.
Affiliations: National Hospital for Neurology and Neurosurgery (GB)
Warneford Hospital (GB)
The Royal Free Hospital (GB)
Corresponding author: Dolan, R.J.
ORCID: Smith, K.A.
Cowen, P.J.
Friston, K.J.
Dolan, R.J.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 1999-08
Volume: 10
Issue: 2
Pages: 163-172
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1006/nimg.1999.0455
OpenAlex: W2030196595
Cited by: 288
References: 45
Citations by year: 2026: 5 · 2025: 6 · 2024: 18 · 2023: 9 · 2022: 14 · 2021: 15 · 2020: 8 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 16 · 2015: 16 · 2014: 17 · 2013: 21 · 2012: 14
FWCI: 1.57
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Max Planck Digital Library (submittedVersion, other-oa)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: tryptophan depletion, serotonin, habenula, dorsal raphe nucleus, serotonergic system, depression, amygdala, anterior cingulate cortex, mood disorders, depressive mood
MeSH terms: Adult, Amygdala, Arousal, Attention, Brain Mapping, Major Depressive Disorder, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Raphe Nuclei, Recurrence, Serotonin, Tomography, Emission-Computed, Tryptophan, Verbal Behavior, Habenula

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Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion

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