The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Regional Differences in the CBF and BOLD Responses to Hypercapnia: A Combined PET and fMRI Study
Abstract
Previous fMRI studies of the cerebrovascular response to hypercapnia have shown signal change in cerebral gray matter, but not in white matter. Therefore, the objective of the present study was to compare (15)O PET and T *(2)-weighted MRI during a hypercapnic challenge. The measurements were performed under similar conditions of hypercapnia, which were induced by inhalation of 5 or 7% CO(2). The baseline rCBF values were 65.1 ml hg(-1) min(-1) for temporal gray matter and 28.7 ml hg(-1) min(-1) for white matter. By linear regression, the increases in rCBF during hypercapnia were 23.0 and 7. 2 ml hg(-1) min(-1) kPa(-1) for gray and white matter. The signal changes were 6.9 and 1.9% for the FLASH sequence and were 3.8 and 1. 7% for the EPI sequence at comparable echo times. The regional differences in percentage signal change were significantly reduced when normalized by regional flow values. A deconvolution analysis is introduced to model the relation between fMRI signal and end-expiratory CO(2) level. Temporal parameters, such as mean transit time, were derived from this analysis and suggested a slower response in white matter than in gray matter regions. It was concluded that the differences in the magnitude of the fMRI response can largely be attributed to differences in flow and that there is a considerable difference in the time course of the response between gray and white matter.
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“The changes in breathing are meditation-specific, and the brain (de) activations could be interpreted as meditation-related mechanisms, when they are potentially due to physiological noise.12,96”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [96]
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“Moreover, recent neuroimaging evidence shows that the role of the AIC in cognitive and affective interactions influences how individuals make decisions that involve risk [51, 52].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [51]
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Resting-state fMRI confounds and cleanup
Murphy, K., Birn, R. M., & Bandettini, P. A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.001 · Cited by 666
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Metadata
- Authors
- Rostrup, E., Law, I., Blinkenberg, M., Larsson, H. B. W., Born, A. P., Holm, S., & Paulson, O. B.
- Affiliations
- Hvidovre Hospital (DK)
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 11
- Issue
- 2
- Pages
- 87-97
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2075514568
- Cited by
- 216
- References
- 29
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 18 · 2013: 10 · 2012: 11
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- hypercapnia, cerebral blood flow, BOLD signal, cerebrovascular response, gray matter, white matter, regional variation, deconvolution, mean transit time, end-expiratory CO2, 15O PET, T2-weighted MRI, FLASH sequence
- MeSH terms
- Adult, Blood Flow Velocity, Brain, Brain Mapping, Carbon Dioxide, Female, Humans, Hypercapnia, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Reference Values, Regional Blood Flow, Tomography, Emission-Computed
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