The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Regulation ofp53downstream genes
Open accessAbstract
The p53 tumor suppressor is the most commonly mutated gene in human cancer. p53 protein is stabilized in response to different checkpoints activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in diverse biological effects, such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. The stable p53 protein is activated by phosphorylation, dephosphorylation and acetylation yielding a potent sequence-specific DNA-binding transcription factor. The wide range of p53's biological effects can in part be explained by its activation of expression of a number of target genes including p21WAFI, GADD45, 14-3-3 sigma, bax, Fas/APO1, KILLER/DR5, PIG3, Tsp1, IGF-BP3 and others. This review will focus on the transcriptional targets of p53, their regulation by p53, and their relative importance in carrying out the biological effects of p53.
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Cites
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Cited by
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Blinded by the Light: The Growing Complexity of p53
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PUMA, a Novel Proapoptotic Gene, Is Induced by p53
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Metadata
- Authors
- El-Deiry, W. S.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 1998
- Volume
- 8
- Issue
- 5
- Pages
- 345-357
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W165254100
- Cited by
- 800
- References
- 18
- FWCI
- 19.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
