The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
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Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine residues including S20, a site that is particularly important in regulating stability and function of the protein. Because no known kinase has been identified that can modify this site, HeLa nuclear extracts were fractionated and S20 phosphorylation was followed. We discovered that a S20 kinase activity copurifies with the human homolog of the Schizosaccharomyces pombe checkpoint kinase, Chk1 (hCHK1). We confirmed that recombinant hCHK1, but not a kinase-defective version of hCHK1, can phosphorylate p53 in vitro at S20. Additional inducible amino- and carboxy-terminal sites in p53 are also phosphorylated by hCHK1, indicating that this is an unusually versatile protein kinase. It is interesting that hCHK1 strongly prefers tetrameric to monomeric p53 in vitro, consistent with our observation that phosphorylation of amino-terminal sites in vivo requires that p53 be oligomeric. Regulation of the levels and activity of hCHK1 in transfected cells is directly correlated with the levels of p53; expression of either a kinase-defective hCHK1 or antisense hCHK1 leads to reduced levels of cotransfected p53, whereas overexpression of wild-type hCHK1 or the kinase domain of hCHK1 results in increased levels of expressed p53 protein. The human homolog of the second S. pombe checkpoint kinase, Cds1 (CHK2/hCds1), phosphorylates tetrameric p53 but not monomeric p53 in vitro at sites similar to those phosphorylated by hCHK1 kinase, suggesting that both checkpoint kinases can play roles in regulating p53 after DNA damage.
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hChk2 phosphorylates p53 at Ser20.
“and hChk2, in turn, phosphorylates yet another amino-terminal Ser residue (Ser 20) in p53”
From Cell cycle checkpoint signaling through the ATM and ATR kinases (2001) · cites this paper as Shieh et al. 2000
These phosphorylation events disrupt p53-Mdm2 and Mdm2-DAXX interactions and promote degradation of Mdm2 and Mdm4.
“These phosphorylation events contribute to disrupting the p53-Mdm2 (Chehab et al., 2000; Shieh et al., 2000), and Mdm2-DAXX (Tang et al., 2013) interactions, as well as to the degradation of Mdm2 and Mdm4 (Stommel and Wahl, 2004; Chen et al., 2005; Pereg et al., 2005, 2006; LeBron et al., 2006).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Shieh et al., 2000
p53 is phosphorylated at Ser20 by Chk2 after IR, resulting in p53's dissociation from Mdm2 and its subsequent stabilization.
“p53 is phosphorylated at Ser20 by the checkpoint kinase Chk2 after IR, which results in p53's dissociation from Mdm2 and its subsequent stabilization”
From USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 (2010) · cites this paper as Shieh et al., 2000
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p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506 · see citing works
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · see citing works
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113 · see citing works
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · see citing works
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80416-x · Cited by 2,100 · see citing works
Self-citationCell Cycle Checkpoints: Preventing an Identity Crisis
Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,047 · see citing works
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works
Self-citationEnhanced Phosphorylation of p53 by ATM in Response to DNA Damage
Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works
Self-citationOncoprotein MDM2 conceals the activation domain of tumour suppressor p53
Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., & Vogelstein, B. (1993) · Nature · doi:10.1038/362857a0 · Cited by 1,447 · see citing works
Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341 · see citing works
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322 · see citing works
Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320 · see citing works
The complexity of p53 modulation: emerging patterns from divergent signalsPreprint
Giaccia, A. J., & Kastan, M. B. (1998) · Genes & Development · doi:10.1101/gad.12.19.2973 · Cited by 1,303 · see citing works
DNA damage activates p53 through a phosphorylation–acetylation cascade
Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204 · see citing works
A role for ATR in the DNA damage-induced phosphorylation of p53
Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046 · see citing works
Self-citation[36] Eukaryotic gene transcription with purified components
Dignam, J. D., Martin, P. L., Shastry, B. S., & Roeder, R. G. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01039-3 · Cited by 963 · see citing works
Regulation of the specific DNA binding function of p53
Hupp, T. R., Meek, D. W., Midgley, C., & Lane, D. P. (1992) · Cell · doi:10.1016/0092-8674(92)90562-q · Cited by 910 · see citing works
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
Bell, D. W., Varley, J. M., Szydlo, T. E., Kang, D. H., Wahrer, D. C. R., Shannon, K. E., Lubratovich, M. L., Verselis, S. J., Isselbacher, K. J., Fraumeni, J. F., et al. (1999) · Science · doi:10.1126/science.286.5449.2528 · Cited by 899 · see citing works
DNA damage induces phosphorylation of the amino terminus of p53
Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development · doi:10.1101/gad.11.24.3471 · Cited by 818 · see citing works
Self-citationChk2/hCds1 functions as a DNA damage checkpoint in G<sub>1</sub>by stabilizing p53
Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.278 · Cited by 805 · see citing works
Regulation ofp53downstream genes
El‐Deiry, W. S. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0097 · Cited by 797 · see citing works
Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chernova, O. B., & Stark, G. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.1 · Cited by 725 · see citing works
THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA
Lavin, M. F., & Shiloh, Y. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.177 · Cited by 644 · see citing works
Prives, C. (1998) · Cell · doi:10.1016/s0092-8674(00)81774-2 · Cited by 623 · see citing works
Self-citationPhosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.
Chehab, N. H., Malikzay, A., Stavridi, E. S., & Halazonetis, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13777 · Cited by 583 · see citing works
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
Lopez‐Girona, A., Furnari, B. A., Mondésert, O., & Russell, P. R. (1999) · Nature · doi:10.1038/16488 · Cited by 574 · see citing works
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
Furnari, B. A., Rhind, N., & Russell, P. R. (1997) · Science · doi:10.1126/science.277.5331.1495 · Cited by 542 · see citing works
(1998) · PubMed · Cited by 525 · see citing works
ATM associates with and phosphorylates p53: mapping the region of interaction
Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S. P., Gatei, M. H., Hobson, K., Taya, Y., Gabrielli, B. G., Chan, D. W., Lees‐Miller, S. P., et al. (1998) · Nature Genetics · doi:10.1038/3882 · Cited by 481 · see citing works
Self-citationRapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., & Shkedy, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14973 · Cited by 461 · see citing works
Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2
Walworth, N. C., Davey, S. K., & Beach, D. (1993) · Nature · doi:10.1038/363368a0 · Cited by 452 · see citing works
Regulation of p53 function and stability by phosphorylation.
Ashcroft, M., Kubbutat, M. H. G., & Vousden, K. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1751 · Cited by 452 · see citing works
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
Chaturvedi, P., Eng, W.-K., Zhu, Y., Mattern, M. R., Mishra, R., Hurle, M. R., Zhang, X., Annan, R. S., Lu, Q., Faucette, L. F., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202925 · Cited by 420 · see citing works
Lees‐Miller, S. P., Chen, Y. R., & Anderson, C. W. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.12.6472 · Cited by 405 · see citing works
rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage Checkpoint
Walworth, N. C., & Bernards, R. (1996) · Science · doi:10.1126/science.271.5247.353 · Cited by 397 · see citing works
Lindsay, H. D., Griffiths, D. J. F., Edwards, R. J., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N. C., & Carr, A. M. (1998) · Genes & Development · doi:10.1101/gad.12.3.382 · Cited by 385 · see citing works
Fiol, C. J., Mahrenholz, A. M., Wang, Y., Roeske, R. W., & Roach, P. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47901-x · Cited by 367 · see citing works
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
Unger, T., Juven‐Gershon, T., Moallem, E., Berger, M., Sionov, R. V., Lozano, G., Oren, M., & Haupt, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1805 · Cited by 365 · see citing works
Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
Zeng, Y., Forbes, K. C., Wu, Z., Moreno, S., Piwnica-Worms, H. M., & Enoch, T. (1998) · Nature · doi:10.1038/26766 · Cited by 341 · see citing works
Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases
Wang, Y., & Prives, C. (1995) · Nature · doi:10.1038/376088a0 · Cited by 336 · see citing works
Self-citationp53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
MIDGLEY, C. A., & Lane, D. P. (1997) · Oncogene · doi:10.1038/sj.onc.1201459 · Cited by 313 · see citing works
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Blasina, A., de Weyer, I. V., Laus, M. C., Luyten, W. H. M. L., Parker, A. E., & McGowan, C. H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80041-4 · Cited by 301 · see citing works
Shieh, S.-Y., Taya, Y., & Prives, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1815 · Cited by 299 · see citing works
Self-citationBaudier, J., Delphin, C., Grünwald, D., Khochbin, S., & Lawrence, J. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11627 · Cited by 285 · see citing works
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
Meek, D. W., Simon, S., Kikkawa, U., & Eckhart, W. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07524.x · Cited by 277 · see citing works
Brown, A. L., Lee, C. H., Schwarz, J. K., Mitiku, N., Piwnica-Worms, H. M., & Chung, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3745 · Cited by 260 · see citing works
Milne, D., Campbell, L. E., Campbell, D. G., & Meek, D. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5511 · Cited by 257 · see citing works
Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53
Sakaguchi, K., Sakamoto, H., Lewis, M. S., Anderson, C. W., Erickson, J. W., Appella, E., & Xie, D. (1997) · Biochemistry · doi:10.1021/bi970759w · Cited by 247 · see citing works
(1997) · PubMed · Cited by 243 · see citing works
Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1
Furnari, B. A., Blasina, A., Boddy, M. N., McGowan, C. H., & Russell, P. R. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.833 · Cited by 217 · see citing works
Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation
Kapoor, M., & Lozano, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2834 · Cited by 209 · see citing works
Cuddihy, A. R., Hoi-Tao Wong, A., Wai Ning Tam, N., Li, S., & Koromilas, A. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202620 · Cited by 203 · see citing works
p53-Dependent cell cycle control: response to genotoxic stress
Schwartz, D., & Rotter, V. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0095 · Cited by 195 · see citing works
DNA damage checkpoints update: getting molecular
Weinert, T. A. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80140-8 · Cited by 192 · see citing works
Multisite Phosphorylation and the Integration of Stress Signals at p53
Meek, D. W. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(97)00119-8 · Cited by 185 · see citing works
p53 Is Phosphorylated by CDK7-Cyclin H in a p36MAT1-Dependent Manner
Ko, L. J., Shieh, S.-Y., Chen, X., Jayaraman, L., Tamai, K., Taya, Y., Prives, C. L., & Pan, Z. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.7220 · Cited by 171 · see citing works
Self-citationLu, H., Taya, Y., Ikeda, M., & Levine, A. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6399 · Cited by 162 · see citing works
Self-citationAnalysis of Rad3 and Chk1 protein kinases defines different checkpoint responses
Martinho, R. G., Lindsay, H. D., Flaggs, G., DeMaggio, A. J., Hoekstra, M. F., Carr, A. M., & Bentley, N. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7239 · Cited by 161 · see citing works
Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.
Milne, D., Campbell, D. G., Caudwell, F. B., & Meek, D. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37101-6 · Cited by 154 · see citing works
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation
Blattner, C., Tobiasch, E., Litfen, M., Rahmsdorf, H. J., & Herrlich, P. (1999) · Oncogene · doi:10.1038/sj.onc.1202480 · Cited by 151 · see citing works
Cell cycle-dependent and ATM-independent expression of human Chk1 kinase
Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Terasawa, M., Tachibana, A., Ikeda, K., & Nakanishi, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202706 · Cited by 150 · see citing works
Lees‐Miller, S. P., Chen, Y.-R., & Anderson, C. W. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.12.6472-6481.1990 · Cited by 148 · see citing works
CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers
Bertoni, F., Codegoni, A. M., Furlan, D., Tibiletti, M. G., Capella, C., & Broggini, M. (1999) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199910)26:2 · Cited by 132 · see citing works
JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases
Hu, M. C. ‐., Qiu, W. R., & Wang, Y. (1997) · Oncogene · doi:10.1038/sj.onc.1201401 · Cited by 124 · see citing works
Milne, D., Rh, P., Campbell, D. G., & Dw, M. (1992) · PubMed · Cited by 122 · see citing works
Conformation-dependent phosphorylation of p53
Adler, V., Pincus, M. R., Minamoto, T., Fuchs, S. Y., Bluth, M. J., Brandt‐Rauf, P. W., Friedman, F. K., Robinson, R. C., Chen, J., Wang, X. W., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1686 · Cited by 120 · see citing works
Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein KinasesPreprint
Hupp, T. R., & Lane, D. P. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.024 · Cited by 109 · see citing works
Basis for the Checkpoint Signal Specificity That Regulates Chk1 and Cds1 Protein Kinases
Brondello, J., Boddy, M. N., Furnari, B. A., & Russell, P. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4262 · Cited by 108 · see citing works
DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site
Blaydes, J. P., & Hupp, T. R. (1998) · Oncogene · doi:10.1038/sj.onc.1202014 · Cited by 107 · see citing works
Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes
Flaggs, G., Plug, A. W., Dunks, K. M., Mundt, K., Ford, J. C., Quiggle, M. R. E., Taylor, E. M., Westphal, C. H., Ashley, T., Hoekstra, M. F., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00417-9 · Cited by 105 · see citing works
Shaulian, E., Zauberman, A., Milner, J., Davies, E. A., & Oren, M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05940.x · Cited by 68 · see citing works
Jamal, S., & Ziff, E. B. (1995) · PubMed · Cited by 59 · see citing works
7 DNA-dependent protein kinase and related proteins
Smith, G. C. M., Divecha, N., Lakin, N. D., & Jackson, S. P. (1999) · Princeton University Press eBooks · doi:10.1515/9781400865048.91 · Cited by 59 · see citing works
Lohrum, M. A. E., & Scheidtmann, K. H. (1996) · PubMed · Cited by 56 · see citing works
Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.
Mayr, G. A., Reed, M. J., Wang, P., Wang, Y., Schweds, J. F., & Tegtmeyer, P. (1995) · PubMed · Cited by 53 · see citing works
Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells
Chen, P., Gatei, M. H., O’Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K., & Lavin, M. F. (1999) · Oncogene · doi:10.1038/sj.onc.1202257 · Cited by 43 · see citing works
Functional dissection of p53 tumor suppressor protein
Jayaraman, L., Freulich, E., & Prives, C. L. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)83020-0 · Cited by 27 · see citing works
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- Chehab, N.H., A. Malikzay, E.S. Stavridi, and T.D. Halazonetis. 1999. Phosphorylation of Ser20 mediates stabilization of hu- man p53 in response to DNA damage. Proc. Natl. Acad. Sci. 96: 13777-13782.
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Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works
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Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M., & Kroemer, G. (2012) · Oncogene · doi:10.1038/onc.2011.384 · Cited by 2,760 · see citing works
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Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works
Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works
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Regulation of the G2/M transition by p53
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Chk1 and Chk2 kinases in checkpoint control and cancer
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Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506 · see citing works
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Cell death by mitotic catastrophe: a molecular definition
Castedo, M., Perfettini, J.-L., Roumier, T., Andreau, K., Medema, R., & Kroemer, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207528 · Cited by 1,269 · see citing works
Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works
Self-citationThe CHEK2-Breast Cancer Consortium (2002) · Nature Genetics · doi:10.1038/ng879 · Cited by 1,104 · see citing works
Role of cell cycle in mediating sensitivity to radiotherapy
Pawlik, T. M., & Keyomarsi, K. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.03.005 · Cited by 1,101 · see citing works
Post‐translational modifications and activation of p53 by genotoxic stresses
Appella, E., & Anderson, C. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02225.x · Cited by 1,071 · see citing works
BRCA1 and BRCA2: 1994 and beyond
Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967 · see citing works
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
Roos, W. P., & Kaina, B. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.01.007 · Cited by 879 · see citing works
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 830 · see citing works
Self-citationChk2/hCds1 functions as a DNA damage checkpoint in G<sub>1</sub>by stabilizing p53
Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.278 · Cited by 805 · see citing works
The many substrates and functions of ATM.
Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.060402.113540 · Cited by 770 · see citing works
Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
Chène, P. (2003) · Nature Reviews Cancer · doi:10.1038/nrc991 · Cited by 765 · see citing works
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
Brooks, C. L., & Gu, W. J. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00003-6 · Cited by 742 · see citing works
Regulation and function of the p53 tumor suppressor protein
Ryan, K. M., Phillips, A. C., & Vousden, K. H. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00216-7 · Cited by 721 · see citing works
Barlev, N. A., Liu, L., Chehab, N. H., Mansfield, K., Harris, K. G., Halazonetis, T. D., & Berger, S. L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00414-2 · Cited by 710 · see citing works
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
Yuan, J., Luo, K., Zhang, L., Cheville, J. C., & Lou, Z. (2010) · Cell · doi:10.1016/j.cell.2009.12.032 · Cited by 637 · see citing works
“For example, p53 is phosphorylated at Ser20 by the checkpoint kinase Chk2 after IR, which results in p53’s dissociation from Mdm2 and its subsequent stabilization (Chehab et al., 2000; Hirao et al., 2000; Shieh et al., 2000).”
Cellular Responses to DNA Damage
Norbury, C. J., & Hickson, I. D. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.367 · Cited by 628 · see citing works
Regulation of HDM2 activity by the ribosomal protein L11
Lohrum, M. A. E., Ludwig, R. L., Kubbutat, M. H. G., Hanlon, M., & Vousden, K. H. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00134-x · Cited by 626 · see citing works
ATM and ATR: networking cellular responses to DNA damage
Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601 · see citing works
Reinhardt, H. C., Aslanian, A., Lees, J. A., & Yaffe, M. B. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.024 · Cited by 593 · see citing works
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
Hofmann, T. G., Möller, A., Sirma, H., Zentgraf, H., Taya, Y., Dröge, W., Will, H., & Schmitz, M. L. (2001) · Nature Cell Biology · doi:10.1038/ncb715 · Cited by 591 · see citing works
Self-citationPhosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
Katayama, H. G., Sasai, K., Kawai, H., Yuan, Z.-M., Bondaruk, J. E., Suzuki, F., Fujii, S., Arlinghaus, R. B., Czerniak, B. A., & Sen, S. (2003) · Nature Genetics · doi:10.1038/ng1279 · Cited by 586 · see citing works
p300/CBP‐mediated p53 acetylation is commonly induced by p53‐activating agents and inhibited by MDM2
Ito, A., Lai, C.-H., Zhao, X., Saito, S., Hamilton, M. H., Appella, E., & Yao, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1331 · Cited by 582 · see citing works
Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
Bar‐Or, R. L., Maya, R. B.-Y., Segel, L. A., Alon, U., Levine, A. J., & Oren, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210171597 · Cited by 579 · see citing works
Mechanisms of human DNA repair: an update
Christmann, M., Tomicic, M. T., Roos, W. P., & Kaina, B. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00287-7 · Cited by 578 · see citing works
Mammalian G1- and S-phase checkpoints in response to DNA damage
Bártek, J., & Lukas, J. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00280-5 · Cited by 573 · see citing works
Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bártek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 560 · see citing works
p53: traffic cop at the crossroads of DNA repair and recombination
Sengupta, S., & Harris, C. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1546 · Cited by 544 · see citing works
Bernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527 · see citing works
Mrc1 transduces signals of DNA replication stress to activate Rad53
Alcasabas, A. A., Osborn, A. J., Bachant, J., Hu, F., Werler, P., Bousset, K., Furuya, K., Diffley, J. F. X., Carr, A. M., & Elledge, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-958 · Cited by 516 · see citing works
Fei, P., & El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206677 · Cited by 497 · see citing works
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
Yang, W. H., Kim, J. E., Nam, H. W., Ju, J., Kim, H. S., Kim, Y. S., & Cho, J. W. (2006) · Nature Cell Biology · doi:10.1038/ncb1470 · Cited by 489 · see citing works
Cell cycle checkpoint signaling:
Pietenpol, J. A., & Stewart, Z. A. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00460-2 · Cited by 472 · see citing works
A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer
Vahteristo, P., Bártková, J., Eerola, H., Syrjäkoski, K., Ojala, S., Kilpivaara, O., Tamminen, A., Kononen, J., Aittomäki, K., Heikkilä, P., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341943 · Cited by 467 · see citing works
Pathways governing G1/S transition and their response to DNA damage
Bartek, J. J., & Lukas, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02114-7 · Cited by 467 · see citing works
Gaiddon, C., Lokshin, M., Ahn, J., Zhang, T., & Prives, C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1874-1887.2001 · Cited by 464 · see citing works
Self-citationRoles of Chk1 in cell biology and cancer therapy
Zhang, Y., & Hunter, T. (2014) · International Journal of Cancer · doi:10.1002/ijc.28226 · Cited by 462 · see citing works
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
Lin, W.-C., Lin, F., & Nevins, J. R. (2001) · PubMed Central · Cited by 440 · see citing works
Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription
Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C. W., Appella, E., Nakanishi, M., Suzuki, H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf506 · Cited by 435 · see citing works
Homologous recombinational repair of DNA ensures mammalian chromosome stability
Thompson, L. H., & Schild, D. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00115-4 · Cited by 426 · see citing works
Durocher, D., & Jackson, S. P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03294-x · Cited by 421 · see citing works
Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes & Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works
Recombinational DNA repair and human disease
Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417 · see citing works
Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53
Ollmann, M. M., Young, L. M., Como, C. J. D., Karim, F. D., Belvin, M. P., Robertson, S., Whittaker, K. L., Demsky, M., Fisher, W. W., Buchman, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80626-1 · Cited by 413 · see citing works
Self-citationPML nuclear bodies: dynamic sensors of DNA damage and cellular stress
Dellaire, G., & Bazett‐Jones, D. P. (2004) · BioEssays · doi:10.1002/bies.20089 · Cited by 404 · see citing works
Hirao, A., Cheung, A., Duncan, G. S., Girard, P.-M., Elia, A., Wakeham, A. C., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6521-6532.2002 · Cited by 404 · see citing works
Chk2 kinase — a busy messenger
Bártek, J., Falck, J., & Lukas, J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35103059 · Cited by 400 · see citing works
Ahn, J. Y., Schwarz, J. K., Piwnica-Worms, H. M., & Canman, C. E. (2000) · PubMed · Cited by 396 · see citing works
Self-citationp53 modifications: exquisite decorations of the powerful guardian
Liu, Y., Tavana, O., & Gu, W. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz060 · Cited by 392 · see citing works
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
Zhou, B. S., & Bártek, J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1296 · Cited by 390 · see citing works
Cell cycle checkpoints and their inactivation in human cancer
Molinari, M. (2000) · Cell Proliferation · doi:10.1046/j.1365-2184.2000.00191.x · Cited by 389 · see citing works
Chk2 activates E2F-1 in response to DNA damage
Stevens, C., Smith, L. M., & Thangue, N. B. L. (2003) · Nature Cell Biology · doi:10.1038/ncb974 · Cited by 386 · see citing works
The evolution of diverse biological responses to DNA damage: insights from yeast and p53
Wahl, G. M., & Carr, A. M. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-e277 · Cited by 376 · see citing works
Xu, X., Qiao, W., Linke, S. P., Cao, L., Li, W., Furth, P. A., Harris, C. C., & Deng, C. (2001) · Nature Genetics · doi:10.1038/90108 · Cited by 372 · see citing works
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
O’Shea, C. C., Johnson, L., Bagus, B., Choi, S., Nicholas, C. R., Shen, A., Boyle, L., Pandey, K., Soria, C. T., Kunich, J., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.11.012 · Cited by 370 · see citing works
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
Anderson, L., Henderson, C., & Adachi, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1719-1729.2001 · Cited by 367 · see citing works
Checking out the G2/M transition
Smits, V. A. J., & Medema, R. H. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00204-4 · Cited by 357 · see citing works
Bao, Y., Wang, L., Shi, L., Yun, F., Liu, X., Chen, Y., Chen, C., Ren, Y., & Jia, Y. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0162-0 · Cited by 354 · see citing works
Molecular Mechanism of the Interaction between MDM2 and p53
Schön, O., Friedler, A., Bycroft, M., Freund, S. M. V., & Fersht, A. R. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00852-5 · Cited by 349 · see citing works
Targeting CDK2 in cancer: challenges and opportunities for therapy
Tadesse, S., Anshabo, A. T., Portman, N., Lim, E., Tilley, W. D., Caldon, C. E., & Wang, S. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.12.001 · Cited by 344 · see citing works
A role for p53 in base excision repair
Zhou, J., Ahn, J., Wilson, S. H., & Prives, C. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.914 · Cited by 333 · see citing works
Self-citationMultiple roles of the tumor suppressor p53
Bargonetti, J., & Manfredi, J. J. (2002) · Current Opinion in Oncology · doi:10.1097/00001622-200201000-00015 · Cited by 332 · see citing works
p53 Acetylation: Regulation and Consequences
Reed, S. M., & Quelle, D. E. (2014) · Cancers · doi:10.3390/cancers7010030 · Cited by 330 · see citing works
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
Lou, Z., Minter‐Dykhouse, K., Wu, X., & Chen, J. (2003) · Nature · doi:10.1038/nature01447 · Cited by 328 · see citing works
Woods, D. B., & Vousden, K. H. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5141 · Cited by 318 · see citing works
Activation and activities of the p53 tumour suppressor protein
Bálint, É., & Vousden, K. H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2128 · Cited by 310 · see citing works
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
Melchionna, R., Chen, X., Blasina, A., & McGowan, C. H. (2000) · Nature Cell Biology · doi:10.1038/35036406 · Cited by 307 · see citing works
Mutations in CHEK2 Associated with Prostate Cancer Risk
Dong, X., Wang, L., Taniguchi, K., Wang, X., Cunningham, J. M., McDonnell, S. K., Qian, C., Marks, A. F., Slager, S. L., Peterson, B. J., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/346094 · Cited by 306 · see citing works
ATM: Genome stability, neuronal development, and cancer cross paths
(2001) · Advances in Cancer Research · doi:10.1016/s0065-230x(01)83007-4 · Cited by 299 · see citing works
The p53 network: cellular and systemic DNA damage responses in cancer and aging
Vaddavalli, P. L., & Schumacher, B. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.02.010 · Cited by 295 · see citing works
Mir, S. E., Hamer, P. C. D. W., Krawczyk, P. M., Balaj, L., Claes, A., Niers, J. M., van Tilborg, A. A. G., Zwinderman, A. H., Geerts, D., Kaspers, G. J. L., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.011 · Cited by 294 · see citing works
Buschmann, T., Potapova, O., Bar‐Shira, A., Ivanov, V. N., Fuchs, S. Y., Henderson, S. C., Fried, V. A., Minamoto, T., Alarcon-Vargas, D., Pincus, M. R., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2743-2754.2001 · Cited by 292 · see citing works
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
Antoni, L., Sodha, N., Collins, I., & Garrett, M. D. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2251 · Cited by 287 · see citing works
Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1
Boddy, M. N., Lopez‐Girona, A., Shanahan, P., Interthal, H., Heyer, W., & Russell, P. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8758-8766.2000 · Cited by 287 · see citing works
Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening
Simmons, S. O., Fan, C., & Ramabhadran, R. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp140 · Cited by 280 · see citing works
Control of the G2/M Transition
Stark, G. R., & Taylor, W. R. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:3:227 · Cited by 279 · see citing works
Zhao, Y., Lu, S., Wu, L., Chai, G., Wang, H., Chen, Y., Sun, J. T., Yu, Y., Zhou, W., Zheng, Q., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2782-2790.2006 · Cited by 277 · see citing works
The role of tetramerization in p53 function
Chêne, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204373 · Cited by 273 · see citing works
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
Chen, L., Gilkes, D. M., Pan, Y., Lane, W. S., & Chen, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600812 · Cited by 260 · see citing works
Mailand, N., Bekker-Jensen, S., Bartek, J., & Lukas, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.016 · Cited by 258 · see citing works
ATM, a central controller of cellular responses to DNA damage
Khanna, K. K., Lavin, M. F., Jackson, S. P., & Mulhern, T. D. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400874 · Cited by 251 · see citing works
Mechanism of p53 stabilization by ATM after DNA damage
Cheng, Q., & Chen, J. (2010) · Cell Cycle · doi:10.4161/cc.9.3.10556 · Cited by 248 · see citing works
Hong, Y., & Stambrook, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401346101 · Cited by 248 · see citing works
Nucleoside analogs: molecular mechanisms signaling cell death
Ewald, B., Sampath, D., & Plunkett, W. K. (2008) · Oncogene · doi:10.1038/onc.2008.316 · Cited by 246 · see citing works
Christmann, M., & Kaina, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt635 · Cited by 245 · see citing works
Tan, Y., Raychaudhuri, P., & Costa, R. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01068-06 · Cited by 245 · see citing works
Lu, X., Nguyen, T., Moon, S.-H., Darlington, Y. F., Sommer, M., & Donehower, L. A. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9127-x · Cited by 244 · see citing works
Ahn, J., Urist, M. J., & Prives, C. L. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.033 · Cited by 240 · see citing works
Self-citationPML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
Yang, S., Kuo, C. S., Bisi, J., & Kim, M. K. (2002) · Nature Cell Biology · doi:10.1038/ncb869 · Cited by 238 · see citing works
- Authors
- Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C.
- Affiliations
- Seisen University (JP)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-02-01
- Volume
- 14
- Issue
- 3
- Pages
- 289-300
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316358
- OpenAlex
- W2120921507
- Cited by
- 972
- References
- 84
- Citations by year
- 2026: 11 · 2025: 4 · 2024: 15 · 2023: 22 · 2022: 21 · 2021: 21 · 2020: 28 · 2019: 26 · 2018: 22 · 2017: 19 · 2016: 22 · 2015: 24 · 2014: 39 · 2013: 38 · 2012: 42
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Princess Takamatsu Cancer Research Fund
- National Institutes of Health (CA58316)
- National Cancer Institute (R37CA058316, R01CA058316, CA 58316)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- p53 phosphorylation, Chk1, Chk2, checkpoint kinase, DNA damage response, p53 oligomerization, p53 stabilization, Schizosaccharomyces pombe, kinase activity
- MeSH terms
- Checkpoint Kinase 1, DNA Damage, HeLa Cells, Humans, Phosphorylation, Protein Kinases, Recombinant Proteins, Blotting, Western, Tumor Suppressor Protein p53, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Schizosaccharomyces pombe Proteins, Checkpoint Kinase 2
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