Intramolecular chaperones: polypeptide extensions that modulate protein folding

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PapD-like chaperones provide the missing information for folding of pilin proteins

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Conserved Structural and Sequence Elements Implicated in the Processing of Gene-encoded Circular Proteins

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The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursorPreprint

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Signal Peptide and Propeptide Optimization for Heterologous Protein Secretion in Lactococcus lactis

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Structural and Functional Analysis of the CspB Protease Required for Clostridium Spore Germination

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Heterologous Protein Secretion by Bacillus Species

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The intramolecular chaperone-mediated protein folding

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Folding Pathway Mediated by an Intramolecular Chaperone

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Isolation and Characterization of Metalloproteases with a Novel Domain Structure by Construction and Screening of Metagenomic Libraries

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Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3

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Folding Pathway Mediated by an Intramolecular Chaperone

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Processing of peptide and hormone precursors at the dibasic cleavage sites

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The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF

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Insights from Bacterial Subtilases into the Mechanisms of Intramolecular Chaperone-Mediated Activation of Furin

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Germinants and Their Receptors in Clostridia

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Proteasome assembly

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Cloning, sequencing, expression, and characterization of protealysin, a novel neutral proteinase from Serratia proteamaculans representing a new group of thermolysin-like proteases with short N-terminal region of precursor

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Four New Crystal Structures of Tk-subtilisin in Unautoprocessed, Autoprocessed and Mature Forms: Insight into Structural Changes during Maturation

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Independent Intramolecular Mediators of Folding, Activity, and Inhibition for the Plasmodium falciparum Cysteine Protease Falcipain-2

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Folding of the Plasmodium falciparum Cysteine Protease Falcipain-2 Is Mediated by a Chaperone-like Peptide and Not the Prodomain

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Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom

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The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides

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Bacterial adhesins: structural studies reveal chaperone function and pilus biogenesis

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The Metalloprotease ofListeria monocytogenesControls Cell Wall Translocation of the Broad-Range Phospholipase C

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Propeptides as modulators of functional activity of proteases

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Folding pathway mediated by an intramolecular chaperone: the structural and functional characterization of the aqualysin I propeptide

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The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals

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The Metalloprotease ofListeria monocytogenesIs Activated by Intramolecular Autocatalysis

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Crystal Structure of a Subtilisin Homologue, Tk-SP, from Thermococcus kodakaraensis: Requirement of a C-terminal β-Jelly Roll Domain for Hyperstability

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Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species

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A new approach for alteration of protease functions: pro-sequence engineering

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N‐terminal domains of native multidomain proteins have the potential to assist de novo folding of their downstream domains in vivo by acting as solubility enhancers

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Folding Pathway Mediated by an Intramolecular Chaperone: Intrinsically Unstructured Propeptide Modulates Stochastic Activation of Subtilisin

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Multifunctional aspartic peptidase prosegments

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Reassembly of Active Caspase-3 Is Facilitated by the Propeptide

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Enhanced activity of Rhizomucor miehei lipase by directed evolution with simultaneous evolution of the propeptide

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Effects of pre- and pro-sequence of thaumatin on the secretion by Pichia pastoris

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Identification of residues in the Pseudomonas aeruginosa elastase propeptide required for chaperone and secretion activities

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Determination of the Domain of the <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> Cell Surface Proteinase PrtB Involved in Attachment to the Cell Wall after Heterologous Expression of the <i>prtB</i> Gene in <i>Lactococcus lactis</i>

Germond, J.-E., Delley, M., Gilbert, C., & Atlan, D. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.6.3377-3384.2003 · Cited by 36 · see citing works

Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression in Treponema denticola

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cDNA cloning of an alginate lyase from a marine gastropod Aplysia kurodai and assessment of catalytically important residues of this enzyme

Rahman, M. M., Inoue, A., Tanaka, H., & Ojima, T. (2011) · Biochimie · doi:10.1016/j.biochi.2011.06.004 · Cited by 34 · see citing works

The pro‐peptide of proNGF: Structure formation and intramolecular association with NGF

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Positive Selection Dictates the Choice between Kinetic and Thermodynamic Protein Folding and Stability in Subtilases

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The Enzymology of PC1 and PC2

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Folding Pathway Mediated by an Intramolecular Chaperone

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Structural Organization of Precursors of Thermolysin-like Proteinases

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Requirement of Left-Handed Glycine Residue for High Stability of the Tk-Subtilisin Propeptide as Revealed by Mutational and Crystallographic Analyses

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A Redundant Role of Human Thyroid Peroxidase Propeptide for Cellular, Enzymatic, and Immunological Activity

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Pro-interleukin (IL)-1β Shares a Core Region of Stability as Compared with Mature IL-1β While Maintaining a Distinctly Different Configurational Landscape

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Directed evolution of Tk-subtilisin from a hyperthermophilic archaeon: identification of a single amino acid substitution responsible for low-temperature adaptation

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Endoproteolytic Cleavage of Human Thyroperoxidase

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Functional Roles of Furin in Cardio-Cerebrovascular Diseases

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cDNA cloning and bacterial expression of a PL-14 alginate lyase from a herbivorous marine snail Littorina brevicula

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Propeptides Are Sufficient to Regulate Organelle-Specific pH-Dependent Activation of Furin and Proprotein Convertase 1/3

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Identification of Critical Residues in the Propeptide of LasA Protease of Pseudomonas aeruginosa Involved in the Formation of a Stable Mature Protease

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Characterization of a recombinantly expressed proteinase K‐like enzyme from a psychrotrophic Serratia sp.

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Bacterial Actin-Specific Endoproteases Grimelysin and Protealysin as Virulence Factors Contributing to the Invasive Activities of Serratia

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The Mechanism by Which a Propeptide-encoded pH Sensor Regulates Spatiotemporal Activation of Furin

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Functional analysis of the C-terminal propeptide of keratinase from Bacillus licheniformis BBE11-1 and its effect on the production of keratinase in Bacillus subtilis

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Functional analysis of the propeptides of subtilisin E and aqualysin I as intramolecular chaperones

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Large Propeptides of Fungal β-N-Acetylhexosaminidases Are Novel Enzyme Regulators That Must Be Intracellularly Processed to Control Activity, Dimerization, and Secretion into the Extracellular Environment

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Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism

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Requirement of Ca 2+ Ions for the Hyperthermostability of Tk-Subtilisin from Thermococcus kodakarensis

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Cloning of feather-degrading minor extracellular protease from Bacillus cereus DCUW: dissection of the structural domains

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Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family

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Cryptopain-1, a cysteine protease ofCryptosporidium parvum, does not require the pro-domain for folding

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Formation of the High-Affinity Calcium Binding Site in Pro-subtilisin E with the Insertion Sequence IS1 of Pro-Tk-subtilisin

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Substrate-induced activation of a trapped IMC-mediated protein folding intermediate.

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Total chemical synthesis and oxidative folding of δ‐conotoxin PVIA containing an N‐terminal propeptide

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Functional analysis of propeptide as an intramolecular chaperone for in vivo folding of subtilisin nattokinase

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Accelerated maturation of Tk‐subtilisin by a L eu→ P romutation at the C ‐terminus of the propeptide, which reduces the binding of the propeptide to T k‐subtilisin

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Novel Inhibitory Function of the Rhizomucor miehei Lipase Propeptide and Three-Dimensional Structures of Its Complexes with the Enzyme

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A Posttranslationally Regulated Protease, VheA, Is Involved in the Liberation of Juveniles from Parental Spheroids in Volvox carteri

Fukada, K., Inoue, T., & Shiraishi, H. (2006) · The Plant Cell · doi:10.1105/tpc.106.041343 · Cited by 18 · see citing works

Autotomic Behavior of the Propeptide in Propeptide-mediated Folding of Prosubtilisin E

Falzon, L., Patel, S. S., Chen, Y.-J., & Inouye, M. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.019 · Cited by 17 · see citing works

Molecular and Biochemical Properties of a Cysteine Protease of Acanthamoeba castellanii

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The role of substrate specificity and metal binding in defining the activity and structure of an intracellular subtilisin

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Recombinant prosegment peptide acts as a folding catalyst and inhibitor of native pepsin

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Analysis of the effect of potato carboxypeptidase inhibitor pro‐sequence on the folding of the mature protein

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The Propeptide of the Metalloprotease ofListeria monocytogenesControls Compartmentalization of the Zymogen during Intracellular Infection

O'Neil, H. S., Forster, B. M., Roberts, K. L., Chambers, A. J., Bitar, A. P., & Marquis, H. (2009) · Journal of Bacteriology · doi:10.1128/jb.01168-08 · Cited by 14 · see citing works

Crystal structure of native β‐N‐acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide

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Two components of the rhpPC operon coordinately regulate the type III secretion system and bacterial fitness in Pseudomonas savastanoi pv. phaseolicola

Li, K., Zhu, Y., Yan, W., Deng, X., Xiao, Y., Song, L., Fang, R., Jia, Y., & Tang, X. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007673 · Cited by 14 · see citing works

Functional Secretion of a Type 1 Antifreeze Protein Analogue by Optimization of Promoter, Signal Peptide, Prosequence, and Terminator in Lactococcus lactis

Yeh, C., HUANG, X.-H., & Sue, C.-W. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801580s · Cited by 14 · see citing works

Constitutive Expression in Komagataella phaffii of Mature Rhizopus oryzae Lipase Jointly with Its Truncated Prosequence Improves Production and the Biocatalyst Operational Stability

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Expression in Pichia pastoris and characterization of Rhizomucor miehei lipases containing a new propeptide region

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Insights into the Maturation of Hyperthermophilic Pyrolysin and the Roles of Its N-Terminal Propeptide and Long C-Terminal Extension

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pH-Dependent Activation of Streptomyces hygroscopicus Transglutaminase Mediated by Intein

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