The proteasome: overview of structure and functions

THE UBIQUITIN SYSTEM

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STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

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Structure of 20S proteasome from yeast at 2.4Å resolution

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The Proteasome: Paradigm of a Self-Compartmentalizing Protease

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THE UBIQUITIN 26S PROTEASOME PROTEOLYTIC PATHWAY

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The proteasome: a suitable antineoplastic target

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Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

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Diversity of degradation signals in the ubiquitin–proteasome system

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Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

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Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

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Proteasome subunit Rpn13 is a novel ubiquitin receptor

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Antigen processing by the proteasome

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Multiple Associated Proteins Regulate Proteasome Structure and Function

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Regulation of CD8 + T Cell Development by Thymus-Specific Proteasomes

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Molecular mechanisms of proteasome assembly

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Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes

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Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

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MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

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Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry

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The Structure of the Mammalian 20S Proteasome at 2.75 Å Resolution

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The base of the proteasome regulatory particle exhibits chaperone-like activity

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Structural basis for the activation of 20S proteasomes by 11S regulators

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The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

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Proteasome subunit Rpn1 binds ubiquitin-like protein domains

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Altered peptidase and viral-specific T cell response in LMP2 mutant mice

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A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible Subunits

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THE PROTEASOME

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Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14

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Endoproteolytic Activity of the Proteasome

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Autocatalytic Subunit Processing Couples Active Site Formation in the 20S Proteasome to Completion of Assembly

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Proteasome and peptidase function in MHC-class-I-mediated antigen presentation

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Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

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Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

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Delivery of ubiquitinated substrates to protein-unfolding machines

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Hybrid Proteasomes

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Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

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Protein degradation and the generation of MHC class I-presented peptides

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Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

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PA200, a nuclear proteasome activator involved in DNA repair

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Ump1p Is Required for Proper Maturation of the 20S Proteasome and Becomes Its Substrate upon Completion of the Assembly

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Signal integration and diversification through the p62 scaffold protein

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IFN-γ-induced immune adaptation of the proteasome system is an accelerated and transient response

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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

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The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28

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Regulated protein degradation

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Ubiquitin-Independent Degradation of Cell-Cycle Inhibitors by the REGγ Proteasome

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The SRC-3/AIB1 Coactivator Is Degraded in a Ubiquitin- and ATP-Independent Manner by the REGγ Proteasome

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Ubiquitin- and ATP-Independent Proteolytic Turnover of p21 by the REGγ-Proteasome Pathway

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The proteasome activator 11 S REG (PA28) and Class I antigen presentation

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Mass Spectrometric Characterization of the Affinity-Purified Human 26S Proteasome Complex

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An Integrated Mass Spectrometry-based Proteomic Approach

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A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes

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A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

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The proteasome: a utility tool for transcription?

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THE PROTEASOME AND PROTEASOME INHIBITORS IN CANCER THERAPY

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Proteasomes: Machines for All Reasons

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The 1.9 Å Structure of a Proteasome-11S Activator Complex and Implications for Proteasome-PAN/PA700 Interactions

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The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome

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Molecular chaperones: assisting assembly in addition to folding

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Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes

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ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome.

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20S Proteasome Assembly Is Orchestrated by Two Distinct Pairs of Chaperones in Yeast and in Mammals

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A Ubiquitin Stress Response Induces Altered Proteasome Composition

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The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair

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Critical role of PA28γ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis

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Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite

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Protein partners of deubiquitinating enzymes

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The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle

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The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting.

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Growth Retardation in Mice Lacking the Proteasome Activator PA28γ

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A proteasome for all occasions

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Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.

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Immunoproteasome assembly and antigen presentation in mice lacking both PA28α and PA28β

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The proteasome and its role in the degradation of oxidized proteins

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Proteasomes: Structure and Biology

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Dissecting β‐ring assembly pathway of the mammalian 20S proteasome

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β‐Subunit appendages promote 20S proteasome assembly by overcoming an Ump1‐dependent checkpoint

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Cooperation of Multiple Chaperones Required for the Assembly of Mammalian 20S Proteasomes

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A multimeric assembly factor controls the formation of alternative 20S proteasomes

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Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites

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Proteasome activator PA28γ regulates p53 by enhancing its MDM2‐mediated degradation

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REGγ, a proteasome activator and beyond?

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Proteasome Activator PA200 Is Required for Normal Spermatogenesis

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Intramolecular chaperones: polypeptide extensions that modulate protein folding

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Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

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cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome

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Possible mechanism of nuclear translocation of proteasomes

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Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(β5i) incorporation into 20 S proteasomes 1 1Edited by R. Huber

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Molecular properties of the proteasome activator PA28 family proteins and γ‐interferon regulation

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