CoChat
Sign Up
Cited by 65

The DOI matches its Crossref record.

The Importance of Fiber Biopersistence and Lung Dose in Determining the Chronic Inhalation Effects of X607, RCF1, and Chrysotile Asbestos in Rats

Hesterberg, T.W., Hart, G.A., Chevalier, J., Miiller, W.C., Hamilton, R.D., Bauer, J., Thevenaz, P.·1998·Toxicology and Applied Pharmacology
DOI 10.1006/taap.1998.8522
Open this paper in CoChat — free account

Abstract

The chronic inhalation effects in rats of X607 (a rapidly dissolving synthetic vitreous fiber) were compared with those previously reported for RCF1 (a refractory ceramic synthetic vitreous fiber) and chrysotile asbestos. Of primary concern was the importance of biopersistence as a mechanism of fiber toxicity. Fischer rats were exposed to fiber aerosol by nose-only inhalation for 6 h/day, 5 days/week for 2 years. X607 and RCF1 aerosols were similar in concentration (approximately 200 fibers/cc) and average dimensions (approximately 20 x 1 microns). Chrysotile aerosol was higher in concentration (10,600 fibers/cc) and an order of magnitude smaller in average dimensions. Lung fiber deposition after 6 h inhalation was greater for X607 than for RCF1. However, at later time points, fibers/lung (especially long fibers) were much lower for X607 than for RCF1, suggesting less biopersistence for X607. X607 was neither fibrogenic nor tumorigenic and induced only minimal lung cellularity that reversed after exposure was terminated. In contrast, RCF1 and chrysotile asbestos induced pulmonary fibrosis and thoracic neoplasms (chrysotile induced 32% more pulmonary neoplasms than RCF1). Lung deposition and fiber lengths did not explain the toxicologic differences between the three fibers. Fiber biodurability, including chemical and physical parameters, appears to be a major toxicologic determinant here. Chemical analysis of lung fibers revealed rapid leaching of X607 compared to RCF1. In in…

Overview

Integrity signals

Registry

Crossref · 10.1006/taap.1998.8522

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 30

  1. Bernstein, 1996, Evaluation of soluble fibers using the inhalation biopersistence model, a nine-fiber comparison, Inhal. Tox., 8, 345, 10.3109/08958379609052913 · DOI
  2. Bernstein, 1995, Evalution of the oncogenic potential of man-made vitreous fibers: the inhalation model, Annals of Occupational Hygiene, 39, 661, 10.1093/annhyg/39.5.661 · DOI
  3. Cannon, 1983, The flow-past chamber: An improved nose-only exposer system for rodents, Am. Ind. Hyg. Assoc. J., 44, 923, 10.1080/15298668391405959 · DOI
  4. Hammad, Y. Y. 1984, Deposition and elimination of MMMF, Biological Effects of Synthetic Mineral Fibers, 2, 126, 142, Academic Press, California
  5. Hart, G. A. Kathman, L. M. Hesterberg, T. W. 1994, In vitro cytotoxicity of asbestos and man-made vitreous fibers: Roles of fiber length, diameter and composition · DOI · Paper page
  6. Hesterberg, 1997, Chronic inhalation study of fiber glass and amosite asbestos in hamsters: Twelve-month preliminary results, Environ. Health Perspec., 105, 1223, 10.1289/ehp.97105s51223 · DOI
  7. Hesterberg, 1998, Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation, Toxicol. Appl. Pharmacol., 10.1006/taap.1998.8472 · DOI · Paper page
  8. Hesterberg, 1993, Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats, Fundam. Appl. Toxicol., 20, 464, 10.1006/faat.1993.1057 · DOI · Paper page
  9. Hesterberg, 1996, Biopersistence of man-made vitreous fibers and crocidolite asbestos in the rat lung following inhalation, Fundam. Appl. Toxicol., 29, 267, 10.1006/faat.1996.0031 · DOI · Paper page
  10. Hesterberg, 1996, Physical and chemical transformation of synthetic vitreous fibres in the lung and in vitro, J. Occup. Health Safety–Aust, NZ, 12, 345
  11. Hesterberg, 1996, Use of lung toxicity and lung particle clearance to estimate the maximum tolerated dose (MTD) for a fiber glass chronic inhalation study in the rat, Fundam. Appl. Toxicol., 32, 31, 10.1006/faat.1996.0104 · DOI
  12. Hill, J. W. 1980, Review of the epidemiology of synthetic mineral fibers, Biologic Effects of Mineral Fibres, J. C. Wagner, 979, 983, IARC, Lyon
  13. Hughes, 1993, Follow up study of workers exposed to man made mineral fibres, Br. J. Ind. Med., 50, 658
  14. Law, 1990, Solubility of polymeric organic fibers and man-made vitreous fibers in gambles solution, Inhalation Toxicology, 2, 321, 10.3109/08958379009145261 · DOI
  15. LeBouffant, 1987, Experimental study of long term effects of MMMF on rat lungs, Ann. Occup. Hyg., 31, 765, 10.1093/annhyg/31.4B.765 · DOI
  16. Marsh, 1996, Mortality among United States rock wool and slag wool workers: 1989 Update, J. Occup. Health Safety–Aust, NZ., 12, 297
  17. Marsh, 1990, Mortality among a cohort of US man-made mineral fiber workers: 1985 Follow-up, J. Occup. Med., 32, 594, 10.1097/00043764-199007000-00009 · DOI
  18. Mast, 1995, Multiple-dose chronic inhalation toxicity study of size-separated kaolin refractory ceramic fiber in male fischer 344 rats, Inhal. Toxicol., 7, 469, 10.3109/08958379509015209 · DOI
  19. Mast, 1995, Studies on the chronic toxicity (inhalation) of refractory ceramic fiber in male Fischer 344 rats, Inhal. Toxicol., 7, 425, 10.3109/08958379509015208 · DOI · Paper page
  20. McConnell, 1994, Chronic inhalation study of size-separated rock and slag wool insulation fibers in Fischer 344/N rats, Inhal. Toxicol., 6, 571, 10.3109/08958379409003042 · DOI · Paper page
  21. McConnell, 1995, Chronic inhalation toxicity of a kaolin based refractory ceramic fiber (RCF) in Syrian golden hamsters, Inhal. Toxicol., 7, 503, 10.3109/08958379509015210 · DOI · Paper page
  22. Pott, F. Schlipkoter, H. W. Ziem, U. Spurny, K. Huth, F. 1984a, New results from implantation experiments with mineral fibres, Biological Effects of Synthetic Mineral Fibres. Proceedings of a WHO/IARC Conference, 2, 286, 302, WHO, Copenhagen
  23. Saracci, 1982, Synthetic vitreous fibers and workers health. An overview of the epidemiologic evidence, Scand. J. Work Environ. Health, 8, 234, 10.5271/sjweh.2471 · DOI
  24. Smith, 1987, Long-term effects in hamster and rats exposed chronically to synthetic vitreous fibres, Ann. Occup. Hyg., 31, 731, 10.1093/annhyg/31.4B.731 · DOI
  25. Stanton, 1977, Carcinogenicity of fibrous glass: Pleural response in the rat in relation to fiber dimension, J. Natl. Cancer Inst., 58, 587, 10.1093/jnci/58.3.587 · DOI · Paper page
  26. Stanton, 1981, Relation of particle dimension to carcinogenicity in amphibate asbestoses and other fibrous minerals, J. Natl. Cancer Inst., 67, 959
  27. Stanton, 1972, Mechanisms of mesothelioma induction with asbestos and fibrous glass, J. Natl. Cancer Inst., 48, 797
  28. Wagner, J. C. Berry, G. B. Hull, R. J. Munday, D. E. Skidmore, J. W. 1984, Animal experiments with MMM(V)F— Effects of inhalation and intrapleural inoculation in rats, Biological Effects of Synthetic Mineral Fibers. Proceedings of WHO/IARC Conference, 2, 209, 234, World Health Organization, Copenhagen
  29. Warheit, 1990, Species comparison of alveolar deposition patterns of inhaled particles, Exp. Lung Res., 16, 83, 10.3109/01902149009087874 · DOI
  30. Zoitos, 1997, In vitromeasurement of fiber dissolution rate relevant to biopersistence at Neutral pH: An interlaboratory round robin, Inhal. Toxicol., 9, 525, 10.1080/089583797198051 · DOI

Cited by

Sorted by citations

See all 65

Metadata

Authors
Hesterberg, T. W., Hart, G. A., Chevalier, J., Miiller, W. C., Hamilton, R. D., Bauer, J., & Thevenaz, P.
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
1998-11
Volume
153
Issue
1
Pages
68-82
ISSN
0041-008X
DOI
10.1006/taap.1998.8522
Cited by
65
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The Importance of Fiber Biopersistence and Lung Dose in Determining the Chronic Inhalation Effects of X607, RCF1, and Chrysotile Asbestos in Rats. https://app.cochat.ai/papers/10.1006/taap.1998.8522
The paper
Hesterberg, T. W., Hart, G. A., Chevalier, J., Miiller, W. C., Hamilton, R. D., Bauer, J., & Thevenaz, P. (1998). The Importance of Fiber Biopersistence and Lung Dose in Determining the Chronic Inhalation Effects of X607, RCF1, and Chrysotile Asbestos in Rats. Toxicology and Applied Pharmacology. https://doi.org/10.1006/taap.1998.8522