Cited by 241Cancer, Hypoxia, and MetabolismErythropoietin and Anemia TreatmentAngiogenesis and VEGF in Cancer

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Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

Semenza, Gregg L., Agani, Faton, Feldser, David, Lyer, Narayan, Kotch, Lori, Laughner, Erik, Yu, 1]Aimee·2006·Advances in Experimental Medicine and Biology

DOI 10.1007/0-306-46825-5_12

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Abstract

Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality, including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart failure. In these disease states, hypoxia induces changes in gene expression in target organs that either fail to result in adequate adaptation or directly contribute to disease pathogenesis. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that is expressed in response to cellular hypoxia and mediates multiple cellular and systemic homeostatic responses to hypoxia. Recent studies have provided evidence that important pathophysiological responses to hypoxia in pulmonary hypertension, myocardial ischemia, and cancer are mediated by HIF-1. Pharmacologic and gene therapy strategies designed to modulate HIF-1 activity may represent a novel and effective therapeutic approach to these common disorders.

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Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
Self-citation
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citation
Untitled work
(1989) · PubMed · Cited by 3,343
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citation
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Self-citation
Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Self-citation
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914
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Authors: Semenza, G. L., Agani, F., Feldser, D., Lyer, N., Kotch, L., Laughner, E., & Yu, 1.
Affiliations: Johns Hopkins University (US)
ORCID: Semenza, Gregg L.
Feldser, David
Venue: Advances in Experimental Medicine and Biology
Publisher: Kluwer Academic Publishers
Published: 2006-03-05
Volume: 475
Pages: 123-130
DOI: 10.1007/0-306-46825-5_12
OpenAlex: W2116889376
Cited by: 241
References: 33
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 12 · 2015: 9 · 2014: 5 · 2013: 13 · 2012: 11
FWCI: 40.79
Type: book chapter
Language: en
Open access: closed
Locations: Kluwer Academic Publishers eBooks (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Johns Hopkins University
National Institutes of Health (5r01dk039869-16)
National Heart, Lung, and Blood Institute (R01HL55338, R01HL055338)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK39869)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: hypoxia, HIF-1, ischemic heart disease, stroke, cancer, chronic lung disease, congestive heart failure, pulmonary hypertension, myocardial ischemia, gene expression, transcriptional regulation, gene therapy
MeSH terms: Animals, Hypoxia, DNA-Binding Proteins, Embryonic and Fetal Development, Humans, Hypertension, Pulmonary, Lymphokines, Myocardial Revascularization, Neoplasms, Nuclear Proteins, Transcription Factors, Genetic Therapy, Gene Expression, Endothelial Growth Factors, Mice, Knockout, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

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