Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981

Untitled work

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617

Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476

Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway

Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094

Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob / ob and dietary obese mice

Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840

Pulmonary Arterial Hypertension

McLaughlin, V. V., & McGoon, M. D. (2006) · Circulation · doi:10.1161/circulationaha.104.503540 · Cited by 667

Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801 , Involved in Apoptosis

Shoshani, T., Faerman, A., Mett, I., Zelin, E., Tenne, T., Gorodin, S., Moshel, Y., Elbaz, S., Budanov, A., Chajut, A., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2283-2293.2002 · Cited by 546

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 556

Physiological roles for ecto-5’-nucleotidase (CD73)

Colgan, S. P., Eltzschig, H. K., Eckle, T. D. L. G., & Thompson, L. F. (2006) · Purinergic Signalling · doi:10.1007/s11302-005-5302-5 · Cited by 496

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471

Regulation of HIF-1α Stability through S-Nitrosylation

Li, F., Sonveaux, P., Rabbani, Z. N., Liu, S., Yan, B., Huang, Q., Vujašković, Ž., Dewhirst, M. W., & Li, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.024 · Cited by 444

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368

Decreased Cardiac Expression of Vascular Endothelial Growth Factor and Its Receptors in Insulin-Resistant and Diabetic States

Chou, E. L., Suzuma, I., Way, K. J., Opland, D. M., Clermont, A. C., Naruse, K., Suzuma, K., Bowling, N. L., Vlahos, C. J., Aiello, L. P., et al. (2002) · Circulation · doi:10.1161/hc0302.102143 · Cited by 339

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

Gong, H., Chao, Y., Xiang, J., Han, X., Song, G., Feng, L., Liu, J., Yang, G., Chen, Q., & Liu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b00068 · Cited by 323

The role of low-grade inflammation in the polycystic ovary syndrome

Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 310

Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1α Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression

Peng, X.-H., Karna, P., Cao, Z., Jiang, B., Zhou, M., & Yang, L. P. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603414200 · Cited by 298

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

Zhang, L., Huang, G., Li, X., Zhang, Y., Jiang, Y., Shen, J., Liu, J., Wang, Q., Zhu, J., Feng, X., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-108 · Cited by 303

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

Siddiq, A., Ayoub, I. A., Chavez, J. C., Aminova, L. R., Shah, S., LaManna, J. C., Patton, S. M., Connor, J. R., Cherny, R. A., Volitakis, I., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504963200 · Cited by 282

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of β 2 integrin gene expression

Kong, T., Eltzschig, H. K., Karhausen, J., Colgan, S. P., & Shelley, C. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401339101 · Cited by 242

Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish

van der Meer, D. L. M., van den Thillart, G. E. E. J. M., Witte, F., Bakker, M., Besser, J., Richardson, M. K., Spaink, H. P., Leito, J. T. D., & Bagowski, C. P. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00089.2005 · Cited by 238

Serum Levels of Vascular Endothelial Growth Factor Are Elevated in Patients with Obstructive Sleep Apnea and Severe Nighttime Hypoxia

Schulz, R., Hummel, C., Heinemann, S., Seeger, W., & Grimminger, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2101062 · Cited by 228

Association of hypoxia‐inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

Sivridis, E., Giatromanolaki, A., Gatter, K. C., Harris, A. L., Koukourakis, M. I., & for the Tumor and Angiogenesis Research Group (2002) · Cancer · doi:10.1002/cncr.10774 · Cited by 218

Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells

Santilli, G., Lamorte, G., Carlessi, L., Ferrari, D., Nodari, L. R., Binda, E., Delia, D., Vescovi, A. L., & Filippis, L. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008575 · Cited by 198

Molecular Mechanisms for Early Brain Injury After Subarachnoid Hemorrhage

Ostrowski, R. P., Colohan, A. R. T., & Zhang, J. H. (2006) · Springer eBooks · doi:10.1007/978-0-387-30383-3_13 · Cited by 192

Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia

Kuhlicke, J., Frick, J.-S., Morote–Garcia, J. C., Rosenberger, P., & Eltzschig, H. K. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001364 · Cited by 190

Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Janaszak‐Jasiecka, A., Siekierzycka, A., Płoska, A., Dobrucki, I. T., & Kalinowski, L. (2021) · Biomolecules · doi:10.3390/biom11070982 · Cited by 197

Divergent effects of hypoxia on dendritic cell functions

Mancino, A., Schioppa, T., Larghi, P., Pasqualini, F., Nebuloni, M., Chen, I., Sozzani, S., Austyn, J. M., Mantovani, A., & Sica, A. (2008) · Blood · doi:10.1182/blood-2008-02-142091 · Cited by 191

Vascular endothelial growth factor and related molecules in acute lung injury

Mura, M., dos Santos, C. C., Stewart, D., & Liu, M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00202.2004 · Cited by 179

Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

Kilic, M., Kasperczyk, H., Fulda, S., & Debatin, K. (2006) · Oncogene · doi:10.1038/sj.onc.1210008 · Cited by 170

Ferroptosis in Neurological Diseases

Ren, J., Sun, X., Yan, X., Guo, Z., & Yang, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00218 · Cited by 163

Dephosphorylation of Cell Cycle–regulated Proteins Correlates with Anoxia-induced Suspended Animation in Caenorhabditis elegans

Padilla, P. A., Nystul, T. G., Zager, R. A., Johnson, A. C. M., & Roth, M. B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0594 · Cited by 161

Glomeruloid Microvascular Proliferation Orchestrated by VPF/VEGF

Brat, D. J., & Meir, E. G. V. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64025-4 · Cited by 156

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

Bartoszewska, S., & Collawn, J. F. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00212-1 · Cited by 155

Increase of SUMO-1 expression in response to hypoxia: Direct interaction with HIF-1α in adult mouse brain and heart in vivo

Shao, R., Zhang, F.-P., Tian, F., Anders Friberg, P., Wang, X., Sjöland, H., & Billig, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.079 · Cited by 149

Mitochondrial Dysfunction in COPD Patients with Low Body Mass Index

Rabinovich, R. A., Bastos, R., Ardite, E., Llinàs, L., Orozco-Levi, M., Gea, J., Vilaró, J., Barberà, J. A., Rodríguez-Roisin, R., Fernández-Checa, J. C., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00086306 · Cited by 144

The Role of Hypoxia Inducible Factor 1 in Cobalt Chloride Induced Cell Death in Mouse Embryonic Fibroblasts

Vengellur, A. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh278 · Cited by 142

Hypoxia-Inducible Factor-2α Transactivates Abcg2 and Promotes Cytoprotection in Cardiac Side Population Cells

Martin, C. M., Ferdous, A., Gallardo, T., Humphries, C., Sadek, H., Caprioli, A., Garcia, J. A., Szweda, L. I., Garry, M. G., & Garry, D. J. (2008) · Circulation Research · doi:10.1161/circresaha.107.161729 · Cited by 133

Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Muthana, M., Giannoudis, A., Scott, S. D., Fang, H., Coffelt, S. B., Morrow, F. J., Murdoch, C., Burton, J., Cross, N. A., Burke, B., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2349 · Cited by 127

Antitumor activity of pyrvinium pamoate, 6‐(dimethylamino)‐2‐[2‐(2,5‐dimethyl‐1‐phenyl‐1 H‐pyrrol‐3‐yl)ethenyl]‐1‐methyl‐quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation

Esumi, H., Lu, J., Kurashima, Y., & Hanaoka, T. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03330.x · Cited by 127

Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

Salnikov, A. V., Liu, L., Platen, M., Gladkich, J., Salnikova, O. V., Ryschich, E., Mattern, J., Moldenhauer, G., Werner, J., Schemmer, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046391 · Cited by 132

Neuroprotective and neuritogenic activities of novel multimodal iron‐chelating drugs in motor‐neuron‐like NSC‐34 cells and transgenic mouse model of amyotrophic lateral sclerosis

Kupershmidt, L., Weinreb, O., Amit, T., Mandel, S. A., Carrì, M. T., & Youdim, M. B. H. (2009) · The FASEB Journal · doi:10.1096/fj.09-130047 · Cited by 123

Enhancement of Hypoxia-Induced Tumor Cell Death In vitro and Radiation Therapy In vivo by Use of Small Interfering RNA Targeted to Hypoxia-Inducible Factor-1α

Zhang, X., Kon, T., Wang, H., Li, F., Huang, Q., Rabbani, Z. N., Kirkpatrick, J. P., Vujaskovic, Z., Dewhirst, M. W., & Li, C.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2301 · Cited by 120

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

Chen, C., Hu, Q., Yan, J., Yang, X., Shi, X., Lei, J., Chen, L., Huang, H., Han, J., Zhang, J. H., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.010 · Cited by 122

Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface

Eltzschig, H. K., MacManus, C. F., & Colgan, S. P. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2008.01.006 · Cited by 121

Hypoxia-inducible factor-1α signaling in aquaporin upregulation after traumatic brain injury

Ding, J. Y., Kreipke, C. W., Speirs, S. L., Schafer, P. C., Schafer, S., & Rafols, J. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.077 · Cited by 103

The Role of Nitric Oxide in Myocardial Repair and Remodeling

Otani, H. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2453 · Cited by 108

JNK1 Mediates Degradation HIF-1α by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70

Zhang, D., Li, J., Costa, M., Gao, J., & Huang, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-0448 · Cited by 99

Selective induction of integrin βi by hypoxia‐inducible factor: implications for wound healing

Keely, S., Glover, L. E., MacManus, C. F., Campbell, E. L., Scully, M. M., Furuta, G. T., & Colgan, S. P. (2008) · The FASEB Journal · doi:10.1096/fj.08-125344 · Cited by 102

Genetic and Biologic Progression in Astrocytomas and Their Relation to Angiogenic Dysregulation

Brat, D. J., Castellano-Sanchez, A. A., Kaur, B., & Meir, E. G. V. (2002) · Advances in Anatomic Pathology · doi:10.1097/00125480-200201000-00004 · Cited by 96

Stem cell-based delivery of Hypoxamir-210 to the infarcted heart: implications on stem cell survival and preservation of infarcted heart function

Kim, H. W., Jiang, S., Ashraf, M., & Haider, K. H. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0920-1 · Cited by 94

Apoptosis-Resistance of Hypoxic Cells

Dong, Z., Wang, J. Z., Yu, F. X., & Venkatachalam, M. A. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63693-0 · Cited by 99

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia

Ariazi, J. L., Duffy, K. J., Adams, D. F., Fitch, D. M., Luo, L., Pappalardi, M. B., Biju, M. P., DiFilippo, E. H., Shaw, T., Wiggall, K., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.242503 · Cited by 94

Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis

Goteri, G., Lucarini, G., Montik, N., Zizzi, A., Stramazzotti, D., Fabris, G., Tranquilli, A. L., & Ciavattini, A. (2009) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318182c2be · Cited by 88

Obesity, sleep apnea, and cancer

Almendros, I., Martínez‐García, M. Á., Farré, R., & Gozal, D. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0549-z · Cited by 93

Hypoxia/reoxygenation: A dynamic regulator of lysyl oxidase‐facilitated breast cancer migration

Postovit, L.-M. M., Abbott, D. E., Raimondi, S. L., Wheaton, W. W., Margaryan, N. V., Sullivan, R., Jansen, M. K., Csiszár, K., Hendrix, M. J. C., & Kirschmann, D. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21517 · Cited by 88

Fhl-1, a New Key Protein in Pulmonary Hypertension

Kwapiszewska, G., Wygrecka, M., Marsh, L. M., Schmitt, S., Troesser, R., Wilhelm, J., Helmus, K., Eul, B. G., Zakrzewicz, A., Ghofrani, H. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.761916 · Cited by 88

Cardiomyopathy Associated with Microcirculation Dysfunction in Laminin α4 Chain-deficient Mice

Wang, J., Hoshijima, M., Lam, J. T., Zhou, Z., Jokiel, A., Dalton, N. D., Hultenby, K. R., Ruiz‐Lozano, P., ROSS, J. R., Tryggvason, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505061200 · Cited by 87

A Group of Novel HIF‐1α Inhibitors, Glyceollins, Blocks HIF‐1α Synthesis and Decreases Its Stability via Inhibition of the PI3K/AKT/mTOR Pathway and Hsp90 Binding

Lee, S., Jee, J., Bae, J., Liu, K., & Lee, Y. M. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.24813 · Cited by 86

Hypoxia Selection of Death-resistant Cells

Dong, Z., & Wang, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312225200 · Cited by 86

Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion induced focal ischemia rat model

Chen, C., Hu, Q., Yan, J., Lei, J., Qin, L., Shi, X., Luan, L., Yang, L., Wang, K., Han, J., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.004652.x · Cited by 85

Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia

Wójciak‐Stothard, B., Zhao, L., Oliver, E., Dubois, O., Wu, Y., Kardassis, D., Vasilaki, E., Huang, M., Mitchell, J. A., Mackenzie, L. S., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.264473 · Cited by 84

Identification and function of hypoxia-response genes in Drosophila melanogaster

Liu, G., Roy, J., & Johnson, E. A. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00262.2005 · Cited by 82

Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue

Malik, I. A., Moriconi, F., Sheikh, N., Naz, N., Khan, S., Dudás, J., Mansuroglu, T., Hess, C. F., Rave‐Fränk, M., Christiansen, H., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090505 · Cited by 81

Effect of hypoxia on Ad5 infection, transgene expression and replication

Shen, B. H., & Hermiston, T. W. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302448 · Cited by 84

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs

Mercurio, V., Pirozzi, F., Lazzarini, E., Marone, G., Rizzo, P., Agnetti, G., Tocchetti, C. G., Ghigo, A., & Ameri, P. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.04.008 · Cited by 80

Dexmedetomidine protects against oxygen–glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells

Zhang, F., Ding, T., Yu, L., Zhong, Y., Dai, H., & Yan, M. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01382.x · Cited by 79

A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant–iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate

Weinreb, O., Amit, T., & Youdim, M. B. H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.011 · Cited by 78

Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide

Li, B., Chen, M., Liu, X., & Guo, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.028 · Cited by 78

Alterations in TGF-β1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension

Mata‐Greenwood, E., Meyrick, B. O., Steinhorn, R. H., Fineman, J. R., & Black, S. M. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00171.2002 · Cited by 77

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

Dai, X.-Y., Zhuang, L., Wang, D., Zhou, T., Chang, L.-L., Gai, R., Zhu, D., Yang, B., Zhu, H., & He, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.6903 · Cited by 74

From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia

Martín, D., & Windsor, J. S. (2008) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.068296 · Cited by 73

Induced Inhibition of Ischemic/Hypoxic Injury by APIP, a Novel Apaf-1-interacting Protein

Cho, D., Hong, Y., Lee, H., Woo, H., Pyo, J.-O., Mak, T. W., & Jung, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405747200 · Cited by 70

Multiple across-strain and within-strain QTLs suggest highly complex genetic architecture for hypoxia tolerance in channel catfish

Wang, X., Liu, S., Jiang, C., Geng, X., Zhou, T., Li, N., Bao, L., Li, Y., Yao, J., Yang, Y., et al. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1256-2 · Cited by 70

Cytoprotective Effects of Hypoxia against Cisplatin-Induced Tubular Cell Apoptosis

Wang, J., Biju, M. P., Wang, M.-H., Haase, V. H., & Dong, Z. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121371 · Cited by 68

Antioxidant therapeutics: Pandora′s box

Day, B. J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.047 · Cited by 67

Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1α

Huang, L., Ao, Q., Zhang, Q., Yang, X., Xing, H., Li, F., Chen, G., Zhou, J., Wang, S., Xu, G., et al. (2009) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-009-0675-4 · Cited by 66

Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation

Zhu, X.-Y., Daghini, E., Chade, A., Lavi, R., Claudio Napoli, A., Lerman, A., & Lerman, L. O. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.09.029 · Cited by 65

Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage

Tulsawani, R., Kelly, L. S., Fatma, N., Chhunchha, B., Kubo, E., Kumar, A., & Singh, D. P. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-125 · Cited by 66

Oxygen in the regulation of intestinal epithelial transport

Ward, J. B. J., Keely, S., & Keely, S. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270249 · Cited by 65

COMMD1: A Multifunctional Regulatory Protein

Riera‐Romo, M. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26151 · Cited by 67

Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension

Mata‐Greenwood, E., Meyrick, B. O., Soifer, S. J., Fineman, J. R., & Black, S. M. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00388.2002 · Cited by 65

mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α

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