Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011

Interneurons of the hippocampus

Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,478

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728

Role of Endogenous Cannabinoids in Synaptic Signaling

Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,616

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586

Brain monoglyceride lipase participating in endocannabinoid inactivation

Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373

Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

Katona, I., Sperlágh, B., Sı́k, A., Käfalvi, A., Vizi, E. S., Mackie, K., & Freund, T. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04544.1999 · Cited by 1,218

CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity

Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Gutiérrez, S. O., van der Stelt, M., et al. (2003) · Science · doi:10.1126/science.1088208 · Cited by 1,208

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ 1 Opioid Receptor Mechanism

Tanda, G., Pontieri, F. E., & Chiara, G. D. (1997) · Science · doi:10.1126/science.276.5321.2048 · Cited by 1,085

Endocannabinoids and Heterogeneity of Glial Cells in Brain Function

Scheller, A., & Kirchhoff, F. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2016.00024 · Cited by 28

Methamphetamine-seeking behavior is due to inhibition of nicotinic cholinergic transmission by activation of cannabinoid CB1 receptors

Hiranita, T., Nawata, Y., Sakimura, K., & Yamamoto, T. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.012 · Cited by 26

Effects of Cannabis on Glutamatergic Neurotransmission: The Interplay between Cannabinoids and Glutamate

Chowdhury, K. U., Holden, M. E., Wiley, M. T., Suppiramaniam, V. D., & Reed, M. N. (2024) · Cells · doi:10.3390/cells13131130 · Cited by 25

The Yin and Yang of Cannabis: A Systematic Review of Human Neuroimaging Evidence of the Differential Effects of Δ9-Tetrahydrocannabinol and Cannabidiol

Gunasekera, B., Davies, C., Martín‐Santos, R., & Bhattacharyya, S. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.10.007 · Cited by 27

Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice

Shapiro, L. E., Gado, F., Manera, C., & Escayg, A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108448 · Cited by 25

Cannabinoid Receptor Type 2 Ligands: An Analysis of Granted Patents Since 2010

Brennecke, B., Gazzi, T., Atz, K., Fingerle, J., Kuner, P., Schindler, T., WECK, G. D., Nazaré, M., & Grether, U. (2021) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2021-0002 · Cited by 25

Prenatal cannabinoid exposure and altered neurotransmission

Pinky, P. D., Bloemer, J., Smith, W. D., Moore, T., Hong, H., Suppiramaniam, V. D., & Reed, M. N. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.018 · Cited by 26

CB2 Receptor Involvement in the Treatment of Substance Use Disorders

Navarrete, F., García‐Gutiérrez, M. S., Gasparyan, A., Navarro, D., & Manzanares, J. (2021) · Biomolecules · doi:10.3390/biom11111556 · Cited by 27

Exposure to cannabinoid agonist WIN 55,212-2 during early adolescence increases alcohol preference and anxiety in CD1 mice

Frontera, J. L., Pini, V. M. G., Messore, F., & Brusco, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.018 · Cited by 24

On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors

Pucci, M., Zaplatić, E., Bonaventura, M. V. M. D., Bonaventura, E. M. D., Cristofaro, P. D., Maccarrone, M., Cifani, C., & D’Addario, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010398 · Cited by 27

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Vaseghi, S., Arjmandi-Rad, S., Nasehi, M., & Zarrindast, M. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113440 · Cited by 24

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Raux, P., Drutel, G., Revest, J., & Vallée, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13034 · Cited by 24

Update on the controversial identity of cells expressing cnr2 gene in the nervous system

Grabon, W., Bodennec, J., Rheims, S., Belmeguenaï, A., & Bezin, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13977 · Cited by 24

Identification ofN‐arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1receptors

Redmond, W. J., Cawston, E. E., Grimsey, N. L., Stuart, J. M., Edington, A. R., Glass, M., & Connor, M. A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13341 · Cited by 24

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Freundt-Revilla, J., Heinrich, F., Zoerner, A. A., Gesell, F. K., Beyerbach, M., Shamir, M. H., Oevermann, A., Baumgärtner, W., & Tipold, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0187197 · Cited by 24

Association of Marijuana Use with Changes in Cognitive Processing Speed and Flexibility for 17 Years in HIV-Seropositive and HIV-Seronegative Men

Okafor, C. N., Plankey, M. W., Li, M. J., Chen, X., Surkan, P. J., SHOPTAW, S. J., Martin, E. M., Cohen, R. A., Sacktor, N. C., & Cook, R. L. (2019) · Substance Use & Misuse · doi:10.1080/10826084.2018.1495736 · Cited by 24

CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing

Aiello, F., Afflitto, G. G., Li, J.-P. O., Martucci, A., Cesareo, M., & Nucci, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124036 · Cited by 24

Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis

Khan, H., Ghori, F. K., Ghani, U., Javed, A., & Zahid, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07223-5 · Cited by 24

Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB 1 R) “Cis-On” Agonist

Rodríguez‐Soacha, D. A., Steinmüller, S. A. M., Işbilir, A., Fender, J., Deventer, M. H., Ramírez, Y. A., Tutov, A., Sotriffer, C., Stove, C. P., Lorenz, K., et al. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00160 · Cited by 23

Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease

Tadaiesky, M. T., Dombrowski, P. A., Cunha, C. D., & Takahashi, R. N. (2010) · Parkinson s Disease · doi:10.4061/2010/238491 · Cited by 23

Molecular Mechanisms of Cannabis Signaling in the Brain

Ronan, P. J., Wongngamnit, N., & Beresford, T. P. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.10.002 · Cited by 25

Cannabinoids and the Cannabinoid Receptors: An Overview

Lu, D., & Potter, D. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00068-5 · Cited by 23

Intrinsic Frontolimbic Connectivity and Mood Symptoms in Young Adult Cannabis Users

Shollenbarger, S. G., Thomas, A. M., Wade, N. E., Gruber, S. A., Tapert, S. F., Filbey, F. M., & Lisdahl, K. M. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00311 · Cited by 24

The role of the endocannabinoid system in autism spectrum disorders: Evidence from mouse studies

Pietropaolo, S., Bellocchio, L., Bouzón‐Arnáiz, I., & Yee, B. K. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.016 · Cited by 24

The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models

Pietropaolo, S., & Marsicano, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.031 · Cited by 23

Maternal separation: Does it hold the potential to model consequences of postpartum depression?

Mundorf, A., Bölükbas, I., & Freund, N. (2022) · Developmental Psychobiology · doi:10.1002/dev.22219 · Cited by 27

Entropy drives the ligand recognition in G-protein-coupled receptor subtypes

Yang, X., Zhou, P., Shen, S., Hu, Q., Tian, C., Xia, A., Wang, Y., Yang, Z., Nan, J., Zhou, Y., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2401091121 · Cited by 22

The altered state of consciousness induced by Δ9-THC

Murray, C. H., & Desikan, B. S. (2022) · Consciousness and Cognition · doi:10.1016/j.concog.2022.103357 · Cited by 22

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ9‐tetrahydrocannabinol

Flores, Á., Julià‐Hernández, M., Maldonado, R. J., & Berrendero, F. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13440 · Cited by 22

Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain

Perdikaris, P., Tsarouchi, M., Fanarioti, Ε., Natsaridis, E., Mitsacos, A., & Giompres, P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.005 · Cited by 23

Chronic pain and cannabinoids. Great expectations or a christmas carol

Pascual, D., Sánchez-Robles, E., García, M. M., & Goicoechea, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.033 · Cited by 22

Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes

Kim, H. J. J., Zagzoog, A., Black, T., Baccetto, S. L., Ezeaka, U. C., & Laprairie, R. B. (2022) · Pharmacology Research & Perspectives · doi:10.1002/prp2.950 · Cited by 22

Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells

Stanslowsky, N., Jahn, K., Venneri, A., Naujock, M., Haase, A., Martin, U., Frieling, H., & Wegner, F. (2016) · Addiction Biology · doi:10.1111/adb.12394 · Cited by 22

Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence

Safi, K., Sobieraj, J., Błaszkiewicz, M., Żyła, J., Salata, B., & Dzierżanowski, T. (2024) · Biomedicines · doi:10.3390/biomedicines12020307 · Cited by 21

1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability

Riether, D., Wu, L., Cirillo, P. F., Berry, A. K., Walker, E. R. H., Ermann, M., Noya-Marino, B., Jenkins, J. E., Albaugh, D., Albrecht, C., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.02.017 · Cited by 21

Design, Synthesis, and Pharmacological Properties of New Heteroarylpyridine/Heteroarylpyrimidine Derivatives as CB2 Cannabinoid Receptor Partial Agonists

Tabrizi, M. A., Baraldi, P. G., Saponaro, G., Moorman, A. R., Romagnoli, R., Preti, D., Baraldi, S., Corciulo, C., Vincenzi, F., Borea, P. A., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301527r · Cited by 21

Cannabinoids in Health and Disease

Meccariello, R., & Chianese, R. (2016) · InTech eBooks · doi:10.5772/61595 · Cited by 22

How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?

Vaseghi, S., Nasehi, M., & Zarrindast, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.018 · Cited by 21

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis

Theunissen, E. L., Reckweg, J. T., Hutten, N. R. P. W., Kuypers, K. P. C., Toennes, S. W., Neukamm, M. A., Halter, S., & Ramaekers, J. G. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05768-0 · Cited by 21

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Jelsing, J., Larsen, P. J., & Vrang, N. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.07.011 · Cited by 21

Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy

Ortega, Á., Salazar, J. J., Galbán, N., Rojas, M., Ariza, D. V., Chávez-Castillo, M., Nava, M., Riaño-Garzón, M., Díaz-Camargo, E. A., Medina, Ó., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084196 · Cited by 22

A critical assessment of the abuse, dependence and associated safety risks of naturally occurring and synthetic cannabinoids

Heal, D. J., Gosden, J., & Smith, S. L. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1322434 · Cited by 20

Involvement of the nucleus accumbens shell glutamatergic system in ACPA-induced impairment of inhibitory avoidance memory consolidation

Rasekhi, K., Oryan, S., Nasehi, M., & Zarrindast, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.006 · Cited by 20

Molecular Imaging of the Cannabinoid System in Idiopathic Parkinson's Disease

Cilia, R. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.08.004 · Cited by 20

Medication overuse headache in patients with chronic migraine using cannabis: A case–referent study

Zhang, N., & Woldeamanuel, Y. W. (2021) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14195 · Cited by 19

Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB1R expression or estrous cyclicity

Chadwick, B. J., Saylor, A. J., & López, H. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.006 · Cited by 19

Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder

Bedse, G., Centanni, S. W., Winder, D. G., & Patel, S. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14159 · Cited by 19

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Wu, M. M., Zhang, X., Asher, M. J., & Thayer, S. A. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146467 · Cited by 19

The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia

Gerdeman, G. L., & Fernández‐Ruíz, J. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_21 · Cited by 19

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Prete, M. M., Feitosa, G. T. B., Ribeiro, M. I., Fidalgo, T. M., & Sanchez, Z. M. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112698 · Cited by 18

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

Ferrisi, R., Gado, F., Polini, B., Ricardi, C., Mohamed, K. A., Stevenson, L., Ortore, G., Rapposelli, S., Saccomanni, G., Pertwee, R. G., et al. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.984069 · Cited by 18

Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer’s Disease

Rathod, S., & Agrawal, Y. O. (2023) · Current Drug Research Reviews · doi:10.2174/2589977515666230502104021 · Cited by 18

Sex‐specific behavioural, metabolic, and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice

Corli, G., Roda, E., Tirri, M., Bilel, S., Luca, F. D., Rossi, S. S., Gaudio, R. M., De‐Giorgio, F., Fattore, L., Locatelli, C., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16311 · Cited by 18

Cannabinoids: Novel Therapies For Arthritis?

Dunn, S. L., Wilkinson, J. M., Crawford, A., Maitre, C. L. L., & Bunning, R. A. D. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.20 · Cited by 18

Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function

Towe, S. L., Meade, C. S., Cloak, C. C., Bell, R. P., Baptiste, J., & Chang, L. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09921-y · Cited by 18

Marijuana use and major depressive disorder are additively associated with reduced verbal learning and altered cortical thickness

Radoman, M., Hoeppner, S. S., Schuster, R. M., Evins, A. E., & Gilman, J. M. (2019) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-019-00704-4 · Cited by 18

Understanding Cannabinoid Psychoactivity with Mouse Genetic Models

Mackie, K. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050280 · Cited by 18

Cannabinoids: Emerging sleep modulator

Low, Z. X. B., Lee, X. R., Soga, T., Goh, B. H., Alex, D., & Kumari, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115102 · Cited by 17

Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial

Weizman, L., Sharon, H., Dayan, L., Espaniol, J., Brill, S., Nahman‐Averbuch, H., Hendler, T., & Jacob, G. (2024) · CNS Drugs · doi:10.1007/s40263-024-01085-0 · Cited by 17

Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity

Saliba, S. W., Bonifacino, T., Serchov, T., Bonanno, G., de Oliveira, A. C. P., & Fiebich, B. L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00566 · Cited by 17

Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility

Kichloo, A., Albosta, M. S., Aljadah, M. M., El‐amir, Z., Goldar, G., Khan, M. Z., Dahiya, D. S., Vallabhaneni, S., Wani, F., & Singh, J. (2021) · SAGE Open Medicine · doi:10.1177/20503121211000909 · Cited by 18

Sex-specific and social experience-dependent oxytocin–endocannabinoid interactions in the nucleus accumbens: implications for social behaviour

Borie, A. M., Young, L. J., & Liu, R. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0057 · Cited by 17

Endocannabinoid-Binding Receptors as Drug Targets

Gómez‐Cañas, M., Rodríguez‐Cueto, C., Satta, V., Hernández-Fisac, I., Navarro, E., & Fernández‐Ruíz, J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2728-0_6 · Cited by 17

Combined neuroprotective action of adenosine A1 and cannabinoid CB1 receptors against NMDA-induced excitotoxicity in the hippocampus

Serpa, A., Pinto, I., Bernardino, L. I., & Cascalheira, J. F. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.06.005 · Cited by 17

Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality

Carrascosa, A. J., Navarrete, F., Saldaña, R., García‐Gutiérrez, M. S., Moreno, B. M., Navarro, D., Gómez-Guijarro, F. M., Gasparyan, A., Murcia-Sánchez, E., Torregrosa, A. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116268 · Cited by 16

CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus

Shafiei-Jahani, P., Yan, S., Kazemi, M. H., Li, X., Akbari, A., Sakano, K., Sakano, Y., Hurrell, B. P., & Akbari, O. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114434 · Cited by 17

Angiotensin II-induced activation of central AT1 receptors exerts endocannabinoid-mediated gastroprotective effect in rats

Gyires, K., Rónai, A. Z., Zádori, Z., Tóth, V. É., Németh, J., Szekeres, M., & Hunyady, L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.002 · Cited by 16

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Expression and localization of CB1R, NAPE-PLD, and FAAH in the vervet monkey nucleus accumbens

Kucera, R., Bouskila, J., Elkrief, L., Fink‐Jensen, A., Palmour, R. M., Bouchard, J., & Ptito, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-26826-2 · Cited by 16

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Brugnatelli, V., Turco, F., Freo, U., & Zanette, G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00371 · Cited by 16

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Escelsior, A., Sterlini, B., Murri, M. B., Serafini, G., Aguglia, A., da Silva, B. P., Corradi, A. M., Valente, P., & Amore, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112734 · Cited by 16

Sex Differences in Neuropsychological Functioning are Domain-Specific in Adolescent and Young Adult Regular Cannabis Users

Savulich, G., Rychik, N., Lamberth, E., Hareli, M., Evins, A. E., Sahakian, B. J., & Schuster, R. M. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617720001435 · Cited by 17

Endocannabinoid Signaling in the Striatum

Lovinger, D. M., Davis, M. I., & Costa, R. M. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00009-3 · Cited by 16

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Hjorth, S., Karlsson, C., Jučaitė, A., Varnäs, K., Hamrén, U. W., Johnström, P., Gulyás, B. Z., Donohue, S. R., Pike, V. W., Halldin, C., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.002 · Cited by 16

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Bannigan, P., Evans, J. C., & Allen, C. J. (2020) · Cannabis and Cannabinoid Research · doi:10.1089/can.2020.0003 · Cited by 19

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Scott, J. C. (2022) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2022.06.002 · Cited by 16

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