Regulation of excitability by potassium channels
Abstract
Neurons express a large number of different voltage-gated potassium (Kv) channels with distinct biophysical and biochemical properties. Possibly, this diversity reflects the need to regulate and fine-tune neuronal excitability at various levels of complexity in space and time. In this context, Kv channels operating in the subthreshold range of action- potential firing are of particular interest. It is likely that these Kv channels play a prominent role in both propagating and integrating dendritic signaling, as well as axonal action-potential firing and propagation.
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SGK1 modulates neuron excitability by regulating K+ channels.
“SGK1 modulate neuron excitability by regulating the K+ channel”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Pongs, 2008
SGK1 helps regulate cellular osmoregulation primarily through activation of key ion channels.
“SGK1 helps regulate cellular osmoregulation, primarily through the activation of key ion channels”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Pongs, 2008
Cites
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781 · see citing works
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity
Hoshi, N., Langeberg, L. K., & Scott, J. D. (2005) · Nature Cell Biology · doi:10.1038/ncb1315 · Cited by 183 · see citing works
Zhang, L., & McBain, C. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020997 · Cited by 74 · see citing works
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Significance of SGK1 in the regulation of neuronal function
Lang, F., Strutz-Seebohm, N., Seebohm, G., & Lang, U. E. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190926 · Cited by 170 · see citing works
Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works
- Authors
- Pongs, O.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Pongs, O.
- Venue
- Results and Problems in Cell Differentiation
- Publisher
- Springer Berlin Heidelberg
- Published
- 2007-06-19
- Volume
- 44
- Pages
- 145-161
- OpenAlex
- W218827578
- Cited by
- 37
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 2.74
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- voltage-gated potassium channels, neuronal excitability, dendritic signaling, action potential propagation, axonal action potentials, neural integration
- MeSH terms
- Animals, Humans, Nervous System Diseases, Neurons, Ion Channel Gating, Excitatory Postsynaptic Potentials, Potassium Channels, Voltage-Gated
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